• 한국해양바이오학회지
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• 제7권2호
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• pp.35-41
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• 2015

Whales are marine mammals that are fully adapted to aquatic environment. Whales breathe by lungs so they require adaptive system to low oxygen concentration (hypoxia) while deep and prolonged diving. However, the study for the molecular mechanism underlying cetacean adaptation to hypoxia has been limited. Hypoxia-inducible factor (HIF) is the central transcription factor that regulates hypoxia-related gene expression. Here we identified HIF-binding sites in whale genome by phylogenetic footprinting and analyzed HIF-target genes to understand how whales cope with hypoxia. By comparison with the HIF-target genes of terrestrial mammals, it was suggested that whales may retain unique adaptation mechanisms to hypoxia.

• 대한안전경영과학회지
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• 제15권1호
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• pp.293-301
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• 2013

The purpose of this study is to introduce the limit of previously used six sigma quality process evaluation metrics, $Z_{st}$ and $P_{pk}$, and a solution to overcome this drawback by using a metric based on performance evaluation of Z-factor quality innovation. Case analysis on projects from national six sigma contest from 2011 to 2012 is performed and literature review on new drug development HTS (High Throughput Screening) is used to propose innovative performance evaluation metrics. This research shows that experimental study on six sigma evaluation metric, $Z_{st}$ and $P_{pk}$, have no significance difference between industrial type (Manufacturing, Semi-Public Institute, Public Institute) and CTQ type (Product Technology Type CTQ, Process Technology Type CTQ). Following discovery characterize this quality improvement as fixed target type project. As newly developed moving target type of quality innovation performance metric Z-Factor is used for evaluating experimental study, hypothetical analysis suggests that $Z_{st}$ and $P_{pk}$ share different relationship or even show reciprocal relationship. Constraints of the study are relatively small sample size of only 37 projects from past 2 years and conflict on having interview and communication with six sigma quality practitioner for qualitative experimental study. Both moving target type six sigma innovation project and fixed target type improvement project or quality circle enables efficient ways for a better understanding and quality practitioner use by applying quality innovation performance metric. Downside of fixed target type quality performance evaluation metric, $Z_{st}$ and $P_{pk}$, is presented through experimental study. In contrast, advantage of this study is that high throughput requiring product technology, process technology and quantum leap typed innovation effect is evaluated based on precision and accuracy and Z-Factor that enables relative comparison between enterprises is proposed and implemented.

• The Journal of the Acoustical Society of Korea
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• 제22권1E호
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• pp.19-25
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• 2003

Ryu et al. recently proposed a multiple target angle-tracking algorithm without a data association problem. This algorithm, however, shows the degraded performance on evasive maneuvering targets, because the estimated signal subspace is d,:graded in the algorithm. In this Paper, we proposed a new algorithm, in which VFF-PASTd (Variable Forgetting Factor PASTd) algorithm is applied to Ryu's algorithm to effectively handle the evasive target tracking with better time-varying signal subspace.

• 해양환경안전학회:학술대회논문집
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• 해양환경안전학회 2009년도 춘계학술발표회
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• pp.71-75
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• 2009

본 연구는 AHP를 이용한 항만국 통제 표적점검 평가법을 제안한다. 기존 항만국통제 TFV(Target Factor Values)는 단순한 평가법이기 때문에 보다 합리적이고 객관적인 평가법인 AHP법을 이용하였다. 그러나 AHP법은 상대평가법이기 때문에 대체안 추가시 가중치 재산정해야 한다. 따라서 이러한 해결을 위해 절대평가법을 이용하였다. 또한 최근 IMO에서 해양사고율을 항만국 통제 TFV에 포함하려고 추진중이기 때문에 해양사고 항목을 평가에 포함하였다. 마지막으로 몇척의 선박을 대상사례로 평가를 수행하였다.

• 대한원격탐사학회:학술대회논문집
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• 대한원격탐사학회 2006년도 Proceedings of ISRS 2006 PORSEC Volume I
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• pp.79-81
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• 2006

Geostationary ocean satellite, unlike other sun-synchronous polar-orbit satellites, will be able to take a picture of a large region several times a day (almost with every one hour interval). For geostationary satellite, the target region is fixed though the location of sun is changed always. Thus, the ocean signal of a given target point is largely dependent on time. In other words, the ocean signal detected by geostationary satellite sensor must translate to the signal of target when both sun and satellite are located in nadir, using another correction model. This correction is performed with a standardization of signal throughout relative geometric relationship among satellite - sun - target points. One signal value of a selected pixel point of the target region of Geostationary Ocean Colour Imager (GOCI) would be set up as a standard, and the ratio of all remained pixel point can be calculated. This relative ratio called bidirectional factor, the result of modelling of spatiotemporal variation of bidirectional factor is shown.

