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Synthesis and Antiinflammatory Activity of 1,5-Diarylimidazoles  

Tuyen Truong Ngoc (College of Pharmacy, Kangwon National University)
Sin Kwang-Seog (College of Pharmacy, Kangwon National University)
Kim Hyun Pyo (College of Pharmacy, Kangwon National University)
Park Haeil (College of Pharmacy, Kangwon National University)
Publication Information
Archives of Pharmacal Research / v.28, no.9, 2005 , pp. 1013-1018 More about this Journal
Abstract
A number of 1,5-diarylimidazoles has been synthesized and evaluated for their inhibitory activities of COX-2 catalyzed $PGE_2$ production. 1,5-Diarylimidazoles were obtained from imimes and p-toluenesulfonylmethyl cyanide (TosMIC). Imines were prepared from commercially available amines and aldehydes. Among the compounds tested, 1-(2,4-difluorophenyl)-5-(4­methylsulfonylphenyl)imidazole (2r) showed strong inhibitory activity, however, most diarylimidazoles exhibited little to low inhibitory activities against COX-2 catalyzed $PGE_2$ production.
Keywords
1,5-Diarylimidazoles; COX-2; Prostaglandin production inhibition; Antiinflamatory activity;
Citations & Related Records

Times Cited By Web Of Science : 5  (Related Records In Web of Science)
Times Cited By SCOPUS : 5
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