• The Journal of the Korea institute of electronic communication sciences
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• v.10 no.10
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• pp.1079-1086
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• 2015

This paper introduces the architecture of OUTPUT module that is suitable using in safety related system having SIL4 and proposes the quantitative target that is required for OUTPUT module. Especially, only output type that is made up Relay output signal and analog signal among various output ways is applied in output module that is a part of safety related system. The FMEA(Failure Modes and Effect Analysis), FTA(Fault Tree Analysis) are used as analysis method. As a result, it proposes to the architecture and failure frequency of the Output module that is used in SIL4 safety related system.

• Journal of the Korean Institute of Gas
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• v.6 no.1 s.17
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• pp.66-73
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• 2002

In this study a new SIS evaluation method based on the reliability analysis has been developed. It evaluates the Safety Integrity Level (SIL) using the Fault Tree Analysis (FTA), and when the SIL falls short of the systems target level, through the reliability analysis and system retrofit, this method will satisfy the aimed SIL. A hazard evaluation was carried out on the 415V Diesel BUS to verify the SIL evaluation method based on the reliability analysis. The availability of the original 415V Diesel BUS was $99.40\%$, which comes under the category of SIL 2. After exchanging the diesel generator and the isolator switch using the developed evaluation method, the availability rose to $99.94\%$, SIL 3. By applying the method presented in this study, not only will it reduce the maintenance cost due to the prevention of accidents and reduction of loss, but also maximize the reliability of the system.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.22 no.1
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• pp.107-115
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• 2012

The level of information protection is relatively low, in comparison with the informatisation in this country. The budget for information protection is also quite marginal at 5% of the entire information-related policy budget. The passive information protection practices by companies, which focus more on the aftermaths, lead to repeated expenses for risk management. The responses to the violation of information protection should be changed from the current aftermaths-oriented focus to prevention and early detection of possible violations. We should also realize that the response to a violation of protected information is not a responsibility of an individual but a joint responsibility of the nation and the industry. South Korea has been working towards to building a systematic foundation since 2004 when guidelines were announced regarding the information protection policy and the safety diagnosis. The current level of safety policies cannot provide a perfect protection against actual violation cases in administrative, technological and physical ways. This research evaluates the level of prevention that the current systematic protection policy offers, and discusses its limitation and possible ways for improvement. It also recommends a list effective measures for protection against information violation that companies can employ to maintain the actual target safety level.

• Safety and Health at Work
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• v.3 no.3
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• pp.224-234
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• 2012

Objectives: This study was conducted in order to obtain information concerning the health hazards that may result from a 13 week inhalation exposure of n-pentane in Sprague-Dawley rats. Methods: This study was conducted in accordance with the Organization for Economic Co-operation and Development (OECD) guidelines for the testing of chemicals No. 413 'Subchronic inhalation toxicity: 90-day study (as revised in 2009)'. The rats were divided into 4 groups (10 male and 10 female rats in each group), and were exposed to 0, 340, 1,530, and 6,885 ppm n-pentane in each exposure chamber for 6 hour/day, 5 days/week, for 13 weeks. All of the rats were sacrificed at the end of the treatment period. During the test period, clinical signs, mortality, body weights, food consumption, ophthalmoscopy, locomotion activity, urinalysis, hematology, serum biochemistry, gross findings, organ weights, and histopathology were assessed. Results: During the period of testing, there were no treatment related effects on the clinical findings, body weight, food consumption, ophthalmoscopy, urinalysis, hematology, serum biochemistry, gross findings, relative organ weight, and histopathological findings. Conclusion: The no-observable-adverse-effect level (NOAEL) of n-pentane is evaluated as being more than 6,885 ppm (20.3 mg/L) in both male and female rats. n-pentane was not a classified specific target organ toxicity in the globally harmonized classification system (GHS).

