• Archives of Pharmacal Research
• /
• v.28 no.9
• /
• pp.1002-1012
• /
• 2005

5-Substituted 4-oxo-2-thioxo-1,,2,3,4-tetrahydropyrimidine were synthesized by interaction of 4­oxo-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-sulfonylhydrazide with some aldehydes to give the corresponding Schiff-bases, which after cyclization gave corresponding thiazolidinones. For some of the thiazolidinones, Mannich bases reaction was carried out. All the derivatives were tested for their possible inhibitory effect on Schistosoma mansoni cercarial elastase (CE). Only, N'-(4-methylbenzyledine)-4-oxo-2-thioxo-1,2 ,3,4-tetrahydropyrimidine-5-sulfonylhydrazide was found to have potent inhibitory effect on the CE activity with $IC_{50} = 264{\mu}M.$ Upon its use as a paint for mice tails before infection with S. mansoni cercariae, the compound formulated in jojoba oil caused a significant reduction ($93\%$; P-value = 0.0002) in the worm burden. IgG & IgM in mice sera were measured by using several S. mansoni antigens by ELISA. Sera from treated infected mice (TIM) 2, 4, and 6 weeks (W) post infection (PI) showed 1.2 folds lower, 1.2 folds higher, 1.7 folds lower IgM reactivity against soluble cercarial antigenic preparation (CAP), respectively, when compared with sera collected from infected untreated mice (IUM). Sera from TIM 2, 4, and 6WPI showed 1.3, 1.6, and 1.7 folds higher IgG reactivity, respectively against CAP than the IgG reactivity from IUM. Sera from TIM 2, 4 and 6WPI showed 1.5, 1.2 folds lower and 1.4 folds higher IgM reactivity, respectively against soluble worm antigenic preparation (SWAP) when compared with sera collected from IUM. Sera from TIM 2, 4, and 6WPI showed 1.4, 1 folds lower and 1 fold higher IgG reactivity, respectivley to SWAP when compared with sera from IUM. Sera from TIM 2, 4, and 6WPI had generaly lower IgM and IgG reactivities against soluble egg antigen (SEA) when compared with sera from IUM.

• Proceedings of the Korean Society of Tribologists and Lubrication Engineers Conference
• /
• 2005.10a
• /
• pp.3-17
• /
• 2005

• 수도
• /
• v.24 no.1 s.82
• /
• pp.18-27
• /
• 1997

• Communications of the Korean Institute of Information Scientists and Engineers
• /
• v.26 no.7
• /
• pp.60-66
• /
• 2008

• Transportation Technology and Policy
• /
• v.2 no.3
• /
• pp.45-51
• /
• 2005

• The monthly packaging world
• /
• s.279
• /
• pp.52-54
• /
• 2016

• Proceedings of the KSME Conference
• /
• 2003.04a
• /
• pp.1717-1723
• /
• 2003

Experimental study is conducted to investigate the cooling performance of impinging jet from microtube using Joule-Thomson effect to apply practical applications. And also the heat transfer characteristics of a impinging jet itself and the impinging jet with Joule-Thomson effect are tested to make a comparative study of the two different general ideas. For this propose, two kinds of copper microtubes which have 200 tim and 300 tim in inner diameter respectively were tested and $N_2$ was used as a working fluid. In case of impinging jet without Joule-Thomson effect, heat transfer coefficients distributions were similar to those of normal impinging jet. But in impinging jet with Joule-Thomson effect, the heat transfer coefficients decrease as jet-to-surface increases contrary to the case of the normal jet. As a result, much higher heat transfer coefficients are obtained with Joule-Thomson effect than those of the normal jet without J-T effect.

• Journal of the Korea Safety Management & Science
• /
• v.9 no.1
• /
• pp.187-195
• /
• 2007

There are many Korea companies who are introducing many kinds of management renovation methods in order to attain more management achievement. So many personnels under CEO are trying to change themselves to fit those kinds of management renovation methods. Now, all kinds of books for supervisors have published, but it is not easy for those supervisors to understand those books as those books do not fit for their own companies situation. The best management methods in the best companies in U.S.A. actually can not be well introduced in Korea. So, the management methods should be changed with the environment's changing. Therefore, the company management is the process to suit the continue changing environment.

• Proceedings of the Safety Management and Science Conference
• /
• 2007.04a
• /
• pp.363-371
• /
• 2007

There are many Korea companies who are introducing many kinds of management renovation methods in order to attain more management achievement. So many personnels under CEO are frying to change themselves to fit those kinds of management renovation methods. Now, all kinds of books for supervisors have published, but it is not easy for those supervisors to understand those books as those books do not fit for their own companies situation. The best management methods in the best companies in U.S.A. actually can not be well introduced in Korea. So, the management methods should be changed with the environment's changing. Therefore, the company management is the process to suit the continue changing environment.

• Journal of Information Management
• /
• v.30 no.3
• /
• pp.55-72
• /
• 1999

It is purposed to give an explanation of the constitution, major distinction and providing function of TIMS(Technology Information Management System) developed by KINITI(Korea INstitute of Industry and Technology Information). And, it is intended to help companies to manage information effectively by providing the model of information management of company.