Journal of Pharmaceutical Investigation
- Volume 23 Issue 1
- /
- Pages.51-53
- /
- 1993
- /
- 2093-5552(pISSN)
- /
- 2093-6214(eISSN)
Evaluation of Physical Properties of Mucosal Adhesive Tablets (I):-Adhesive Force-
점막 부착정제의 물성평가(I):-부착력-
- Park, Kwang-Sin (Research Laboratories, Dong-A Pharm. Co.) ;
- Chung, Bee-Hwan (Research Laboratories, Dong-A Pharm. Co.) ;
- Cha, Bong-Jin (Research Laboratories, Dong-A Pharm. Co.) ;
- Kwon, Jong-Won (Research Laboratories, Dong-A Pharm. Co.)
- Published : 1993.03.20
Abstract
Mucoadhesive tablets containing hydroxypropylcellulose-H (HPC) and carbopol 934 (CP) were prepared from direct compression. Their adhesive forces and water absorptions were investigated by using mouse peritoneal membrane and 1.5% agar plate, respectively. Adhesive force was significantly improved with increasing CP concentration, but was not affected by compression force and addition of disintegrants. And adhesive force to mouse peritioneal membrane was increased as fixing time increased. In conclusion, adequate adhesive force can be obtained by control of CP/HPC ratio and fixing time.