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Establishment of a Murine Model for Radiation-induced Bone Loss in Growing C3H/HeN Mice (성장기 마우스에서 방사선 유도 골소실 동물모델 확립)

  • Jang, Jong-Sik;Moon, Changjong;Kim, Jong-Choon;Bae, Chun-Sik;Kang, Seong-Soo;Jung, Uhee;Jo, Sung-Kee;Kim, Sung-Ho
    • Journal of Radiation Protection and Research
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    • v.40 no.1
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    • pp.10-16
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    • 2015
  • Bone changes are common sequela of irradiation in growing animal. The purpose of this study was to establish an experimental model of radiation-induced bone loss in growing mice using micro-computed tomography (${\mu}CT$). The extent of changes following 2 Gy gamma irradiation ($2Gy{\cdot}min^{-1}$) was studied at 4, 8 or 12 weeks after exposure. Mice that received 0.5, 1.0, 2.0 or 4.0 Gy of gamma-rays were examined 8 weeks after irradiation. Tibiae were analyzed using ${\mu}CT$. Serum alkaline phosphatase (ALP) and biomechanical properties were measured and the osteoclast surface was examined. A significant loss of trabecular bone in tibiae was evident 8 weeks after exposure. Measurements performed after irradiation showed a dose-related decrease in trabecular bone volume fraction (BV/TV) and bone mineral density (BMD), respectively. The best-fitting dose-response curves were linear-quadratic. Taking the controls into accounts, the lines of best fit were as follows: BV/TV (%) = $0.9584D^2-6.0168D+20.377$ ($r^2$ = 0.946, D = dose in Gy) and BMD ($mg{\cdot}cm^{-3}$) = $8.8115D^2-56.197D+194.41$ ($r^2$ = 0.999, D = dose in Gy). Body weight did not differ among the groups. No dose-dependent differences were apparent among the groups with regard to mechanical and anatomical properties of tibia, serum ALP and osteoclast activity. The findings provide the basis required for better understanding of the results that will be obtained in any further studies of radiation-induced bone responses.

