• Korean Journal of Exercise Nutrition
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• v.24 no.2
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• pp.11-21
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• 2020

[Purpose] Doxorubicin (DOX) is a potent anti-cancer drug that appears to have severe myotoxicity due to accumulation. The skeletal muscle has a regeneration capacity through satellite cell activation when exposed to extracellular stimulus or damage. Endurance exercise (EXE) is a therapeutic strategy that improves pathological features and contributes to muscle homeostasis. Thus, this study investigated the effect of EXE training in mitigating chronic DOX-induced myotoxicity. [Methods] Male C57BL/6J mice were housed and allowed to acclimatize with free access to food and water. All the mice were randomly divided into four groups: sedentary control (CON, n=9), exercise training (EXE, n=9), doxorubicin treatment (DOX, n=9), doxorubicin treatment and exercise training (DOX+EXE, n=9) groups. The animals were intraperitoneally injected with 5 mg/kg/week of DOX treatment for 4 weeks, and EXE training was initiated for treadmill adaptation for 1 week and then performed for 4 weeks. Both sides of the soleus (SOL) muscle tissues were dissected and weighed after 24 hours of the last training sessions. [Results] DOX chemotherapy induced an abnormal myofiber's phenotype and transition of myosin heavy chain (MHC) isoforms. The paired box 7 (PAX7) and myoblast determination protein 1 (MYOD) protein levels were triggered by DOX, while no alterations were shown for the myogenin (MYOG). DOX remarkably impaired the a-actinin (ACTN) protein, but the EXE training seems to repair it. DOX-induced myotoxicity stimulated the expression of the forkhead box O3 (FOXO3a) protein, which was accurately controlled and adjusted by the EXE training. However, the FOXO3a-mediated downstream markers were not associated with DOX and EXE. [Conclusion] EXE postconditioning provides protective effects against chronic DOX-induced myotoxicity, and should be recommended to alleviate cancer chemotherapy-induced late-onset myotoxicity.

• Korean Journal of Exercise Nutrition
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• v.25 no.1
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• pp.42-55
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• 2021

[Purpose] This study investigated the effects of marine phytoplankton supplementation (Oceanix®, Tetraselmis chuii) on 1) maximal isometric strength and immune function in healthy humans following a oneweek high-intensity resistance-training program and 2) the proinflammatory cytokine response to exercise in a rat model. [Methods] In the human trial, 22 healthy male and female participants were randomly divided into marine phytoplankton and placebo groups. Following baseline testing, participants underwent a 14-day supplement loading phase before completing five consecutive days of intense resistance training. In the rat model, rats were randomly divided into four groups (n=7 per condition): (i) control, (ii) exercise, (iii) exercise + marine phytoplankton (2.55 mg/kg/day), or (iv) exercise + marine phytoplankton (5.1 mg/kg/day). Rats in the exercising groups performed treadmill exercise 5 days per week for 6 weeks. [Results] In the human model, marine phytoplankton prevented significant declines in the isometric peak rate of force development compared to placebo. Additionally, salivary immunoglobulin A concentration was significantly lower following the resistance training protocol in the placebo group but not in the marine phytoplankton group. Marine phytoplankton in exercising rats decreased intramuscular levels and serum concentrations of tumor necrosis factor-alpha (TNF-α) and interleukin-1 beta (IL-1β) and intramuscular concentrations of malondialdehyde. [Conclusion] Marine phytoplankton prevented decrements in indices of functional exercise recovery and immune function. Mechanistically, these outcomes could be prompted by modulating the oxidative stress and proinflammatory cytokine response to exercise.

