• BMB Reports
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• v.47 no.6
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• pp.311-317
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• 2014

microRNAs (miRNAs) are a class of small, non-coding RNAs that play critical posttranscriptional regulatory roles typically through targeting of the 3'-untranslated region of messenger RNA (mRNA). Mature miRNAs are known to be involved in global cellular processes, such as differentiation, proliferation, apoptosis, and organogenesis, due to their capacity to target multiple mRNAs. Thus, imbalances in the expression and/or activity of miRNAs are involved in the pathogenesis of numerous diseases, including pulmonary arterial hypertension (PAH). PAH is a progressive disease characterized by vascular remodeling due to excessive proliferation of pulmonary artery endothelial cells (PAECs) and pulmonary artery smooth muscle cells (PASMCs). Recently, studies have evaluated the roles of miRNAs involved in the pathogenesis of PAH in these pulmonary vascular cells. This review provides an overview of recent discoveries on the role of miRNAs in the pathogenesis of PAH and discusses the potential for miRNAs as therapeutic targets and biomarkers of PAH.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.10 no.9
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• pp.4405-4418
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• 2016

Automatic image completion techniques have difficulty processing images in which the target region has multiple planes or is non-facade. Here, we propose a new image completion method that uses belief propagation based on planar priorities. We first calculate planar information, which includes planar projection parameters, plane segments, and repetitive regularity extractions within the plane. Next, we convert this planar information into planar guide knowledge using the prior probabilities of patch transforms and offsets. Using the energy of the discrete Markov Random Field (MRF), we then define an objective function for image completion that uses the planar guide knowledge. Finally, in order to effectively optimize the MRF, we propose a new optimization scheme, termed Planar Priority-belief propagation that includes message-scheduling-based planar priority and dynamic label cropping. The results of experiment show that our approach exhibits advanced performance compared with existing approaches.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.10 no.9
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• pp.4419-4441
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• 2016

A cause of vehicle accidents is the reduced visibility due to bad weather conditions such as fog. Therefore, an onboard vision system should take visibility detection into account. In this paper, we propose a simple and effective approach for measuring the visibility distance using a single camera placed onboard a moving vehicle. The proposed algorithm is controlled by a few parameters and mainly includes camera parameter estimation, region of interest (ROI) estimation and visibility computation. Thanks to the ROI extraction, the position of the inflection point may be measured in practice. Thus, combined with the estimated camera parameters, the visibility distance of the input foggy image can be computed with a single camera and just the presence of road and sky in the scene. To assess the accuracy of the proposed approach, a reference target based visibility detection method is also introduced. The comparative study and quantitative evaluation show that the proposed method can obtain good visibility detection results with relatively fast speed.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.22 no.2
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• pp.428-436
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• 1998

A TCS slip control system improves acceleration capability and steerability on slippery roads through engine torgue and/or brake torque control. This research mainly deals with the engine control algorithm via the adjustment of the engine throttle angle. The following new control strategy is proposed and investigated ; the TCS slip controller whose input is the difference between the desired driving wheel speed corresponding to the optimum slip ratio and the actual speed yields the target engine torque and then estimates the throttle angle based on the engine performance curve. Various simulation and hardware-in-the-loop simulation have been carried out. The results show the proposed strategy may compensate for the inherent nonlinearity between variation of the throttle angle and variation of the engine torque and produce better performance than the previous strategies without the engine map, especially in the high speed region.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.53 no.2
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• pp.160-168
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• 2017

In this study, we propose a method of optimal placement technique of artificial reef considering characteristics of sea areas and provide basic data for efficient budget execution. In addition, we will contribute to increasing the economic efficiency by improving the fisheries productivity by suggesting the scientific basis for the policy data and the increase of the catch through the resource creation based on the ecological information about the biology. Especially, in order to establish the effective disposition (optimum separation distance) of artificial reef considering characteristics of biological and engineering factors, it is necessary to review the artificial reef installation management regulations and investigate the biological effects of artificial reef facilities, is needed. Through this, it is expected that the ground data of the direction of the policy promotion will be derived by suggesting the placement condition of the artificial reef complex which can maximize the resource composition effect according to the target fish species.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2005.06a
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• pp.668-671
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• 2005

Carbon nanotubes exhibit strong fluorescence emissions in the region of near infrared regions where most biomolecules are transparent. Such signals are highly sensitive to environment variations as well as adsorption of specific biomolecules. In this research, single walled carbon nanotubes(SWNTs) are assembled with different types of DNAs and used to target specific types of DNAs. Dot blot investigations and corresponding raman spectroscopy observations demonstrated excellent selectivity of carbon nanotube-DNA bioconjugates. The results show possibility of using SWNT as generic nano-bio markers for precise detection of different kinds of genes.

