• Journal of Pharmaceutical Investigation
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• v.38 no.2
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• pp.127-134
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• 2008

Peroral administration is the most convenient one for the administration of pharmaceutically active compounds. Most of poorly water-soluble drugs administered via the oral route, however, remain poorly available due to their precipitation in the gastrointestinal (GI) tract and low permeability through intestinal mucosa. In this study, one of drug delivery carriers, lipid nanoparticles (LNPs) were designed in order to reduce side effects and improve solubility and stability in GI tract of the poorly water soluble drugs. However, plain LNPs are generally unstable in the GI tract and susceptible to the action of acids, bile salts and enzymes. Accordingly, the surface of LNPs was modified with polyethylene glycol (PEG) for the purpose of improving solubility and GI stability of paclitaxel (PTX) in vitro. PEG-modified LNPs containing PTX was prepared by spontaneous emulsification and solvent evaporation (SESE) method and characterized for mean particle diameter, entrapping efficiency, zeta potential value and in vitro GI stability. Mean particle diameter and zeta potential value of PEG-modified LNP containing PTX showed approximately 86.9 nm and -22.9 mV, respectively. PTX entrapping efficiency was about 70.5% determined by UV/VIS spectrophotometer. Futhermore, change of particle diameter of PTX-loaded PEG-LNPs in simulated GI fluids and bile fluid was evaluated as a criteria of GI stability. Particle diameter of PTX-loaded PEG-LNPs were preserved under 200 nm for 6 hrs in simulated GI fluids and bile fluid at $37^{\circ}C$ when DSPE-mPEG2000 was added to formulation of LNPs above 4 mole ratio. As a result, PEG-modified LNPs improved stability of plain LNPs that would aggregate in simulated GI fluids and bile solution. These results indicate that LNPs modified with biocompatible and nontoxic polymer such as PEG might be useful for enhancement of GI stability of poorly water-soluble drugs and they might affect PTX absorption affirmatively in gastrointestinal mucosa.

• Journal of Electrical Engineering and Technology
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• v.6 no.4
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• pp.447-458
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• 2011

In this paper, a novel flywheel energy storage device, called the flexible power conditioner, which integrates both the characteristics of the flywheel energy storage and the doubly-fed induction machine, is proposed to improve power system stability. A prototype is developed and its principle, composition, and design are described in detail. The control system is investigated and the operating characteristics are analyzed. The test results based on the prototype are presented and evaluated. The test results illustrate that the prototype meets the design requirement on power regulation and starting, and provides a cost-effective and effective means to improve power system stability.

• Tribology and Lubricants
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• v.29 no.6
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• pp.392-396
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• 2013

Biodiesel fuels contain unsaturated fatty acid ester, which can easily oxidize, especially when exposed to ultraviolet light. The products formed by this oxidation give rise to sediment or gum formation. As a result, the fuel can contribute to the corrosion and plugging of the filter pump. Antioxidants have been used in an effort to stabilize biodiesels, but there is still a need for a biodiesel composition with improved oxidation stability. In general, good fuel compositions should provide synergistic combinations of a biodiesel and antioxidants. Our work involved the synthesis of antioxidants to improve the oxidative stability of biodiesel fuel.

• Journal of the Korean Society of Environmental Restoration Technology
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• v.2 no.1
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• pp.94-102
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• 1999

The retaining wall is a structure which was made for changing land form in many construction. The first role of the retaining wall is to maintain the slope stability. But recently, the amount of retaining wall have been increasing because of the expansion of construction works and the amenity of urban environment have been decreasing because of environmental destruction and the scenic heterogeneity. So we should consider the slope stability and ecological stability at the same time. The purpose of this study is to develop the retaining wall revegetation technology using the Eco-Stone, the structure of co-satisfying which included the slope stability and the revegetation effect. Eco-Stone is a structure which has high stability for earth pressure, settlement and drainage. And cost and term of construction works also have been decreased. Eco-Stone structure is one of factors composing the ecological network which is harmonize with surrounding environment. In this way, it is expected that the ecological habitats of various species would be restored.

• Wind and Structures
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• v.37 no.1
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• pp.39-56
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• 2023

To ensure the wind stability of a long-span suspension bridge during deck erection under skew wind, based on the aerostatic and self-excited aerodynamic force models under skew wind, a computational approach of refined flutter analysis for long-span bridges under skew wind is firstly established, in which the effects of structural nonlinearity, the static wind action and full-mode coupling etc are fully considered, and the corresponding computational procedure is programmed. By taking the Runyang suspension bridge over the Yangtze River as example, the flutter stability of the bridge in completion under skew wind is then analyzed with the aerodynamic parameters of a similar bridge deck measured from the sectional model wind tunnel test under skew wind. Finally, through simulating the girder segments erected symmetrically from the midspan to towers, from the towers to midspan and simultaneously from the towers and midspan to the quarter points, respectively, the evolutions of flutter stability limits during the deck erection under skew wind are investigated numerically, the favorable aerodynamically deck erection sequence is proposed, and the influences of skew wind and static wind effect on the flutter stability of suspension bridge under construction are ascertained.

