• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7653-7658
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• 2015

Background: NAD(P)H:quinone oxidoreductase 1 (NQO1) is part of the antioxidant defence system involved in detoxification. This study aimed to analyze the influence of NQO1 (C609T) genetic polymorphism in non small cell lung cancer (NSCLC)as a putative risk factor. Materials and Methods: Present study included 100 cases of NSCLC (adenocarcinoma) patients and 100 age and sex matched healthy controls. NQO1 (C609T) genotyping was performed by allele specific PCR for assessment of putative associations with clinical outcome and genotypes of. The association of the polymorphism with the survival of NSCLC patients' was analyzed by Kaplan-Meier method. Results: In Indian NSCLC (adenocarcinoma) patients increased risk of developing NSCLC was found to be associated with NQO1 609TT genotype [OR 3.68(0.90-14.98), RR 2.04(0.78-5.31)] for CT [OR 2.91(1.58-5.34), RR 1.74(1.23-2.44) p=0.0005 for CT], for CT+TT [ OR 3.26(1.82-5.82), RR 1.87(1.34-2.61) p<0.0001 for CT+TT]. A significant difference (p=0.0009) was observed in genotype distribution among cases and healthy controls. Patients with CT+TT genotype exhibited a significant poor overall survival compared with patients displaying homozygous CC genotype (p=0.03) and when survival independently compared with CC, TT and CT genotype was also found to be significantly associated (p=0.02). Overall median survival times were CT 6.0 months, TT 8.2 months, and CT + TT (6.4 months)]. Conclusions: The present study revealed that NQO1 CT, TT and CT+TT genotypes may be associated with clinical outcome and risk of developing NSCLC in the Indian population.

• Asian Pacific Journal of Cancer Prevention
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• 제15권17호
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• pp.7337-7341
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• 2014

Background: The physiological role of vitamin D extends beyond bone health and calcium-phosphate homeostasis to effects on cancer risk, mainly for colorectal cancer. Vitamin D may have an anticancer effect in colorectal cancer mediated by binding of the active form $1,25(OH)_2D$ to the vitamin D receptor (VDR). The Taq1 VDR gene polymorphism, a C-to-T base substitution (rs731236) in exon 9 may influence its expression and function. The aim of this study wass to determine the 25(OH)D vitamin D level and to investigate the association between circulating vitamin D level and Taq1VDR gene polymorphism among Jordanian colorectal cancer patients. Materials and Methods: This case control study enrolled ninety-three patients and one hundred and two healthy Jordanian volunteers from AL-Basheer Hospital/Amman (2012-2013). Ethical approval and signed consent forms were obtained from all participants before sample collection. 25(OH)D levels were determined by competitive immunoassay Elecsys (Roche Diagnostic, France). DNA was extracted (Promega, USA) and amplified by PCR followed by VDR Taq1 restriction enzyme digestion. The genotype distribution was evaluated by paired t-test and chi-square. Comparison between vitamin D levels among CRC and control were assessed by odds ratio with 95% confidence interval. Results: The vitamin D serum level was significantly lower among colorectal cancer patients (8.34 ng/ml) compared to the healthy control group (21.02ng/ml). Patients deficient in vitamin D (less than 10.0 ng/ml) had increased colorectal cancer risk 19.2 fold compared to control. Only 2.2% of CRC patients had optimal vitamin D compared to 23.5% among healthy control. TT, Tt and tt Taq1 genotype frequencies among CRC cases was 35.5%, 50.5% and 14% compared to 43.1%, 41.2% and 15.7% among healthy control; respectively. CRC patients had lower mean vitamin D level among TT ($8.91{\pm}4.31$) and Tt ($9.15{\pm}5.25$) genotypes compared to control ($21.3{\pm}8.31$) and ($19.3{\pm}7.68$); respectively. Conclusions: There is significant association between low 25(OH)D serum level and colorectal cancer risk. The VDRTaq1 polymorphism was associated with increased colorectal cancer risk among patient with VDRTaq1 TT and Tt genotypes. Understanding the functional mechanism of VDRTaq1 TT and Tt may provide a strategy for colorectal cancer prevention and treatment.

