• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.39 no.9
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• pp.839-847
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• 2011

This paper proposes a new guidance law for increasing the lethality of munitions. The well known PNG (Proportional Navigation Guidance) is inadequate for the munitions because of some weaknesses. Even if the munition does not have the impact point error, the acceleration command is non zero because the line-of-sight changes at all times in flight. Therefore, we use a difference between a target and an impact point. This proposed guidance law is similar to PNG in the form, but this guidance law concentrates a correction rate of flight path angle instead of the LOS (Line of Sight) rate. The correction of flight path angle is defined as the amount of impact point error. This impact point error can be calculated by neural networks rapidly. Finally, we show that the simulation results prove the suitability of this law.

• Journal of Sensor Science and Technology
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• v.13 no.3
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• pp.218-223
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• 2004

Thin film gas sensor based on tin oxide was fabricated and its characteristics were examined. Target gas is acetonitrile ($CH_{3}CN$) that is simulant gas of blood agent gas. Sensing materials are $SnO_{2}$, $SnO_{2}$/Pt, and (Sn/Pt)oxidation with thickness from $1000{\AA}$ to $3000{\AA}$. Sensor was consisted of sensing electrode with interdigit (IDT) type in front side and a heater in back side. Its dimension was $7{\times}10{\times}0.6mm^{3}$. Fabricated sensor was measured as flow type and monitored real time using PC. The optimal sensing material for $CH_{3}CN$ was {Sn($3000{\AA}$)/Pt($30{\AA}$)}oxidation and its sensitivity and operating temperature were 30%, $300^{\circ}C$ in $CH_{3}CN$ 3 ppm.

• Journal of the Institute of Convergence Signal Processing
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• v.8 no.1
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• pp.78-83
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• 2007

Robot collects surrounding information to recognize tile unknown environment by using various sensors such as visual, infrared ray and ultra sonic sensors. Although visual sensor is the most popular one, it has some difficulties in collecting data in dark or too bright environment due to sensitivity of the light. It also requests significant amount of calculation on collecting data from certain images with marked, straight and curved ones. As an alternative, ultra sonic sensor can simply overcome this visual sensing system's flaw and easily be used. It is easier than visual system, especially in case of collecting data on object and distance in dark environment. Ultra sonic sensor can replace the expensive visual sensing system not only in avoiding obstacles but also in reaching to the target area smoothly. The purpose of this paper is to develop the algorithm to optimize the environmental recognition, path planning and free-ranging by minimizing errors caused by inaccurate information and by considering characteristics of the ultra sonic rays such as refraction and diffusion. This paper also realizes the system that can recognize the environment and make the appropriate path planning by applying the algorithm on this moving robot.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.16 no.12S
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• pp.1217-1223
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• 2003

Nerve gas sensor based on tin oxide was fabricated and its characteristics were examined. Target gas is dimethyl methyl phosphonate(C$_3$ $H_{9}$ $O_3$P, DMMP) that is simulant gas of nerve gas. Sensing materials were Sn $O_2$ added a-Al$_2$ $O_3$ with 0∼20wt.% and were physically mixed each material. They were deposited by screen printing method on alumina substrate. The sensor device was consisted of sensing electrode with interdigit(IDT) type in front and a heater in back side. Total size of device was 7${\times}$10${\times}$0.6㎣. Crystallite size & phase identification and morphology of fabricated Sn $O_2$ powders were analyzed by X-ray diffraction and by a scanning electron microscope, respectively. Fabricated sensor was measured as flow type and resistance change of sensing material was monitored as real time using LabVIEW program. The best sensitivity was 75% at adding 4wt.% $\alpha$-Al$_2$ $O_3$, operating temperature 30$0^{\circ}C$ to DMMP 0.5ppm. Response and recovery time were about 1 and 3min., respectively. Repetition measurement was very good with $\pm$3％ in full scale.TEX>$\pm$3％ in full scale.

