• Molecules and Cells
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• 제41권2호
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• pp.140-149
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• 2018

The $TIS21^{/BTG2/PC3}$ gene belongs to the antiproliferative gene (APRO) family and exhibits tumor suppressive activity. However, here we report that TIS21 controls lipid metabolism, rather than cell proliferation, under fasting condition. Using microarray analysis, whole gene expression changes were investigated in liver of TIS21 knockout (TIS21-KO) mice after 20 h fasting and compared with wild type (WT). Peroxisome proliferator-activated receptor alpha ($PPAR{\alpha}$) target gene expression was almost absent in contrast to increased lipid synthesis in the TIS21-KO mice compared to WT mice. Immunohistochemistry with hematoxylin and eosin staining revealed that lipid deposition was focal in the TIS21-KO liver as opposed to the diffuse and homogeneous pattern in the WT liver after 24 h starvation. In addition, cathepsin E expression was over 10 times higher in the TIS21-KO liver than that in the WT, as opposed to the significant reduction of thioltransferase in both adult and fetal livers. At present, we cannot account for the role of cathepsin E. However, downregulation of glutaredoxin 2 thioltransferase expression might affect hypoxic damage in the TIS21-KO liver. We suggest that the $TIS21^{/BTG2}$ gene might be essential to maintain energy metabolism and reducing power in the liver under fasting condition.

• BMB Reports
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• 제35권6호
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• pp.609-614
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• 2002

The remodeling process of bone is accompanied by complex changes in the expression levels of various genes. Several approaches have been employed to detect differentially-expressed genes in regard to osteoclast differentiation. In order to identify the genes that are involved in osteoclast differentiation, we used a cDNA-array-nylon membrane. Among 1,200 genes that showed ameasurable signal, 19 genes were chosen for further study. Eleven genes were up-regulated; eight genes were down-regulated. TIS21 was one of the up-regulated genes which were highly expressed in mature osteoclasts. To verify the cDNA microarray results, we carried out RT-PCR and real-time RT-PCR for the TIS21 gene. The TIS21 mRNA level was higher in differentiated-osteoclasts when compared to undifferentiated bone-marrow macrophages. Furthermore, the treatment with $1\;{\mu}M$ of a TIS21 antisense oligonucleotide reduced the formation of osteoclasts from the bone-marrow-precursor cells by ~30%. These results provide evidence for the potential role of TIS21 in the differentiation of osteoclasts.

• 정보과학회 컴퓨팅의 실제 논문지
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• 제21권10호
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• pp.645-650
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• 2015

메모리 반도체 패키지 검사 공정에서 TIS(Tester Interface Software)는 디바이스가 검사 장비에 투입 될 때부터 배출될 때까지 검사 장비가 디바이스 검사를 진행하는데 필요한 모든 소프트웨어 기능을 제공한다. 하지만, 공정에서 사용되는 장비와 장비를 제어하기 위한 컴퓨터 및 운영체제의 종류가 다양하여 동일한 기능을 수행해야 하는 TIS가 테스터 장비마다 독립적으로 개발 및 운영되고 있다. 이는 많은 시간과 비용을 요구할 뿐만 아니라 소프트웨어의 품질에도 많은 영향을 미치고 있으며, 이러한 문제는 추가되는 장비의 종류가 증가할수록 심화될 것이다. 본 논문에서는 이러한 문제를 해결하기 위해 이종 장비와 운영체제에 적용 가능한 CTIS(Cross-platform Tester Interface Software)을 제안한다.

• 한국전자파학회논문지
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• 제21권1호
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• pp.90-97
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• 2010

본 논문에서는 GSM, DCS, PCS, WCDMA 대역을 지원하는 휴대폰 단말기의 무선 성능을 개선시키기 위한 PIFA(Planar Inverted-F Antenna) 구조와 접지면의 형태에 대해 연구하였다. 다중 공진을 유도하기 위해 안테나 방사체를 다수의 전류 경로를 가진 가지 구조로 설계한 후에 특정 방사체 아래쪽에 방사체와 유사한 모양의 접지면을 배치함으로써 안테나의 공진 특성과 방사 효율을 개선시켜 휴대폰 단말기의 무선 성능을 개선할 수 있는 설계 방법에 대해 제안한다. 실제 휴대폰 단말기를 통해 제안된 안테나와 접지면 구조에 대한 무선 성능을 측정한 결과, 적용 이전에 비해 GSM 대역의 TRP(Total Radiated Power)는 2.0 dB, TIS(Total Isotropic Sensitivity)는 3.7 dB 향상되었으며, DCS 대역 TRP와 TIS는 각각 2.2 dB, 2.0 dB가 향상되는 결과를 얻었다. 또한 PCS 대역 TRP, TIS는 0.8 dB, 1.5 dB 향상되었으며, WCDMA 대역 TRP, TIS는 1.3 dB, 0.7 dB 향상되었다.