• Asian Pacific Journal of Cancer Prevention
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• 제15권20호
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• pp.8725-8734
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• 2014

The transforming growth factor-${\beta}1$ (TGF-${\beta}1$) gene 29 T/C polymorphism is thought to be associated with breast cancer risk. However, reports are largely conflicting and underpowered. We therefore conducted a meta-analysis of all available case-control studies relating the TGF-${\beta}1$ 29T/C polymorphism to the risk of developing breast cancer by including a total of 31 articles involving 24,021 cases and 31,820 controls. Pooled ORs were generated for the allele contrasts, with additive genetic, dominant genetic and recessive genetic models. Subgroup analysis was also performed by ethnicity for the TGF-${\beta}1$ 29T/C polymorphism. No association was found in the overall analysis (C vs T: OR=1.028, 95% CI=0.949-1.114, p-value 0.500; CC vs TC: OR= 1.022, 95% CI=0.963-1.085, p-value 0.478; CC vs TT: OR= 1.054, 95% CI=0.898-1.236, p-value 0.522; CC vs TT+ TC: OR= 1.031, 95% CI=0.946-1.124, p-value 0.482; TT vs CC+TC: OR= 0.945, 95% CI=0.827-1.080, p-value 0.403). Similarly, in the subgroup analysis by ethnicity, no association was found in Caucasian (C vs T: OR= 1.041, 95% CI=0.932-1.162, p-value 0.475; CC vs TC: OR= 1.031, 95% CI=0.951-1.118, p-value 0.464; CC vs TT: OR= 1.081, 95% CI=0.865-1.351, p-value 0.493; CC vs TT+TC: OR= 1.047, 95% CI=0.929-1.180, p-value 0.453; TT vs CC+TC: OR= 0.929, 95% CI=0.775-1.114, p-value 0.429;) and Asian populations (C vs T: OR= 1.004, 95% CI=0.908-1.111, p-value 0.931; CC vs TC: OR= 0.991, 95% CI=0.896-1.097, p-value 0.865; CC vs TT: OR= 1.015, 95% CI=0.848-1.214, p-value 0.871; CC vs TT+TC: OR= 1.000, 95% CI=0.909-1.101, p-value 0.994; TT vs CC+TC: OR= 0.967, 95% CI=0.808-1.159, p-value 0.720;). No evidence of publication bias was detected during the analysis. No significant association with breast cancer risk was demonstrated overall or on subgroup (Caucasian and Asian) analysis. It can be concluded that TGF-${\beta}1$ 29T/C polymorphism does not play a role in breast cancer susceptibility in overall or ethnicity-specific manner.

• 조명전기설비학회논문지
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• 제24권1호
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• pp.56-62
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• 2010

본 논문에서는 IEC 60364에서 제시하고 있는 접지계통(TT접지계통, TN-S 접지계통 및 TN-C)의 누전차단기 동작특성 및 보호도체의 임피던스변화에 따른 Loop Impedance 특성분석을 실시하였다. 분석결과 Loop Impedance의 경우 저항성분과 인턱턴스성분에 영향을 받는 것으로 나타났다. 접지계통별 전류 전압특성은 TN-S 접지계통 및 TN-C 접지계통의 경우 사고전류가 높고 접촉전압이 낮은 특성을 나타낸 반면 TT 접지계통의 경우 사고전류는 낮고 접촉전압이 높게 나타남을 확인하였다.

• Natural Product Sciences
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• 제19권3호
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• pp.263-268
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• 2013

The inhibitory effects of adipogenesis on ethyl acetate (EtOAc) fraction from leaves of the Tulip tree (TT) were evaluated. Exposure to TT EtOAc fraction (25~200 ${\mu}g/mL$) for a 72 hr incubation period did not significantly change cell viability. TT EtOAc fraction, with concentrations of 100 and 200 ${\mu}g/mL$, inhibited lipid accumulation in 3T3-L1 adipocytes in a dose dependent manner in adipogenesis. The expression of $PPAR{\gamma}$ and $C/EBP{\alpha}$, essential adipogenic markers, was significantly decreased when TT EtOAc fraction was added to cells for 8 days as compared with the untreated control group. These results suggest that TT EtOAc fraction might be a potential therapeutic agent as an effective, natural alternative material for obesity treatment.

• 한국통신학회논문지
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• 제27권6B호
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• pp.616-624
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• 2002

인공 위성을 이용한 위성 통신망에서는 위성의 위치, 성능, 그리고 동작을 제어하는 관제신호(Telemetry, Tracking and Command, TT&C)채널의 보호가 요구된다. 본 논문에서는 관제신호의 생성 및 수행의 보안을 위하여 사용되는 인증 알고리즘의 취약점을 분석하고 부가적인 계산량을 크게 증가시키지 않으면서도 키 복구 공격(key recovery attack)에 대해 구조적으로 보완하는 인증 알고리즘을 제안하고 검증하였다. 제안한 인증 알고리즘은 입력으로 사용되는 관제신호 데이터의 크기와 메시지 인증 코드의 크기를 변경하지 않아 기존의 위성 시스템에 그대로 적용 가능하며 키 복구 공격에 대한 계산 복잡도를 기존의 2$^{55}$번의 수행에서 2$^{111}$ 번으로 증가시켜 divest의 권고만을 만족시킬 수 있음을 보인다.

