• Journal of Animal Science and Technology
• /
• v.64 no.6
• /
• pp.1117-1131
• /
• 2022

Previous studies reported that Bifidobacterium animalis ssp. lactis HY8002 (HY8002) improved intestinal integrity and had immunomodulatory effects. Lactobacillus plantarum HY7717 (HY7717) was screened in vitro from among 21 other lactic acid bacteria (LAB) and demonstrated nitric oxide (NO) production. The aims of this study were to investigate the individual and combined ex vivo and in vivo effects of LAB strains HY8002 and HY7717 at immunostimulating mice that have been challenged with an immunosuppressant drug. The combination of HY8002 and HY7717 increased the secretion of cytokines such as interferon (IFN)-γ, interleukin (IL)-12, and tumor necrosis factor (TNF)-α in splenocytes. In a cyclophosphamide (CTX)-induced immunosuppression model, administration of the foregoing LAB combination improved the splenic and hematological indices, activated natural killer (NK) cells, and up-regulated plasma immunoglobulins and cytokines. Moreover, this combination treatment increased Toll-like receptor 2 (TLR2) expression. The ability of the combination treatment to upregulate IFN-γ and TNF-α in the splenocytes was inhibited by anti-TLR2 antibody. Hence, the immune responses stimulated by the combination of HY8002 and HY7717 are associated with TLR2 activation. The preceding findings suggest that the combination of the HY8002 and HY7717 LAB strains could prove to be a beneficial and efficacious immunostimulant probiotic supplement. The combination of the two probiotic strains will be applied on the dairy foods including yogurt and cheese.

• Geomechanics and Engineering
• /
• v.22 no.3
• /
• pp.255-264
• /
• 2020

With the ongoing development of deep mining of coal resources, some coal mine dynamic disasters have exhibited characteristics of both coal-gas outbursts and rockbursts. Therefore, research is required on the mechanism of rockburst-outburst coupling disaster. In this study, the failure characteristics of coal-rock combination structures were investigated using lab-scale physical simulation experiments. The energy criterion of the rockburst-outburst coupling disaster was obtained, and the mechanism of the disaster induced by the gas-solid coupling instability of the coal-rock combination structure was determined. The experimental results indicate that the damage of the coal-rock structure is significantly different from that of a coal body. The influence of the coal-rock structure should be considered in the study of rockburst-outburst coupling disaster. The deformation degree of the roof is controlled by the more significant main role of the gas pressure and the difference in the strength between the rock body and the coal body. The outburst holes and spall characteristics of the coal body after the failure of the coal-rock structure are strongly affected by the difference in strength between the roof and the coal body. The research results provide an in-depth understanding of the mechanism of rockburst-outburst coupling disasters in deep mining.

• Fashion & Textile Research Journal
• /
• v.6 no.2
• /
• pp.239-244
• /
• 2004

On the whole the various medium colors were developed by repeat dyeing with different colorants after dyeing with one colorant in case of natural dyeing. In this study, in order to obtain various colors on wool fabrics with Gardenia and Sappan wood colorants, pre-mordanting and combination dyeing were carried out. Gardenia and Sappan wood used as natural colorants for combination dyeing showed good miscibility in dye bath, Metal compounds containing alum, copper and iron were used for pre-mordants. The various medium colors such as yellow-red were obtained according to various metal compounds for pre-mordants and various mixing portion of these natural colorants. The surface reflactance spectra and color characteristics of wool fabrics by mordanting and combination dyeing were investigated.

• Fashion & Textile Research Journal
• /
• v.4 no.2
• /
• pp.192-197
• /
• 2002

On the whole the various medium colors were developed by repeat dyeing with different colorants after dyeing with one colorant in case of natural dyeing. In this study, however in order to obtain various colors on silk fabrics with natural dyes, pre-mordanting and combination dyeing were carried out. Metal compounds containing alum, copper and iron were used for pre-mordants. Gardenia and Sappan wood were used as colorants for combination dyeing. In combination dyeing of Gardenia and Sappan wood, these two natural colorants showed good miscibility in dye bath. The various colors were obtained according to various metal compounds for pre-mordants and various mixing portion of Gardenia and Sappan wood.

