• Development and Reproduction
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• v.18 no.1
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• pp.1-11
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• 2014

Early growth response 1 (Egr1) is a zinc-finger transcription factor to direct second-wave gene expression leading to cell growth, differentiation and/or apoptosis. While it is well-known that Egr1 controls transcription of an array of targets in various cell types, downstream target gene(s) whose transcription is regulated by Egr1 in the uterus has not been identified yet. Thus, we have tried to identify a list of potential target genes of Egr1 in the uterus by performing multi-step in silico promoter analyses. Analyses of mRNA microarray data provided a cohort of genes (102 genes) which were differentially expressed (DEGs) in the uterus between Egr1(+/+) and Egr1(-/-) mice. In mice, the frequency of putative EGR1 binding sites (EBS) in the promoter of DEGs is significantly higher than that of randomly selected non-DEGs, although it is not correlated with expression levels of DEGs. Furthermore, EBS are considerably enriched within -500 bp of DEG's promoters. Comparative analyses for EBS of DEGs with the promoters of other species provided power to distinguish DEGs with higher probability as EGR1 direct target genes. Eleven EBS in the promoters of 9 genes among analyzed DEGs are conserved between various species including human. In conclusion, this study provides evidence that analyses of mRNA expression profiles followed by two-step in silico analyses could provide a list of putative Egr1 direct target genes in the uterus where any known direct target genes are yet reported for further functional studies.

• Korean Journal of Exercise Nutrition
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• v.25 no.3
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• pp.28-35
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• 2021

[Purpose] As Panax ginseng C. A. Meyer (ginseng) exhibits various physiological activities and is associated with exercise, we investigated the potential active components of ginseng and related target genes through network pharmacological analysis. Additionally, we analyzed the association between ginseng-related genes, such as the G-protein-coupled receptors (GPCRs), and improved exercise capacity. [Methods] Active compounds in ginseng and the related target genes were searched in the Traditional Chinese Medicine Database and Analysis Platform (TCMSP). Gene ontology functional analysis was performed to identify biological processes related to the collected genes, and a compound-target network was visualized using Cytoscape 3.7.2. [Results] A total of 21 ginseng active compounds were detected, and 110 targets regulated by 17 active substances were identified. We found that the active compound protein was involved in the biological process of adrenergic receptor activity in 80%, G-protein-coupled neurotransmitter in 10%, and leucocyte adhesion to arteries in 10%. Additionally, the biological response centered on adrenergic receptor activity showed a close relationship with G protein through the beta-1 adrenergic receptor gene reactivity. [Conclusion] According to bioavailability analysis, ginseng comprises 21 active compounds. Furthermore, we investigated the ginseng-stimulated gene activation using ontology analysis. GPCR, a gene upregulated by ginseng, is positively correlated to exercise. Therefore, if a study on this factor is conducted, it will provide useful basic data for improving exercise performance and health.

• Journal of Korean Society of Rural Planning
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• v.20 no.1
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• pp.105-113
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• 2014

This study analyzed settlement motivation, life satisfaction factors, policy requirement targeting return farmers on mountain village. 8 target villages where return farmers live at least 10 people were selected according as cooperation of the local governments through literature by considering the area of the whole country. The return farmers in target villages were conducted a face to face survey with village headman's pre-coordination from February to September 2013. A total of 94 surveys were performed and 87 copies were used in the analysis. According to the results, the most important factor influenced the decision to be a return farmer was "my family health(3.97)". The correlation analysis was performed to examine factors related with satisfaction of "return farmer life in general". The result showed that "change of physical health" was the most important correlativity with 0.544 correlation coefficient and 0.05 significant level and "family relationship" was followed with 0.424 correlation coefficient and 0.05 significant level. According to the "important factor for the successful return-farmer life", 42.7% of respondents chose "harmonious relationships with local residents" and "stable source of income" was chosen by 29.3% of residents. A questionnaire for the analysis of policy requirements showed that "education system related Forestry(Agriculture)" was the highest demand with 4.oo points. The result can be used as a basis for establishing policies with activation of mountain villages to attract to constantly increasing population of return farmers.

• Journal of the Korean housing association
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• v.14 no.4
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• pp.49-56
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• 2003

The object of this study is to analyze the influential factors of characteristics of residential locations by age, and to offer a groundwork that can be utilized to direct setting of residential development and housing policies. The main findings are drawn as follows: First, it determines the age groupings which can describe the distribution pattern of residential location, which is broken down into two social subgroups - the older group aged 50 and over, and the younger group, being our educational target. Second, actuality of our education is to influence residential location. Third, four groups that can describe residential location are abstracted. Fourth, the prime of manhood and old age prime of life have been superior within inner zone, while middle age and those who are obliged to support the older group have been superior around the outer zone.

