• Asian Pacific Journal of Cancer Prevention
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• v.16 no.12
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• pp.5059-5062
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• 2015

Background: ALL is an irredeemable disease due to the resistance to treatment. There are several influences which are involved in such resistance to chemotherapy, including oxidative stress as a result of the generation of reactive oxygen species (ROS) and presence of hypodiploid cells. Cluster of differentiation 26 (CD26), also known as dipeptidyl peptidase-4, is a 110 kDa, multifunctional, membrane-bound glycoprotein. Aim and objectives: The aim of this study was to evaluate the clinical significance of serum CD26 in patients with acute lymphoblastic leukaemia patients in the post remission induction phase, as well as the relationship between CD26 activity and the oxidative stress status. Materials and Methods: CD26, total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI), in addition to activity of related enzymes myeloperoxidase, glutathione-s-transferase and xanthine oxidase, were analysed in sixty children with acute lymphoblastic leukaemia in the post remission induction phase. Results: The study showed significant elevation in CD26, TOS and OSI levels in patients with acute lymphoblastic leukaemia in the post remission induction phase in comparison to healthy control samples. In contrast, myeloperoxidase, glutathione-s-transferase and xanthine oxidase activities were decreased significantly. A significant correlation between CD26 concentration and some oxidative stress parameters was evident in ALL patients. Conclusions: Serum levels of CD26 appear to be useful as a new biomarker of oxidative stress in children with acute lymphoblastic leukaemia in the post remission induction phase, and levels of antioxidants must be regularly estimated during the treatment of children with ALL.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.13 no.6
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• pp.1091-1098
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• 2009

In this paper, we designed the authentication system for home network service and applied it to actual sensor nodes. The pair-wise pre-distribution key skim is applied for prevention of authentication key from sniffing on the wireless sensor networks. The authentication key and data are encrypted by using the CBC mode RC5 algorithm based on the SPINS. The experimental environment consists of a base station (BS)and sensor nodes and each sensor node sends both sensing data and the encrypted authentication key to the BS. For simulations we set up some what-if scenarios of security menaces in home network service.Slightly modified the TOS_Msg data arrays of TinyOS is suggested to store 8-byte authentication key which can enable data encryption and authentication at the each sensor node. As a result, malfunction caused by communication between BS and nodes of other groups of added nodes having malicious purpose can be protected. Also, we confirmed that a critical data of home networking service like vital signal can be transmitted securely through this system by encryption technique.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.11 no.5
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• pp.1760-1767
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• 2010

FAT compounds photocatalysts were prepared with $TiOSO_4{\cdot}xH_2O$ (TOS) by a sol-gel method. The samples were characterized by scanning electron microscopy (SEM), BET specific surface area, X-ray diffraction analysis (XRD) and energy dispersive X-ray spectroscopy (EDX). The SEM results showed that ferric compounds and titanium dioxide were fixed onto the AC surfaces. The XRD results showed that Fe-AC/$TiO_2$ composites mostly contained anatase phase. EDX showed the presence of C, O, and Ti with Fe peaks in all samples. The photocatalytic activities were evaluated by the photocatalytic oxidation of methylene blue (MB) solution, via compare photodegradation of MB solution under visible light and UV light separately. Fe-AC/$TiO_2$ composites had an excellent photocatalytic under strong visible light irradiation. A small amount of Fe ions in AC/$TiO_2$ particles could obviously enhance their photocatalytic activity.

• Plant Resources
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• v.8 no.1
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• pp.60-66
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• 2005

Lysine is the first essential amino acid for optimal nutrient quality in rice grain. For the narrow genetic diversities of lysine contents in rice, somaclonal variation was the source of mutation in our breeding program. Biochemical selection was conducted using 1 mM S-(2-aminoethyl) cysteine followed by two passages of 5 mM lysine plus threonine in the callus subculture medium. The lysine contents in endosperm of all progenies recovered from the biochemical selection were higher than those of their donor cultivar 'Hwayeongbyeo'. These elevated lysine levels of mutants were successfully transmitted to $M_4$ generation. The lysine contents in endosperm varied 3.85 to $4.80\%$ compare to their donor cultivar 'Hwayeongbyeo' was $3.85\%$. Three of high-lysine germplasms, Lys-l, Lys-2 and Lys-7 were selected by biochemical selection and rapid screening methods. DNA analysis showed that a new insertion of Tos 17 which mapped to rice chromosome 11 on the high-lysine mutant, Lys-2.

• The Transactions of the Korea Information Processing Society
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• v.5 no.3
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• pp.662-670
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• 1998

In order to overcome the problems with first generation expert systems at the symbol level, recently various knowledge level development techniques of second generation expert systems have been proposed. But, these techniques are conceptual modelling techniques. This paper modifies and complements these conceptual modelling techniques and proposes a Task Object Modelling (TOM) technique as a practical knowledge level expert system development technique. This paper defines a Task Object(TO) as a knowledge unit consisted of a goal, execution conditions, behaviour knowledge, and so on. And, we define a Task Object Diagram(TOD) to depict structual, dynamic, and functional aspects of TO easily. We also define Inference Types as basic units to describe behaviour knowledge of TOs. In order to utilize the proposed TOM technique as not a simple conceptual modelling technique but a practical second generalion expert system development technique, we implement a TOD editor, a TO editor, and TO processing algorithm based on the state of TOs. Also we implement a Inference Types Library, in which each inference type is corresponded to an IRE(Jntelligent Rules Element) method, to transform the defined inference types into IRE methods automatically.

