• Restorative Dentistry and Endodontics
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• 제25권3호
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• pp.407-420
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• 2000

삼차신경절의 뉴런이 구강악안면영역에서의 촉각, 입각, 온도각 및 통각 등 다양한 감각을 중추신경계로 전달하는 역할을 하는 것은 주지의 사실이다. 이러한 신경전달에 있어서 이온통로는 감각정보를 전달하는데 핵심적인 역할을 수행하며 특히 소디움 통로는 활동전위의 발생에 중요하다. 소디움 통로는 tetrodotoxin-sensitive(TTX-s) 및 tetrodotoxin-resistant(TTX-r) 통로로 나누어지는 데 이 중 TTX-r 통로에 발생되는 tetrodotoxin-resistant sodium current(TTX-r $I_{Na}$)는 capsaicin에 민감한 일차구심신경세포에서 유해자극에 의해 통각신호를 발생시키고 전달하는데 중요하다. 또한 칼슘 통로는 시냅스 전도에 있어서 필수적인 역할을 수행하고 있다 한편 치과영역에서 치수의 진정 목적으로 eugenol이 흔히 사용되고 있다. 그러나 eugenol의 그 작용 기전에 대해서 현재까지 이온 통로에 대한 상세한 결과가 없는 실정이며 최근의 보고에 의하면 eugenol이 capsaicin 수용기를 통하여 감각신경에 대한 억제작용을 나타낸다고 한다. 따라서 본 실험은 eugenol과 capsaicin이 흰쥐의 삼차신경절의 TTX-r $I_{Na}$와 칼슘통로에 어떠한 영향을 미치는지를 알아보고 eugenol이 capsaicin 수용기를 통하여 작용하는지를 검증하고자 시행되었다. 삼차신경절 뉴런은 100~150g의 흰쥐의 삼차신경절로부터 외과적으로 절제하여 통법의 화학적 및 기계적 처리를 통해 단일세포로 분리하였고 이를 whole-cell patch clamp 방법을 이용하여 시행한 바 다음과 같은 결론을 얻었다. 1. 1mM의 dugenol은 흰쥐 삼차신경절 뉴런의 TTX-r $I_{Na}$와 HVA $I_{Ca}$를 억제하였다. 2. $1{\mu}m$의 capsaicin은 흰쥐 삼차신경절 뉴런의 TTX-r $I_{Na}$와 HVA $I_{Ca}$를 억제하였다. 3. Capsazepine은 capsaicin의 HVA $I_{Ca}$에 대한 억제작용을 차단하였다. 4. Capsazepine은 capsaicin의 HVA $I_{Ca}$에 대한 억제작용을 차단하지 못하였다. 결론적으로 eugenol과 capsaicin은 tetrodotoxin-resistant sodium current(TTX-r $I_{Na}$)와 high voltage-activated calcium current(HVA $I_{Ca}$)를 모두 억제하는 것으로 나타났으며, 이러한 작용이 통각의 발생과 시냅스 전달과정을 차단하여 치수 진정 목적으로 많이 사용하는 eugenol의 작용기전으로 판단된다. 한편 capsaicin의 길항제인 capsazepine을 전처치하였을 때에도 eugenol의 HVA $I_{Ca}$에 대한 억제효과는 변화가 없었다. 이와같은 결과로 보아 HVA $I_{Ca}$에 관한 한 eugenol은 capsaicin 수용기를 통하여 나타나지 않는 것으로 사료된다.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2011년도 춘계학술대회 논문집
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• pp.28-34
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• 2011

The carbody underframe of TTX vehicle should be modified a lot for the installation of new devices such as an active suspension system between the bogie and the carbody of TTX vehicle, because the carbody underframe is one body structure consisting of a center sill welded with a carbody bolster. Modification operation of the carbody takes a lot of time and cost, because the huge sized carbody structure should be moved to a machining apparatus and machined to guarantee the manufacture accuracy of new device installation brackets. For this reason, modification operation improvement is needed to install new devices more efficiently between the bogie and the carbody. This paper introduce the development of 'bogie/carbody interface bolster' that not only supports the carbody weight but also enables new devices to be installed more efficiently between the bogie and the carbody. This development has advantage to reduce working time and cost to install new devices such as an active suspension system between the bogie and the carbody by minimizing the modification of the carbody of TTX vehicle.

• 전기학회논문지P
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• 제58권4호
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• pp.416-421
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• 2009

Recently, the new Korean Tilting Train Express(TTX) which maintains a speed on the curve railway line is developed. Electric railways, including the TTX, have electrical problems that could bring about serious accidents. For such reasons, the electric railway's electrical problems, electrical harmonic and others, have been studied briskly. Thus, TTX's electrical problems also need leading studies because the new Korean TTX will operate earnestly in 2012. The results could be used hereafter diagnosis of it's components and train conditions. In the paper, electrical signals in TTX operation were measured to analyze electrical harmonic. In addition, after the electrical signals were measured to operating mode (coasting mode, acceleration mode and regenerative breaking mode) respectively in test section(Ho-nam line, Chung-buk line, Jung-ang line and Tae-baek line). The electrical harmonics considered operating modes triparted were analysed and evaluated.

