• Journal of Life Science
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• v.28 no.6
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• pp.753-763
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• 2018

Cysteine cathepsins are lysosomal enzymes that belong to the papain family and can induce the degradation of damaged proteins through the endo-lysosomal pathway. It is highly upregulated in many cancers by regulating gene amplification and transcriptional, translational, and post-transcriptional modifications. Cathepsin S is part of the cysteine cathepsin family. Many studies have demonstrated that cathepsin S not only plays a specific role in MHC class II antigen presentation but also plays a crucial role in cancers. Cathepsin S is more stable at a neutral pH compared to other cysteine cathepsins, which supports the importance of cathepsin S in disease microenvironments. Therefore, the dysregulation of cathepsin S has participated in a variety of pathological processes, including cancer, arthritis, and cardiovascular disease. Furthermore, a decrease or depletion in the expression of cathepsin S has been implicated in the processes of tumor growth, invasion, metastasis, and angiogenesis. Taken together, cathepsin S has been suggested as an attractive therapeutic target for cancer therapy. In this review, the known involvement of cathepsin S in diseases, particularly with respect to recent work indicating its role in cancer therapy, is examined. An overview of current literature on the inhibitors of cathepsin S as a therapeutic target for cancer is also provided.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.3
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• pp.554-559
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• 2016

Cheongju has been a continuously expanding city due to housing development and new town construction since the 1980s. With time, many urban problems have arisen, such as commercial decline, and degradation of the residential environment in inner city. To revitalize the inner city, this study proposed some planning strategies through the linkage of separated urban regeneration projects maximizing its effectiveness. Therefore, firstly, this study selected the target area in the inner city and identified the cause of the declination and deterioration pattern. Secondly, the main issues were derived by reviewing the locational characteristics and the potential of the target area. Finally, four strategies and detailed projects were suggested for the target area for revitalization of the inner city. Although the effectiveness cannot yet be verified due to its under realization, the results derived from the citizen's participation are having a very important impact and they can be a useful reference for similar planning.

• Journal of KIISE:Software and Applications
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• v.31 no.10
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• pp.1320-1331
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• 2004

A video adaptation system translates the source video stream into appropriate video stream while satisfying the network and client constraints and maximizing the video quality as much as possible. This paper proposes a semi-dynamic video adaptation scheme, in which several intermediate video streams and the information for the measuring of video quality are generated statically. The intermediate video streams are generated by reducing the resolution of the video stream by a power of two several times, and they are stored as the intermediate video streams on the video server. The statically generated information for the input video stream consists of the degrees of smoothness for each frame rate and the degree of frame definition for each pixel bit rate. It helps to dynamically generate the target video stream according to the client's QoS at run-time as quickly as possible. Experimental result shows that the proposed adaptation scheme can generate the target video stream about thirty times faster while keeping the quality degradation as less than 2% comparing to the target video stream that is totally dynamically generated, although the extra storages for the intermediate video streams are required.

• The Journal of Korean Institute of Communications and Information Sciences
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• v.33 no.6A
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• pp.624-634
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• 2008

The mobile station which is about to do handover in IEEE 802.16e networks scans its neighboring base station channels to decide its next target base station. However, due to the lack of location information of its subscribers, the serving base station cannot provide any reliable candidate channel which is actually attachable by the scanning mobile stations, which makes the mobile station suffer from the long scanning time. Sometimes, long scanning time may cause the degradation of quality of service due to repeatable scan-duration or failure to start the handover procedure in time. To overcome these problems, in this paper, we propose a new protocol so called fast group scanning scheme, in which multiple mobile stations form a group to scan their neighboring base station channels simultaneously. Main contribution of this proposal is to find and decide a reliable target base station within a short scanning time. The fast group scanning scheme can be deployed to the cell network of the serving base station with a dynamic neighboring base station list management.

• Journal of KIISE
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• v.45 no.1
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• pp.9-14
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• 2018

Tar is a Linux command that combines several files into a single file. Combining multiple small files into large files increases the compression efficiency and data transfer speed. However, tar has a problem in that smaller target files, result in a lower performance. In this paper, we show that this performance degradation occurs when tar reads the data from the target files and propose qtar (quick tar) to solve this problem via flash-level remapping. When the size of an I/O request is less than 1 MB, the I/O performance decreases proportionally to the decrease in size of the I/O request. Since tar reads the data of files one by one, a smaller file size results in a lower performance. Therefore, the remapping technique is implemented in qtar to read data from the target files at the maximum I/O size regardless of the size of each file. Our evaluations show that the execution time with qtar is reduced by up to 3.4 times compared to that with tar.

