• 대한환경공학회지
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• 제36권7호
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• pp.492-497
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• 2014

해수담수화 시설에서 전처리와 역삼투막(reverse osmosis, RO) 공정의 유기물 제거특성을 살펴보고, 유기물의 특성변화가 막오염 지수에 미치는 영향을 조사하였다. 연구에서 비교된 전처리 공정은 다중여재여과(dual media filter, DMF), 가압형 정밀여과(MF), 침지형정밀여과(SMF) 이다. 유기물의 특성변화를 알아보기 위해 원수와 공정별 처리수의 탁도, $UVA_{254}$, DOC, size exclusion chromatography (SEC), fluorescence excitation emission matrix (FEEM), transparent exopolymer particles (TEP) 등을 분석하였다. 이온성 물질과 무기물 항목은 전처리 공정의 종류에 관계없이 처리되지 않았고 RO공정을 거치면서 99% 이상 제거되었다. 유기물에 의한 막오염에 큰 영향을 미치는 소수성 유기물은 전처리를 통해 상대적으로 제거가 용이하였다. 전처리 공정의 유기물 제거율은 막여과 공정(MF, SMF)이 기존 DMF 공정에 비해 높았다. 처리수내 유기물의 농도가 감소할수록 막오염지수 중 하나인 silt density index (SDI) 값도 감소하였다. MF로 전처리한 경우 SDI값이 가장 낮게 나타났는데, 처리수 내의 $0.1-0.4{\mu}m$ TEP 농도가 MF와 SMF 막오염지수의 차이와 상관관계를 보였다.

• Asian Pacific Journal of Cancer Prevention
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• 제17권4호
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• pp.2019-2025
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• 2016

Hepatocellular carcinoma (HCC) is major health problem with high mortality rates, especially in patients with hepatitis B virus (HBV) infection. Telomerase function is one of common mechanisms affecting genome stability and cancer development. Recent studies demonstrated that genetic polymorphisms of telomerase associated genes such as telomerase associated protein 1 (TEP1) rs1713449 and PIN2/TERF1-interacting telomerase inhibitor 1 (PINX1) rs1469557 may be associated with risk of HCC and other cancers. In this study, 325 patients with HCC and 539 non-HCC groups [193 healthy controls, 80 patients with HBV-related liver cirrhosis (LC) and 266 patients with HBV-related chronic hepatitis (CH)] were enrolled to explore genetic polymorphisms of both SNPs using the allelic discrimination method based on MGB probe TaqMan real time PCR. We demonstrated that all genotypes of both genes were in Hardy-Wienberg equilibrium (P>0.05). Moreover, there was no significant association between rs1713449 genotypes and HCC risk, HCC progression and overall survival (P>0.05). Interestingly, we observed positive association of rs1469557 with risk of HCC when compared with the LC group under dominant (CC versus CT+TT, OR=1.89, 95% CI= 1.06-3.40, P=0.031) and allelic (C versus T alleles, OR=1.75, 95% CI=1.04-2.94, P=0.033) models, respectively. Moreover, overall survival of HCC patients with CC genotype of rs1469557 was significantly higher than non-CC genotype (Log-rank P=0.015). These findings suggest that PINX1 rs1469557 but not TEP1 rs1469557 might play a role in HCC progression in Thai patients with LC and be used as the prognosis marker to predict overall survival in HCC patients.

• 생명과학회지
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• 제18권1호
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• pp.96-102
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• 2008

이상의 연구 결과에 의하면 piceatannol의 처리에 의한 U937 세포의 증식억제는 세포주기 S기 arrest 및 apoptosis 유발과 뚜렷한 연관성이 있었다. 또한 piceatannol은 hTERT 및 TEP-1 유전자의 발현 저하와 연관된 telomerase 활성의 저하 효과도 나타내었으나, COXs의 발현 및 PGE2의 생성에는 큰 변화를 주지 못하였다. 따라서 본 연구의 결과는 암세포에서 높게 발현되는 telomerase 활성 조절제로서 piceatannol의 적용이 가능함을 보여주며, 이는 piceatannol의 항암작용을 이해하는데 매우 유용한 자료라 생각한다.