• 한국전자파학회논문지
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• 제21권7호
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• pp.752-760
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• 2010

본 논문에서는 리더간 간섭이 EPCglobal Generation-2(Gen-2) RFID(Radio Frequency Identification) 시스템의 성능에 미치는 영향을 물리 계층과 MAC 계층을 모두 고려하여 분석하였다. 이를 위해 기존의 태그 충돌만을 고려한 Gen-2 프로토콜 성능 분석 연구에 리더간 간섭을 추가하여, 실제 UHF RFID 시스템 운용 상황과 유사한 환경에서 성능을 분석할 수 있는 모델을 제안하였다. 제안한 모델은 DTMC(Discrete Time Markov Chain) 모델에 다른 리더에 의해 발생하는 리더간 간섭 확률을 결합한 것으로, 간섭 리더의 수에 따른 QSR(Query Success Rate)와 TIS(Tag Identification Speed)의 변화를 정량적으로 분석할 수 있다. 시뮬레이션을 검증하기 위하여 이론치와 비교한 결과, 100개 이상의 태그를 갖는 경우 이론치와 차이를 보이지 않았다. 분석 결과, EPCglobal Gen-2 프로토콜에서 간섭 리더 1기당 TIS가 10 tags/sec씩 감소되는 것을 확인하였다.

• 한국통신학회논문지
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• 제21권9호
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• pp.2328-2340
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• 1996

Until now, the transmission of data for VOD(Video on Demenad) was based on a real time modelling of video data. Markow Modulated Fluid Sources(MMFS) and Markow Modulated Poisson Sources(MMPS) are the most widely used modelling methods. But the charactersitics of the VBR(Variable Bit Rate) signal prevents modelling from actually being "real-time". Also these methods call for the use of large buffers for the abolishment of cell loss. These modelling methods are, of course, useful i case of teleconferences where a real time modelling of video traffic is inevitable, but they are insufficient in cases where the characteristic infomation of video traffic can be obtained beforehand-cases such as VOD. Video data is speial in that if one file is preprocessed all other products can simply be copied from that onepreprocessed file. This characteristic helps reduce the overhead arising from the job of drawing out characteristic information to almost zero. But still, compared to the existing real time modelling method data transmission using characteristic information succeeds in raising the efficiency of data transmission. In tis paper we will outline a method of dta transmission which use the characteristic information of each video stream, and evaluate this method through some experiments.periments.

• The Plant Pathology Journal
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• 제39권6호
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• pp.566-574
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• 2023

The aim of this study was to investigate the regulation of lantipeptide production in Streptomyces globisporus SP6C4, which produces the novel antifungal lantipeptides conprimycin and grisin, and to identify the role of cytochrome P450 (P450) in tis regulation. To investigate the regulation of lantipeptide production, we created gene deletion mutants, including ΔP450, ΔtsrD, ΔlanM, ΔP450ΔtsrD, and ΔP450ΔlanM. These mutants were characterized in terms of their morphology, sporulation, attachment, and antifungal activity against Fusarium oxysporum. The gene deletion mutants showed distinct characteristics compared to the wild-type strain. Among them, the ΔP450ΔlanM double mutant exhibited a recovery of antifungal activity against F. oxysporum, indicating that P450 plays a significant role in regulating lantipeptide production in S. globisporus SP6C4. Our findings highlight the significant role of P450 in the regulation of lantipeptide production and morphological processes in S. globisporus. The results suggest a potential link between P450-mediated metabolic pathways and the regulation of growth and secondary metabolism in SP6C4, thereby highlighting P450 as a putative target for the development of new antifungal agents.

• PNF and Movement
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• 제14권3호
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• pp.237-244
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• 2016

