• Title/Summary/Keyword: TCi

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An Association Study of the 5-HTTLPR and COMT Genes Polymorphisms and Personality Traits (5-HTTLPR과 COMT 유전자 다형성과 성격 특성에 대한 연합연구)

  • Ha, Jee-Hyun;Ham, Byung-Joo;Ryu, Sung-Gon;Hwang, Tae-Yeon;Lee, Jong-Gook;Lee, Yu-Sang;Lee, Jung-Sik;Kang, Dae Yeob;Choi, Ihn-Geun;Lee, Min Soo
    • Korean Journal of Biological Psychiatry
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    • v.11 no.2
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    • pp.88-93
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    • 2004
  • Background:Serotonin transporter gene-linked polymorphism region(5-HTTLPR) and catechol-O-methyltransferase( COMT) genes are thought to be important factors in some personality traits and the etiology of anxiety disorder. The goal of this study was to determine the role of these genes in personality traits. Method:The participants included 116 healthy adults with no history of psychiatric disorders and other physical illness for the last 6 months. All participants were tested by Temperament and Character Inventory(TCI). The 5-HTTLPR, COMT val158met gene polymorphisms were analyzed with PCR(Polymerase Chain Reaction). Differences on TCI dimensions and sub-scales among groups were examined with t-test and ANOVA. Result:There were possible relationships of the 5-HTTLPR with self-transcendence(P=0.050) and COMT val158met polymorphism with cooperativeness(P=0.053). Conclusion:We found associations between 5-HTTLPR, COMT polymorphisms and the some TCI character dimensions. Further studies of polymorphisms of other genes and their interactions may clarify the complex relationship between personality and genes.

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Temperament and Character in Cannabis and Methamphetamine Abusers (대마초 및 메스암페타민 남용자들의 기질 및 성격 특성)

  • Kwon, Min;Min, Jung-Ah;Choi, Ji-Hye;Kim, Dai-Jin
    • Korean Journal of Biological Psychiatry
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    • v.19 no.2
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    • pp.99-105
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    • 2012
  • Objectives : This study aims to identify temperament and characteristics of cannabis and methamphetamine abusers for elucidating psycho-biological variables related to certain substance abuse. Methods : A total of 320 patients who registered in the 'Hepatitis C cohorts study of intravenous drug users' between March 2006 and March 2010 participated in this study. Data on demographic variables were obtained and the Temperament and Character Inventory (TCI) and measures for nicotine dependence, alcohol dependence, depression and anxiety were assessed. After comparing TCI between cannabis, methamphetamine, and co-abusers, correlations between TCI and other clinical variables were examined. Results : The methamphetamine abuser group showed significantly higher scores in Novelty Seeking (NS2) and Harm Avoidance (HA3) in temperament than the cannabis abuser and co-abuser groups, whereas the cannabis abuser group had higher scores in purposefulness (SD2), congruent second nature (SD5), and self-directedness (SD) in character than the methamphetamine abuser group. In addition, temperaments and characters correlated with various psychiatric symptoms. Conclusions : We found the differences in temperament and characters among cannabis abusers, methamphetamine abusers. These findings might contribute to further understanding of mechanisms of cannabis and methamphetamine abuse.

The Association among the Genetic Polymorphism of Dopamine D4 Receptor, Temperament and Alcohol Drinking Behavior in Young Korean Adults (초기 성인기 한국인에서 도파민 D4 수용체의 유전적 다형성, 기질특성, 음주행동 사이의 연관성)

  • Nam, Yeong-Woo;Lee, Sang-Ick;Shin, Chul-Jin;Son, Jung-Woo;Kim, Sie-Kyeong
    • Korean Journal of Biological Psychiatry
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    • v.18 no.2
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    • pp.101-108
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    • 2011
  • Objectives The aim of this study is to explore the association among DRD4 polymorphism, temperament and alcohol drinking behavior of Koreans in their early adulthood. Method Participants were 172 healthy Korean adults (mean age $28.1{\pm}0.8$). Their temperament was assessed with the Temperament and Character Inventory (TCI) and their alcohol drinking behavior were evaluated with a self-reported questionnaire including the CAGE and the Korean version of Alcohol Use Disorder Identification Test (AUDIT-K). DRD4 exon III 48 base pair variable number of tandem repeats (VNTR) was genotyped by PCR. Results No significant association was found between DRD4 polymorphism and TCI temperament dimension (novelty seeking, harm avoidance, reward dependence, and persistence) as well as alcohol drinking behavior scales. However, novelty seeking was significantly associated with alcohol drinking behavior. The higher level of novelty seeking was associated with the higher severity index of drinking (B = -0.225, p < 0.001) and problematic alcohol use on the CAGE and AUDIT-K [Odds Ratio (OR) = 1.111, 95% Confidence Interval (CI) 1.021-1.209, p = 0.015, OR = 1.087, 95% CI 1.009-1.170, p = 0.028]. Conclusion In our study, while there is no significant association of DRD4 polymorphism with temperament and alcohol drinking behavior, novelty seeking affects problematic alcohol use. Results suggest that novelty seeking may play an important role in problematic alcohol use in young Korean adults.