• The Korean Journal of Pain
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• v.37 no.3
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• pp.233-246
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• 2024

Background: Ferrostatin-1 and liproxstatin-1, both ferroptosis inhibitors, protect cells. Liproxstatin-1 decreases morphine tolerance. Yet, ferrostatin-1's effect on morphine tolerance remains unexplored. This study aimed to evaluate the influence of ferrostatin-1 on the advancement of morphine tolerance and understand the underlying mechanisms in male rats. Methods: This experiment involved 36 adult male Wistar albino rats with an average weight ranging from 220 to 260 g. These rats were categorized into six groups: Control, single dose ferrostatin-1, single dose morphine, single dose ferrostatin-1 + morphine, morphine tolerance (twice daily for five days), and ferrostatin-1 + morphine tolerance (twice daily for five days). The antinociceptive action was evaluated using both the hot plate and tail-flick tests. After completing the analgesic tests, tissue samples were gathered from the dorsal root ganglia (DRG) for subsequent analysis. The levels of glutathione, glutathione peroxidase 4 (GPX4), and nuclear factor erythroid 2-related factor 2 (Nrf2), along with the measurements of total oxidant status (TOS) and total antioxidant status (TAS), were assessed in the tissues of the DRG. Results: After tolerance development, the administration of ferrostatin-1 resulted in a significant decrease in morphine tolerance (P < 0.001). Additionally, ferrostatin-1 treatment led to elevated levels of glutathione, GPX4, Nrf2, and TOS (P < 0.001), while simultaneously causing a decrease in TAS levels (P < 0.001). Conclusions: The study found that ferrostatin-1 can reduce morphine tolerance by suppressing ferroptosis and reducing oxidative stress in DRG neurons, suggesting it as a potential therapy for preventing morphine tolerance.

• Proceedings of the IEEK Conference
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• 2005.11a
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• pp.1193-1196
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• 2005

In this paper, we presents a new multimedia service transmit method using IPv6. The IPv6 provides the address system of 128 bit and the address space which is infinite it provides. But it will not become the IPv4 and interchange not to be, it uses the DSTM Transition mechanism which will reach and the IPv4 center in the packet header the service type it will be able to support the service class of multi type (TOS) it secures the weak point of data transfer delay it puts a base in the IPv6. The efficiency of this proposed technique have been proven by MPEG-4 streaming video streaming of the IPv6 namely, 6Xtream embodied a order form/live streaming server and the client which it uses to be possible in base and real-time decoding method.

• Industrial Engineering and Management Systems
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• v.6 no.2
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• pp.106-118
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• 2007

This paper present a new optimization model to generate aggregate production planning by considering electric cost. The new Time Of Switching (TOS) electric type is introduced by switching over Time Of Day (TOD) and Time Of Use (TOU) electric types to minimize the electric cost. The fuzzy demand and Dynamic inventory tracking with multiple plant capacity are modeled to cover the uncertain demand of customer. The constraint for minimum hour limitation of plant running per one start up event is introduced to minimize plants idle time. Furthermore; the Optimal Weight Moving Average Factor for customer demand forecasting is introduced by monthly factors to reduce forecasting error. Application is illustrated for multiple cement mill plants. The mathematical model was formulated in spreadsheet format. Then the spreadsheet-solver technique was used as a tool to solve the model. A simulation running on part of the system in a test for six months shows the optimal solution could save 60% of the actual cost.

• Archives of Pharmacal Research
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• v.28 no.9
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• pp.1013-1018
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• 2005

A number of 1,5-diarylimidazoles has been synthesized and evaluated for their inhibitory activities of COX-2 catalyzed $PGE_2$ production. 1,5-Diarylimidazoles were obtained from imimes and p-toluenesulfonylmethyl cyanide (TosMIC). Imines were prepared from commercially available amines and aldehydes. Among the compounds tested, 1-(2,4-difluorophenyl)-5-(4­methylsulfonylphenyl)imidazole (2r) showed strong inhibitory activity, however, most diarylimidazoles exhibited little to low inhibitory activities against COX-2 catalyzed $PGE_2$ production.

• Proceedings of the Korea Information Processing Society Conference
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• 2005.05a
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• pp.1525-1528
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• 2005

본 논문에서는 초고속인터넷 망에서 VoIP 서비스 제공시 적용할수 있는 망별 QoS 제공기술을 소개하고 이러한 QoS 기술들을 이용하여 통화품질을 개선할수 있는 방안을 제시하였다 . 초고속인터넷망의 QoS 기술은 적용방법에 따라 다양한데 본 논문에서는 IEEE 802.1P, IP TOS 기술, DIFFFSERV 기술, Traffic classification & Queuing, ATM QoS 기술 등을 소개하고 이러한 기술을 사용하여 초고속인터넷망중 Metro EtherNet 망, ADSL 망을 중심으로 VoIP 서비스시 성능을 향상 할 수 있는 방안을 제시하였다