• 한국통신학회논문지
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• 제27권6B호
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• pp.616-624
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• 2002

인공 위성을 이용한 위성 통신망에서는 위성의 위치, 성능, 그리고 동작을 제어하는 관제신호(Telemetry, Tracking and Command, TT&C)채널의 보호가 요구된다. 본 논문에서는 관제신호의 생성 및 수행의 보안을 위하여 사용되는 인증 알고리즘의 취약점을 분석하고 부가적인 계산량을 크게 증가시키지 않으면서도 키 복구 공격(key recovery attack)에 대해 구조적으로 보완하는 인증 알고리즘을 제안하고 검증하였다. 제안한 인증 알고리즘은 입력으로 사용되는 관제신호 데이터의 크기와 메시지 인증 코드의 크기를 변경하지 않아 기존의 위성 시스템에 그대로 적용 가능하며 키 복구 공격에 대한 계산 복잡도를 기존의 2$^{55}$번의 수행에서 2$^{111}$ 번으로 증가시켜 divest의 권고만을 만족시킬 수 있음을 보인다.

• 대한기계학회논문집A
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• 제38권6호
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• pp.655-662
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• 2014

본 논문에서는 상온과 원전 설계온도에서 증기발생기 전열관의 축방향과 원주방향 응력-변형률 거동과 인장물성치를 파악하기 위해서, 튜브 시편과 링 시편을 이용하여 상온과 $343^{\circ}C$에서 Alloy 690TT 전열관에 대한 인장시험을 수행하였다. 축방향 인장시험 결과 상온과 $343^{\circ}C$에서 모두 항복점 현상이 관찰되었으며, $343^{\circ}C$에서는 Serration이 관찰되었다. 축방향과 원주방향 모두 상온에 비해 $343^{\circ}C$에서 강도는 감소하였으나 연신율은 거의 변화가 없었다. $343^{\circ}C$에서 가공경화율은 상온에 비해 약간 감소하였으나, 가공경화 거동의 변화는 없었다. 시험 온도에 관계없이 축방향에 비해 원주방향의 항복강도와 인장강도가 약 5 10% 정도 낮았다. 시편 방향에 관계없이 상온 대비 $343^{\circ}C$에서 Alloy 690TT 전열관의 항복강도와 인장강도 감소는 ASME Sec.II의 온도 보정계수에 의해 예측된 것보다 큰 것으로 확인되었다.

• 조명전기설비학회논문지
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• 제24권1호
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• pp.56-62
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• 2010

본 논문에서는 IEC 60364에서 제시하고 있는 접지계통(TT접지계통, TN-S 접지계통 및 TN-C)의 누전차단기 동작특성 및 보호도체의 임피던스변화에 따른 Loop Impedance 특성분석을 실시하였다. 분석결과 Loop Impedance의 경우 저항성분과 인턱턴스성분에 영향을 받는 것으로 나타났다. 접지계통별 전류 전압특성은 TN-S 접지계통 및 TN-C 접지계통의 경우 사고전류가 높고 접촉전압이 낮은 특성을 나타낸 반면 TT 접지계통의 경우 사고전류는 낮고 접촉전압이 높게 나타남을 확인하였다.

• Journal of Microbiology and Biotechnology
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• 제29권12호
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• pp.1938-1946
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• 2019

Isomaltooligosaccharides (IMOs) have good prebiotic effects, and long IMOs (LIMOs) with a degree of polymerization (DP) of 7 or above show improved effects. However, they are not yet commercially available, and require costly enzymes and processes for production. The N-terminal region of the thermostable Thermoanaerobacter thermocopriae cycloisomaltooligosaccharide glucanotransferase (TtCITase) shows cyclic isomaltooligosaccharide (CI)-producing activity owing to a catalytic domain of glycoside hydrolase (GH) family 66 and carbohydrate-binding module (CBM) 35. In the present study, we elucidated the activity of the C-terminal region of TtCITase (TtCITase-C; Met740-Phe1,559), including a CBM35-like region and the GH family 15 domain. The domain was successfully cloned, expressed, and purified as a single protein with a molecular mass of 115 kDa. TtCITase-C exhibited optimal activity at 40℃ and pH 5.5, and retained 100% activity at pH 5.5 after 18-h incubation. TtCITase-C synthesized α-1,6 glucosyl products with over seven degrees of polymerization (DP) by an α-1,6 glucosyl transfer reaction from maltopentaose, isomaltopentaose, or commercialized maltodextrins as substrates. These results indicate that TtCITase-C could be used for the production of α-1,6 glucosyl oligosaccharides with over DP7 (LIMOs) in a more cost-effective manner, without requiring cyclodextran.