Purpose: This case report examines the influence of proprioceptive neuromuscular facilitation (PNF) combined with a dynamic neuromuscular stabilization approach on balance in patients with cerebellar atrophy. Methods: The target subject of this case report was a 34-year-old woman who was informed of the purpose of this research and voluntarily agreed to participate in it. The case report conformed to research ethics based on the Helsinki Declaration. The target subject was confirmed to have cerebellar atrophy from an unknown cause in 2009 and was diagnosed with slight ataxia. At that time, she could carry out daily activities without physical therapy. On May 19, 2015, she suffered both a subdural hemorrhage (SDH) and subarachnoid hemorrhage (SAH) in a traffic accident. She was urgently moved to the emergency room and managed by nonsurgical treatment, and then, the cerebellar atrophy and ataxia gradually deteriorated. To evaluate the patient's balance capacity before and after intervention, the trunk impairment scale (TIS), trunk impairment scale (OLST) during eye-closing/opening, timed up and go test (TUG), and visual analogue scale (VAS) were conducted. The PNF intervention program was executed for 30 min, four times a week, for three weeks. Results: The TIS and OLST during eye-closing/opening were improved by as much as a point, by 8.15 s and 6.21 s, respectively, after applying the PNF program. TUG and VAS decreased by 1.33 s and 3 points, respectively, after intervention. According to the result, the OLST during eye-closing/opening and VAS improved remarkably in comparison with those before intervention. Conclusion: As the final result of the case report, PNF intervention combined with DNSA more effectively improved the static balance capacity, such as the OLST during eye-closing/opening and VAS, compared to the dynamic balance capacity. In addition, the intervention duration and period of the exercise program are recommended to be more than 1 h a day for four weeks considering the learning ability of a patient with cerebellar atrophy.

• 대한약침학회지
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• 제20권2호
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• pp.132-138
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• 2017

Objectives: We report the results of three case studies on the clinical efect of ascending kidney water and descending heart fre (AKDH) pharmacopuncture on patients with Hwa-Byung. Methods: Tis study involved three patients, all female, who had been admitted to a hospital of traditional Korean medicine and had been diagnosed as having Hwa-Byung by using the Hwa-Byung Structure Clinical Interview for DSM-IV. AKDH pharmacopuncture is administered by injecting pharmacopuncture at a specifc acupoint to change from a state of water-fre disharmony to one of water-fre harmony. For our three patients, Hwangyeonhaedoktang (黃連解毒湯) pharmacopuncture was injected at GB21 and GB20 on both sides; a total of 0.4 cc was injected, with 0.1 cc being injected at each point. Fel ursi, Bezora bovis and moschus (BUM) pharmacopuncture was injected at CV17, CV12, and CV6; a total of 0.15 cc was injected, with 0.05 cc being injected at each point. Treatment was done daily. Progress was evaluated using the Hwa-Byung diagnostic interview (HBDIS), beck depression inventory (BDI), and numeric rating scale (NRS) scores. Results: For the frst patient (case 1), after treatment, the HBDIS score was reduced from 44 to 30 points, the BDI score from 37 to 14, and the NRS score from 10 to 7. For the second patient (case 2), after treatment, the HBDIS score was reduced from 41 to 27 points, the BDI score from 13 to 7, and the NRS score from 10 to 5. For the third patient (case 3), after treatment, the HBDIS score was reduced from 42 to 28 points, the BDI score from 12 to 9, and the NRS score from 10 to 4. Conclusion: Ascending kidney water and descending heart fre pharmacopuncture treatment can be efective for improving ascending kidney water and descending heart fre energy and can be used to alleviate Hwa-Byung.

• Journal of Chest Surgery
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• 제29권6호
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• pp.632-638
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• 1996

저자는 1985년 1월부터 1995년 12월까지 강북 삼성병원 흉부외과에서 수술치험한 42례의 원발성 종 격동 종양 및 낭종을 대상으로 후향적 임상분석을 실시하였다. 환자는27례의 남자와 15례의 여자로 구성되었다. 10개월의 영아부터 76세의 노인에 이르기까지 평균 연령은 40세 였다. 환자는 흉선종 12례 (28.6 %), 생식세포종 8례 (19.0 %), 원발성 낭종 7례 (16.7 %), 신경 종양 6례 (14.3 %)와 기타 종격동 종양 9례로 구성되었다. 종양의 3)례 (78.6 %)는 조직학적으로 양성이 었고, 9례 (21.4 %)는 악성 이 었다. 임상증세는 흉통, 호흡곤란, 기 침과 같은 호흡기증세로 주로 나타났다. 악성 종양을 지닌 환자는 전례 에서, 양성 환자는 55 %에서 입원당시에 증세가 나타났다. 환자 모두는 조직학적 진단과 절제를 위해 수술을 시행하였다. 2례의 유육종을 제외한 모든 양성의 종격동종양은 완전절제가 가능하였고 경과양호하였다. 그리고 일부 악성종양은 완전절제가 불가능하여 부분절제 및 항암 화학요법 혹은 방사선치료를 병용하였다. 술후 합병증은 7례(18%)였고 사망례는 없다. 결론적으로, 종격동종양은 개흥을 하기전에 다양하고 예측하기 어려운 愎昺㏏\ulcorner\ulcorner오랫동안 흉부외 과 의사에게는 관심의 대상이 되어왔으며, 적극적인 수술 및 다양한 병합요법으로 좋은 결과를 가져올 수 있다고 여겨진다.