The Information Support Strategy for Global Technology Commercialization of SME by Analysis of the Global Technology Commercialization Programs (해외 글로벌 기술사업화 프로그램 분석을 통한 중소기업 글로벌 기술사업화 정보지원 방안)

  • Eo, Jin-Won;Jeong, Suk-Jae;Han, Hyuk;Choi, Yun-Jeong
    • Journal of Convergence Society for SMB
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    • v.2 no.2
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    • pp.27-34
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    • 2012
  • This study aims to achieve the following goal. Goal is to do the comparative analysis through the in-depth investigation of global technology commercialization agencies and program. In the era of global competition, The change to the innovation-driven economy through the creation and diffusion of technology is accelerating in the world. For the global technology and market changes and efficient information management, systematic support system for local SMEs is required. To this end, we researched and analyzed the level of technology and commercialization trends in major foreign countries, and major domestic and international institutes, and technology commercialization programs. Based on this, we draw the domestic SMEs' expansion strategy and information support plan to enter the global market.

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Change of Temperament and Personality in Post-traumatic Stress Disorders (외상후 스트레스장애에서 기질 및 성격의 변화)

  • Choi, Hyosun;Kim, Daeho;Kim, Eunkyeong
    • Korean Journal of Psychosomatic Medicine
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    • v.28 no.2
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    • pp.155-160
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    • 2020
  • Objectives : This study investigate to identify the stability of temperament and personality characteristics of patients including Posttraumatic Stress Disorder (PTSD) patients. Methods : The number of subjects was 102, of which 33 were PTSD patients and 69 were non-PTSD patients. To demonstrate the change in individual temperament and personality characteristics, Temperament and Character Inventory (TCI) were administered repeatedly on the subjects. Repeated measures ANOVA and simple main effects analysis were conducted. Results : When analysed by dividing the subjects into PTSD groups and non-PTSD groups, the differences between the primary and secondary tests did not appear in the non-PTSD groups, but the differences between the primary and secondary tests were significant in Harm Avoidance (HA), Reward Dependence (RD), Self-Directedness (SD), Cooperativeness (C). In addition, it was noted that the time and group interaction effects of HA, RD, SD and C were significant, and that the main effects of time of HA, RD, SD and C were significant. Conclusions : This study is meaningful in that in the course of experience and recovery of traumatic events, we have clinically confirmed that changes in the temperament, known as stable variables, are possible.

Determinants of Korea's Trade before and after the 2008 Financial Crisis Activating Augmented Gravity Model (중력모형을 이용한 2008년 금융위기 전후 한국의 교역결정요인 분석)

  • Lee, Doowon;Kim, Donghee;Park, Seokwon
    • International Area Studies Review
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    • v.16 no.1
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    • pp.243-274
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    • 2012
  • This research analyzes the determinants of Korea's trade using the Gravity model, Chow test and panel data anaysis. According to the pooled panel OLS analysis using the gravity model and Chow-test, Korea's trade patterns before and after the 2008 financial crisis are heterogeneous. Variables of basic gravity model, GDP per capita, distance, and population, identically showed positive and significant correlation with trade volume before and after financial crisis, but also equally showed the decrease in absolute value of coefficient. On the other hands, Overseas Direct Investments(ODI) variable showed the increase in absolute value of coefficient. But TCI was no longer significant. This research is significant in that it is able to show the strategy for the long term growth in Korea's volume of international trade through econometric analysis based on data of 55 trading partner of Korea.

The Effects of Harm Avoidance Temperament on Depression: Dual Mediating Effects of Ambivalence over Emotional Expressiveness and Distress Tolerance (대학생의 위험회피 기질이 우울에 미치는 영향: 정서표현 양가성과 고통 감내력의 이중매개효과)

  • Gu, Minji;Lee, Soo Jin
    • The Journal of the Korea Contents Association
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    • v.22 no.2
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    • pp.411-419
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    • 2022
  • The aim of this research was to verify the mediating effects of ambivalence over emotional expressiveness and distress tolerance on the relationship between harm avoidance and depression. A total of 403 university students completed TCI-RS(Temperament and Character Inventory-Revised Short version), AEQ-K(Ambivalence over Emotional Expressiveness Questionnaire-Korean), DTS (Distress Tolerance Scale) and CES-D(The Center for Epidemiologic Studies Depression Scale). The results revealed that harm avoidance and ambivalence over emotional expressiveness were positively related with depression, and negatively related with distress tolerance. In addition, the relationship of harm avoidance and depression was successively mediated by ambivalence over emotional expressiveness and distress tolerance. That is, the motivation of emotional expression conflict may have an effect on depression and the distress tolerance would play an important role in therapeutic intervention of depression.