공중파 TV 방송프로그램에 나타난 식품영양정보 분석(2002-2003넌)-뉴스, 건강관련 정보프로그램, 드라마

  • 문현경;장영주
    • Proceedings of the KSCN Conference
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    • 2003.11a
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    • pp.1086-1087
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    • 2003
  • 오늘날 급변하는 사회경제적 환경 때문에 현대인의 영양과 건강에 대한 관심은 날이 갈수록 높아지고 있어 대중매체에서도 영양과 건강에 대한 정보를 전달하는 경우가 많아지고 있다. 특히 방송매체 중 공중파 TV 프로그램에서의 정보들은 쉽게 접할 수 있어 올바른 영양 및 건강생활을 위한 정보나 실천지침을 국민들에게 전달되는 통로서의 긍정적인 부분도 있으나 시간상 제작환경상 등의 제약으로 인해 왜곡된 정보를 전달하는 부정적인 부분도 있다. 이에 건강관련 식품영양정보 모니터링을 통해 객관적인 평가와 문제점을 파악한 후 유형별로 분류, 분석하여 개선방안을 마련하기 위해서 본 연구에서는 방송매체중 공중파 TV프로그램 중 정확한 보도와 정보전달을 목적으로 하는 프로그램과 드라마 중 가족드라마를 선정하여 건강관련 식품영양정보의 양적 질적 현황을 파악하고자 하였다. 건강관련 식품영양 정보들에 대한 건수, 시간수, 주제, 취재원, 적절성과 부적절성 평가 및 부적절성의 요인들을 양적 질적으로 평가하여 연도별 비교분석을 하였다. 2002년도 4월 30일부터 2003년 9월 30일까지 모니터링 전문 교육을 마친 식품영양학 전공 모니터원이 조사기간 중 담당 프로그램을 모니터하여 각 프로그램에 나타난 식품영양정보의 양과 질을 조사하여 SPSS 통계팩키지를 사용하여 빈도 및 평균분석을 하였다. 총 모니터건수는 15,226건이었으며, 이중 총 건강관련정보건수는 5,623건으로 36.9%를, 식품영양관련 정보는 4,848건으로 31.8%를 차지하는 것으로 분석되었다. 총 건강관련 정보 대비 식품영양정보건수의 비율은 86.2%로 높게 나타났다. 뉴스프로그램의 총 건강관련 정보수는 17.9%에서 16.1%, 식품영양정보수의 비율은 6.6%에서 3.6%로 낮아졌으며, 건강정보프로그램의 총 건강관련 정보수는 51.5% 에서 94.6%, 식품영양정보수의 비율은 32.4%에서 57.4%로 높게 나타났다. 드라마의 식생활관련 장면 방송시간비율은 20.8%에서 17.2%로 낮게 나타났다. 뉴스프로그램에서 건강관련정보가 가장 많이 보도되는 달은 2002년 10월, 2003년 9월로 나타났다. 건강관련 정보의 주제로는 뉴스프로그램은 질환, 건강정보프로그램은 음식, 어린이교육프로그램은 식품, 노인정보프로그램은 생활습관이 가장 높게 나타났다. 정보의 취재원으로는 전문가와 일반인의 인터뷰가 73.7%로 가장 많았다. 식품영양정보의 부적절한 평가율은 뉴스는 49.3%에서 72.2%로, 건강정보프로그램은 54.0%에서 67.8%로 2002년보다 2003년도에 높게 나타났으나, 드라마는 63.2%에서 16.2%로 낮게 나타났으며, 어린이교육프로그램 40.0%, 노인정보프로그램 17.9%인 것으로 나타났다. 드라마의 식생활 장면에서 음식의 양이 부적절한 경우는 28.6%에서 15.8%로 낮아졌으나, 음주장면의 경우 10.7%에서 11.5%로 증가하였음은 앞으로 개선이 필요하다고 생각된다. 흡연 장면의 경우 드라마상의 흡연장면 방송금지 선언의 여파로 1.6%에서 0.2%로 감소하였다. 뉴스 및 정보프로그램에서는 부적절한 평가를 받은 정보들은 적정섭취량이나 실생활에 활용할 실천방안 등에 대한 제시가 없는 경우가 가장 많았으며, 전문용어에 대한 설명부족, 영양가 비교기준이 다르거나, 식품 등의 효과에 대한 내용이 과장된 경우가 많았다. 드라마의 경우 음주, 커피, 야식 등 불필요한 식사장면이 많이 나오거나 음식의 양이 사람수에 비해 많다라는 평가가 가장 높게 나타났다. 연구 결과 TV 프로그램에서 다루는 건강관련 정보기사가 차지하는 비율과 이중 식품영양정보기사가 차지하는 비율이 높아지고 있으나 건강관련정보기사의 질적인 평가에서는 부적절한 평가를 받은 비율도 함께 높아지고 있어 이의 개선이 시급히 요구된다.

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ON THE SUPERSTABILITY OF SOME FUNCTIONAL INEQUALITIES WITH THE UNBOUNDED CAUCHY DIFFERENCE (x+y)-f(x)f(y)

  • Jung, Soon-Mo
    • Communications of the Korean Mathematical Society
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    • v.12 no.2
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    • pp.287-291
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    • 1997
  • Assume $H_i : R_+ \times R_+ \to R_+ (i = 1, 2)$ are monotonically increasing (in both variables), homogeneous mapping for which $H_1(tu, tv) = t^p(H_1(u, v) (p > 0)$ and $H_2(u, v)^{t^q} (q \leq 1)$ hold for $t, u, v \geq 0$. Using an idea from the paper of Baker, Lawrence and Zorzitto [2], the superstability problems of the functional inequalities $\Vert f(x+y) - f(x)f(y) \Vert \leq H_i (\Vert x \Vert, \Vert y \Vert)$ shall be investigated.

