• Progress in Medical Physics
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• v.13 no.4
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• pp.224-228
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• 2002

Myocardial tagging technique such as spatial modulation of magnetization (SPAMM) allows the study of myocardial motion with high accuracy. However, the accuracy of the estimation of tag intersection can be affected by tagline spacing. The aim of this study was to investigate the relationship between tagline spacing of SPAMM image and tagging contrast-to-noise ratio (CNR) in in-vivo study. Two healthy volunteers were undergone electrocardiographically triggered MR imaging with SPAMM-based tagging pulse sequence at a 1.5T MR scanner. Horizontally modulated stripe patterns were imposed with a range from 3.6 to 9.6 mm of tagline spacing. Images of the left ventricle(LV) wall were acquired at the mid-ventricle level during cardiac cycle with FE-EPI (TR/TE = 5.8/2.2 msec, FA= 10$^{\circ}$. Tagging CNR for each image was calculated with a software which developed in our group. During contraction, tagging CNR was more rapidly decreased in case of narrow tagline spacing than in case of wide tagline spacing. In the same heart phase, CNR was increased corresponding with tagline spacing. Especially, at the fully contracted heart phase, CNR was more rapidly increased than the other heart phases as a function of tagline spacing. The results indicated that the optimization of tagline spacing provides better tagging CNR in order to analyze the myocardial motion more accurately.

• Korean Journal of Veterinary Research
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• v.49 no.1
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• pp.45-57
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• 2009

The molecular genetic characterization of Aujeszky's disease virus (ADV) Yangsan strain (ADVYS), a Korean isolate, was investigated by analyzing the electrophoresis patterns and the physical maps of the viral DNA digested with various endonucleases. To establish DNA library for ADV-YS, twelve major BamHI restricted segments were cloned. Each location of the segments in the ADV genome was determined by sequence comparison with the sequences reported in Genbank and those sequences of the both termini of the segments. Physical maps were constructed based on the electrophoresis patterns of the digested viral DNA by restriction endonuclease and the results of Southern blot analyses with various DIG labeled probes originated from those of enzyme restricted segments of virulent (Shope) and avirulent (Bartha) strain. Comparing ADV-YS with a standard strain of Kaplan in the maps of restriction enzymes, following major respects were identified: (i) disappearance of BamHI restriction site between the first and second BamHI segments, (ii) creation of the BamHI restriction site in the fifth segment, and (iii) generation of the BglII site in the unique short (US) region. The genome of ADV-YS also contains a type 2 herpesvirus DNA molecule (in which the US region only inverts itself relative to the unique longregion) like all other ADV strains except Norden strain(type3), analyzed up to date. The size of the ADV genome estimated from the sizes of the restriction enzyme fragments, was approximately 145.3 kb (BamHI) or 145.4 kb (BglII). BamHI enzyme cleavage patterns were compared among the five Korean ADV isolates: Yangsan, Yongin, Dangjin, Jincheon and Iksan strains. Difference either in the number or in the size of the DNA fragments, suspected regions of termini of IR and TR, could be detected among all five strains.

• Journal of Ginseng Research
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• v.23 no.4
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• pp.235-238
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• 1999

ATP-sensitive $K^+$ channels $(K_{ATP})$ are expressed in vascular smooth muscle cells, skeletal muscle cells, pancreatic ${\beta}$ cells, neurons and epithelial cells. $K_{ATP}$ contributes to regulate membrane potential to control vascular tone, to protect myocardial ischemia, and to regulate insulin secretion in pancreatic ${\beta}$ cells. We previously demonstrated that ginseng saponins and ginsenoside $Rg_3$ activated maxi $Ca^{2+}-activated\;K^+$ channel, and this might cause vasodilation. Because $K_{ATP}$ plays an important roles to regulate the resting membrane potential in vascular smooth muscle cells, we investigated whether ginsenoside $Rg_3$ produces vasodilation by activating $K_{ATP}$ We showed in this study that $K_{ATP}$ is expressed in rabbit coronary artery smooth muscle cells. $K_{ATP}$ was inwardly rectifying and was inhibited by intemal application of ATP. Micromolar minoxidil activated, but glyburide inhibited the activity of $K_{ATP}$ Ginsenoside $Rg_3$ relieved inactivaiton of whole-cell $K_{ATP}$ current without affecting the peak amplitude of $K_{ATP}$ currents presumably due to more opening of the channels.