• Smart Structures and Systems
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• v.31 no.1
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• pp.69-78
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• 2023

The purpose of this paper is to develop a scalable grey predictive controller with unavoidable random delays. Grey prediction is proposed to solve problems caused by incorrect parameter selection and to eliminate the effects of dynamic coupling between degrees of freedom (DOFs) in nonlinear systems. To address the stability problem, this study develops an improved gray-predictive adaptive fuzzy controller, which can not only solve the implementation problem by determining the stability of the system, but also apply the Linear Matrix Inequality (LMI) law to calculate Fuzzy change parameters. Fuzzy logic controllers manipulate robotic systems to improve their control performance. The stability is proved using Lyapunov stability theorem. In this article, the authors compare different controllers and the proposed predictive controller can significantly reduce the vibration of offshore platforms while keeping the required control force within an ideal small range. This paper presents a robust fuzzy control design that uses a model-based approach to overcome the effects of modeling errors. To guarantee the asymptotic stability of large nonlinear systems with multiple lags, the stability criterion is derived from the direct Lyapunov method. Based on this criterion and a distributed control system, a set of model-based fuzzy controllers is synthesized to stabilize large-scale nonlinear systems with multiple delays.

• Journal of Animal Science and Technology
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• v.66 no.2
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• pp.412-424
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• 2024

Lairage, a part of the animal welfare practices, has been known to mitigate pre-slaughter stress in animals. However, research investigating the relationship between lairage and pork meat quality remains scarce. In this study, we conducted a comparative analysis of the physicochemical quality and storage stability of pork from pigs subjected to immediate slaughter (CON) and those provided with a 24 h lairage before slaughter (LRG) over a 7-day storage period. The loins from 20 castrated pigs in each group, respectively, were collected at 1, 3, 5, and 7 days and used for analysis of meat quality and storage stability, including pH, meat color, moisture, water holding capacity, drip loss, cooking loss, shear force, fatty acid composition, lipid oxidation, antioxidant activity, and electrical resistance. Overall, there were no significant differences in physicochemical meat quality parameters between CON and LRG groups. Similarly, no differences were observed in the storage stability of pork including 2-thiobarbituric acid reactive substances, 2,2-diphenyl-1-picrylhydrazyl radical scavenging activity and electrical resistance. However, the proportion of unsaturated fatty acids was significantly higher in LRG compared to CON. In conclusion, 24 h lairage for castrated pigs had limited impact on meat quality and storage stability but led to an increase in the unsaturated fatty acid proportion.

• Journal of Institute of Convergence Technology
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• v.10 no.1
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• pp.41-45
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• 2020

This paper presents the effects of a virtual mass on the stability boundary of a virtual spring in the haptic system with first-order-hold. The virtual rigid body is modeled as a virtual spring and a virtual mass. When first-order-hold is applied, we analyze the stability boundary of the virtual spring through the simulation according to the virtual mass and the sampling time. As the virtual mass increases, the stability boundary of the virtual spring gradually increases and then decreases after reaching the maximum value. The results are compared with the stability boundary in the haptic system with zero-order-hold. When a virtual mass is small, the stability boundary of a virtual spring in the system with first-order-hold is larger than that in the system with zero-order-hold.

• Journal of Electrical Engineering and Technology
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• v.1 no.1
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• pp.8-15
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• 2006

Since the power swing depends on the operating time of the relay, the swing's magnitude can be reduced by an autoreclosure relaying system with an optimal reclosing algorithm. This paper proposes a method for stability improvement using optimal reclosure relaying. An optimal reclosure algorithm is applied to identify both temporary and permanent faults, and to predict system stability by applying WAM and high speed communication technology. It provides optimal control by predicting and determining the degree of stability, considering the real time transient stability using EEEAC. For temporary faults, the algorithm determines the system's stability and either recloses optimally for stable systems, or inserts series capacitance before optimal reclosure for unstable systems. It also applies an optimal reclosure algorithm to minimize shock and damage to the power system when reclosure fails due to permanent faults.

• Journal of Korea Ship Safrty Technology Authority
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• s.22
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• pp.19-33
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• 2007

According to amendments of ship safety act which comes into force from 4 Nov. 2007, the amended stability criteria should be applied to the small vessels of 12m or more in length. In this paper, the dimensions of domestic small vessels and the casualty reports of capsizing accidents are analyzed. And 58 ships are sampled, modeled for the investigation of the stability performance. Based on the regression analysis of the model ship's allowable metacentric-heights under several stability requirements, stability criteria for small fishing vessels and cargo ships are proposed.