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A Pilot Study on Factors Associated with Presentation Delay in Patients Affected with Head and Neck Cancers

  • Baishya, Nizara;Das, Ashok Kumar;Krishnatreya, Manigreeva;Das, Anupam;Das, Kishore;Kataki, Amal Chandra;Nandy, Pintu
    • Asian Pacific Journal of Cancer Prevention
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    • v.16 no.11
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    • pp.4715-4718
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    • 2015
  • Background: Patient delay can contribute to a poor outcome in the management of head and neck cancers (HNC). The main objective of the present study was to investigate the factors associated with patient delay in our population. Materials and Methods: Patients with cancers of the head and neck attending a regional cancer center of North East India were consecutively interviewed during the period from June 2014 to November 2014. The participation of patients was voluntary. The questionnaire included information on age, gender, residential status, educational qualification, monthly family income, any family history of cancer, and history of prior awareness on cancer from television (TV) program and awareness program. Results: Of 311 (n) patients, with an age range of 14-88 years (mean 55.4 years), 81.7% were males and 18.3% females (M:F=4.4). The overall median delay was 90 days (range=7 days-365 days), in illiterate patients the median delay was 90 days and 60 days in literate patients (P=0.002), the median delay in patients who had watched cancer awareness program on TV was 60 days and in patients who were unaware about cancer information from TV program had a median delay of 90 days (p=0.00021) and delay of <10 weeks was seen in 139 (44.6%) patients, a delay of 10-20 weeks in 98 (31.5%) patients, and a delay of 20-30 weeks in 63 (20.2%) patients. Conclusions: Education and awareness had a significant impact in reduction of median patient delay in our HNC cases.

The Relationship between Types of Leisure Activity and Blood Types - Focus on Collegians of Public Health Departments and Non-Public Health Departments of DHC - (혈액형에 따른 여가활동 유형 -대구보건대학 보건계열 및 비보건계열 학생들을 중심으로-)

  • Yoon, In-Sook;Kim, Hye-Jong
    • Korean Journal of Clinical Laboratory Science
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    • v.38 no.1
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    • pp.65-71
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    • 2006
  • We examined the relationship between the basic characteristics and types of leisure activities according to blood types. It was based on questionnaires answered by 441 collegians in public health departments and 282 in non-public health departments in Daegu Health College in March, 2005. The frequency of leisure activity of once or twice a week or less during weekdays was the most common.: The most common frequencies for all blood types were between 1 and 2 hours on weekdays and between 3 and 5 hours on the weekends or holidays. As far as the type of leisure activities during the weekdays was concerned, in the case of public health departments, blood type A was interested in computer games and then watching TV, blood type B was attracted to watching TV and listening to music, blood type AB was into watching TV, computer games, and listening to music, and blood type O was keen on watching TV and computer games in that order. The type of leisure activity according to blood types in public health departments was shown to be significantly different (p<0.05). The type of future leisure activity was shown to be significantly different between public health departments and non-public health departments (p<0.05). The type of present leisure activity preferred by collegians, according to the study, was entertainment such as computer games for most blood types. The type of future leisure activities was related to the field of tourism and sports. The collegians need to have more advanced and positive leisure activities.

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Hemodynamic evaluation of the Ionescu-Shiley pericardial xenograft heart valve (Ionescue-Shiley 인조판막을 이용한 판막대치술의 혈류역학적 성적)