• Proceedings of the ESK Conference
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• 1997.10a
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• pp.196-204
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• 1997

우리 나라는 한해에 안전사고로 인해 12만 .+-. 2만명정도의 재해자를 발생시키고 있으며, 재해의 천국이라는 오명까지 얻게 되었다. 따라서 본 연구는 우리나라의 산업안전관리자의 안전의식을 분석함으로써 재해발생의 감소에 일조를 하고자 함을 본 연구의 목적으로 한다. 연구기간은 1997년 3월에서 8월까지며, 총 200여명의 강원지역의 산업안전관리자들을 대상 으로 설문조사하여, 그중 불성실하게 답한 것을 제외한 183명의 관리자들의 응답결과를 토 대로 통계분석을 실시하였다. 연구내용은 안전의식에 대한 설문조사를 통하여 그들의 근무 조건과 안전에 대한 지식정도, 현 직장에의 만족과 불만족요인과 자주 쓰는 재해통해방법들을 조사하여 우리나라의 안전관리자들의 현 상황을 유추해 보고자 시도하였다. 분석결과 183명 중 여성은 불과 3명뿐이며, 83%가 기혼이며, 대졸은 전체의 25.1%이며, 59.6%가 고졸이며 , 전문대졸은 15.2%나 되었다. 전담 안전관리자는 전체의 8%에 불과했으며, 대부분 겸임을 하고 있었다. 놀라운 것은 안전관리자들의 92.6%가 안전관리자격증이 없었으며, 2급이 4.7% 에 불과했다. 과거에 부상을 당한 경험이 있는 안전관리자는 전체의 26.3%에 달해 회사가 부상을 당한 근로자를 안전부서로 발령한다는 사실을 확인할 수 있었다. 다친 원인의 50%가 시설물 결함으로 나타나 작업환경개선이 시급함을 알 수가 있었다. 우리나라도 선진국과 같은 교욱담당의 NIOSH와 제재담당의 OSHA와 같은 기관의 설립이 보다 효율적이고 근본적인 안전 관리의 문제해결책이라고 사료된다. 열악한 중소기업에 나라에서 안전교육을 담당해 주는 대신 기업은 근로자들에게 보다 안전한 환경을 제공해야 된다는 것이 이러한 기관설립의 목적이라고 하겠다. 더 나아가 이를 총괄하는 안전관리청의 신설이 보다 근본적인 문제해결을 제공해 줄 수 있을 것으로 사료된다.의 결과는 자전거 에르고노미터의 결과가 트레드밀의 결과에 87.60%정도 나타났다.음을 관찰하였다. 특히 vitamin C와 E의 병용투여는 상승적으로 적용하여 간세포손상을 더욱 억제시킴을 알 수 있었다.mance and on TFP(Total Factor Productivity) growth which is a pure measure of firm performance. To utilize the advantage of panel data, FEM(Fixed Effect Model) and REM(Random Effect Model) were used. The empirical result shows that the entropy index as a measurement of inter-business relatedness is not significant but technological relatedness index is significant. OLS estimates on pooled data were considerably different from FEM or REM estimates on panel data. By introducing interaction effect among the three variables for business portfolio properties, we obtained three findings. First, only VI (Vertical integration) has a significant positive correlation with ROS. Second, when using TFP growth as an dependent variable, both TR(Technological Relatedness) and f[ are significant and positively related to the

• Proceedings of the ESK Conference
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• 1997.10a
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• pp.142-151
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• 1997