• 대한기계학회논문집A
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• 제30권6호
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• pp.684-690
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• 2006

This study proposes and validates a new column type electric power steering system (EPS-TT). It is driven by a uni-directional motor and two electro-magnetic clutches. The assist motor produces assist torque in only one direction and two clutches transmit the torque to the column of steering system in either left or right direction with respect to the steering input. A full order and a reduced order models are developed to evaluate the EPS-TT. Models are also used to investigate the vehicle responses. A PID control logic is designed to control the torque of the assist motor. A driver model is applied to the system and the resulting performances are analyzed. The results show that the performances of the full order model are similar to those of reduced order model. The results also prove that the performances achieved by the EPS-TT are improved compared to those of a conventional EPS-TT across the frequency domain.

• 한국원자력학회:학술대회논문집
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• 한국원자력학회 1996년도 추계학술발표회논문집(2)
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• pp.481-486
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• 1996

원자력 발전소의 증기 발생기 전열관으로 사용되는 합금 600MA는 미세 구조에 관계없이 가성 용액에서 입계 균열이 발생한다. 본 연구에서는 합금 600 2종과 합금 690 2종의 이음매없는 관 및 진공 용해한 합금 690M 2종의 MA 및 TT재에 대한 부식 조건의 변화에 응력 부식 균열 특성을 일정연신율법(CERT) 및 C-ring법으로 평가하였다. 가성 응력 부식 균열 저항성에 미치는 TT처리의 효과는 용액 조건에 관계없이 TT처리를 행하게 되면 응력 부식 균열에 대한 저항성이 증가하는 것으로 나타났으며, 분극 저항성과는 직접적인 관계가 나타나지 않고 다른 미세 조직 등에 의한 영향을 더 크게 받고 있는 것으로 판단된다. 가성 용액에서의 응력 부식 균열 저항성에 미치는 SO$_4$$^{=}$ 이온의 첨가 효과는 TT처리의 유무에 관계없이 응력 부식 균열 저항성을 크게 감소시키고 있다. 한편 합금 690의 가성 응력부식 균열 저항성에 미치는 Mo의 효과는 Mo이 첨가될수록 응력 부식 균열 저항성이 증가하는 것으로 나타났다.

• 한국컴퓨터정보학회:학술대회논문집
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• 한국컴퓨터정보학회 2022년도 제65차 동계학술대회논문집 30권1호
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• pp.283-284
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• 2022

본 논문은 TTS를 사용해 사용자들에게 E-Book 및 뉴스를 보고 들을 수 있는 기능을 제공한다. 사용자 및 개발자가 직접 녹음한 TTS를 사용해 원하는 목소리, 배속과 같은 기능을 제공한다. 기존 TTS를 사용한 E-Book 사이트들은 광고가 많아 가독성의 문제와 유료 서비스인 반면에 본 논문에서 제안한 웹은 다양한 연령층의 사용자들이 사용하기 쉽게 메뉴의 간편화를 통해 다양한 E-Book 및 뉴스 기능을 제공함으로써 보다 직관적이고 쉽게 전자문서를 읽을 수 있도록 하였다.

• 대한기계학회논문집A
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• 제39권3호
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• pp.269-273
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• 2015

일차수응력부식균열 개시 모델과 거시적 현상학적인 손상역학 접근론에 기반한 유한요소 손상해석을 수행하여 Alloy 600TT 로 제작된 원전 증기발생기 전열관에 발생하는 일렬 원주방향 표면 일차수응력부식균열의 성장에 미치는 균열 간격의 영향을 고찰하였다. 기존 연구 결과와의 비교를 통해 손상해석 방법의 타당성을 검증하였다. 검증된 방법을 일렬 원주방향 표면 일차수응력부식균열에 적용하였다. 적용한 결과, 단일 균열에 비하여 일렬 균열의 경우 보다 빠른 합체시간과 관통시간을 보이며 균열 간격이 증가할수록 합체시간과 관통시간은 증가함을 확인하였다. 또한 일정 간격이상으로 두 균열이 떨어지면 합체 이전에 관통될 수 있음을 확인하였다.