  • Jeong, Won-Sang;Kim, Geun-Ho
    • Journal of Chest Surgery
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    • v.17 no.2
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    • pp.223-230
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    • 1984
  • Since January 1977 to the end of September 1982, total 60 Ionescu-Shiley pericardial xenograft heart valves were implanted for valve replacement in 50 patients at the Han Yang University Hospital. The operative procedures were as follow: Mitral valve replacement [MVR] in 25 patients, Mitral valve replacement [MVR] and Tricuspid valve [TV] annuloplasty in 7 patients, Aortic valve replacement [AVR] in 8 patients, Aortic valve replacement [AVR] and Mitral valve replacement [MVR] in 8 patients. Aortic valve replacement [AVR] and Mitral valve replacement [MVR] and Tricuspid valve [TV] annuloplasty in 2 patients. To evaluate the immediate hemodynamic changes after valve replacements, the pressures of each cardiac chamber and ulmonary artery were checked before and after valve replacement on the operation table. Right ventricle [RV] pressure was decreased from 52.09\ulcorner6.71 to 45.57\ulcorner5.03 mmHg, Pulmonary artery [PA] pressure was decreased from 45.97\ulcorner2.69 to 41.00\ulcorner3.99 mmHg, and Left atrium [LA] pressure was decreased from 30.33\ulcorner13.02 to 22.76\ulcorner.97 mmHg before and after valve replacement. In MVR group, RV pressure was decreased from 49.17\ulcorner7.89 to 43.14\ulcorner4.14 mmHg, PA pressure was decreased from 44.67\ulcorner3.18 to 38.67\ulcorner2.85 mmHg, and LA pressure was decreased from 31.46\ulcorner13.47 to 21.91\ulcorner.17 mmHg. In AVR group, RV pressure was decreased from 53.0\ulcorner7.44 to 44.71 \ulcorner3.24 mmHg, PA pressure was decreased from 34.83\ulcorner0.73 to 31.86\ulcorner.36 mmHg, and LA pressure was not changed. In double valve replacement [MVR and AVR] group, RV pressure was decreased from 57.50\ulcorner3.82 to 42.50\ulcorner.80 mmHg, PA pressure was decreased from 51.17\ulcorner1.42 to 43.33\ulcorner4.53mmHig, and LA pressure was decreased from 34.33\ulcorner2.09 to 25.50\ulcorner0.21 mmHg. But in the group where MVR and TV annuloplasty were performed, preoperative RV and PA pressure were markedly increased and no pressure decrease in RV and PA noticed after valve replacement. This study shows good immediate postoperative hemodynamic results after valve replacement using Ionescu-Shiley xenograft valve except in the cases of MVR and TV annuloplasty and advanced disease with pulmonary hypertension.

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Effect of Intermittent Parathyroid Hormone Administration on the Microstructure of Jaw Bone in the Ovariectomized Rats

  • Kang, Kang-su;Kim, Kun-hyoung;Heo, Hyun-a;Park, Suhyun;Pyo, Sung-woon
    • Journal of Korean Dental Science
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    • v.8 no.2
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    • pp.65-73
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    • 2015
  • Purpose: Parathyroid hormone (PTH) therapy has drawn attention, as an alternative to anti-resorptive drugs since PTH accelerates bone density by anabolic action. The purpose of this study was to identify the effect of intermittent PTH administration on jaw bones of rat undergone bilateral ovariectomy. Materials and Methods: Nine female Sprague-Dawley rats were divided into three groups. PTH group was ovariectomized (OVX) to induce osteoporosis and PTH $30{\mu}g/kg$ was administered 1 week after the surgery. In OVX group, ovariectomy was performed and only vehicle was administered by subcutaneous injection 3 times per week. Control group was subjected to sham surgery. The animals were sacrificed 8 weeks after the surgery and specimens were obtained from ilium and upper and lower jaw bones. Histological investigation was carried out by using an optical microscope and micro-computed tomography was taken to examine structural property changes in each bone sample. Result: In the ilium, the bone volume ratio (bone volume/total volume, BV/TV) of PTH, OVX and control groups was $53.75%{\pm}7.57%$, $50.61%{\pm}12.89%$, $76.20%{\pm}5.92%$ (P=0.061) and bone mineral density (BMD) was $1.12{\pm}0.09$, $0.88{\pm}0.48$, $1.38{\pm}0.07g/cm^3$ (P=0.061). In the mandible, BV/TV of PTH, OVX and control groups was $64.60%{\pm}12.17%$, $58.26%{\pm}9.63%$, $67.54%{\pm}14.74%$(P=0.670) and BMD was $1.21{\pm}0.17$, $1.19{\pm}0.13$, $1.27{\pm}0.18g/cm^3$ (P=0.587). In the maxilla, BV/TV of PTH, OVX and control groups was $61.19%{\pm}8.92%$, $52.50%{\pm}11.22%$, $64.60%{\pm}12.17%$ (P=0.430) and BMD was $1.20{\pm}0.11$, $1.11{\pm}0.16$, $1.21{\pm}0.17g/cm^3$ (P=0.561). No statistically significant difference was found in any variables in all groups. Histological observation revealed that the ilium in OVX group demonstrated sparsely formed trabecular bones compared with other groups. However, upper and lower trabecular bones did not present significant differences. Conclusion: Intermittent administration of PTH appears to affect the microstructure of rat jaw bones, but statistical significance was not found. However, the measurements in this study partly implicated the possible anabolic effect of PTH in vivo.