• 한국항공운항학회지
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• 제25권2호
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• pp.12-17
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• 2017

Manned aircraft structural design is based on structural safety factor of 1.5, and this safety factor is equivalent to a probability of failure of between 10-2 and 10-3. The target failure probability of FARs is between 10-6 and 10-9 per flight according to aircraft type. NATO released STANAG 4703 to established the airworthiness requirements for small UAV which is less than 150kg. STANAG 4703 requires the Target Level of Safety according to MTOW. The requirements of failure probability for small UAV is between 10-4 and 10-5. In this paper, requirements of airworthiness certification for small UAV were investigated and the relationship of safety factors to the probability of structural failure is analyzed to reduce measure of safety factor and structural weight of unmanned aircraft.

• Bulletin of the Korean Chemical Society
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• 제15권1호
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• pp.74-77
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• 1994

Rare earth elements (REE) were individual separated by applying the gradient elution via HPLC using ${\alpha}-hydroxyisobutyric$ acid (HIBA) as an eluent. However, the overlap of Y and Dy peaks was too severe to obtain the resolution of these two peaks. The target transformation factor analysis (TTFA) was applied to resolve the elution peaks of Y and Dy. [A]$_{raw}$ formed from the absorbances of mixed solution was factor analyzed. The abstract factor analysis(AFA) was used to determine the number of components that contributed to the poorly resolved peaks. The error theory in the AFA showed that the number of components was 2. The test vectors which correspond to pure component were selected from the standard solutions of Y and Dy. TTFA was accomplished by target testing. The results showed that the resolution of two peaks as well as the determination of Y and Dy were possible by the factor analysis.

• 대한화학회지
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• 제36권5호
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• pp.720-726
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• 1992

겹쳐 나타나는 X-선 형광 스펙트라에서 얻은 다변수 데이타를 해석하기 위하여 다변수분석법인 인자분석법을 적용하였다. Pb와 As의 피크가 겹쳐 있는 11개 표준시료의 X-선 형광 스펙트라를 파장분산형기기로 $33.50∼34.50^{\circ}$에서 측정하였다. 8개 시료의 피크세기로 데이타 매트릭스를 구성하고 AFA(Abstract Factor Analysis)를 수행하였다. 그 결과 인자의 수가 3으로 나타났으며 표준시료에 함유된 8개 원소를 타겟트 테스트한 결과 Pb, As 및 Cu로 판명되었다. 농도 기지인 시험시료에서 상기 원소들의 농도를 피크의 겹침에 무관하게 TTFA(Target Transformation Factor Analysis)에 의해 결정하였다.

• Journal of Digestive Cancer Research
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• 제1권1호
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• pp.24-28
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• 2013

위암은 최근 50년간 5년 생존율에 있어서 미약하게만 상승되었다. 이에 따라 위암에 대한 분자생물학적 치료에 대한 여러 연구가 진행되고 있다. 이에 진행성, 전이성 위암에서의 분자생물학적 치료에 대해 살펴보고자 한다. 위암의 분자생물학적 치료의 타켓으로는 EGFR (Epidermal growth factor receptor), HER(Human epidermal growth factor receptor), VEGF (Vascular endothelial growth factor receptor)를 들 수 있다. 대표적으로 분자생물학적 치료 중 trastuzumab은 HER2과발현 환자에게 유용하게 사용될 수 있어, 기존 항암화학요법에 복합투여해 볼 수 있다. Trastuzumab와 그 밖의 여러 분자생물학적 제재에 대해 본 연구에서 살펴보고자 한다.

• 해양환경안전학회:학술대회논문집
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• 해양환경안전학회 2006년도 추계학술발표회
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• pp.181-186
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• 2006

정지궤도위성은 태양 궤도위성과는 달리 넓은 지역의 매시간 측정이 가능하다. 정지 위성은 관측영역은 항상 고정되어 있으나 태양의 위치가 항상 변하므로 한 주어진 지점의 해수 신호의 크기는 기간에 따라 변하게 된다. 반면에 태양 궤도 위성은 하루 통일한 시간대에서 동일한 영역을 촬영하기 때문에 신호의 크기의 변화가 없다. 즉, 정지해양 위성에서 관측된 신호의 크기는 태양과 위성이 항상 수직 방향에 위치한다고 가정할 때 얻어지는 신호의 크기로 변경되어야한다. 이와 같은 신호의 보정은 지속적으로 변화하는 태양, 위성과 관측점의 기하학적인 위치변화에 따라 나타나게 되는데 이를 양방향 계수 (Bidirectional Factor) 라고 한다. 본 연구에서는 태양의 위치와 기하학적인 요인을 계산, 대기권 밖의 총 방사휘도와 반사율을 계산하였다. 그리고 양방향계수, 즉 관측점과 관측지점 사이의 규격화된 해면방사휘도$([L_W]_N)$의 비를 모의실험을 통해 확인하였다. 1년간의 값을 영상화 하였고 보다 정확한 양방향 계수 (Bidirectional Factor)를 얻기 위해 다양한 조건의 모의실험의 필요성을 제시하였다.