• Title/Summary/Keyword: Tau

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Preparation of Ampholyte Grafted Hollow-fiber Membrane and Its Adsorption Characteristic on Metallic Ions (양성전해질 고정막의 제조 및 그것의 금속이온 흡착 특성)

  • Choi, Hyuk-Jun;Park, Sang-Jin;Kim, Min
    • Membrane Journal
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    • v.20 no.2
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    • pp.151-158
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    • 2010
  • This paper presents the synthesis of ampholyte immobilized hollow-fiber membranes and adsorption characteristic of metallic ions. This is prepared by radiation induced grafting polymerization of an epoxy group containing Glycidyl methacrylate (GMA) onto an existing polyethylene porous hollow-fiber membrane. Ampholyte ion-exchanged alkalic group, $-NH_2$ (amine function) of Taurine (TAU) is reacted with glycidyl of GMA for the synthesis of stable membrane. However, Sodium sulfite (SS) membrane is also prepared by making chemical bonds with GMA of porous hollow-fiber membrane for the comparison of adsorption characteristic of metallic ions. These are called as TAU and SS membranes, respectively. It is shown that TAU membrane shows a steady flux, 0.9 m/h regardless of the density of TAU, while the flux of SS membrane decreases rapidly as the density of $SO_3H$ group increases. SS membrane showed a negligible flux. TAU membrane with the density 0.8 mmol/g shows the amount of metallic ions adsorbed in the following order, Cu > Cd > Mg > Sb > Pb. In general, TAU membrane with high density and reaction time showed the high amount of metallic ions adsorbed and flux.

A Study of Gerontological Nursing Curriculum (노인간호학 교과과정에 대한 조사연구)

  • 전시자;공은숙;김귀분;김남초;김주희;김춘길;김희경;노유자;송미순
    • Journal of Korean Academy of Nursing
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    • v.31 no.5
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    • pp.808-817
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    • 2001
  • To survey the present status of the gerontological nursing course at three year diploma programs, baccalaureate degree programs(BSN), and graduate programs in Korea, and to analyze the contents of the syllabus and gerontological nursing textbooks to provide the basic data in developing a standard model for gerontological nursing curriculum. Method: Data was collected from all the nursing programs in Korea from Nov. 2000 to Feb. 2001 by mail and fax. Result: The gerontological nursing courses has been offered 36 diploma program, 40 BSN, and 17 graduate programs. And the credits of the gerontological nursing course offered by the program were as follows : one credit (10 diploma and 8 BSN), two credits (22 diploma and 29 BSN), and three credits (1 BSN). The contents of curri- culum were analyzed by comparing the core curriculum of NGNA. The majority of the schools included Gerontological Nursing in General, Theory of Aging, Aging Processes, Care Plan Options, and Common Health Problems. The subjects which very few school cover are Legal/ Ethical Issues, Evaluation, Regulatory & Reimbursement Issues, Education Issues, Nursing Research in Gerontology, and Environmental Issues of Older Adults. There were some differences in these results among diploma courses, BSNs, and graduate schools. The gerontological nursing textbooks contained similar contents to those of the diploma and the baccalaureate programs.

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Production of superoxide anion, nitric oxide and tumor necrosis factor-$\alpha$ by cultured murine peritoneal leukocytes is inhibited by taurine chloramine

  • Kim, Chaekyun;Park, Eunkyue;Michael R. Quinn
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 1996.04a
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    • pp.177-177
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    • 1996
  • Taurine Chloramine (Tau-Cl) inhibits production of nitric oxide(NO) and tumor necrosis factor-alpha (TNF-${\alpha}$) in activated peritoneal macrophages, similar In that previously reported for activated RAW 264.7 cells. In addition, the effect of Tau-Cl and taurine on superoxide anion (O$\_$2/$\^$-/) Production in murine peritoneal exudate polymorphonuclear leukocytes (PMN) was examined. Tau-Cl inhibited O$\_$2/$\^$-/ production in a manner that was dose-dependent and reversible, Taurine also inhibited O$\_$2/$\^$-/ production by stimulated PMN, but at higher concentrations and to a lesser extent than Tau-Cl. The effects of taurine on O$\_$2/$\^$-/ production was attributed to the in vitro formation of Tau-Cl catalyzed by PMN associated halide-dependent myeloperoxidase. In contrast, production of NO and TNF-${\alpha}$ by activated peritoneal exudate macrophages was inhibited by Tau-Cl while taurine was without effect. These data lend support to the notion that Tau-Cl may participate ill the inflammatory responses by modulating production of inflammatory mediators.

