• 한국항공우주학회지
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• 제39권9호
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• pp.839-847
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• 2011

이 논문에서는 포탄의 정밀도 향상을 위한 새로운 유도기법을 제안한다. 미사일 연구에서 널리 사용되고 있는 비례항법 유도기법은 몇 가지의 문제점 때문에 포탄에 적용하기는 힘들다. 비행 중 발생하는 시선각의 변화 때문에 탄착 오차가 없는 경우에도 가속도 명령을 생성하며, 가속도 명령에 의해 만들어지는 비행경로 또한 포탄에 적용이 불가능하다. 이러한 문제를 해결하기 위해 표적과 포탄의 탄착점 오차를 이용하여 유도 기법을 구성하였다. 기본 구성은 비례항법 유도기법과 유사하지만 시선각 변화 대신 경로 수정각을 사용한다. 경로 수정각은 현재 속도와 표적을 향하는 속도의 사이각이며 탄착점 오차로 추정할 수 있다. 탄착점 예측 속도와 정확도를 높이기 위해 신경회로망을 사용하였으며 비례항법 유도기법 결과와 비교하여 이 유도 기법의 적합성을 검증하였다.

• 센서학회지
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• 제13권3호
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• pp.218-223
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• 2004

Thin film gas sensor based on tin oxide was fabricated and its characteristics were examined. Target gas is acetonitrile ($CH_{3}CN$) that is simulant gas of blood agent gas. Sensing materials are $SnO_{2}$, $SnO_{2}$/Pt, and (Sn/Pt)oxidation with thickness from $1000{\AA}$ to $3000{\AA}$. Sensor was consisted of sensing electrode with interdigit (IDT) type in front side and a heater in back side. Its dimension was $7{\times}10{\times}0.6mm^{3}$. Fabricated sensor was measured as flow type and monitored real time using PC. The optimal sensing material for $CH_{3}CN$ was {Sn($3000{\AA}$)/Pt($30{\AA}$)}oxidation and its sensitivity and operating temperature were 30%, $300^{\circ}C$ in $CH_{3}CN$ 3 ppm.

• 융합신호처리학회논문지
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• 제8권1호
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• pp.78-83
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• 2007

로봇이 미지의 환경에서 주위의 정보를 추출하여 인식하기 위해 비젼 센서, 적외선 센서, 초음파 센서 등을 이용해 주변 정보를 얻는다. 그 중 가장 많이 사용되고 있는 비젼 센서는 빛에 대한 간섭에 민감하여 어두운 곳이나 밝은 곳에서는 데이터 추출이 어려우며, 표시 된 마크나 직선 성분 및 곡선의 이미지를 통해 데이터를 추출함에 있어 많은 계산을 요구한다.반면 초음파 센서는 비젼 시스템의 단점을 극복하고 쉽게 사용할 수 있는 센서이다. 특히 어두운 곳의 물체 정보 및 거리 정보를 얻을 수 있고 비젼 시스템보다 사용하기 간단하다. 본 논문에서는 초음파 빔의 왜곡 및 산란의 특성을 고려하여 부정확 정보에 대한 오차를 줄여 환경 인식, 경로 계획 및 자율 주행의 극대화를 시키기 위한 알고리즘을 연구 및 개발한다. 그리고 알고리즘을 실제 이동 로봇에 적용하여 경로 계획 및 환경 인식이 가능한 시스템을 구현한다.

• 한국전기전자재료학회논문지
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• 제16권12S호
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• pp.1217-1223
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• 2003

Nerve gas sensor based on tin oxide was fabricated and its characteristics were examined. Target gas is dimethyl methyl phosphonate(C$_3$ $H_{9}$ $O_3$P, DMMP) that is simulant gas of nerve gas. Sensing materials were Sn $O_2$ added a-Al$_2$ $O_3$ with 0∼20wt.% and were physically mixed each material. They were deposited by screen printing method on alumina substrate. The sensor device was consisted of sensing electrode with interdigit(IDT) type in front and a heater in back side. Total size of device was 7${\times}$10${\times}$0.6㎣. Crystallite size & phase identification and morphology of fabricated Sn $O_2$ powders were analyzed by X-ray diffraction and by a scanning electron microscope, respectively. Fabricated sensor was measured as flow type and resistance change of sensing material was monitored as real time using LabVIEW program. The best sensitivity was 75% at adding 4wt.% $\alpha$-Al$_2$ $O_3$, operating temperature 30$0^{\circ}C$ to DMMP 0.5ppm. Response and recovery time were about 1 and 3min., respectively. Repetition measurement was very good with $\pm$3％ in full scale.TEX>$\pm$3％ in full scale.