• Journal of Fashion Business
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• v.26 no.4
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• pp.112-122
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• 2022

The purpose of this study is to investigate the effect of using socks combined with EMS on ankle pain reduction and ankle function improvement in home training participants. In this study, the conductive fabric was combined using socks that can properly compress the ankle. First, VAS was measured during EMS training after fatigue was induced and compared with fatigue during rest. It was confirmed that the level of VAS after EMS training was lower than after rest and fatigue. It was also confirmed that EMS training, which combines EMS with socks, was effective in reducing pain. The experimental action is a measurement action of WBLT and lying posture, and the situation before and after EMS training was compared by performing 30 minutes on the treadmill to cause delayed muscle pain during exercise. As a result of this study, it was found that pain reduction and ROM function were improved when electrical stimulation was performed using EMS socks. It was also confirmed that the application of electrical stimulation to EMS socks effected on ankle fatigue and function improvement. From the study results, it is expected that wearing socks equipped with EMS significantly reduces ankle injuries and improves functional recovery for home training participants.

• The Journal of Korean Academy of Orthopedic Manual Physical Therapy
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• v.28 no.2
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• pp.57-65
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• 2022

Background: This study examined the effects of adding fibular repositioning taping (FRT) to ankle mobilization with movement taping (AMT) on the ankle range of motion (ROM), balance, and gait performance in patients with chronic stroke with limited ankle dorsiflexion. Methods: The participants were randomized into the control (n=15) and AMT+FRT groups (n=15). The control groups applied only non-elastic taping on the affected ankle, and the AMT+FRT groups also applied non-elastic taping to the inferior tibiofibular joint. Both groups performed treadmill walking for 10 minutes. The ankle dorsiflexion passive ROM, balance, gait velocity, and cadence were measured before and after the intervention. Results: Both groups showed a significant difference after the intervention in the dorsiflexion ROM (p<.01), balance (p<.01), and gait performance (p<.01). On the other hand, no significant difference was observed between the two groups (p>.05). Conclusion: AMT improved ankle dorsiflexion passive ROM, balance, gait velocity, and cadence in patients with chronic stroke, but there was no difference between the two groups. Therefore, the addition of FRT to AMT does not influence the ankle dorsiflexion ROM, balance, and gait performance in patients with chronic stroke.

• International Journal of High-Rise Buildings
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• v.11 no.4
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• pp.347-362
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• 2022

Current vibration serviceability assessment criteria for wind-induced vibrations in tall buildings are based largely on human 'perception' thresholds which are shown not to be directly translatable to human 'acceptability' of vibrations. There is also a considerable debate about both the metrics and criteria for vibration acceptability, such as frequency of occurrence or peak vs mean vibration, and how these might vary with the nature of the vibration. Furthermore, the design criteria are necessarily simplified for ease of application so cannot account for a range of environmental, situational and human factors that may enhance or diminish the impact of vibrations on serviceability. The dual-site VSimulators facility was created specifically to provide an experimental platform to address gaps in understanding of human response to building vibration. This paper considers how VSimulators can be used to inform general design guidance and support design of specific buildings for habitability, in terms of vibration, which allow engineers and clients to make informed decisions with regard to sustainable design, in terms of energy and financial cost. This paper first provides a brief overview of current vibration serviceability assessment guidelines, and the current understanding and limitations of occupants' acceptability of wind-induced motion in tall buildings. It then describes how the dual-site VSimulators facility at the Universities of Bath and Exeter can be used to assess the effects of motion and environment on human comfort, wellbeing and productivity with examples of how the facility capabilities have been used to provide new, human experience based experimental research approaches.

• The Journal of the Society of Stroke on Korean Medicine
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• v.14 no.1
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• pp.49-60
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• 2013

■ Objectives The aim of this study is to analyze the change of gait pattern by the taping therapy in a hemiplegic patient. ■ Methods We conducted the taping therapy for 7 days to affected ankle joint of hemiplegic patient and analyzed the change of gait pattern using Treadmill Gait analysis equipment(Zebris Co.Ltd FDM-T) ■ Results In terms of affected side, cadence, total double support, step length and stance phase decreased, while swing phase and step time increased by taping therapy. In terms of unaffected side, step length increased by taping therapy. Center of pressure intersection point moved to posterior and affected side in cyclogram pattern. ■ Conclusion Taping therapy to affected ankle joint of hemiplegic patient would be advantages to gait improvement in hemiplegic patients.