본 연구는 주부들의 주활동공간인 부엌가구와 공간의 설계에 있어사용하기 편리하며 가사활동에 따 른 피로를 경감시키고 요통과 같은 주부직업병을 예방할 수 있는 부엌가구와 공간의 개발에 그 목적을 두었다. 연구는 먼저 수도권의 32평형 규모의 아파트150가구를 대상으로 설문조사를 실시하였으며, 만 24시간동안의 실제 가사활동을 Video로 촬영하여 동작분석을 실시하였다. 그 결과 주부들은 수납의 용 이성과 공간의 크기, 작업대의 높이 등을 가장 많은 개선사항으로 지적하였으며, 절반이상의 주부들이 앉은 자세에서 작업이 이루어졌으면 좋겠다고 응답하였다. 또한 동작분석 결과 작업의 70%이상이 개수 대를 중심으로 조리대와 가열대 주변의 한정된 공간에서정적으로 선 자세에서이루어지는 것으로 파악 되었다. 이러한 선 자세에서의 작업에 따른 피로도를 감소시키기 위하여 입좌식 의자를 도입하였으며, 개수대를 씽크대의 'ㄱ'자 코너에 위치하여 주방활동시의 이동거리를 단축하고자 하였다. 피로도의 경감 을 측정하기 위하여 입좌식 의자를 도입한 개선된 씽크대와 기존의 입식씽크대에서 가사활동시 요구되는 주부들의 에너지 대사량을 비교하기 위하여 심장박동수와 산소호흡량을 측정하였다. 실험결과에 따르면 주방에 입좌식의자를 도입한 경우가 가사활동에 요구되는 에너지 소모량이 심장박동수와 산소호흡량의 기준에서 각각 평균적으로 30%와 57.5% 이상이 감소하는 것으로 파악되어 이러한 부엌가구의 도입으로 주부들의 가사활동에따른 피로도가 절반 가까이 감소될 수 있음을 니타내었다. 또한 부엌가구의 재배치 에따른 가사활동시 이동거리가 평균적으로5.5%이상이 감소하는 것으로 나타났다. 본 연구결과를 주방설 계에 적용할 경우 가사활동의 효율성과 편리성이 향샹됨은 물론 가사활동에따른 피로도를 경감 시키고 요통 등의 주부직업병을 예방할 수 있을 것으로 기대된다.1일 1회씩 4회 투여한 군에서도 암수에 상관없이 전 농도 군에서 염색체이상을 나타내지 않아 유전독성을 나타내지 않음을 관찰하였다. 특히 vitamin C와 E의 병용투여는 상승적으로 적용하여 간세포손상을 더욱 억제시킴을 알 수 있었다.mance and on TFP(Total Factor Productivity) growth which is a pure measure of firm performance. To utilize the advantage of panel data, FEM(Fixed Effect Model) and REM(Random Effect Model) were used. The empirical result shows that the entropy index as a measurement of inter-business relatedness is not significant but technological relatedness index is significant. OLS estimates on pooled data were considerably different from FEM or REM estimates on panel data. By introducing interaction effect among the three variables for business portfolio properties, we obtained three findings. First, only VI (Vertical integration) has a significant positive correlation with ROS. Second, when using TFP growth as an dependent variable, both TR(Technological Relatedness) and f[ are signif

• Journal of the Korean Chemical Society
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• v.39 no.4
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• pp.237-243
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• 1995

The measurments of neutral semiquinone radicals, which were formed from the laser flash photolysis of anthraquinone (AQ) in the mixed solvents were carried out by the time resolved electron spin resonance (trESR) spectroscopy. The chemically induced dynamic electron polarization (CIDEP) spectra of the neutral semiquinone radical (AQH${\cdot}$) and semiquinone radical anion (AQ${\cdot}$-) were successively detected in the laser flash photolysis of AQ in the mixtures of 2-propanol (PrOH) and triethylamine (TEA). The neutral semiquinone radical was short-lived with the half-life of 0.8 ${\mu}sec$, whereas the semiquinone radical anion was relatively stable and then its cwESR could be observed. The rate constant of the spin-depolarization of semiquinone radical anion was $2.6{\times}10^5 sec^{-1}$ and the decay of the radical anion was the first order reaction with the rate constant of $3.0{\times}10^2\; sec^{-1}$. No CIDEP of semiquinone radical anion was observed in the mixture of PrOH and the lower concentration of TEA than 2 percent. The CIDEP spectrum of the neutral semiquinone radical was detected in the mixture of benzene and TEA with the half-life of 3.0 ${\mu}sec$. The neutral semiquinone radical could not be detected by cwESR. Neither CIDEP nor ESR absorption could be observed in PrOH, TEA or benzene only.