• Journal of Pharmacopuncture
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• v.19 no.3
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• pp.213-224
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• 2016

Objectives: Ginseng Rh2+ is enzyme-treated ginseng extract containing high amounts of converted ginsenosides, such as compound k, Rh2, Rg3, which have potent anticancer activity. We conducted general and genetic toxicity tests to evaluate the safety of ginseng Rh2+. Methods: An acute oral toxicity test was performed at a high-level dose of 4,000 mg/kg/day in Sprague-Dawley (SD) rats. A 14-day range-finding study was also conducted to set dose levels for the 90-day study. A subchronic 90-day toxicity study was performed at dose levels of 1,000 and 2,000 mg/kg/day to investigate the no-observed-adverse-effect level (NOAEL) of ginseng Rh2+ and target organs. To identify the mutagenic potential of ginseng Rh2+, we conducted a bacterial reverse mutation test (Ames test) using amino-acid-requiring strains of Salmonella typhimurium and Escherichia coli (E. coli), a chromosome aberration test with Chinese hamster lung (CHL) cells, and an in vivo micronucleus test using ICR mice bone marrow as recommended by the Korean Ministry of Food and Drug Safety. Results: According to the results of the acute oral toxicity study, the approximate lethal dose (ALD) of ginseng Rh2+ was estimated to be higher than 4,000 mg/kg. For the 90-day study, no toxicological effect of ginseng Rh2+ was observed in body-weight changes, food consumption, clinical signs, organ weights, histopathology, ophthalmology, and clinical pathology. The NOAEL of ginseng Rh2+ was established to be 2,000 mg/kg/day, and no target organ was found in this test. In addition, no evidence of mutagenicity was found either on the in vitro genotoxicity tests, including the Ames test and the chromosome aberration test, or on the in vivo in mice bone marrow micronucleus test. Conclusion: On the basis of our findings, ginseng Rh2+ is a non-toxic material with no genotoxicity. We expect that ginseng Rh2+ may be used as a novel adjuvant anticancer agent that is safe for long-term administration.

• Journal of the Korean Society of Safety
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• v.35 no.1
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• pp.107-115
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• 2020

This paper introduces the first vital area identification (VAI) process for the physical protection of nuclear power plants (NPPs) during low power and shutdown (LPSD) operation. This LPSD VAI is based on the 3rd generation VAI method which very efficiently utilizes probabilistic safety assessment (PSA) event trees (ETs). This LPSD VAI process was implemented to the virtual NPP during LPSD operation in this study. Korea Atomic Energy Research Institute (KAERI) had developed the 2nd generation full power VAI method that utilizes whole internal and external (fire and flooding) PSA results of NPPs during full power operation. In order to minimize the huge burden of the 2nd generation full power VAI method, the 3rd generation full power VAI method was developed, which utilizes ETs and minimal PSA fault trees instead of using the whole PSA fault tree. In the 3rd generation full power VAI method, (1) PSA ETs are analyzed, (2) minimal mitigation systems for avoiding core damage are selected from ETs by calculating system-level target sets and prevention sets, (3) relatively small sabotage fault tree that has the systems in the shortest system-level prevention set is composed, (4) room-level target sets and prevention sets are calculated from this small sabotage fault tree, and (5) the rooms in the shortest prevention set are defined as vital areas that should be protected. Currently, the 3rd generation full power VAI method is being employed for the VAI of Korean NPPs. This study is the first development and application of the 3rd generation VAI method to the LPSD VAI of NPP. For the LPSD VAI, (1) many LPSD ETs are classified into a few representative LPSD ETs based on the functional similarity of accident scenarios, (2) a few representative LPSD ETs are simplified with some VAI rules, and then (3) the 3rd generation VAI is performed as mentioned in the previous paragraph. It is well known that the shortest room-level prevention sets that are calculated by the 2nd and 3rd generation VAI methods are identical.

