• Title/Summary/Keyword: Tablets

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A Study on the Mg-Loss of Al-Alloy Melt by $C_2C_{l6}$-Tablet Degassing (Al 합금용탕(合金熔湯)의 $C_2C_{l6}$정제(錠劑)-탈(脫)가스에 의한 Mg의 손실(損失))

  • Lee, Zin-Hyoung
    • Journal of Korea Foundry Society
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    • v.1 no.3
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    • pp.14-18
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    • 1981
  • The Mg-loss of AlSi 7% melts containing from 0 to 0.8% Mg during the Hexachloroethane tablet degassing was investigated. The results of the experiment was discussed in view of the free energy change and kinetics of $MgCl_2$ formation. The melts with Mg content less than 0.5% showed a Mg-loss proportional to Mg-content, while it was constant at about 24% of the weight of tablets, when Mg content of the melt became more than 0.5 %. The rate of Mg-loss was drastically reduced, when the amount of tablets used at a time increased ver a certain limit for a given melt quantity.

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Analysis of Dancheong Technique Used in the Middle Tablets of the Royal Palace Plaque during the Joseon Period (조선시대 궁궐 편액 복판의 단청 기법 연구)

  • Koo, Uk-Hee
    • Journal of architectural history
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    • v.26 no.6
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    • pp.55-66
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    • 2017
  • This study attempted to analyze how dancheong for palace tablets during the Joseon period was designed as related to what plans and what materials were being used. It also investigated how this unique culture formed. The results found the following: First, the tablet dancheong unveiled through literature was designed using diverse techniques such as jinchae and yeokcheongchil. In jinchae, shell powder was applied to the tablet as the first lacquering, and then was colored. Second, in lacquer, maechil, chaesaekchil and jeohyeoptaechil were used. In yeokcheongchil, vegetable black, oil ash and perilla oil were applied to bitumen. Third, during the Joseon Dynasty, dancheong was applied to a tablet after first lacquering just like the danpihoe lacquering of Jiangsu Sheng, China. This tablet dancheong technique was developed based on a unique Korean lacquering culture that had been handed down from ancient times.

Simultaneous Determination of Salicylic Acid and Aspirin in Commercial Aspirin Tablets

  • Kim, Chong-Kook;Hwang, Sung-Joo
    • Journal of Pharmaceutical Investigation
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    • v.12 no.4
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    • pp.126-131
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    • 1982
  • A quantitative fluorometric method was developed to determine aspirin and salicylic acid in bulk aspirin and commercial aspirin tablets. The excitation maximum for aspirin was observed at 280 nm and the emission maximum was at 335nm. The lowest energy excitation band for salicylic acid was at 308nm and the fluorescence emission band was at 450nm. Excipients, binders, lubricants and impurities did not interfere. Excellent recoveries were obtained for aspirin and salicylic acid. Results obtained by the KP III procedure and the proposed method were compared.

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Effect of Maunfacturing Methods on Content Uniformity of Tablets (제제방법(製劑方法)이 정제(錠劑)의 함량균일성(含量均一性)에 미치는 영향(影響))

  • Lee, Min-Hwa;Choi, Hoo-Kyun;Kim, Kil-Soo
    • Journal of Pharmaceutical Investigation
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    • v.11 no.1
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    • pp.6-14
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    • 1981
  • Safety, efficacy and reliability are the three basic criteria that define the quality of any well-designed pharmaceutical dosage form. Content uniformity directly bears on each of the three criteria defining the quality of drug product. Effect of manufacturing methods and physicochemical properties of the drug on content uniformity of tablets was investigated. Chlorpheniramine maleate and micronized salicylic acid were used as main ingredients. Three different methods for incorporation of main ingredients with diluents were solvent mixing method, geometric dilution method, and simple mixing method. The solvent mixing method was the best one of the three.

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Disintegrating Behavior of A Rapidly Disintegrating Famotidine Tablet Formulation

  • Park, Jeong-Sook;Shin, Kwang-Hyun;Park, Jong-Bum;Lee, Si-Beum;Hwang, Sung-Joo
    • Journal of Pharmaceutical Investigation
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    • v.37 no.5
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    • pp.275-280
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    • 2007
  • A rapidly disintegration famotidine tablet formulation in the oral cavity was developed using microcrystalline cellulose (MCC) and low-substituted hydroxypropyl cellulose (L-HPC), or additionally cropovidone as an internal disintegrant. Effects of disintegrants on the disintegration time in vitro and hardness were evaluated. Average wetting time of the tablets prepared in scale-up manufacturing process was less than 15 sec. Among the formulations tested, the tablet prepared with crospovidone as an internal disintegrant and Emcocel $90M^{(R)}$ as an external disintegrant showed fastest disintegration. These results may suggest that crospovidone and Emcocel $90M^{(R)}$ possessed excellent wetting nature, which result in the rapid disintegration of tablet.