• Journal of Biomedical Engineering Research
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• v.18 no.3
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• pp.243-251
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• 1997

In this paper, we have reported two interesting flow effects arising in the TRFGE sequence using water flow phantom. First, we have shown that the TRFGE sequence is indeed not affected by "in-flow" effect from the unsaturated spins flowing into the imaging slice. Second, the enhancement of "in-plane flow" signal in the readout gradient direction was observed when the TRFGE sequence was used without flow compensation. These two results have many interesting applications in MR imaging other than fMRI. Results obtained were also compared with the results obtained by the conventional gradient echo(CGE) imaging. Experiments were performed at 4.7T MRI/S animal system (Biospec, BRUKER, Switzerland). A cylindrical phantom was made using acryl and a vinyl tube was inserted at the center(Fig. 1). The whole cylinder was filled with water doped with $MnCl_2$ and the center tube was filled with saline which flows in parallel to the main magnetic field along the tube. Tailored RF pulse was designed to have quadratic ($z^2$) phase distribution in slice direction(z). Imaging parameters were TR/TE = 55~85/10msec, flip angle = $30^{\circ}$, slice thickness = 2mm, matrix size = 256${\times}$256, and FOV= 10cm. In-flow effect : Axial images were obtained with and without flow using the CGE and TRFGE sequences, respectively. The flow direction was perpendicular to the image slice. In-plane flow : Sagittal images were obtained with and without flow using the TRGE sequence. The readout gradient was applied in parallel to the flow direction. We have observed that the "in-flow" effect did not affect the TRFGE image, while "in-plane flow" running along the readout gradient direction enhanced the signal in the TRFGE sequence when flow compensation gradient scheme was not used.

• Journal of Radiation Industry
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• v.6 no.1
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• pp.31-40
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• 2012

There are two methods to fabricate the readout electronic to a large-area CMOS image sensor (LACIS). One is to design and manufacture the sensor part and signal processing electronics in a single chip and the other is to integrate both parts with bump bonding or wire bonding after manufacturing both parts separately. The latter method has an advantage of the high yield because the optimized and specialized fabrication process can be chosen in designing and manufacturing each part. In this paper, LACIS chip, that is optimized design for the latter method of fabrication, is presented. The LACIS chip consists of a 3-TR pixel photodiode array, row driver (or called as a gate driver) circuit, and bonding pads to the external readout ICs. Among 4 types of the photodiode structure available in a standard CMOS process, $N_{photo}/P_{epi}$ type photodiode showed the highest quantum efficiency in the simulation study, though it requires one additional mask to control the doping concentration of $N_{photo}$ layer. The optimized channel widths and lengths of 3 pixel transistors are also determined by simulation. The select transistor is not significantly affected by channel length and width. But source follower transistor is strongly influenced by length and width. In row driver, to reduce signal time delay by high capacitance at output node, three stage inverter drivers are used. And channel width of the inverter driver increases gradually in each step. The sensor has very long metal wire that is about 170 mm. The repeater consisted of inverters is applied proper amount of pixel rows. It can help to reduce the long metal-line delay.

• Toxicological Research
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• v.35 no.1
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• pp.45-63
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• 2019