• Journal of Information Processing Systems
• /
• v.15 no.6
• /
• pp.1489-1502
• /
• 2019

This work introduces a novel unweighted combination method (UCSS) for business failure perdition (BFP). With considering features of BFP in the age of big data, UCSS integrates the quantitative and qualitative analysis by utilizing soft set theory (SS). We adopt the conventional expert system (ES) as the basic qualitative classifier, the logistic regression model (LR) and the support vector machine (SVM) as basic quantitative classifiers. Unlike other traditional combination methods, we employ soft set theory to integrate the results of each basic classifier without weighting. In this way, UCSS inherits the advantages of ES, LR, SVM, and SS. To verify the performance of UCSS, it is applied to real datasets. We adopt ES, LR, SVM, combination models utilizing the equal weight approach (CMEW), neural network algorithm (CMNN), rough set and D-S evidence theory (CMRD), and the receiver operating characteristic curve (ROC) and SS (CFBSS) as benchmarks. The superior performance of UCSS has been verified by the empirical experiments.

• Journal of the Korean Society of Safety
• /
• v.20 no.2 s.70
• /
• pp.38-43
• /
• 2005

Several nuclear power plants reported that they often found the combination cracks, which consist of longitudinal and circumferential cracks in the tubes. For the burst pressure of a tube with a single longitudinal or circumferential crack several experimental equations have been proposed in published literatures. But for the combination crack appropriate fracture criterion has not been proposed yet. In this study the burst pressures of a tube with a longitudinal crack or a T-type combination crack consisting of longitudinal and circumferential cracks were obtained experimentally and analytically. Fracture parameters such as crack opening angle (COA) were investigated by using elastic plastic analysis. Also the burst pressure far a T-type combination crack located near a tubesheet was considered to develop a length-based criterion. Because most of the axial, circumferential or combination cracks initiate in roll transition zone near the tubesheet.

• Geomechanics and Engineering
• /
• v.24 no.2
• /
• pp.179-191
• /
• 2021

In this study, the strength and failure mechanism of red sandstones with combined defects were investigated by uniaxial compression tests on red sandstones with different crack angles using two-dimensional particle flow code numerical software, and their mechanical parameters and failure process were studied and analyzed. The results showed that the mechanical characteristics such as peak strength, peak strain, and elastic modulus of the samples with prefabricated combined defects were significantly inferior than those of the intact samples. With increasing crack angle from 15° to 60°, the weakening area of cracks increased, elastic modulus, peak strength, and peak strain gradually reduced, the total number of cracks increased, and more strain energy was released. In addition, the samples underwent initial brittle failure to plastic failure stage, and the failure form was more significant, leading to peeling phenomenon. However, with increasing crack angle from 75° to 90°, the crack-hole combination shared the stress concentration at the tip of the crack-crack combination, resulted in a gradual increase in elastic modulus, peak strain and peak strength, but a decrease in the number of total cracks, the release of strain energy reduced, the plastic failure state weakened, and the spalling phenomenon slowed down. On this basis, the samples with 30° and 45° crack-crack combination were selected for further experimental investigation. Through comparative analysis between the experimental and simulation results, the failure strength and final failure mode with cracks propagation of samples were found to be relatively similar.

• Journal of the Korean Society of Manufacturing Technology Engineers
• /
• v.7 no.5
• /
• pp.113-119
• /
• 1998

Air spring has the advantages to be nearly constant in natural frequency inspite of load change, and to be able to control height level. Half-long taper spring has the advantages to function as well link as spring. Thus to utilize two type spring's advantages, half-long taper spring and air spring are combined and used. In this study, the theory to calculate the characteristics in combination is developed.

• Bulletin of the Korean Chemical Society
• /
• v.11 no.3
• /
• pp.181-183
• /
• 1990

• International Journal of Naval Architecture and Ocean Engineering
• /
• v.10 no.6
• /
• pp.730-740
• /
• 2018

Hydrofoil is the direct component to generate thrust for underwater glider. It is significant to improve propulsion efficiency of hydrofoil. This study optimizes the shape of a hydrofoil using Free-Form Deformation (FFD) parametric approach and Surrogate-based Optimization (SBO) algorithm. FFD approach performs a volume outside the hydrofoil and the position changes of control points in the volume parameterize hydrofoil's geometric shape. SBO with adaptive parallel sampling method is regarded as a promising approach for CFD-based optimization. Combination of existing sampling methods is being widely used recently. This paper chooses several well-known methods for combination. Investigations are implemented to figure out how many and which methods should be included and the best combination strategy is provided. As the hydrofoil can be stretched from airfoil, the optimizations are carried out on a 2D airfoil and a 3D hydrofoil, respectively. The lift-drag ratios are compared among optimized and original hydrofoils. Results show that both lift-drag-ratios of optimized hydrofoils improve more than 90%. Besides, this paper preliminarily explores the optimization of hydrofoil with root-tip-ratio. Results show that optimizing 3D hydrofoil directly achieves slightly better results than 2D airfoil.