• Animal Bioscience
• /
• v.35 no.11
• /
• pp.1800-1807
• /
• 2022

Objective: This study aimed to determine the effect of different cooling sessions (CSs) as a water conservation strategy on physiological, and production responses and welfare in Holstein Friesian cows during subtropical summer in Pakistan. Methods: Twenty-one cows were subjected to three CS in a completely randomized design. The treatments were: i) eleven hours continuous cooling with sprinklers - control (CNT), ii) four CS, and iii) two CS. The CNT represented the practices of the commercial dairy farms in the area, while the other CSs were used as water reduction strategies. Each CS lasted for 1 h with a 12 min cycle (3 min water on and 9 min off) with a sprinkler flow rate of 1.25 L/min. Results: The average temperature humidity index of the shed and the outside open area were 81.9 and 82.5, respectively. The results showed that both physiological responses were highest in the 2CS group followed by the CNT and the 4CS (p = 0.001). The CNT and 4CS groups had similar milk yield (p = 0.040). The 4CS group had more lying and eating times than the CNT and 2CS groups (p = 0.000). The cortisol level in the 2CS group was 2.0 and 2.2 ㎍/dL more than the CNT and the 4CS groups, respectively (p = 0.000). Conclusion: In conclusion, the 4CS was more efficient in cooling the cows and had better welfare, as it yielded similar milk yield, and better physiological responses than the CNT despite using 90% less water.

• Steel and Composite Structures
• /
• v.41 no.6
• /
• pp.873-886
• /
• 2021

In this paper, an analytical solution for thermodynamic response of functionally graded (FG) sandwich plates resting on variable elastic foundation is performed by using a quasi 3D shear deformation plate theory. The displacement field used in the present study contains undetermined integral terms and involves only four unknown functions with including stretching effect. The FG sandwich plate is considered to be subject to a time harmonic sinusoidal temperature field across its thickness with any combined boundary conditions. Equations of motion are derived from Hamilton's principle. The numerical results are compared with the existing results of quasi-3D shear deformation theories and an excellent agreement is observed. Several numerical examples for fundamental frequency, deflection, stress and variable elastic foundation parameter's analysis of FG sandwich plates are presented and discussed considering different material gradients, layer thickness ratios, thickness-to-length ratios and boundary conditions. The results of the present study reveal that the nature of the elastic foundation, the boundary conditions and the thermodynamic loading affect the response of the FG plate especially in the case of a thick plate.

• Tunnel and Underground Space
• /
• v.32 no.6
• /
• pp.411-434
• /
• 2022

In deep geological disposal concept for spent nuclear fuel, it is well-known that rock mass at near-field experiences the thermal-hydraulic-mechanical (THM) coupled behavior. The mechanical properties of rock changes during the coupled process, and it is important to consider the changes into the analysis of numerical simulation and in-situ tests for long-term stability evaluation of nuclear waste disposal repository. This report collected the previous studies on indirect coupled behaviors of rock. The effects of water saturation and temperature on some mechanical properties of rock was considered, while the change in hydraulic conductivity of rock due to stress was included in the indirect coupled behavior.

• IEMEK Journal of Embedded Systems and Applications
• /
• v.17 no.1
• /
• pp.9-17
• /
• 2022

As the COVID-19 pandemic situation worsens, the time spent indoors increases, and the exposure to indoor environmental pollution such as indoor air pollution and noise also increases, causing problems such as deterioration of human health, stress, and discord between neighbors. This paper designs and implements a system that measures and monitors indoor air quality and noise, which are representative evaluation criteria of the indoor environment. The system proposed in this paper consists of a particulate matter measurement subsystem that measures and corrects the concentration of particulate matters to monitor indoor air quality, and a noise measurement subsystem that detects changes in sound and converts it to a sound pressure level. The concentration of indoor particulate matters is measured using a laser-based light scattering method, and an error caused by temperature and humidity is compensated in this paper. For indoor noise measurement, the voltage measured through a microphone is basically measured, Fourier transform is performed to classify it by frequency, and then A-weighting is performed to correct loudness equality. Then, the RMS value is obtained, high-frequency noise is removed by performing time-weighting, and then SPL is obtained. Finally, the equivalent noise level for 1 minute and 5 minutes are calculated to show the indoor noise level. In order to classify noise into direct impact sound and air transmission noise, a piezo vibration sensors is mounted to determine the presence or absence of direct impact transmitted through the wall. For performance evaluation, the error of particulate matter measurement is analyzed through TSI's AM510 instrument. and compare the noise error with CEM's noise measurement system.