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The Prediction of Chaos Time Series Utilizing Inclined Vector (기울기백터를 이용한 카오스 시계열에 대한 예측)

  • Weon, Sek-Jun
    • The KIPS Transactions:PartB
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    • v.9B no.4
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    • pp.421-428
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    • 2002
  • The local prediction method utilizing embedding vector loses the prediction power when the parameter r estimation is not exact for predicting the chaos time series induced from the high order differential equation. In spite of the fact that there have been a lot of suggestions regarding how to estimate the delay time ($\tau$), no specific method is proposed to apply to any time series. The inclinded linear model, which utilizes inclinded netter, yields satisfying degree of prediction power without estimating exact delay time ($\tau$). The usefulness of this approach has been indicated not only theoretically but also in practical situation when the method w8s applied to economical time series analysis.

Molecular and Cellular Basis of Neurodegeneration in Alzheimer's Disease

  • Jeong, Sangyun
    • Molecules and Cells
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    • v.40 no.9
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    • pp.613-620
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    • 2017
  • The most common form of senile dementia is Alzheimer's disease (AD), which is characterized by the extracellular deposition of amyloid ${\beta}-peptide$ ($A{\beta}$) plaques and the intracellular formation of neurofibrillary tangles (NFTs) in the cerebral cortex. Tau abnormalities are commonly observed in many neurodegenerative diseases including AD, Parkinson's disease, and Pick's disease. Interestingly, tau-mediated formation of NFTs in AD brains shows better correlation with cognitive impairment than $A{\beta}$ plaque accumulation; pathological tau alone is sufficient to elicit frontotemporal dementia, but it does not cause AD. A growing amount of evidence suggests that soluble $A{\beta}$ oligomers in concert with hyperphosphorylated tau (pTau) serve as the major pathogenic drivers of neurodegeneration in AD. Increased $A{\beta}$ oligomers trigger neuronal dysfunction and network alternations in learning and memory circuitry prior to clinical onset of AD, leading to cognitive decline. Furthermore, accumulated damage to mitochondria in the course of aging, which is the best-known nongenetic risk factor for AD, may collaborate with soluble $A{\beta}$ and pTau to induce synapse loss and cognitive impairment in AD. In this review, I summarize and discuss the current knowledge of the molecular and cellular biology of AD and also the mechanisms that underlie $A{\beta}-mediated$ neurodegeneration.

Gene Expression of Taurine Transporter and Taurine Biosynthetic Enzyme During Embryonic Development

  • Yoon, Seyng-Hyun;Kim, Ha-Won
    • Proceedings of the Korean Society of Applied Pharmacology
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    • 2003.11a
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    • pp.87-87
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    • 2003
  • Taurine (2-aminoethanesulfonic acid, $^{+}NH_3CH_2CH_2{SO_3}^{-}$) is endogenous $\beta$-amino acid which is essential in fetal nutrition and development and is present in abundant quantities in several tissues of fetus. In utero, taurine deficiency causes abnormal development and abnormal function of brain, retina, kidney and myocardium. Thus, transfer of taurine into fetus is important during embryonic development. Taurine transporter (TauT) has 12 hydrophobic membrane -spanning domains, which is typical of the $Na^{+}$- and $Cl^{-}$-dependent transporter gene family. Among the various biosynthetic enzymes of taurine, cysteine sulfinic acid decarboxylase (CSD) is the rate-limiting enzyme for biosynthesis of taurine. However, the enzyme activities of taurine biosynthesis are limited in early stage of embryonic development. To analyze the expression period of TauT and CSD during embryonic development, we have investigated the gene expression of TauT and CSD using reverse transcriptase polymerase chain reaction (RT-PCR) in mouse and chicken embryos. RT-PCR anaylsis revealed that both TauT and CSD mRNAs were already expressed at Day-4.5 in mouse embryo. In chicken whole embryo, TauT and CSD mRNAs began to appear on developing times of 48 hrs and 12 hrs, respectively. TauT mRNA was detected in the organs of heart, brain and eye of the day-3 chicken embryo. Our data show that TauT and CSD mRNAs were expressed in early stage of embryonic development.

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Factors Affecting Sustainable Tourism Development in Ba Ria-Vung Tau, Vietnam