• Journal of Korean Society for Geospatial Information Science
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• v.20 no.4
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• pp.77-87
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• 2012

Discussion on North Korea as UN-REDD (Reduced Emissions from Deforestation and Degradation in developing countries) project target continues with a view to preventing deforestation and to securing CER(certified emission reduction) for South Korea. However, due to North Korea's political shutdown, it is hard to acquire information required for the REDD project registration. This research intends to acquire objective data using satellite images in the Mt. Geumgang. More than 20% of entire forested area were disappeared during the past two decades mainly due to conversion into agricultural farming land. Further, it is expected that persistent deforestation will go on. The reduction potential of the carbon emission is estimated as approximately 617,000 tCO2/year~663.000 tCO2/year. Thus, Mt. Geumgang is considered as realistic REDD target, which is attractive to South Korea, given that the obligation to reduce greenhouse gas emission is likely to be imposed upon the country. Further, political and social benefits due to reduced military conflict make Mt. Geumgang as UN-REDD project target invaluable.

• Journal of Korea Society of Industrial Information Systems
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• v.11 no.3
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• pp.15-19
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• 2006

In shallow water active sonar environment, reverberation which is a non-white noise is one of the main source of performance degradation of target detection. In this case, the received signal is whitened before applying matched filter known as an optimum filter in the presence of white noise. However implementation of this method is very difficult because of the non-stationary characteristic of reverberation. Traditionally reverberation is assumed local stationary. In this paper, we estimate a range of stationary of reverberation signal, and then propose a pre-whitening method which improve the performance of pre-whitening block normalized matched filter in presence of non-white reverberation noise. Proposed whitener shows better whitening performance than traditional whitener because it use later as well as before reverberation of target signal. To evaluate performance of the proposed whitener, an actual measurement data sampled at the East-Sea is used for computer simulation. The target detector with new whitener is shown better performance than detector with traditional whitener.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.19 no.1
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• pp.61-68
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• 2015

Noise reduction is necessary to compensate for the degradation of recognition performance by various types of noises. Among many noise reduction techniques using microphone array, generalized sidelobe canceller (GSC) has been widely applied to reduce nonstationary noises. The performance of GSC is directly affected by its adaptation mode controller (AMC). That is, accurate target speech detection is essential to guarantee the sufficient noise reduction in pure noise intervals and the less distortion in target speech intervals. Thus, this paper proposes an improved AMC design technique in which the power ratio of the output of fixed beamforming to that of blocking matrix is calculated frequency bandwise and probabilistically modeled by mixture Gaussians for each class. Experimental results show that the proposed algorithm outperforms conventional AMCs in receiver operating curves (ROC) and output SNRs.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.18 no.10
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• pp.2403-2408
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• 2014

We designate multiple target areas for the advertisement disseminations in order to resolve the problem of advertisement transmission efficiency degradation due to overlapped device-to-device (D2D) transmissions and unnecessary advertisement transmissions. We here propose an efficient advertisement dissemination algorithm based on pre-selected target areas considering user density. In our proposed algorithm, relay nodes are gradually selected according to the locations of the target areas. We mathematically analyze D2D advertisement coverages of our proposed algorithm, and compare the various simulation results of the proposed algorithm with those of the conventional algorithm according to the several simulation scenarios via intensive simulations.

• The Journal of the Acoustical Society of Korea
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• v.41 no.4
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• pp.446-460
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• 2022

In this paper, we propose an algorithm to improve target detection rate degradation due to direct blast in a bi-static sonar systems with high duty cycle using an adaptive filters. It is very important to suppress the direct blast in the aforementioned sonar systems because it has a fatal effect on the actual system operation. In this paper, the performance was evaluated by applying the Normalized Least Mean Square (NLMS) and Recursive Least Square (RLS) algorithms to the simulation and sea experimental data. The beam signals of the target and direct blast bearings were used as the input and desired signals, respectively. By optimizing the difference between the two signals, the direct blast is removed and only the target signal is remained. As a result of evaluating the results of the matched filter in the simulation, it was confirmed that the direct blast was removed to the noise level in both Linear Frequency Modultated (LFM) and Generalized Sinusoidal Frequency Modulated (GSFM), and in the case of GSFM, the target sidelobe decreased by more than 20 dB, thereby improving performance. In the sea experiment, it was confirmed that the LFM reduced the level of the transmitted direct wave by 10 dB, the GSFM reduced the level of the transmitted direct wave by about 4 dB, and the side lobe of the target decreased by about 4 dB, thereby improving the performance.