• Asian Pacific Journal of Cancer Prevention
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• 제16권17호
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• pp.7653-7658
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• 2015

Background: NAD(P)H:quinone oxidoreductase 1 (NQO1) is part of the antioxidant defence system involved in detoxification. This study aimed to analyze the influence of NQO1 (C609T) genetic polymorphism in non small cell lung cancer (NSCLC)as a putative risk factor. Materials and Methods: Present study included 100 cases of NSCLC (adenocarcinoma) patients and 100 age and sex matched healthy controls. NQO1 (C609T) genotyping was performed by allele specific PCR for assessment of putative associations with clinical outcome and genotypes of. The association of the polymorphism with the survival of NSCLC patients' was analyzed by Kaplan-Meier method. Results: In Indian NSCLC (adenocarcinoma) patients increased risk of developing NSCLC was found to be associated with NQO1 609TT genotype [OR 3.68(0.90-14.98), RR 2.04(0.78-5.31)] for CT [OR 2.91(1.58-5.34), RR 1.74(1.23-2.44) p=0.0005 for CT], for CT+TT [ OR 3.26(1.82-5.82), RR 1.87(1.34-2.61) p<0.0001 for CT+TT]. A significant difference (p=0.0009) was observed in genotype distribution among cases and healthy controls. Patients with CT+TT genotype exhibited a significant poor overall survival compared with patients displaying homozygous CC genotype (p=0.03) and when survival independently compared with CC, TT and CT genotype was also found to be significantly associated (p=0.02). Overall median survival times were CT 6.0 months, TT 8.2 months, and CT + TT (6.4 months)]. Conclusions: The present study revealed that NQO1 CT, TT and CT+TT genotypes may be associated with clinical outcome and risk of developing NSCLC in the Indian population.

• 한국항공우주학회지
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• 제32권8호
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• pp.151-160
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• 2004

• 한국우주과학회:학술대회논문집(한국우주과학회보)
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• 한국우주과학회 1998년도 한국우주과학회보 제7권1호
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• pp.38-38
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• 1998

No Abstract.See Full-text

• Asian Pacific Journal of Cancer Prevention
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• 제16권13호
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• pp.5515-5519
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• 2015

The single nucleotide polymorphism (SNP) ss469415590 in the interferon lambda-4 (IFNL4) gene has recently been reported to have an association with treatment response in chronic hepatitis C. However, any importance of the SNP in association with response to pegylated interferon (PEG-IFN) therapy in patients with chronic hepatitis B (CHB) is unclear. We retrospectively analyzed data for Thai patients with CHB treated with PEG-IFN for 48 weeks. Virological response (VR) for HBeAg-positive CHB was defined as HBeAg seroconversion plus HBV DNA level <2,000 IU/mL at 24 weeks post-treatment. VR for HBeAg-negative CHB was defined as an HBV DNA level <2,000 IU/mL at 48 weeks. The SNP was identified by real time PCR using the TaqMan genotyping assay with MGB probes. A total 254 patients (107 HBeAg-positive and 147 HBeAg-negative) were enrolled in the study. The distribution of TT/TT, ${\Delta}G/TT$ and ${\Delta}G/{\Delta}G$ genotypes was 221 (87.0%), 32 (12.6%) and 1 (0.4%), respectively. Patients with non-TT/TT genotypes had significantly higher baseline HBV DNA levels than patients with the TT/TT genotype. In HBeAg-positive CHB, 41.2% of patients with TT/TT genotype versus 50.0% with non-TT/TT genotype achieved VR (P=0.593). In HBeAg-negative CHB, the corresponding figures were 40.3% and 43.5%, respectively (P=0.777). There was no significant correlation between the SNP genotypes and HBsAg clearance in both groups of patients. In summary, ss469415590 genotypes were not associated with response to PEG-IFN in Thai patients with HBeAg-positive and HBeAg-negative CHB.

• Genomics & Informatics
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• 제11권4호
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• pp.263-271
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• 2013

We investigated the contribution of genetic variations of KLF5 to basal metabolic rate (BMR) and resting metabolic rate (RMR) and the inhibition of obesity in Korean children. A variation of KLF5 (rs3782933) was genotyped in 62 Korean children. Using multiple linear regression analysis, we developed a model to predict BMR in children. We divided them into several groups; normal versus overweight by body mass index (BMI) and low BMR versus high BMR by BMR. There were no differences in the distributions of alleles and genotypes between each group. The genetic variation of KLF5 gene showed a significant correlation with several clinical factors, such as BMR, muscle, low-density lipoprotein cholesterol, and insulin. Children with the TT had significantly higher BMR than those with CC (p=0.030). The highest muscle was observed in the children with TT compared with CC (p=0.032). The insulin and C-peptide values were higher in children with TT than those with CC (p=0.029 vs. p=0.004, respectively). In linear regression analysis, BMI and muscle mass were correlated with BMR, whereas insulin and C-peptide were not associated with BMR. In the high-BMR group, we observed that higher muscle, fat mass, and C-peptide affect the increase of BMR in children with TT (p < 0.001, p < 0.001, and p=0.018, respectively), while Rohrer's index could explain the usual decrease in BMR (adjust $r^2$=1.000, p < 0.001, respectively). We identified a novel association between TT of KLF5 rs3782933 and BMR in Korean children. We could make better use of the variation within KLF5 in a future clinical intervention study of obesity.

• Natural Product Sciences
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• 제19권3호
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• pp.263-268
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• 2013

The inhibitory effects of adipogenesis on ethyl acetate (EtOAc) fraction from leaves of the Tulip tree (TT) were evaluated. Exposure to TT EtOAc fraction (25~200 ${\mu}g/mL$) for a 72 hr incubation period did not significantly change cell viability. TT EtOAc fraction, with concentrations of 100 and 200 ${\mu}g/mL$, inhibited lipid accumulation in 3T3-L1 adipocytes in a dose dependent manner in adipogenesis. The expression of $PPAR{\gamma}$ and $C/EBP{\alpha}$, essential adipogenic markers, was significantly decreased when TT EtOAc fraction was added to cells for 8 days as compared with the untreated control group. These results suggest that TT EtOAc fraction might be a potential therapeutic agent as an effective, natural alternative material for obesity treatment.