• 한국철도학회논문집
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• 제7권3호
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• pp.193-199
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• 2004

Numerical analysis of aerodynamic characteristics was differently performed according to the running situation of the Korean Tilting Train eXpress(TTX) that would be introduced for an improvement in efficiency of the used railroad track. Fluent 6.0 was used for the analysis of Non-tilting case, Tilting case and Passing-by case with the model of TTX. As a result, the aerodynamic drag had little difference between Tilting and Non-tilting case. However, pressure contour under the train of Tilting case was not symmetry because the gap between a train and the ground was different at both sides. In Passing-by case attraction and counterattraction occurred alternately and affected to the opposite train. When two trains were side by side, the maximum attraction was generated especially. Through an analysis of pressure wave in tunnel a large variation of pressure was generated by the bluff nose of TTX. The results in this study would be good data for the aerodynamic characteristic on TTX and provide important information to judgment of running safety.

• 한국복합재료학회:학술대회논문집
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• 한국복합재료학회 2004년도 추계학술발표대회 논문집
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• pp.203-206
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• 2004

Tilting train has been developed to increase the operational speed of the trains on conventional lines which have many curves. This train are tilted at curves to compensate for unbalanced carbody centrifugal acceleration to a greater extent than compensation produced by the track cant, so that passengers do not feel centrifugal acceleration and thus trains can run at higher speed at curves. This paper developed PDM(product data managemnet) to make a system engineering of TTX(tilting train express) with maximum operation speed 180 km/h.

• 한국철도학회:학술대회논문집
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• 한국철도학회 2005년도 춘계학술대회 논문집
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• pp.157-162
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• 2005

This paper describes the system implementation of TMS(Train Management System) to be applied to a TTX(Korea Tilting eXpress). For better safety and reliability of vehicle, increased quantity and fast transmission of data between TC(Train Computer) and CC(Car Computer) and control equipment of train is required. To satisfy these requirements, this system uses RTOS(Real Time OS) so that do realtime data management, And it is implemented to minimize the noise inflow and a signal level reduction of the communication line. Also it is designed to suitable interface of a TTX vehicle and is verified by laboratory test.

• 한국복합재료학회:학술대회논문집
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• 한국복합재료학회 2004년도 춘계학술발표대회 논문집
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• pp.43-46
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• 2004

Through investing the criteria and evaluation for fire performance of interior components, this paper introduce the testing items and requirements for Flammability, Smoke density, and Toxicity properties of TTX(Tilting Train eXpress) interior parts. Next time, all trains including TTX will be occupied the components with superior fire-resistance and the sensing and monitoring system for fire in train.

• 시스템엔지니어링워크숍
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• 통권1호
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• pp.145-149
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• 2003

Systems engineering test and evaluation technology development program for (Korea) Express Tilting Train(TTX) system in progress is a national large system development program that is not only a large-size and complex but also muti-disciplinary in nature. For the TTX test and evaluation technology development, verification requirements that could verify system function and performance, should be derived from system specification. Hereafter, this could be listed as items of test. System engineering process establishes traceability between items of test and system requirements. These tasks could be accomplished by the schema. Using the Core, a system engineering tool, TTX program could be database and oter system related to TTX program will be developed effectively and efficiency.

• 한국복합재료학회:학술대회논문집
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• 한국복합재료학회 2004년도 추계학술발표대회 논문집
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• pp.212-215
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• 2004

The hybrid composite carbody structures were considered as the carbody system of Korean Tilting Train eXpress(TTX) to achieve the lightweight design. The TTX carbodies are composed of the carbody shell made of the sandwich composite structure and the undeframe made of the metal structure. The sandwich structures were used to minimize the weight of carbody, and the metal underframe was used to modify the design easily and to keep the strength of underframe by the installation of the electrical equipments. The sandwich carbody structures will be cured in an autoclave. In this paper, the manufacturing processes of the TTX carbody structures were introduced briefly.

• 한국철도학회논문집
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• 제7권2호
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• pp.77-84
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• 2004

In order to determine the most suitable material system for achieving the lightweight design while fulfilling the design requirements of carbody structures of Korean Tilting Train eXpress(TTX), aluminum carbody. composite carbody, and hybrid carbody combined with aluminum and composite structures were considered in the present study. The finite-element analysis was used to verify the design requirements or the TTX carbody structures with the material system considered in the design stages. The stresses in the carbody structures and deflections of underframe against static load cases were used as design criteria. The results show that the hybrid carbody structures are beneficial with regard to weight savings and structural integrity in comparison to aluminum and composite carbody structures.