• Journal of the Korea Institute of Military Science and Technology
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• v.14 no.1
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• pp.114-122
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• 2011

In this paper, we have identified the system instability factors in a bistatic radar system using pulse chasing and considered their effects on the bistatic receiver's MTI(Moving Target Indication) improvement performance. The pulse chasing is a method to efficiently scan a restricted search area within the limited transmitter power and time in a bistatic radar and to track a series of transmitted pulses using the receiver beam which has ideally matched to the pulse propagation rate. In this paper, we have discussed the interrelationship between the pulse chasing and time and frequency/phase synchronization and described the effects of the identified system instability factors on two kinds of MTI filter configuration, single delay-line and double delay-line, in the bistatic radar. And also, we have confirmed that the overall system improvement is restricted by a lower improvement factor among identified them, and discussed the allowable tolerance of the time and frequency/phase synchronization in the bistatic system.

• Transactions on Electrical and Electronic Materials
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• v.2 no.3
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• pp.24-27
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• 2001

The end point of oxide chemical mechanical polishing (CMP) have determined by polishing time calculated from removal rate and target thickness of oxide. This study is about control of oxide removal amounts on the shallow trench isolation (STI) patterned wafers using removal rate and thickness of blanket (non-patterned) wafers. At first, it was investigated the removal properties of PETEOS blanket wafers, and then it was compared with the removal properties and the planarization (step height) as a function of polishing time of the specific STI patterned wafers. We found that there is a relationship between the oxide removal amounts of blanket and patterned wafers. We analyzed this relationship, and the post CMP thickness of patterned wafers could be controlled by removal rate and removal target thickness of blanket wafers. As the result of correlation analysis, we confirmed that there was the strong correlation between patterned and blanket wafer (correlation factor: 0.7109). So, we could confirm the repeatability as applying for STI CMP process from the obtained linear formula. As the result of repeatability test, the differences of calculated polishing time and actual polishing time was about 3.48 seconds. If this time is converted into the thickness, then it is from 104 $\AA$ to 167 $\AA$. It is possible to be ignored because process margin is about 1800 $\AA$.

• Genomics & Informatics
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• v.13 no.3
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• pp.76-80
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• 2015

Type 2 diabetes mellitus is a complex metabolic disorder associated with multiple genetic, developmental and environmental factors. The recent advances in gene expression microarray technologies as well as network-based analysis methodologies provide groundbreaking opportunities to study type 2 diabetes mellitus. In the present study, we used previously published gene expression microarray datasets of human skeletal muscle samples collected from 20 insulin sensitive individuals before and after insulin treatment in order to construct insulin-mediated regulatory network. Based on a motif discovery method implemented by iRegulon, a Cytoscape app, we identified 25 candidate regulons, motifs of which were enriched among the promoters of 478 up-regulated genes and 82 down-regulated genes. We then looked for a hierarchical network of the candidate regulators, in such a way that the conditional combination of their expression changes may explain those of their target genes. Using Genomica, a software tool for regulatory network construction, we obtained a hierarchical network of eight regulons that were used to map insulin downstream signaling network. Taken together, the results illustrate the benefits of combining completely different methods such as motif-based regulatory factor discovery and expression level-based construction of regulatory network of their target genes in understanding insulin induced biological processes and signaling pathways.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2009.10a
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• pp.850-854
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• 2009

Approximate analysis for a building installed with a friction damper is revisited to get insight of its dynamic behavior. Energy balance equation is used to have a closed analytical form solution of dynamic magnification factor (DMF) for the building with combined viscous and friction damping. It is found out that DMF is dependent on friction force ratio and resonance frequency. Linear transfer function from input external force to output building displacement is obtained by simplifying DMF equation. Root mean square of building displacement is derived under earthquake-like random excitation. Finally, design of friction damper is proposed by processing target control ratio, damping ratio factor, and friction force in sequence.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2004.10a
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• pp.92-96
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• 2004

In this paper, polishing method using bonded magnetic abrasive particle has been applied to the micro mold polishing. Through process control using the Run-to-Run control, it tried to form the surface roughness In order to grasp the influence of the surface roughness which is reached by selection of control factor and the factor, a design of experiment was been processed. The study is processed with a purpose of to embody and to maintain the surface roughness of nano scale by the basis of an influence between a control factor and the factors which has been selected in this way. As a result, the result of the process control converged at a target value of surface roughness Ra 10nm and Rmax 50nm

• Journal of the Korean Data and Information Science Society
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• v.18 no.1
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• pp.123-139
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• 2007

Recently, Super-Super-Market(SSM) is facing more and more difficult situation due to the expansion of hypermarket and target marketing of specialized shop. In this situation, Customer Satisfaction Management(CSM) is emerging as a core business factor to make continuous growth without competitive exclusion. Especially, the first factor in CSM in distribution industry is a Service Quality Satisfaction. In this paper, with a selection of 3-markets as a sample for the research, I have tried to look for necessary Service Quality(SQ) factors in SSM and deduced Service Quality Index(SQI), loyalty and Index of detail factor in SQ through survey. Based on these results, strategic factors required to improve SQ was found and strategic directions for SQ were proposed through matrix portfolio analysis.