• Structural Engineering and Mechanics
• /
• v.81 no.5
• /
• pp.617-631
• /
• 2022

In this paper the viscoelastic responses of four experimental steel-concrete composite beams subjected to highly variable environmental conditions are investigated by means of a finite element (FE) model. Concrete specimens submitted to stepped stress changes are also evaluated to validate the current formulations. Here, two well-known approaches commonly used to solve the viscoelastic constitutive relationship for concrete are employed. The first approach directly solves the integral-type form of the constitutive equation at the macroscopic level, in which aging is included by updating material properties. The second approach is postulated from a rate-type law based on an age-independent Generalized Kelvin rheological model together with Solidification Theory, using a micromechanical based approach. Thus, conceptually both approaches include concrete hardening in two different manners. The aim of this work is to compare and analyze the numerical prediction in terms of long-term deflections of the studied specimens according to both approaches. To accomplish this goal, the performance of several well-known model codes for concrete creep and shrinkage such as ACI 209, CEB-MC90, CEB-MC99, B3, GL 2000 and FIB-2010 are evaluated by means of statistical bias indicators. It is shown that both approaches with minor differences acceptably match the long-term experimental deflection and are able to capture complex oscillatory responses due to variable temperature and relative humidity. Nevertheless, the use of an age-independent scheme as proposed by Solidification Theory may be computationally more advantageous.

• Journal of the Korean Geotechnical Society
• /
• v.38 no.9
• /
• pp.45-52
• /
• 2022

Because discontinuity in the rock mass and contact of soil-structure interaction exhibits coupled thermal-hydromechanical (THM) behavior, it is necessary to develop an interface element based on the full governing equations. In this study, we derive force equilibrium, fluid continuity, and energy equilibrium equations for the interface element. Additionally, we present a stiffness matrix of the elastoplastic mechanical model for the interface element. The developed interface element uses six nodes for displacement and four nodes for water pressure and temperature in a two-dimensional analysis. The fully coupled THM analysis for fluid injection into a fault can model the complicated evolution of injection pressure due to decreasing effective stress in the fault and thermal contraction of the surrounding rock mass. However, the result of hydromechanical analysis ignoring thermal phenomena overestimates hydromechanical variables.

• Journal of Aerospace System Engineering
• /
• v.17 no.4
• /
• pp.18-27
• /
• 2023

In this paper, the structural-thermal-optical performance analysis of the mirror was performed by setting the laser heat source as the boundary condition of the thermal analysis. For the laser heat source model, the Beer-Lambert model considering semi-transparent optical material based on Gaussian beam was selected as the boundary condition, and the mechanical part was not considered, to analyze the performance of only the mirror. As a result of the thermal analysis, thermal stress and thermal deformation data due to temperature change on the surface of the mirror were obtained. The displacement data of the surface due to thermal deformation was fitted to a Zernike polynomial to calculate the optical performance, through which the performance of the mirror when a high-energy laser was incident on the mirror could be predicted.