SATS: Structure-Aware Touch-Based Scrolling

  • Kim, Dohyung;Gweon, Gahgene;Lee, Geehyuk
    • ETRI Journal
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    • v.38 no.6
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    • pp.1104-1113
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    • 2016
  • Non-linear document navigation refers to the process of repeatedly reading a document at different levels to provide an overview, including selective reading to search for useful information within a document under time constraints. Currently, this function is not supported well by small-screen tablets. In this study, we propose the concept of structure-aware touch-based scrolling (SATS), which allows structural document navigation using region-dependent touch gestures for non-sequential navigation within tablets or tablet-sized e-book readers. In SATS, the screen is divided into four vertical sections representing the different structural levels of a document, where dragging into the different sections allows navigating from the macro to micro levels. The implementation of a prototype is presented, as well as details of a comparative evaluation using typical non-sequential navigation tasks performed under time constraints. The results showed that SATS obtained better performance, higher user satisfaction, and a lower usability workload compared with a conventional structural overview interface.

Development of Alternative Assay Method without Hazardous Reagent, Chloroform for Urazamide Tablets in Korean Pharmaceutical Codex (우라자미드 정의 유해시약 대체 시험법의 개발)

  • Lee, Yoo Rim;Kim, Hyun Ji;Seo, Narae;Kim, Kyeong Ho
    • YAKHAK HOEJI
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    • v.58 no.2
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    • pp.125-128
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    • 2014
  • We developed an alternative assay method without hazardous reagent of chloroform for urazamide tablets in Korean Pharmaceutical Codex. The HPLC analytical method was validated by system suitability, linearity, precision, accuracy and robustness. The linearity of the calibration curves in the desired concentration range is good ($r^2$ >0.999). Precision was obtained less than RSD 1.17%. Accuracy was obtained with recoveries in range of 98.12% and 99.47%. The developed assay could be expected to become valuable tools for revising the Korean Pharmaceutical Codex.

Effect of Mixing Ratios of Active Ingredient on Content Uniformity of Tablets (주약의 혼합비율이 정제의 함량균일성에 미치는 영향)

  • 김길수
    • YAKHAK HOEJI
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    • v.31 no.5
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    • pp.343-346
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    • 1987
  • The effect of mixing ratios of active ingredient on the content uniformity of tablets was studied using caffeine as active ingredient and hydroxypropyl starch as diluent. In the case that caffeine content was not more than 1%, the standard deviation of individual tablet assays was inversely proportional to caffeine content. In the case of more than 1%, the standard deviation was constant independently of caffeine content. In the case that the designed tablet weight was not more than 200mg, the standard deviation of individual tablet assays was inversley proportional to tablet weight designed. In the case of more than 200mg, it was constant and the results for weight variation against the designed weight showed same tendency.

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Evaluation of Physical Properties of Mucosal Adhesive Tablets (I):-Adhesive Force- (점막 부착정제의 물성평가(I):-부착력-)

  • Park, Kwang-Sin;Chung, Bee-Hwan;Cha, Bong-Jin;Kwon, Jong-Won
    • Journal of Pharmaceutical Investigation
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    • v.23 no.1
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    • pp.51-53
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    • 1993
  • Mucoadhesive tablets containing hydroxypropylcellulose-H (HPC) and carbopol 934 (CP) were prepared from direct compression. Their adhesive forces and water absorptions were investigated by using mouse peritoneal membrane and 1.5% agar plate, respectively. Adhesive force was significantly improved with increasing CP concentration, but was not affected by compression force and addition of disintegrants. And adhesive force to mouse peritioneal membrane was increased as fixing time increased. In conclusion, adequate adhesive force can be obtained by control of CP/HPC ratio and fixing time.

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Statistical Consideration on the Similarity in Dissolution Profile of Two Fast Releasing Tablets (속용성 정제간의 용출유사성에 대한 통계학적 고찰)

  • Cho, Jung-Hwan;Lee, Se-Hee;Kim, Hee-Sun;Oh, Seaung-Youl
    • Journal of Pharmaceutical Investigation
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    • v.30 no.2
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    • pp.85-91
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    • 2000
  • We have studied the dissolution kinetics of two fast releasing tablets in four media, and the similarity of dissolution profiles was compared using 3 methods. Two of the methods were introduced from statistical algorithm of distance methods, which are maximum distance and Mahalanobis distance. The dissolution kinetics were also analysed using FDA method for similarity evaluation, and the results were compared with those obtained using the distance methods.

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