• Title/Summary/Keyword: Technological Impact

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Impact of AhR, CYP1A1 and GSTM1 Genetic Polymorphisms on TP53 R273G Mutations in Individuals Exposed to Polycyclic Aromatic Hydrocarbons

  • Gao, Meili;Li, Yongfei;Xue, Xiaochang;Long, Jiangang;Chen, Lan;Shah, Walayat;Kong, Yu
    • Asian Pacific Journal of Cancer Prevention
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    • v.15 no.6
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    • pp.2699-2705
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    • 2014
  • This study was to undertaken to investigate the impacts of AhR, CYP1A1, GSTM1 genetic polymorphisms on the R273G mutation in exon 8 of the tumor suppressor p53 gene (TP53) among polycyclic aromatic hydrocarbons (PAHs) exposed to coke-oven workers. One hundred thirteen workers exposed to PAH and 82 control workers were recruited. We genotyped for polymorphisms in the AhR, CYP1A1, GSTM1, and TP53 R273G mutation in blood by PCR methods, and determined the levels of 1-hydroxypyrene as PAH exposure marker in urine using the high pressure liquid chromatography assay. We found that the distribution of alcohol users and the urinary excretion of 1-OHP in the exposed workers were significantly higher than that of the control workers (p=0.004, p<0.001, respectively). Significant differences were observed in the p53 genotype distributions of smoking subjects (p=0.01, 95%CI: 1.23-6.01) and PAH exposure (p=0.008, 95%CI: 1.24-4.48), respectively. Further, significant differences were observed in the p53 exon 8 mutations for the genetic polymorphisms of Lys/Arg for AhR (p=0.02, 95%CI: 0.70-15.86), Val/Val for CYP1A1 (p=0.04, 95%CI: 0.98-19.09) and null for GSTM1 (p=0.02, 95%CI: 1.19-6.26), respectively. Our findings indicated that polymorphisms of PAH metabolic genes, such as AhR, CYP1A1, GSTM1 polymorphisms may interact with p53 genetic variants and may contribute to PAH related cancers.

A Delphi Study of Standardization Strategies for Disruptive Technologies (파괴적 기술 분야에 대한 표준화 전략 연구: 전문가 델파이 조사를 중심으로)

  • Eom, Doyoung;Kim, Dong-hyu;Lee, Heejin
    • Journal of Korea Technology Innovation Society
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    • v.19 no.3
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    • pp.483-510
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    • 2016
  • Disruptive technology is increasingly gaining attention by industries, standards development organizations (SDOs), academia, government and regulatory bodies due to its massive scope of impact on the incumbents and consumers. Companies that take a lead in new technologies intend to dominate the global market by making their technologies into an international standard. However, they tend to seek ways of by-passing the slow procedures of formal SDOs that often hinder prompt action in response to rapid changes in technology and market situations. In the area of disruptive technologies, there is a need to harmonize standardization efforts in formal SDOs for various companies and stakeholders to reap the benefits of technological development and diffusion of innovation. This paper examines the reasons why standardization is more active using market-based mechanisms than through formal SDOs for disruptive technologies. We conducted a Delphi study to investigate standardization strategies in the area of disruptive technologies. This research found that experts understood the core element of disruptive technologies as creating new markets and changing the competition basis in existing industries through the transformation of consumers' behavior. Based on these core characteristics, experts agreed that flexibility and speed are the most important factors for standardization. Results also show that the perception that standardization activities are not directly connected to companies' profit-making is the key barrier to links between research and companies' participation in standardization. This research provides implications for formal SDOs and policymakers.