• 한국의학물리학회지:의학물리
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• 제12권2호
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• pp.141-146
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• 2001

치료효과를 보증하기 위해서는 조사선량의 5% 이내의 선량오차가 방사선생물학적 의미가 높은 것으로 잘 알려져 있다. 따라서 종양치료를 위한 강내조사 선원이나 선형가속기의 고선량율의 선량 평가는 정확하고 안정적 평가가 이루어져야 된다. 선량을 평가 교정하기 위해 전리함의 교정 인정기관의 교정상수를 유지하기 위해 선진국에서는 기하학적으로 고정된 표준선원과 전리함의 사용을 오래 전부터 권고해 왔다. 본 연구는 전리함의 감도 변화를 측정할 수 있는 Sr-90 시험선원을 이용한 임의의 기준 전리함의장기간 안정성이 1.00$\pm$0.01 의 오차 범위에 있음을 알 수 있었고, 고선량률 원격강내조사선원인 Co-60 선원에 대한 기준전리함의 출력선량에 대한 임상측정용 전리함의 출력선량은 평균 0.997 $\pm$ 0.01의 오차범위에서 평가될 수 있었으며, 최대오차는 예상선량에 -2.5% 였다. 이 실험을 통해 반감기가 긴 시험선원을 이용하여 임상 측정용 공기전리함의 안정적 성능을 유지할 수 있음을 알 수 있다.

• Genomics & Informatics
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• 제4권3호
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• pp.97-102
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• 2006

In acute leukemia patients, several successful methods of expression profiling have been used for various purposes, i.e., to identify new disease class, to select a therapeutic target, or to predict chemo-sensitivity and clinical outcome. In the present study, we tested the peripheral blood of 47 acute leukemia patients in an attempt to identify differentially expressed genes in AML and ALL using a Korean-made 10K oligo-nucleotide microarray. Methods: Total RNA was prepared from peripheral blood and amplified for microarray experimentation. SAM (significant analysis of microarray) and PAM (prediction analysis of microarray) were used to select significant genes. The selected genes were tested for in a test group, independently of the training group. Results: We identified 345 differentially expressed genes that differentiated AML and ALL patients (FWER<0.05). Genes were selected using the training group (n=35) and tested for in the test group (n=12). Both training group and test group discriminated AML and ALL patients accurately. Genes that showed relatively high expression in AML patients were deoxynucleotidyl transferase, pre-B lymphocyte gene 3, B-cell linker, CD9 antigen, lymphoid enhancer-binding factor 1, CD79B antigen, and early B-cell factor. Genes highly expressed in ALL patients were annexin A 1, amyloid beta (A4) precursor protein, amyloid beta (A4) precursor-like protein 2, cathepsin C, lysozyme (renal amyloidosis), myeloperoxidase, and hematopoietic prostaglandin D2 synthase. Conclusion: This study provided genome wide molecular signatures of Korean acute leukemia patients, which clearly identify AML and ALL. Given with other reported signatures, these molecular signatures provide a means of achieving a molecular diagnosis in Korean acute leukemia patents.

• BMB Reports
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• 제37권4호
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• pp.493-502
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• 2004

The genetic diversity and species-diagnostic markers in the introduced apple snail, Pomacea canaliculata and in the native Thai apple snails; Pila ampullacea, P. angelica, P. pesmei, and P. polita, were investigated by restriction analysis of COI and are reported for the first time. Twenty-one composite haplotypes showing non-overlapping distributions among species were found. Genetic heterogeneity analysis indicated significant differences between species (P < 0.0001) and within P. pesmei (P < 0.0001) and P. angelica (P < 0.0004). No such heterogeneity was observed in Pomacea canaliculata (P > 0.0036 as modified by the Bonferroni procedure), P. ampullacea (P = 0.0824-1.000) and P. polita (P = 1.0000). A neighbor-joining tree based on genetic distance between pairs of composite haplotypes differentiated all species and indicated that P. angelica and P. pesmei are closely related phylogenetically. In addition, the 16S rDNA of these species was cloned and sequenced. A species-specific PCR for P. canaliculata was successfully developed with a sensitivity of detection of approximately 50 pg of the target DNA template. The amplification of genomic DNA (50 pg and 25 ng) isolated from the fertilized eggs, and juveniles (1, 7, and 15 d after hatching) of Pomacea canaliculata was also successful, and suggested that Pomacea canaliculata and Pila species can be discriminated from the early stages of development.