• Journal of Korean Neurosurgical Society
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• 제29권8호
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• pp.985-994
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• 2000

Objective : There are some advantages of trigeminal evoked potential(TEP) recording compared to other somatosensory evoked potential(SSEP) recordings. The trigeminal sensory pathway has a pure sensory nerve branch, a broader receptive field in cerebral cortex, and a shorter pathway. Despite these advantages, there is little agreement as to what constitutes a normal response and what wave forms truly characterize the intraoperative TEP. This study presents the normative data of TEP recorded on the epidural surface of the rat with a platinum ball electrode. Materials & Methods : Under general anesthesia with urethane, the adult Sprague-Dawley male rats(300-350g) were given electrical stimulation with two stainless steel electrodes which were inserted into the subcutaneous layer of the area around whiskers. A reference electrode was positioned in the temporalis muscle ipsilateral to the recording site. Results : TEPs were recorded in the Par I area of somatosensory cortex and recorded most apparently on the point of 2mm posterior from the bregma and 6mm lateral from the midline. The typical wave form consisted of 5 peaks (N1-P1-N2-P2-N3 according to emerging order, upward negativity). Each latency to corresponding peaks was not influenced by the different intensities of stimulation, especially from 1 to 5mA. Average latencies of 5 peaks were in the following order ; 7.7, 11.1, 15, 22.3, 29.4ms. There was also no significant difference between latencies before and after administration of muscle relaxant(pancuronium). For the electrophysiological localization of recorded waves, the action potential of a single unit was recorded with glass microelectrode(filled with 2M NaCl, $3-5M{\Omega}$) in the thalamus of rat. A sharp wave was recorded in the VPM nucleus, in which the latency was shorter than that of N1. This suggests that all 5 peaks were generated by neural activities in the suprathalamic pathway. Conclusion : In terms of recording near-field potentials, our data also suggests that TEP in the rat may be superior to other SSEPs. In overall, these results may afford normative data for the studies of supratentorial lesions such as hydrocephalus or cerebral ischemia which can have an influence on near-field potentials.

• 통합자연과학논문집
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• 제3권4호
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• pp.237-240
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• 2010

Recently, number of studies for porous silicon have been investigated by many researchers. Multistructured porous silicon (PSi), distributed Bragg reflector (DBR) PSi, has been a topic of interest, because of its unique optical properties. DBR PSi were prepared by an electrochemical etch of $P^{{+}{+}}$-type silicon wafer of resistivity between 0.1 $m{\Omega}cm$ with square wave current density, resulting two different refractive indices. In this work, We have fabricated a simple and portable organic vapor-sensing device based on DBR porous silicon and investigated the optical characteristics of DBR porous silicon. DBR porous silicon have been characterized by FT-IR, Ocean optics 2000 spectrometer. The device used DBR PSi chip has been demonstrated as an excellent gas sensor, showing a great senstivity to a toxic vapor (TEP, DMMP, DEEP) at room temperature.

• International Journal of Naval Architecture and Ocean Engineering
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• 제12권1호
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• pp.146-156
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• 2020

Two High Tensile Strength Steel (EH47) plates with thickness of 70 mm were butt-welded together by multi-pass Submerged Arc Welding (SAW), also the hardness and welding residual stress were investigated experimentally. Based on Thermal-Elastic-Plastic Finite Element (TEP FE) computation, the thermal cycles during entire welding process were obtained, and the HAZ hardness of multi-pass butt welded joint was computed by the hardenability algorithm with considering microstructure evolution. Good agreement of HAZ hardness between the measurement and computational result is observed. The evolution of each phase was drawn to clarify the influence mechanism of thermal cycle on HAZ hardness. Welding residual stress was predicted with considering mechanical response, which was dominantly determined by last cap welds through analyzing its formation process.