Key Factors of the Utilization and Improvement in the National-level Technology Roadmap (국가수준 기술로드맵의 활용도 및 개선사항 영향요인)

  • Park, Sang-Moon;Byun, Do-Young;Son, Seok-Ho
    • Journal of Korea Technology Innovation Society
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    • v.10 no.1
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    • pp.143-164
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    • 2007
  • This paper investigates key factors on the utilization and improvement directions of national-level technology roadmaps for technology strategies. There are increasing interest in technology roadmaps to respond to uncertain environment and explore some possible directions of future technology development. To challenge the catching-up status in innovation, technology roadmap have been widely developed both in private and public sectors. In spite of recent increasing adoption of technology roadmap, there are few empirical studies on the level of utilization and improvement directions of technology roadmap with the viewpoints from science and technology experts in national innovation system. Most of studies on technology roadmaps have argued normative recommendations and made suggestions based on case studies. This paper examines the key factors on the utilization and future direction of national-level technology roadmaps. Based on survey from 320 experts in science and technology area, this paper analyzes the level of utilitation and future improvements of national level technology roadmap. The level of technological capabilities and participation experience on the roadmap development process have significant impact on the utilization of national-level technology roadmaps. Also there are three future directions to increase the usage of national-level technology roadmaps. The national-level technology roadmap should be improved as a more systematic processes including planning, progress, and outputs. Finally, this paper suggests some implications and future guidelines for national-level technology roadmaps.

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The Impact of Corporate Product Innovation on the Firm's Revenue and Financial Stability (제품혁신이 기업의 수익 및 재무안정성에 미치는 영향)

  • Lim, Dong-Geon;Jung, Jin Hwa
    • Journal of Technology Innovation
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    • v.25 no.4
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    • pp.239-261
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    • 2017
  • This paper analyzes how corporate product innovation affects firms' revenue and financial stability, and thereby draws the implications for the corporate strategy for sustainable growth. Corporate product innovation is defined as the development of new products within the firm, including bought-in products. Corporate revenue is measured by per capita sales and its growth rate, while financial stability is measured by debt-to-equity ratio and liquidity ratio. In the empirical analysis, the two-stage estimation method was used to control for the endogeneity of new product development. The data are drawn from the first (2005) to the sixth (2015) wave of the Human Capital Corporate Panel (HCCP) Survey, which are matched to the data from the Korea Investors Service (KIS). The results of the first-stage estimation indicate that product innovation of the firm is promoted by the firm's knowledge capital stock, human resources investment, and market-leading strategy. The second-stage estimation results indicate a positive relationship between the firm's level of activity in product innovation and short-term revenue (per capita sales and its growth), and financial stability (lower debt-to-equity ratio and higher liquidity ratio). These findings confirm that the firm's investment in technology innovation and subsequent product innovation are important strategies to enhance both short-term corporate revenue and long-term financial stability.

A Study on the Measurement and Effect Factors of Productivity of the Korean Ocean Carriers (금융위기 이후 국적 외항선사의 생산성 측정과 영향요인에 관한 연구)

  • Nam, Hyung-Sik;Ahn, Ki-Myung
    • Journal of Navigation and Port Research
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    • v.44 no.4
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    • pp.338-346
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    • 2020
  • In this study, we first measured the Malmquist productivity index by DEA among the Korean ocean carriers. Second, it was intended to present measures to improve productivity by identifying the influence and discriminating power between productivity and the major financial ratios (profitability, financial stability, liquidity, efficiency and value-added productivity). Compared to 2017, there are 11 more shipping carriers with decline in productivity (MPI) than those with an increase in 2018. The increase in productivity is attributed to an increase in the Technology Change Index (TCI) affected by the external environment. There is strong significant correlation between the productivity (MPI) and the management efficiency (CRS). Additionally, the TECI (TECHI) index of the technological efficiency changes from internal factors of the shipping carrier is significantly higher than that of the efficient shipping carrier. This is because of the differences in scale efficiency. The ratio of charter cost/sales is also lower than that of the carriers with high productivity (0.17) and with low productivity (0.21). With 7% of the shipping carrier with MPI>1, only 1% of MPI <1 is found to have a significant impact on its productivity.