• Journal of Korean Society of Occupational and Environmental Hygiene
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• v.21 no.2
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• pp.73-81
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• 2011

The purpose of this study was to obtain scientific information regarding classification and health hazards that may result from a 13 weeks inhalation exposure of isoprene in Sprague-Dawley (SD) rats. The testing method was conducted in accordance with OECD guidelines for the testing of chemicals No. 413. The Rats were divided into 4 groups (10 male and 10 female rats in each group) and exposed to 0, 360, 1,620, 7,300 ppm isoprene in each exposure chamber for 6 h/day, 5 days/week, for 13 weeks. As a result, there were no mortality or abnormality during the period of study and did not show any significant changes of body weight. There were no dose response changes in urinalysis, hematological and serum biochemical value examination. Relative organ weight was increased significantly the right kidney in 7,300 ppm group of male rats. In female rats, relative organ weight of the left kidney and the both lungs in 1,620 ppm group and the left lung and the both kidneys in 7,300 ppm group were increased significantly. But the histopathological findings did not reveal any exposure-related changes. According to the above results, the no observable adverse effect level (NOAEL) of isoprene was 7,300 ppm (20.3 mg/L) in both male and female rats. In conclusion, Isoprene was not classified specific target organ toxicity of the 'Standard for Classification and Labeling of Chemical Substance and Material Safety Data Sheet' (Ministry of Employment and Labor, 2009).

• Journal of the Korean Society of Safety
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• v.6 no.3
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• pp.56-63
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• 1991

This study investigates reliability based design criteria for the erection members, and proposes practical algorithm which is based on Ellingwood's algorithm for the reliability analysis and the derivation of reliability based criteria. The magnitude of the uncertainties associated with load effects are chosen primarily by considering our level of practice. And thus the uncertainties so obtained are applied for the reliability analysis and the derivation of reliability based design criteria. A target reliability($\beta$$_{o}$=2.0) is selected as an appropriate value by analyzing the reliability levels of our current USD and WSD design standards. Them a set of load and resistance factors corresponding to the target reliability is proposed as a reliability based design provision, and furthermore a set of allowable stresses for steel having same level of reliability with the corresponding LRFD criteria is also prepared for the current WSD design provision. It may be concluded that the proposed LRFD reliability based design provisions and the corresponding allowable stresses give more rational design than the current code for erection membars.s.s.

• Toxicological Research
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• v.8 no.2
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• pp.171-177
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• 1992

To investigate a short term screening method for carcinogenic quinone compounds, 8-hydroxydeoxyguanosine (8-OHdG), an oxidative DNA damage, was determined in the kidney and liver DNA isolated from Sprague-Dawley rats after i.p.injection of 7 mg/kg adriamycin (AM), 7mg/kg tetrahydropyranyladriamycin (THP), and 10mg/kg daunomycin (DM) by HPLC-electrochemical detector system. 8-OHdG was also determined from rat hepatocvtes and calf thymus DNA exposed to AM, DM and THP. When rats were treated with DM and THP, 8-OHdG was significantly increased in the kidney compared to control group, and remained at high level (7.9~9.0, 8-OHdG/dG${\times}10^4$)at the end of experiments (48hr after treatment). 8-OHdG level in cultured hepatocyte exposed to AM, DM and THP was 1.5~2 fold higher than control at all time points. (1,2,3,4hr after treatment). From calf thymus DNA exposed to AM, DM and THP, 8-OHdG was 2.5 fold higher than of control. These results suggest that quantitation of 8-OHdG may provide a useful marker for identifying target organ in oxidative chemical carcinogenesis and for short term screening of free radical generating carcinogens.

• Journal of Environmental Science International
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• v.29 no.9
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• pp.871-883
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• 2020

Due to recent heavy rain events, there are increasing demands for adapting infrastructure design, including drainage facilities in urban basins. Therefore, a clear definition of urban rainfall must be provided; however, currently, such a definition is unavailable. In this study, urban rainfall is defined as a rainfall event that has the potential to cause water-related disasters such as floods and landslides in urban areas. Moreover, based on design rainfall, these disasters are defined as those that causes excess design flooding due to certain rainfall events. These heavy rain scenarios require that the design of various urban rainfall facilities consider design rainfall in the target years of their life cycle, for disaster prevention. The average frequency of heavy rain in each region, inland and coastal areas, was analyzed through a frequency analysis of the highest annual rainfall in the past year. The potential change in future rainfall intensity changes the service level of the infrastructure related to hand-to-hand construction; therefore, the target year and design rainfall considering the climate change premium were presented. Finally, the change in dimensional safety according to the RCP8.5 climate change scenario was predicted.