• Progress in Medical Physics
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• v.12 no.2
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• pp.141-146
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• 2001

It is well known that assurance of the radiation therapy needs for an accuracy of $\pm$ 5 % in the delivery of an absorbed dose to target volume. Therefore, the dose evaluation of brachytherapy source and/or linear accelerate beam must be a stability with accuracy. In an advanced country, they recommended to use the radioactive check source for reference air ionization chamber for a stable response of radiation field chamber. In this experiments, the radioactive source Sr-90 and PR-05 air ionization chamber were used for standard source and reference ion chamber. The response of reference ion chamber showed as an 1.000$\pm$ 0.010 uncertainty for 10 years long and the evaliuation f dose discrepancy of clinical field ion chamber showed as 0.997 $\pm$0.011 in a $^{60}$ Co brachytherapy soruce. In our experiments, we can assuarance the long halflife standard source is reliable to preserve the calibration factor of reference chamber in stability.

• Genomics & Informatics
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• v.4 no.3
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• pp.97-102
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• 2006

In acute leukemia patients, several successful methods of expression profiling have been used for various purposes, i.e., to identify new disease class, to select a therapeutic target, or to predict chemo-sensitivity and clinical outcome. In the present study, we tested the peripheral blood of 47 acute leukemia patients in an attempt to identify differentially expressed genes in AML and ALL using a Korean-made 10K oligo-nucleotide microarray. Methods: Total RNA was prepared from peripheral blood and amplified for microarray experimentation. SAM (significant analysis of microarray) and PAM (prediction analysis of microarray) were used to select significant genes. The selected genes were tested for in a test group, independently of the training group. Results: We identified 345 differentially expressed genes that differentiated AML and ALL patients (FWER<0.05). Genes were selected using the training group (n=35) and tested for in the test group (n=12). Both training group and test group discriminated AML and ALL patients accurately. Genes that showed relatively high expression in AML patients were deoxynucleotidyl transferase, pre-B lymphocyte gene 3, B-cell linker, CD9 antigen, lymphoid enhancer-binding factor 1, CD79B antigen, and early B-cell factor. Genes highly expressed in ALL patients were annexin A 1, amyloid beta (A4) precursor protein, amyloid beta (A4) precursor-like protein 2, cathepsin C, lysozyme (renal amyloidosis), myeloperoxidase, and hematopoietic prostaglandin D2 synthase. Conclusion: This study provided genome wide molecular signatures of Korean acute leukemia patients, which clearly identify AML and ALL. Given with other reported signatures, these molecular signatures provide a means of achieving a molecular diagnosis in Korean acute leukemia patents.

• BMB Reports
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• v.37 no.4
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• pp.493-502
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• 2004

The genetic diversity and species-diagnostic markers in the introduced apple snail, Pomacea canaliculata and in the native Thai apple snails; Pila ampullacea, P. angelica, P. pesmei, and P. polita, were investigated by restriction analysis of COI and are reported for the first time. Twenty-one composite haplotypes showing non-overlapping distributions among species were found. Genetic heterogeneity analysis indicated significant differences between species (P < 0.0001) and within P. pesmei (P < 0.0001) and P. angelica (P < 0.0004). No such heterogeneity was observed in Pomacea canaliculata (P > 0.0036 as modified by the Bonferroni procedure), P. ampullacea (P = 0.0824-1.000) and P. polita (P = 1.0000). A neighbor-joining tree based on genetic distance between pairs of composite haplotypes differentiated all species and indicated that P. angelica and P. pesmei are closely related phylogenetically. In addition, the 16S rDNA of these species was cloned and sequenced. A species-specific PCR for P. canaliculata was successfully developed with a sensitivity of detection of approximately 50 pg of the target DNA template. The amplification of genomic DNA (50 pg and 25 ng) isolated from the fertilized eggs, and juveniles (1, 7, and 15 d after hatching) of Pomacea canaliculata was also successful, and suggested that Pomacea canaliculata and Pila species can be discriminated from the early stages of development.