Analyzing Efficiency of Korean Automobile Ports (국내 자동차부두 효율성 분석에 관한 연구)

  • Seo, Jeong Ho;Gong, Jeong Min;Nam, Tae Hyun;Yeo, Gi Tae
    • Journal of Navigation and Port Research
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    • v.41 no.3
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    • pp.127-136
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    • 2017
  • The aim of this study is using DEA-CCR, BCC, and Malmquist analysis to determine the efficiency and productivity of Korean automobile ports. We analyzed eight Korean automobile port terminals, using the number of workers and size of ports as input variables and the number of processed car as output variables. An efficiency analysis of the eight automobile port terminals for the four-year span from 2013 to 2016 revealed efficiency levels of 1 for the CCR, BCC, and the scales for Ulsan port and the Gwangyang port terminal, indicating efficient operation of the terminals. As a result of benchmarking analysis, Gunsan port 1, 2 terminal, Incheon port, Pyeongtaek Dangjin 2 terminal should benchmark Busan Port and Ulsan Port. Conversely, Malmquist analysis showed a slight increase in the production volume from 2013 to 2015, but a decline to 1 or less from 2015 to 2016. In the case of TECI the technology was confirmed as effective at 1 or more from 2014 to 2015. The TCI value was 0.87 for the period from 2015 to 2016. During this period, the TCI index of all terminals was less than 1.

Usefulness of Intravenous Anesthesia Using a Target-controlled Infusion System with Local Anesthesia in Submuscular Breast Augmentation Surgery

  • Chung, Kyu-Jin;Cha, Kyu-Ho;Lee, Jun-Ho;Kim, Yong-Ha;Kim, Tae-Gon;Kim, Il-Guk
    • Archives of Plastic Surgery
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    • v.39 no.5
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    • pp.540-545
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    • 2012
  • Background Patients have anxiety and fear of complications due to general anesthesia. Through new instruments and local anesthetic drugs, a variety of anesthetic methods have been introduced. These methods keep hospital costs down and save time for patients. In particular, the target-controlled infusion (TCI) system maintains a relatively accurate level of plasma concentration, so the depth of anesthesia can be adjusted more easily. We conducted this study to examine whether intravenous anesthesia using the TCI system with propofol and remifentanil would be an effective method of anesthesia in breast augmentation. Methods This study recruited 100 patients who underwent breast augmentation surgery from February to August 2011. Intravenous anesthesia was performed with 10 mg/mL propofol and 50 ${\mu}g/mL$ remifentanil simultaneously administered using two separate modules of a continuous computer-assisted TCI system. The average target concentration was set at 2 ${\mu}g/mL$ and 2 ng/mL for propofol and remifentanil, respectively, and titrated against clinical effect and vital signs. Oxygen saturation, electrocardiography, and respiratory status were continuously measured during surgery. Blood pressure was measured at 5-minute intervals. Information collected includes total duration of surgery, dose of drugs administered during surgery, memory about surgery, and side effects. Results Intraoperatively, there was transient hypotension in two cases and hypoxia in three cases. However, there were no serious complications due to anesthesia such as respiratory difficulty, deep vein thrombosis, or malignant hypertension, for which an endotracheal intubation or reversal agent would have been needed. All the patients were discharged on the day of surgery and able to ambulate normally. Conclusions Our results indicate that anesthetic methods, where the TCI of propofol and remifentanil is used, might replace general anesthesia with endotracheal intubation in breast augmentation surgery.

Growth of Creeping Bentgrass by Application of Compound Fertilizer Containing Microbes (미생물 함유 복합비료 시비에 따른 크리핑 벤트그래스의 생육)

  • Kim, Young-Sun;Lee, Chang-Eun;Ham, Soun-Kyu;Lee, Geung-Joo
    • Weed & Turfgrass Science
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    • v.5 no.1
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    • pp.42-50
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    • 2016
  • Superintendents have been used microbial fertilizers to improve turfgrass growth and quality and to decrease turfgrass diseases in golf course. This study was conducted to investigate the effects of compound fertilizer containing microbe (MF) on the growth and quality of creeping bentgrass with turf color index (TCI), chlorophyll index (ChI), root length, turfgrass density, clipping yield and nutrient content. Treatments were designed as follows; non-fertilizer (NF), compound fertilizer (21-17-17; CF) as control, compound fertilizer (14-6-17) containing microbe. In pot experiment, TCI and ChI of creeping bentgrass in MF plot were similar to those in CF. But clipping dry weight of MF plot increased by 39.1% compared to that of CF plot. At field experiment applied with MF treatment, TCI, ChI, root length, and nutrient content and uptake of creeping bentgrass were similar to those with CF treatment, but turfgrass density with MF higher about 7.9-15.8% than with CF. These results indicated that the application of MF improved growth and quality of creeping bentgrass by enhancing clipping yield and shoot number.