• Journal of Korean Dental Science
• /
• v.16 no.1
• /
• pp.23-34
• /
• 2023

Purpose: This study aims to investigate the force delivery profile of thermoformed aligners (TFA) compared with direct-printed aligners (DPA) and to explore the effect of different activation amounts on forces and moments of respective groups. A secondary objective is to observe the amount of stress relaxation that occurs over the 7~14 days when aligners are maintained in a simulated intraoral environment. Materials and Methods: An in vitro setup was created to quantify forces and moments. It consisted of a three dimensional-printed base plate and segmented maxillary teeth, placed in a semi-enclosed chamber to maintain a temperature of 37℃. Ninety clear aligners were divided into nine groups of ten aligners each based on material types (Zendura, ATMOS, TC-85) and activation amounts. Aligners were created with 0.00, 0.25- and 0.50-mm activations for lingual bodily movement of the upper left central incisor and kept on models in the "stressed" position in a 37℃ water bath. Three force components acting on the upper left lateral incisor, upper left central incisor, and upper right central incisor were measured for each time point, beginning from the initial baseline measurement, 8 hours, 16 hours, 24 hours, 2 days, 3 days, 4 days, 5 days, 6 days, 7 days, and lastly, 14 days. Result: TC-85 aligners in every activation group showed less force on teeth than Zendura and ATMOS. Significant force levels from 0.0 mm activation were present and stayed consistent over the course of 14 days. Comparisons made for baseline measurements to 7-days and 14-days showed statistically significant change from the baseline force level. Conclusion: TC-85 aligners demonstrated lower, more consistent forces with fewer side effects. Aligners can generate forces even when no activation is programmed. No major decreases in force levels over time were observed; the intra-oral clinical simulated environment and length of observation time could contribute to this.

• Analytical Science and Technology
• /
• v.36 no.4
• /
• pp.180-190
• /
• 2023

The presence of process related impurities in any drug or the drug product was associated with its safety, stability and efficacy. The overall literature survey proved that there is no method published on the assessment of process related impurities in brigatinib. In this study, a simple, reliable and stable HPLC qualitative method was reported for quantification of process related impurities with easy and quick extraction procedure. The impurities along with standard brigatinib was resolved on Lichrospher^® C18 (250 mm × 4.6 mm; 5 ㎛ particle size) column in room temperature using methanol, acetonitrile, pH 4.5 phosphate buffer in 55:25:20 (v/v) at 1.0 mL/min as mobile phase and UV detection at 261 nm. The method produces well resolved peaks at retention time of 4.60 min, 12.28 min, 3.37 min, 7.34 min and 8.39 min respectively for brigatinib, impurity A, B, C and D. The method produces a very sensitive detection limit of 0.0065 ㎍/mL, 0.0068 ㎍/mL, 0.0053 ㎍/mL and 0.0058 ㎍/mL for impurity A, B, C and D respectively with calibration curve linear in the concentration range of 22.5-135 ㎍/mL for brigatinib and 0.0225-0.135 ㎍/mL for impurities. The method produces all the validation parameters under the acceptable level and doesn't produces any considerable changes in peak area response while minor changes in the developed method conditions. The method can effectively resolve the unknown stress degradation products along with known impurities with less % degradation. The method can efficiently resolve and quantify the impurities in formulation and hence can suitable for the routine quality analysis of brigatinib in raw material and formulation.

• Journal of Veterinary Clinics
• /
• v.40 no.1
• /
• pp.25-30
• /
• 2023

The ventral midline approach (VMA) and right flank approach (RFA) are common procedures for the sterilization of bitches. This study compared the different parameters viz. total duration of surgery, recovery time, and length of the incision as well as body temperature, heart rate, respiration rate, and SpO2 in each approach. Twenty (20) bitches were divided randomly for the RFA and VMA. Meloxicam (0.2 mg/kg) was administered subcutaneously half an hour before the induction to provide preemptive analgesia. Diazepam and ketamine were administered intravenously at dose rates of 0.25 mg/kg and 2.5 mg/kg, and 0.17 mg/kg and 3.33 mg/kg, respectively to produce and maintain anesthesia. Each parameter was recorded at the pre-operative, operative and post-operative times. The average duration of surgery and length of incision of RFA (16.1 ± 5.13 min and 2.44 ± 0.83 cm) were significantly lower (p < 0.05) than the VMA (21.3 ± 5.48 min and 3.53 ± 0.7 cm). The operated bitches showed hypothermia (p < 0.05) at 1 hour compared to baseline and 24 hours of surgery. Heart and respiration rates increased significantly (p < 0.05) during traction and severing of ovarian ligaments in bitches within the RFA group, but there was no significant difference within VMA approaches. The sedation score was significantly higher (p < 0.05) at 1 hour after surgery in both approaches. Based on the duration of surgery and length of incision RFA approach was quick and minimal skin wound. Further studies on bitches considering molecular investigations of surgical stress are imperative.