• 대한의생명과학회지
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• 제25권4호
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• pp.407-416
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• 2019

Recent years have seen an increase in the incidence of candidiasis caused by non-albicans Candida (NAC) species. In fact, C. glabrata is now second only to C. albicans as the most common cause of invasive candidiasis. Therefore, the rapid genotyping specifically for C. glabrata is required for early diagnosis and treatment of candidiasis. A number of genotyping assays have been developed to differentiate C. glabrata sequence types (STs), but they have several limitations. In the previous study, multi-locus sequence typing (MLST) has performed with a total of 101 C. glabrata clinical isolates to analyze the prevalent C. glabrata STs in Korea. A total of 11 different C. glabrata STs were identified and, among them, ST-138 was the most commonly classified. Thus, a novel probe-based quantitative PCR (qPCR) assay was developed and evaluated for rapid and accurate identification of the predominant C. glabrata ST-138 in Korea. Two primer pairs and hybridization probe sets were designed for the amplification of internal transcribed spacer 1 (ITS1) region and TRP1 gene. Analytical sensitivity of the probe-based qPCR assay was 100 ng to 10 pg and 100 ng to 100 pg (per 1 μL), which target ITS1 region and TRP1 gene, respectively. This assay did not react with any other Candida species and bacteria except C. glabrata. Of the 101 clinical isolates, 99 cases (98%) were concordant with MLST results. This novel probe-based qPCR assay proved to be rapid, sensitive, highly specific, reproducible, and cost-effective than other genotyping assay for C. glabrata ST-138 identification.

• Advances in aircraft and spacecraft science
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• 제1권2호
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• pp.233-251
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• 2014

Each aircraft have to be certified for a specified level of impact energy, for assuring the capability of a safe flight and landing after the impact against a bird at cruise speed. The aim of this research work was to define a scientific and methodological approach to the study of the birdstrike phenomenon against several windshield geometries. A series of numerical simulations have been performed using the explicit finite element solver code LS-Dyna, in order to estimate the windshield-surround structure capability to absorb the bird impact energy, safely and efficiently, according to EASA Certification Specifications 25.631 (2011). The research considers the results obtained about a parametric numerical analysis of a simplified, but realistic, square flat windshield model, as reported in the last work (Grimaldi et al. 2013), where this model was subjected to the impact of a 1.8 kg bird model at 155 m/s to estimate the sensitivity of the target geometry, the impact angle, and the plate curvature on the impact response of the windshield structure. Then on the basis of these results in this paper the topic is focused about the development of a numerical simulation on a complete aircraft windshield-surround model with an innovative configuration. Both simulations have used a FE-SPH coupled approach for the fluid-structure interaction. The main achievement of this research has been the collection of analysis and results obtained on both simplified realistic and complete model analysis, addressed to approach with gained confidence the birdstrike problem. Guidelines for setting up a certification test, together with a design proposal for a test article are an important result of such simulations.

• 한국해안해양공학회지
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• 제14권2호
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• pp.95-107
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• 2002

신뢰성설계법의 적용성을 확대하기 위하여 혼성제 직립 케이슨의 활동에 대한 신뢰성 해석이 수행되었다. 충격쇄파 효과를 고려한 결정론적 설계법에 의하여 단면의 안전성이 자세히 해석되었으며, 특히 신뢰성 해석의 결과를 직접 결정론적 설계법의 결과와 연결시키기 위한 연구가 시도되었다. 해석 결과에 의하면 현재의 결정론적 설계 법에서 적용되고 있는 안전율은 약간 안전 측에 속한다. 또한 동일한 입사조건과 안전율에 대하여 수심이 증가함에 따라 신뢰지수는 감소하는 경향을 보이고 있다. 한편 방파제가 그 기능을 수행하는데 지장이 없을 것으로 예상되는 목표 파괴확률을 설정하고 그 목표 범위내에서 가장 최적의 파괴 확률을 산정하였는데, 입사조건에 따라 약간 씩 다른 최적의 안전율이 추정되었다. 마지막으로 혼성제 케이슨의 단면 결정에 영향을 주는 변수들의 변화에 따른 민감도 분석이 수행되었다. 해석 결과에 의하면 입사각, 주기의 영향이 크게 나타났으며 하상의 경사나 마운드의 두께에 대한 영향의 정도는 상대적으로 낮게 평가되었다.