• 제목/요약/키워드: Target Fusion

검색결과 336건 처리시간 0.035초

다중센서자료 시뮬레이터 설계 및 자료융합 알고리듬 개발 (Design of a Multi-Sensor Data Simulator and Development of Data Fusion Algorithm)

  • 이용재;이자성;고선준;송종화
    • 한국항공우주학회지
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    • 제34권5호
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    • pp.93-100
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    • 2006
  • 본 논문에서는 레이더와 원격측정시스템으로부터 수신되는 다중센서자료를 모사하는 시뮬레이터 설계와 이들 자료를 융합하기 위한 알고리듬 개발에 대하여 소개한다. 설계된 데이터 시뮬레이터는 실제 센서 시스템으로부터 얻게 되는 시간의 비동기, 통신지연, 다중 갱신주기들을 갖는 모의센서 자료를 생성하며 실제적인 센서 모델을 이용하여 측정 잡음을 생성한다. 융합알고리듬은 센서 바이어스 상태를 고려한 PVA모델을 기초로 21차 분산형 칼만 필터로 설계되었고, 센서의 이상이나 정상적이 아닌 측정치를 검출하기 위한 로직도 포함되었다. 설계된 알고리듬을 시뮬레이터에서 생성한 모의 자료 및 실제 자료를 적용하여 검증하였다.

HQSAR Study of Tricyclic Azepine Derivatives as an EGFR (Epidermal Growth Factor Receptor) Inhibitors

  • Chung, Hwan-Won;Lee, Kyu-Whan;Oh, Jung-Soo;Cho, Seung-Joo
    • Molecular & Cellular Toxicology
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    • 제3권3호
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    • pp.159-164
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    • 2007
  • Stimulation of epidermal growth factor receptor (EGFR) is essential in signaling pathway of tumor cells. Thus, EGFR has intensely studied as an anticancer target. We developed hologram quantitative structure activity relationship (HQSAR) models for data set which consists of tricyclic azepine derivatives showing inhibitory activities for EGFR. The optimal HQSAR model was generated with fragment size of 6 to 7 while differentiating fragments having different atom and connectivity. The model showed cross-validated $q^2$ value of 0.61 and non-cross-validated $r^2$ value of 0.93. When the model was validated with an external set excluding one outlier, it gave predictive $r^2$ value of 0.43. The contribution maps generated from this model were used to interpret the atomic contribution of each atom to the overall inhibition activity. This can be used to find more efficient EGFR inhibitors.

Synthesis and Structural Properties of $VO_2$ Thin Films

  • Jin, Zhenlan;Park, Changin;Hwang, Inhui;Han, S.W.
    • 한국진공학회:학술대회논문집
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    • 한국진공학회 2013년도 제45회 하계 정기학술대회 초록집
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    • pp.190.2-190.2
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    • 2013
  • Vanadium dioxide ($VO_2$) has been widely attracted for academic research and industrial applications due to its metal-insulator transition (MIT) temperature close to room temperature. We synthesized VOx film on (0001) sapphire substrate with vanadium target (purity: 99.9%) using DC magnetron sputtering in Ar ambience at a pressure of $10^{-3}$ Torr at $400{\sim}700^{\circ}C$. The VOx film subsequently was annealed at difference temperatures in ambience of Ar and $O_2$ gas mixture at $60{\sim}800^{\circ}C$. The structural properties of the films were investigated using scanning electron microscopic (SEM), x-ray diffraction (XRD) and x-ray absorption fine structure (XAFS) measurements. SEM reveal that small grains formed on the substrates with a roughness surface. XRD shows oriented $VO_2$(020) crystals was deposited on the $Al_2O_3$(006) substrate. From I-V measurements, the electric resistance near its MIT temperature were dramatically changed by ${\sim}10^4$ during heating and cooling the films. We will also discuss the temperature-dependent local structural changes around vanadium atoms using XAFS measurements.