• Journal of Animal Science and Technology
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• 제53권3호
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• pp.195-202
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• 2011

Maintenance of adequate telomere length in developing cells is the most important concern to preserve the integrity of the genome. The length of telomere is strictly regulated by numerous telomere-binding proteins and/or interacting factors. Even though the expression of telomerase in the male reproductive tract has been characterized, developmental expressional profiling of telomerase and other telomere-associated proteins has not been determined in detail. The present study was attempted to examine expression patterns of catalytic subunit (Tert) and RNA component (Terc) of telomerase and two telomerase associated factors, telomerase associated protein 1 (Tep1) and TERF1 (TRF1) interacting nuclear factor 2 (Tinf2) in the testis and seminal vesicle of male rat during postnatal development. The real-time PCR analysis was utilized to quantify mRNA expression of molecules. The abundance of Tep1 mRNA in the testis and seminal vesicle was the highest at 5 months of age. Expressional fluctuation of Tinf2 during postnatal development was found in the testis, while expression of Tinf2 in the seminal vesicle was gradually increased until 5 months of age and then significantly decreased later. mRNA level of Tert gene in the testis was significantly increased at the adult and the elder, while the highest expression of Tert gene in the seminal vesicle was found at 5 months of age. Expression of Terc transcript in the testis and seminal vesicle was the highest at 5 months of age, followed by significant reduction at 1 and 2 years of ages. Such differential gene expression of telomere-associated factors and telomerase components in different male reproductive tissues during postnatal development indicates that maintenance of telomere length would be regulated in tissue- and/or age-specific manners.

• 한국축산식품학회지
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• 제23권1호
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• pp.80-85
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• 2003

티벳산 발효유로부터 분리한 Candida kefyr TFP7의 항균활성 및 항암활성을 검토하기 위하여 PDA배지를 이용한 십진 희석법에 의해 10균주(TFP1∼10)를 분리하여 몇 종의 병원균과 식중독균, 식품과 관련이 있는 세균, 효모, 곰팡이, 녹조류 및 토양으로부터 분리한 방선균 등 18균주에 대하여 항균활성을 조사하였으며, 또한, 9종류의 인체 암세포주에 대하여 항암활성을 비교하였다. 항균활성 검사에서는 Gram 양성균 중 iwicrococcus iuteus ATCC l1880에 대하여 분리균주 (TFP2∼10)와 방선균인 Styeptomyces murinus JCM 4333에 패하여 분리균주(TFP6∼10)가 뚜렷한 생육억제효과를 나타내었다. 한편, 항암활성 검사에서는 SNU-5(human stomach carcinoma), SW-534(human larynx carcinoma)에 대하여 분리 균주(TFP1∼10) 모두 각각 60%, 70%이상의 생육억제 효과를 나타내었다. 특히, 균주 TFP7은 SNU-5, SW-534에 대하여 각각 77.5%, 76.5%의 가장 우수한 생육억제 효과를 나타내었다.

• 한국동물학회:학술대회논문집
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• 한국동물학회 2002년도 공동 춘계학술대회
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• pp.25-32
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• 2002

No Abstract, See Full Text

• 공업화학
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• 제32권4호
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• pp.449-455
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• 2021

복합재료는 단일물질이 갖는 각각의 특성을 복합화 함으로써 우수한 물성을 갖도록 구성한 물질로 금속 및 고분자의 성능을 뛰어넘는 재료로써 각광받고 있다. 다만, 생산시간이 길고, 단가가 비싼 단점이 있어 이를 극복하기 위해 많은 연구가 진행되고 있다. 본 연구에서는 복합재료의 대량생산 시 시간을 단축할 수 있는 에폭시 수지 경화제를 개발하였고, 난연성을 부여하여 이의 적용성을 확대하고자 하였다. 기본 물질로 사용한 에폭시 수지는 bisphenol F 및 resorcinol 구조의 에폭시 2종을 사용하였으며, 난연성을 부여하기 위하여 9,10-dihydro-9-oxa-10-phosphaphenantrene-10-oxide(DOPO)를 이용하여 변성하였다. 첨가제로는 triethylphosphate (TEP) 및 bis[(5-ethyl-2-methyl-1,3,2-dioxaphosphorinan-5-yl)methyl] methyl phosphonate P,P'-dioxide (FR-001)을 사용하여 7종의 조성물을 배합하였고, 열적 특성(겔화시간, 유리전이온도), 난연 성능을 평가하여 high pressure resin transfer molding (HP-RTM) 공법에 적용 가능한 에폭시 기지재를 개발하였다.