• The Journal of the Society of Stroke on Korean Medicine
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• v.14 no.1
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• pp.61-70
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• 2013

■ Objectives The goal of this pilot study is to observe the change of gait pattern in a patient after peroneal nerve electrical stimulation(PNST). ■ Methods We analyzed the gait pattern of stroke patient using treadmill gait analysis system before and after PNST for seven weeks. The PNST was carried out for 20minutes every day except Sunday. In addition, the measurement was carried out every Saturday. At the fifth week, the PNST was not carried out to confirm whether the effect of PNST was disappeared immediately when PNST was not applied. ■ Results After PNST, while heel contact time and heel max force increased and forefoot and midfoot max force decreased, the gait parameters such as cadence, velocity, swing phase, stance phase, total double support, step length, stride length, step time, stride time and forefoot contact time, were not changed. ■ Conclusion Gait of a patient with cerebral stroke was changed positively after PNST.

• The Journal of the Society of Stroke on Korean Medicine
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• v.14 no.1
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• pp.15-22
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• 2013

■ Objectives The aim of this study is to look into the correlation between motor performance and displacement of center of pressure(CoP) in hemiplegic patients with cerebral stroke. ■ Methods We measured manual muscle test(MMT) as motor performance value and, anterior/posterior position(Ant./Post. position) and lateral symmetry of CoP as displacement of CoP values from 129 stroke patients. The gait analysis was carried out using treadmill gait analysis equipment. ■ Results In terms of motor performance, MMT of upper extremity negatively correlated with Ant/Post position of CoP, however, one of lower extremity did not. In addition, MMT of both extremities negatively correlated with lateral symmetry of CoP. ■ Conclusion Displacement of CoP was negatively correlated with hemiplegic patient's motor performance.

• The Journal of the Society of Stroke on Korean Medicine
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• v.14 no.1
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• pp.1-7
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• 2013

The following study reviewed the walking patterns of stroke patients with hemiplegia, which is called hemiplegic gait of stroke patients. Focusing is given to the changes in the distance and temporal factors of walking, which is called spatiotemporal characteristics, throughout the walking cycle. First, we introduced the definitions of essential terms related to gait and its measure. Second, we reviewed the spatiotemporal characteristics of hemiplegic gait. A main issue was that hemiplegic gait showed significant deviations from normal healthy gait. Although hemiplegia is primarily associated with unilateral motor disorder, changes in almost all spatiotemporal parameters used to assess walking were evident on both the involved and uninvolved sides of the body. Last, we reviewed the changes of spatiotemporal parameters of hemiplegic gait according to the prognosis or status of stroke patients, which may help to give a specific intervention for rehabilitation of stroke.

• The Journal of the Society of Stroke on Korean Medicine
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• v.14 no.1
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• pp.80-89
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• 2013

■ Objectives The aim of study is to analyze the change of gait pattern by arm sling in a hemiplegic patient. ■ Methods We analyzed the change of gait pattern under three conditions using Treadmill Gait analysis equipment(Zebris Co.Ltd FDM-T) First, the patient didn't have arm sling on her upper limb, second, the patient have arm sling on her affected upper limb, third, patient have arm sling on her unaffected upper limb. ■ Results In terms of spatiotemporal gait values, swing phase, step time, step length of unaffected lower limb increased. Furthermore, stride time and stride length also increased when the patient had arm sling on her unaffected upper limb. In terms of displacement of Center of pressure(CoP), anterior/posterior position and lateral symmetry of CoP increased. Furthermore, lateral symmetry of decreased when the patient had arm sling on her affected upper limb. ■ Conclusion Arm sling applied on affected side would be advantage to gait improvement in hemiplegic patients.