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Development of an RNA sequencing panel to detect gene fusions in thyroid cancer

  • Kim, Dongmoung;Jung, Seung-Hyun;Chung, Yeun-Jun
    • Genomics & Informatics
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    • 제19권4호
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    • pp.41.1-41.10
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    • 2021
  • In addition to mutations and copy number alterations, gene fusions are commonly identified in cancers. In thyroid cancer, fusions of important cancer-related genes have been commonly reported; however, extant panels do not cover all clinically important gene fusions. In this study, we aimed to develop a custom RNA-based sequencing panel to identify the key fusions in thyroid cancer. Our ThyChase panel was designed to detect 87 types of gene fusion. As quality control of RNA sequencing, five housekeeping genes were included in this panel. When we applied this panel for the analysis of fusions containing reference RNA (HD796), three expected fusions (EML4-ALK, CCDC6-RET, and TPM3-NTRK1) were successfully identified. We confirmed the fusion breakpoint sequences of the three fusions from HD796 by Sanger sequencing. Regarding the limit of detection, this panel could detect the target fusions from a tumor sample containing a 1% fusion-positive tumor cellular fraction. Taken together, our ThyChase panel would be useful to identify gene fusions in the clinical field.

Novel Partitioning Algorithm for a Gaussian Inverse Wishart PHD Filter for Extended Target Tracking

  • Li, Peng;Ge, Hongwei;Yang, Jinlong
    • KSII Transactions on Internet and Information Systems (TIIS)
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    • 제11권11호
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    • pp.5491-5505
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    • 2017
  • Use of the Gaussian inverse Wishart PHD (GIW-PHD) filter has demonstrated promise as an approach to track an unknown number of extended targets. However, the partitioning approaches used in the GIW-PHD filter, such as distance partition with sub-partition (DP-SP), prediction partition (PP) and expectation maximization partition (EMP), fails to provided accurate partition results when targets are spaced closely together and performing maneuvers. In order to improve the performance of a GIW-PHD filter, this paper presents a cooperation partitioning (CP) algorithm to solve the partitioning issue when targets are spaced closely together. In the GIW-PHD filter, the DP-SP is insensitive to target maneuvers but sensitive to the differences in target sizes, while EMP is the opposite. The proposed CP algorithm is a fusion approach of DP-SP and EMP, which employs EMP as a sub-partition approach after DP. Therefore, the CP algorithm will be sensitive to neither target maneuvers nor differences in target sizes. The simulation results show that the use of the proposed CP algorithm will improve the performance of the GIW-PHD filter when targets are spaced closely together.

융합된 다중 센서와 EKF 기반의 무인잠수정의 항법시스템 설계 (Navigation System of UUV Using Multi-Sensor Fusion-Based EKF)

  • 박영식;최원석;한성익;이장명
    • 제어로봇시스템학회논문지
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    • 제22권7호
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    • pp.562-569
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    • 2016
  • This paper proposes a navigation system with a robust localization method for an underwater unmanned vehicle. For robust localization with IMU (Inertial Measurement Unit), a DVL (Doppler Velocity Log), and depth sensors, the EKF (Extended Kalman Filter) has been utilized to fuse multiple nonlinear data. Note that the GPS (Global Positioning System), which can obtain the absolute coordinates of the vehicle, cannot be used in the water. Additionally, the DVL has been used for measuring the relative velocity of the underwater vehicle. The DVL sensor measures the velocity of an object by using Doppler effects, which cause sound frequency changes from the relative velocity between a sound source and an observer. When the vehicle is moving, the motion trajectory to a target position can be recorded by the sensors attached to the vehicle. The performance of the proposed navigation system has been verified through real experiments in which an underwater unmanned vehicle reached a target position by using an IMU as a primary sensor and a DVL as the secondary sensor.

Improved Two-Phase Framework for Facial Emotion Recognition

  • Yoon, Hyunjin;Park, Sangwook;Lee, Yongkwi;Han, Mikyong;Jang, Jong-Hyun
    • ETRI Journal
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    • 제37권6호
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    • pp.1199-1210
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    • 2015
  • Automatic emotion recognition based on facial cues, such as facial action units (AUs), has received huge attention in the last decade due to its wide variety of applications. Current computer-based automated two-phase facial emotion recognition procedures first detect AUs from input images and then infer target emotions from the detected AUs. However, more robust AU detection and AU-to-emotion mapping methods are required to deal with the error accumulation problem inherent in the multiphase scheme. Motivated by our key observation that a single AU detector does not perform equally well for all AUs, we propose a novel two-phase facial emotion recognition framework, where the presence of AUs is detected by group decisions of multiple AU detectors and a target emotion is inferred from the combined AU detection decisions. Our emotion recognition framework consists of three major components - multiple AU detection, AU detection fusion, and AU-to-emotion mapping. The experimental results on two real-world face databases demonstrate an improved performance over the previous two-phase method using a single AU detector in terms of both AU detection accuracy and correct emotion recognition rate.