  • VU, Dong Van;TRAN, Ghi Nha;NGUYEN, Hien Thi Thu;NGUYEN, Cong Van
    • The Journal of Asian Finance, Economics and Business
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    • v.7 no.9
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    • pp.561-572
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    • 2020
  • Sustainable development - including tourism development - is the general trend of all economies. With the orientation to build and develop the tourism industry into a key economic sector and become a tourist center of the Southeast region, Vietnam, Ba Ria-Vung Tau Province is demanding a proper, rational, development policy, while ensuring the development and exploitation of immediate natural advantages, and ensuring long-term sustainable development. The objective of this study is to examine the factors and their trends in sustainable tourism development in Ba Ria-Vung Tau Province, Vietnam. Methods used include descriptive statistical analysis, exploratory factor analysis and regression analysis. Data was collected from the results of a survey of 550 domestic and foreign tourists visiting Ba Ria-Vung Tau. With the help of SPSS statistical software, 12 groups of factors affecting sustainable development were identified including: economy, society, environment, humanistic tourism resources, natural tourism resources, tourism human resources, tourism products and service, tourism quality, infrastructure, technical facilities, governmental management and group of criteria to evaluate sustainable tourism development. The research results show that there are four groups of factors that significantly affect sustainable tourism development in Ba Ria-Vung Tau. These are groups of factors: Society, Environment, Tourism products and service, and Technical facilities.

A Scaling of Velocity and Magnetic field in Decaying Turbulence in Expanding/Collapsing Media

  • Park, Jun-Seong;Ryu, Dong-Su;Cho, Jung-Yeon
    • The Bulletin of The Korean Astronomical Society
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    • v.36 no.2
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    • pp.108.2-108.2
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    • 2011
  • We investigate decaying magnetohydrodynamic (MHD) turbulence by including the effects of expansion and collapse of the background medium. The problem has two time scales, the eddy turn-over time($t_{eddy}$) and the expansion/collapse time scale(${\tau}_H$). The turbulence is expected to behave differently in two regimes of $t_{eddy}$ < ${\tau}_H$ and $t_{eddy}$ > ${\tau}_H$. For instance, for $t_{eddy}$ < ${\tau}_H$, the turbulence would decay more or less as in a static medium. On the other hand, for $t_{eddy}$ > ${\tau}_H$, the effects of expansion and collapse would be dominant. We examine the properties of turbulence in the regimes of $t_{eddy}$ < ${\tau}_H$ and $t_{eddy}$ > ${\tau}_H$. Based on it, we derive a scaling for the time evolution of flow velocity and magnetic field.

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THE CHROMOSPHERIC ACTIVITY ON V711 TAU (V711 TAU의 채층활동)

  • V771TAU의채층활동
    • Journal of Astronomy and Space Sciences
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    • v.14 no.1
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    • pp.59-66
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    • 1997
  • The relationship between Mg II emission line and light variation of V711 Tau has been derived to investigate the chromospheric activity on V711 Tau. First, a shape of an optical light curve was compared with that of ultraviolet constructed from the IUE low resolution spectra. Second, the intensities of Mg II k emission lines have been reduced from IUE high resolution spectra. The intensity of Mg II k line was compared with brightness of the UV light curve at given phase. The Mg II line intensity is maximum at the phase $O.^{P}4$ where the light is minimum. The evidence of chromosperic activity is indicated by the intensity variation of the MgII emission line with orbital phase for V711 Tau.

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Scintillation Characteristics of CsI:X(X=Li+,K+,Rb+ Single Crystals (CsI:X(X=Li+,K+,Rb+단결정의 섬광특성)

  • Gang, Gap-Jung;Doh, Sih-Hong;Lee, Woo-Gyo;Oh, Moon-Young
    • Journal of Sensor Science and Technology
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    • v.12 no.1
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    • pp.1-9
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    • 2003
  • CsI single crystals doped with lithium, potassium or rubidium were grown by using Czochralski method at Ar gas atmosphere. The energy resolutions of CsI(Li:0.2 mole%), CsI(K:0.5 mole%) and CsI(Rb:1.5 mole%) scintillators were 14.5%, 15.9% and 17.0% for $^{137}Cs$(0.662 MeV), respectively. The energy calibration curves of CsI(Li), CsI(K) and CsI(Rb) scintillators were linear for $\gamma$-ray energy. The time resolutions of CsI(Li:0.2 mole%), CsI(K:0.5 mole%) and CsI(Rb:1.5 mole%) scintillators measured by CFT(constant-fraction timing method) were 9.0 ns, 14.7 ns and 9.7 ns, respectively. The fluorescence decay times of CsI(Li:0.2 mole%) scintillator had a fast component and slow one of ${\tau}_1=41.2\;ns$ and ${\tau}_2=483\;ns$, respectively. The fluorescence decay times of CsI(K:0.5 mole%) scintillator were ${\tau}_1=47.2\;ns$ and ${\tau}_2=417\;ns$. And the fluorescence decay times of CsI(Rb:1.5 mole%) scintillator were ${\tau}_1=41.3\;ns$ and ${\tau}_2=553\;ns$. The phosphorescence decay times of CsI(Li:0.2 mole%), CsI(K:0.5 mole%) and CsI(Rb:1.5 mole%) scintillators were 0.51 s, 0.57 s and 0.56 s, respectively.