A Study on the Perception of the Myopia in Children's Mother (학령초기아동 어머니의 근시 인식)

  • Kim, Jin-Hyang;Yang, Soon-Ok
    • The Journal of Korean Academic Society of Nursing Education
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    • v.11 no.2
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    • pp.214-221
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    • 2005
  • Purpose: This study was to investigate the perception of the myopia in early school-aged children's mother and develope myopia preventive education program. Method: Data was collected from June 1th to 24th, 2003. The sample group(two elementary schools in A city)consisted of 105students mother with normal vision(naked vision 1.0 or more), 105 students mother with subnormal vision(0.7 or less). The data was analyzed using S.A.S. For the test of homogeneity and significance of variable, Fisher's Exact test and Student's t-test were used. Results: 1. There was significant difference in perception of being changed the children's eyesight between normal and myopia group(t=7.86, p=.0492). 2. High scores of cause of myopia were distance from TV or computer to viewer and time of watching TV or using computer in both groups. 3. There was significant difference in perception score of cause of myopia in the myopia group was 13.26, and 18.04 in the normal group(t=3.01, p=0.003). Especially in the unbalanced and regulated diet, regulated exercise, distance of eyes reading books and illumination, normal group had more perception score than myopia group. Conclusion: A myopia education program for children and parents should be planed and the effect be verified.

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Reliability evaluation of periodontal disease oral health information on YouTube (동영상 공유 플랫폼에서 치주질환 구강건강정보의 신뢰도 평가)

  • Ji-Hyun Kim;Sun-Hee Hwang;Min-Young Kim
    • Journal of Korean society of Dental Hygiene
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    • v.23 no.6
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    • pp.423-429
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    • 2023
  • Objectives: The study aimed to assess the form, reliability, and quality of information related to periodontal diseases shared on YouTube. Methods: On october 23, 2023, we conducted searches on YouTube using four keywords related to periodontal diseases. The searches retrieved a total of 394 videos from the first five pages for each keyword. Of these, 151 were included in the analysis. Videos were categorized based on the source and usefulness of the information, and their reliability and quality were assessed. Results: Analysis of the information sources revealed that medical websites or TV channels (45.7%) were the most prevalent, whereas commercial websites (2.0%) were the least prevalent. Videos uploaded by physician or hospitals (3.08±0.48) and medical websites or TV channels (3.01±0.94) demonstrated higher reliability. Videos categorized as having good and excellent quality were predominantly from physician or hospital sources (88.2%). Useful information related to periodontal diseases was available in 85.4% of videos, with physician or hospital sources contributing the highest proportion of useful information (52.7%). Conclusions: Videos from physician or hospital sources provide high-quality useful and reliable information. To ensure the provision of more useful and accurate information, the involvement and interest of experts are deemed essential.

A Study on $[Ni_x-Mg_{0.1}-Zn_{(1-x-0.1)}{\cdot}Fe_2O_4]$-Rubber Composite for Electromagnetic Wave Absorber (전파흡수체용 $[Ni_x-Mg_{0.1}-Zn_{(1-x-0.1)}{\cdot}Fe_2O_4]$-Rubber Composite에 관한 연구)

  • 박연준;김동일
    • Journal of the Korean Institute of Navigation
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    • v.22 no.4
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    • pp.69-75
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    • 1998
  • The super wideband electromagnetic wave absorber in RF-A-PF type has been proposed, which can be used for an anechoic chamber, wall material to prevent TV ghost, etc, In this paper, $Ni_x-Mg_{0.1}-Zn_(1-x-0.1){\cdot}Fe_2O_4$ Ferrite Powder has been fabricated. Using this, then, [$Ni_x-Mg_{0.1}-Zn_(1-x-0.1){\cdot}Fe_2O_4$-Rubber composite for RF-layer in the RF-A-PF type absorber has been fabricated and its characteristics has been analyzed. As a result, it has been shown that the $Ni_x-Mg_{0.1}-Zn_(1-x-0.1){\cdot}Fe_2O_4$-Rubber composit with the quantity $_x$ of $Ni_x$ between 0.5 and 0.6 is suitable for the RF-layer in the case of which the grain size is sub-micrometer order.

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