Failure analysis of damaged tungsten monoblock components of upper divertor outer target in EAST fusion device

  • Kang Wang;Ya Xi;Xiang Zan;Dahuan Zhu;Laima Luo;Rui Ding;Yucheng Wu
    • Nuclear Engineering and Technology
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    • 제56권6호
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    • pp.2307-2316
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    • 2024
  • A melting failure of W monoblock components of the upper divertor outer target in EAST occurred during the plasma campaigns in 2019. The failure characters and microstructure evolution of the failed W monoblock have been well investigated on one string (W436 string). Near the strike point region where heat flux density is highest, macroscopic cracks and severe surface damage such as dimensional change, melting and solidification are visible in several W monoblocks. At the same time, debonding, melting and migration of Cu/CuCrZr cooling tube components introduced fatal damage to the structure and function. The heat-induced microstructure evolution in the rest part has been examined via hardness tests and metallography. From the heat flux surface to the cooling tube, hardness increased gradually and the recrystallized grains could be found in the region with the highest temperature, while recrystallization grains also appear in some W monoblocks near the cooling tube area. The detailed microstructure has been investigated by metallography and EBSD. Such cases in EAST provide experiences on the extreme condition of accidental loss of coolant or higher discharge power in future devices.

Structural and Mechanistic Insights into the Tropism of Epstein-Barr Virus

  • Mohl, Britta S.;Chen, Jia;Sathiyamoorthy, Karthik;Jardetzky, Theodore S.;Longnecker, Richard
    • Molecules and Cells
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    • 제39권4호
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    • pp.286-291
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    • 2016
  • Epstein-Barr virus (EBV) is the prototypical ${\gamma}$-herpesvirus and an obligate human pathogen that infects mainly epithelial cells and B cells, which can result in malignancies. EBV infects these target cells by fusing with the viral and cellular lipid bilayer membranes using multiple viral factors and host receptor(s) thus exhibiting a unique complexity in its entry machinery. To enter epithelial cells, EBV requires minimally the conserved core fusion machinery comprised of the glycoproteins gH/gL acting as the receptor-binding complex and gB as the fusogen. EBV can enter B cells using gp42, which binds tightly to gH/gL and interacts with host HLA class II, activating fusion. Previously, we published the individual crystal structures of EBV entry factors, such as gH/gL and gp42, the EBV/host receptor complex, gp42/HLA-DR1, and the fusion protein EBV gB in a postfusion conformation, which allowed us to identify structural determinants and regions critical for receptor-binding and membrane fusion. Recently, we reported different low resolution models of the EBV B cell entry triggering complex (gHgL/gp42/HLA class II) in "open" and "closed" states based on negative-stain single particle electron microscopy, which provide further mechanistic insights. This review summarizes the current knowledge of these key players in EBV entry and how their structures impact receptor-binding and the triggering of gB-mediated fusion.

항공기 센서 실시간 항적 정보와 항공전자 전술데이터링크 정보융합 구조 연구 (A Study on a Information Fusion Architecture of Avionics Realtime Track and Tactical Data Link)

  • 강신우;이영서;박상웅;안태식
    • 한국항행학회논문지
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    • 제26권5호
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    • pp.325-330
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    • 2022
  • 항공기에 탑재된 센서들은 임무 수행에 필수 요소이며 센서들을 통해 얻어진 데이터의 융합은 임무 효율을 높이고 조종사의 부담을 줄이기 위해 적용되고 있다. 센서들로부터 얻어진 데이터를 특정 대상에 대해 일관되고 보다 정리된 형태로 조종사에게 제공하기 위해 데이터 융합이 적용되어 발전하고 있다. 현재 운용되고 있는 군용 항공기는 Link-16 과 같은 전술데이터링크에 연동하여 향상된 전술 상황을 조종사에게 전시하여 임무 효율을 높이고 있다. 항공기에 탑재된 센서가 고성능화 되면서 얻어진 정확도가 향상된 센서 데이터와 전술데이터링크를 통해 수신한 전술상황정보를 융합하여 조종사에게 고신뢰성의 전술상황 및 임무 환경을 제공하고 효율적인 임무 수행과 높은 생존성을 기대할 수 있다. 본 논문에서는 항공기 실시간 센서 데이터와 전술데이터링크를 통해 얻어지는 데이터를 종합된 정보 형태로 제공하기 위한 융합 구조를 보인다.