Risk Identification and Priority method for Overseas LNG Plant Projects - Focusing on Design Phase - (해외 LNG 플랜트 리스크요인 도출 및 우선순위 평가 - 설계단계를 중심으로 -)

  • Jang, Woo-Sik;Hong, Hwa-Uk;Han, Seung-Heon
    • Korean Journal of Construction Engineering and Management
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    • v.12 no.5
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    • pp.146-154
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    • 2011
  • Korean contractors have been maintained sustainable growth since entering into overseas construction market for the first time in 1960' s. In 2010, Korean contractors ordered 761 billion (USD) from overseas markets. Especially, billion (USD) were earned by Korean contractors in overseas plant construction market which account for more than 80% of the total amount by Korean contractors. Nevertheless, many Korean contractors are suffering from lack of technological competitiveness and construction management skills in the design phase compared with global leading contractors. These conditions have directly effect on the success of projects in terms of cost, duration, and quality. So, this study focused on identifying the risk factors and developing risk priority method for the design phase of LNG plant projects whose market is expanding. Research procedures were conducted by the following three steps. First, total 57 risk factors were identified in design phase through extensive literature reviews and experts survey. Second, the authors developed risk priority method which are more suitable for design phase of LNG plant projects by using three criteria, Probability(P), Impact(I), and Coordination Index(CI). Finally, the suitability of risk priority method and practical applicability were verified through expert survey and interview. Consequently, if korean contractors use the suggested risk factors and priority method based on their own know-how and experiences, then more reasonable and rational risk management will be conducted in the design phase of LNG plant projects.

Research of sustainable Social-Economy Business Model Development utilizing Internal Resource -Case study of Incheon International Airport Corporation- (내부자원을 활용한 지속가능한 사회적경제 비즈니스모델 개발 연구 -인천국제공항공사 사례 중심으로-)

  • Kim, Jung-Min;Yang, Dong-Heon;Bang, Sun-Yi
    • Journal of Digital Convergence
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    • v.13 no.12
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    • pp.63-73
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    • 2015
  • Many domestic companies have connections with social enterprise as one of the corporate social responsibility. However, majority of those connections are typically occasional, one-time donation. Therefore, current study focused on how to develop/nurture sustainable business model of social economy, which utilizes the companies' internal resources enabling communities to actually feel the impact. Literature survey for 25 reports and 123 business models for the past 5 years was performed and analyzed in terms of social-economy business models and job creation. It was found that the success factors of the job creation are: internal resources analysis, business model development, and support activities for execution (probono). Based upon the findings, DIDOV (Define-Identify-Design-Optimize-Verify) methodology was used to understand the effects of government policies and technological environment. As an exemplary case, Incheon International airport Corporation was selected and investigated for internal resources and related business models. Finally, 9 social-economy business models are derived for Incheon International airport Corporation in relation to the airport services offered.

Impact of Internal Marketing Factors on Technological Innovation and Perceived Service Quality in Telecommunications (내부마케팅 요인이 조직의 기술혁신과 지각된 서비스 품질에 미치는 영향)

  • Jung, Gap-Jin;Hwang, Hee-Joong;Song, In-Am
    • Journal of Distribution Science
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    • v.13 no.6
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    • pp.87-96
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    • 2015
  • Purpose - Several domestic telecommunication companies have made a considerable effort to continuously grow and survive, and they have strived to thrive in the midst of mature market competition. To overcome this challenging situation and to grow continuously, while still meeting customer needs that are becoming more diverse and complicated with the passage of time, extensive support for internal marketing is essential. Without such internal support, companies face serious limitations and market roadblocks. The communication industry is a high-level service industry and a basic communications industry characteristic is its significant dependence on the employees delivering the services. Therefore, entrepreneurs in the information/communications industry, as well as existing competitors, should look to satisfy external customers through critical investment in internal customers (employees). Therefore, it is important for research to examine how internal factors influence technology innovation and service quality, which are the key drivers for companies that are seeking leading market positions. Research design, data, and methodology - The purpose of this study is to analyze the relationship of technology innovation and perceived service quality with the internal marketing factors in the communication industry and to offer suitable and effective internal marketing suggestions. The independent variables of this study are internal communication, education and training, the support of the executives, reward systems, and empowerment. The dependent variables are technology innovation and perceived service quality. Utilizing these, this paper studies the influence of internal marketing factors on technology innovation and perceived service quality. Results - The study results revealed the following. First, the identified internal marketing factors have a positive effect on technology innovation. Among the five internal marketing factors, three had a significant effect on product innovation, empowerment, the support of executives, and education and training, in this order. Second, the internal marketing factors also had a positive effect on the process innovation of technology innovation. The marketing factors, the support of executives, empowerment, internal communication, and education and training, in this order, significantly affect process innovation. Third, technology innovation had a positive effect on perceived service quality. All of the five service quality factors, namely, tangibles, reliability, assurance, responsibility, and empathy, in this order, significantly affect product innovation. Additionally, tangibles, reliability, responsibility, empathy, and assurance, in this order, significantly affect process innovation. Fourth, product and process innovation significantly affect tangibles and reliability in technology innovation. To enhance tangibles and reliability, process innovation should first be enhanced. Fifth, product and process innovation significantly affect responsibility and empathy in technology innovation. To enhance the responsibility and empathy, process innovation should first be enhanced. Sixth, product and process innovation significantly affect assurance in technology innovation. To enhance the assurance, product innovation should first be enhanced. Conclusions - According to the results, a company's internal marketing factors have a positive and significant effect on technology innovation and, further, product and process innovation have a positive and significant effect on the perceived serviced quality.