• Journal of Microbiology
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• v.42 no.1
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• pp.56-59
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• 2004

Together with the previous reports, my computer survey revealed that several bacteria contain six copies of the type group II intron IntA. The sequence analysis of IntAs showed the high level of homology in the nucleotide sequence (91.9-99.8%). The consensus sequence, 2,270 base pair long, was derived from the nucleotide sequences of all IntA members. The size of the open reading frame intA was 502 amino acids long, that is homologous to reverse transcriptase-like proteins encoded within the group II introns. It was reported that EPEC.IntA and Sf.IntA were inserted into IS911 and IS629, respectively. The sequence of the flanking region IntA was analyzed here. The data show the insertion of EC.IntA into IS629, the insertion of EHEC.IntA into IS3, the insertion of Yp.IntA into IS904-like sequence, and the insertion of EK12.IntA into IS911. Interestingly, these IS elements nested by IntAs were the members of IS3 family elements. The sequences of the IS3 members correspond to the OrfB with the DDE motif conserved in retroviral integrases. Alignment of the flanking sequences of IntAs revealed that the flanking regions -25 to + 10 of insertion sites, that are generally believed to be required for the retrohoming, were not strongly conserved. The data presented here suggests that the retrohoming pathway of IntA seems to differ from those of other group II introns.

• BMB Reports
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• v.29 no.2
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• pp.180-182
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• 1996

One of the essential functions of virus surface proteins is the recognition of specific receptors on target cell membranes, and cellular receptors play an important role in viral pathogenesis. But the earliest steps of hepatitis B virus (HBV) infection, such as hepatocyte receptor interaction with the virus, are poorly understood. Previous work has suggested an important role of the preS1 region of HBV envelope protein in mediating viral binding to hepatocytes. Although hepatitis B virus (HBV) infection appears to be initiated by specific binding of virions to cell membrane structures via one or potentially several viral surface proteins, data showing the identification or isolation of the HBV receptor (s) are not yet available. The receptor-like proteins on the plasma membrane surface of HepG2 cells that bind to PreS1 were separated and identified using affinity chromatography, and the amino-terminal amino acid sequences of the receptor-like proteins were determined.

• Journal of Environmental Health Sciences
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• v.30 no.5 s.81
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• pp.449-454
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• 2004

This study is to calculate Allocation of Pollution Discharges by administrative region for the TMDL (Total Maximum Daily Load) on Tamjin River. TMDL has the water quality target and value ($BOD_5$, 1 ppm) and is calculated by the QUAL2E model. The expected TMDL for Tamjin River is 1,532,360 kg/day. The calculation showed that the main pollutants are due to the non-point sources in Tamjin River and the aqua-farms are another important sources near the bay. And sources from population and livestock should be reduced, especially aqua-farm source should be managed and eliminated first which is over 14,000 ton/day.

• Journal of the Korean Institute of Electrical and Electronic Material Engineers
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• v.24 no.7
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• pp.584-588
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• 2011

The ZnO thin films doped with Ga and Ge (GZO:Ge) were prepared on glass substrate using RF sputtering system. Structural, morphological and optical properties of the films deposited in different temperatures were studied. Proportion of the element of using target was 97 wt% ZnO, 2.5 wt% Ga and 0.5 wt% Ge with 99.99% highly purity. Structural properties of the samples deposited in different temperatures with 200 w RF power were investigated by field emission scanning electron microscopy, FE-SEM images and x-ray diffraction XRD analysis. Atomic force microscopy, AFM images were able to show the grain scales and surface roughness of each film rather clearly than SEM images. it was showed that increasing temperature have better surface smoothness by FE-SEM and AFM images. Transmittance study using UV-Vis spectrometer showed that all the samples have highly transparent in visible region (300~800 nm). In addition, it can be able to calculate bandgap energy from absorbance data obtained with transmittance. The hall resistivity, mobility, and optical band gap energy are influenced by the temperature.