In view of the growing industrial use of Bacterial cellulose (BC), and taking into account that it might become airborne and be inhaled after industrial processing, assessing its potential pulmonary toxic effects assumes high relevance. In this work, the murine model was used to assess the effects of exposure to respirable BC nanofibrils (nBC), obtained by disintegration of BC produced by Komagataeibacter hansenii. Murine bone marrow-derived macrophages ($BMM{\Phi}$) were treated with different doses of nBC (0.02 and 0.2 mg/mL, respectively 1 and $10{\mu}g$ of fibrils) in absence or presence of 0.2% Carboxymethyl Cellulose (nBCMC). Furthermore, mice were instilled intratracheally with nBC or nBCMC at different concentrations and at different time-points and analyzed up to 6 months after treatments. Microcrystaline $Avicel-plus^{(R)}$ CM 2159, a plant-derived cellulose, was used for comparison. Markers of cellular damage (lactate dehydrogenase release and total protein) and oxidative stress (hydrogen peroxidase, reduced glutathione, lipid peroxidation and glutathione peroxidase activity) as well presence of inflammatory cells were evaluated in brochoalveolar lavage (BAL) fluids. Histological analysis of lungs, heart and liver tissues was also performed. BAL analysis showed that exposure to nBCMC or CMC did not induce major alterations in the assessed markers of cell damage, oxidative stress or inflammatory cell numbers in BAL fluid over time, even following cumulative treatments. $Avicel-plus^{(R)}$ CM 2159 significantly increased LDH release, detected 3 months after 4 weekly administrations. However, histological results revealed a chronic inflammatory response and tissue alterations, being hypertrophy of pulmonary arteries (observed 3 months after nBCMC treatment) of particular concern. These histological alterations remained after 6 months in animals treated with nBC, possibly due to foreign body reaction and the organism's inability to remove the fibers. Overall, despite being a safe and biocompatible biomaterial, BC-derived nanofibrils inhalation may lead to lung pathology and pose significant health risks.

• Proceedings of the Korea Water Resources Association Conference
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• 2022.05a
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• pp.335-335
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• 2022

남한상세 기후변화 전망보고서(2021)는 2100년대 강원도 강수량이 현재보다 19% 증가하고, 평균기온이 현재보다 6.5℃ 상승할 것으로 공표했다. 강원도는 영동지역과 영서지역으로 분리돼 기후 차이가 분명하다. 기상청 ASOS 데이터(1986~2020)를 이용해 기후 특성을 확인한 결과 영동지역 강수량은 1,463mm, 평균기온은 10.5℃, 상대습도는 66%로 분석됐고, 영서지역 강수량은 1,307mm, 평균기온은 11℃, 상대습도는 68%로 분석됐다. 영동지역 강수량이 영서지역 강수량보다 약 156mm 더 많으며, 이는 영동지역에서 큰 규모의 우심 피해가 발생할 가능성이 존재함을 의미한다. 강원도 평년 우심 피해 현황을 살펴본 결과 영동지역은 5회(피해액: 62억 원), 영서지역은 24회(피해액: 62억원)가 발생했다. 이는 미래로 갈수록 더 심해질 것으로 판단되며, 이런 기상 재난을 객관적으로 판단할 수 있는 기준이 필요하다. 이에 본 연구에서는 기후변화에 따른 강원도 기후 재난취약성을 평가했다. 이를 위해 기후변화 위험성, 기후변화 민감도, 기후변화 적응능력 지표를 활용해 기후변화 취약성 지표를 선정했다. 기후변화 위험성 지표는 홍수(CWD, Rx5day, R30mm), 가뭄(CDD, SU, TX90p), 폭염(SU, TR, TN90p), 한파(ID, TX10p, FD)로 RCP 8.5 기후변화시나리오를 ETCCDI 지수에 적용했다. 기후변화 민감도와 기후변화 적응능력 지표는 국가통계포털, 강원통계정보, WAMIS에서 자료를 수집해 선정했다. 또한 재난취약성 지표를 4단계(Very Low, Low, High, Very High)로 구분했다. 홍수 취약성 평가 결과 2090년대 원주시, 춘천시, 횡성군이 Low에서 Very High로 단계가 격상됐다. 가뭄 취약성 평가 결과 2090년대 양양군, 영월군, 정선군이 Very Low에서 Very High로 단계가 격상됐다. 폭염 취약성 평가 결과 2090년대 삼척시, 태백시, 영월군이 Very Low에서 Very High로 단계가 격상됐다. 한파 취약성 평가 결과 삼척시, 태백시, 영월군이 High에서 Very Low로 단계가 격하됐다. 고로 강원도는 기후 재난취약성 평가 결과에 따른 미래 기후변화를 대비하고, 각 지역 특성에 맞는 복원력 관점 기후 재난 관리가 필요하다고 사료된다.