A Study on the Improvement of the Policy Utilization of Technology Foresight Using a Scenario : Renewable Energy Scenario (시나리오를 이용한 과학기술예측조사의 정책 활용도 제고에 관한 연구 : 신재생에너지 시나리오)

  • Yim, Hyun;Han, Jong-Min;Son, Seok-Ho;Hwang, Ki-Ha
    • Journal of Technology Innovation
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    • v.18 no.1
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    • pp.53-74
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    • 2010
  • The creation and acceptance of new technologies has been speeding up dramatically in modern times. There are also significant uncertainties about the future shape of markets, governance and social values that will have an important impact on organizations and their capacity to meet their objectives. These rapid technological and social change and uncertainties make the upsurge of interest in technology foresight, giving rise to its emergence as a global concept and policy tool. A wide range of future methods are available for technology foresight. Selection of methods will depend upon several factors, most notably available and the time financial resources, and the objectives of the exercise. Although Delphi has been widely used for many years, scenario becomes very popular in recent years. The use of scenarios can take better account of the complexity and unpredictability of the economic, social and political environments. Scenarios tell the stories describing paths to different futures, which help organizations make better decisions today. In this study, the scenario method was employed to draw the images of the future of renewable energy. Renewable energy grows dramatically in recent years. However, there is still considerable uncertainty with regard to the potential of renewable energy due to environment regulation, energy costs, and political and economic developments in the main supplier countries for oil and natural gas. Scenario can help us to identify the risks and opportunities when we develop the renewable energy, and to prepare for them. The scenario method is expected to be more utilized in the national technology foresight.

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An Analysis of the Economic Effects for the IoT Industry (사물인터넷 산업의 경제적 파급효과 분석)

  • Jeong, Woo-Soo;Kim, Sa-Hyuk;Min, Kyoung-Sik
    • Journal of Internet Computing and Services
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    • v.14 no.5
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    • pp.119-128
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    • 2013
  • As ICT technology becomes advanced, the importance of future internet is emphasized and in part of that, M2M (Machine-to Machine communications) is magnified in terms of importance and usage in public and private sector. M2M is emerging as a next generation strategic industry but there is no existing analyzed data or market classification, so it disrupts establishing policies on the M2M industry. As the technology is progressing, the evolution from M2M to IoT (Internet of Things) has started and many countries actively try to find technological trend through market analysis in order to develop new growth engine. Therefore, in order to strengthen competitiveness, we should secure differentiated capabilities in industry and service. This article examines Korea's domestic market and international market trends in IoT and analyses the economic impact of the IoT industry using quantitative methodology and evaluates relations between the IoT industry and other relevant industries. As a result, the effect of IoT industry on production inducement is KRW474.6 billion; the effect on value-added inducement is KRW314.7 billion; and it is measured that 3,628 jobs will be created by the IoT industry.