• Biomedical Science Letters
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• v.25 no.4
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• pp.407-416
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• 2019

Recent years have seen an increase in the incidence of candidiasis caused by non-albicans Candida (NAC) species. In fact, C. glabrata is now second only to C. albicans as the most common cause of invasive candidiasis. Therefore, the rapid genotyping specifically for C. glabrata is required for early diagnosis and treatment of candidiasis. A number of genotyping assays have been developed to differentiate C. glabrata sequence types (STs), but they have several limitations. In the previous study, multi-locus sequence typing (MLST) has performed with a total of 101 C. glabrata clinical isolates to analyze the prevalent C. glabrata STs in Korea. A total of 11 different C. glabrata STs were identified and, among them, ST-138 was the most commonly classified. Thus, a novel probe-based quantitative PCR (qPCR) assay was developed and evaluated for rapid and accurate identification of the predominant C. glabrata ST-138 in Korea. Two primer pairs and hybridization probe sets were designed for the amplification of internal transcribed spacer 1 (ITS1) region and TRP1 gene. Analytical sensitivity of the probe-based qPCR assay was 100 ng to 10 pg and 100 ng to 100 pg (per 1 μL), which target ITS1 region and TRP1 gene, respectively. This assay did not react with any other Candida species and bacteria except C. glabrata. Of the 101 clinical isolates, 99 cases (98%) were concordant with MLST results. This novel probe-based qPCR assay proved to be rapid, sensitive, highly specific, reproducible, and cost-effective than other genotyping assay for C. glabrata ST-138 identification.

• Advances in aircraft and spacecraft science
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• v.1 no.2
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• pp.233-251
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• 2014

Each aircraft have to be certified for a specified level of impact energy, for assuring the capability of a safe flight and landing after the impact against a bird at cruise speed. The aim of this research work was to define a scientific and methodological approach to the study of the birdstrike phenomenon against several windshield geometries. A series of numerical simulations have been performed using the explicit finite element solver code LS-Dyna, in order to estimate the windshield-surround structure capability to absorb the bird impact energy, safely and efficiently, according to EASA Certification Specifications 25.631 (2011). The research considers the results obtained about a parametric numerical analysis of a simplified, but realistic, square flat windshield model, as reported in the last work (Grimaldi et al. 2013), where this model was subjected to the impact of a 1.8 kg bird model at 155 m/s to estimate the sensitivity of the target geometry, the impact angle, and the plate curvature on the impact response of the windshield structure. Then on the basis of these results in this paper the topic is focused about the development of a numerical simulation on a complete aircraft windshield-surround model with an innovative configuration. Both simulations have used a FE-SPH coupled approach for the fluid-structure interaction. The main achievement of this research has been the collection of analysis and results obtained on both simplified realistic and complete model analysis, addressed to approach with gained confidence the birdstrike problem. Guidelines for setting up a certification test, together with a design proposal for a test article are an important result of such simulations.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.14 no.2
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• pp.95-107
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• 2002

A reliability analysis on sliding of monolithic vertical caisson of composite breakwaters is extensively carried out in order to make the basis for the applicability of reliability-based design method. The required width of caisson of composite breakwaters is determined by the deterministic design method including the effect of impulsive breaking waves as a function of water depth, also studied interactively with the results of reliability analyses. It is found that the safety factor applied in current design may be a little over-weighted magnitude for the sliding of caisson. The reliability index/failure probability is also seen to slowly decrease as the water depth increases for a given wave condition and a safety factor. In addition, optimal safety factor can roughly be evaluated by using the concept of target reliability index for several incident waves. The variations of optimal safety factor may be resulted from the different wave conditions. Finally, it may be concluded from the sensitivity studies that the reliability index may be more depended on the incident wave angles and the wave periodsrather than on the bottom slopes and the thickness of rubble mound.