• Journal of information and communication convergence engineering
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• v.8 no.2
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• pp.219-222
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• 2010

An ubiquitous sensor network (USN) system to monitor the bio information and the emergency of the elderly in the silver town is presented. The USN system consists of the sensor node platforms based on MCU of Atmage128L and RF Chip of CC2420 satisfying IEEE 802.15.4, which includes the bios sensor module such as the electrocardiogram (ECG) sensor and the temperature sensor. Additionally, when an emergency of the elderly is occurred in the silver town, the routing algorithm suitable to find and inform the location of the elderly is proposed, and the proposed routing algorithm is applied to the USN. To collect and manage the ECG data at the PC connected to the sink node, LabView software is used. The bio information and the emergency of the elderly can also be monitored at the client PC by TCP/IP networks in the USN system.

• The KIPS Transactions:PartC
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• v.14C no.4
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• pp.371-382
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• 2007

In this paper, we propose a real-time sensor node platform that efficiently manages periodic and aperiodic tasks. Since existing sensor node platforms available in literature focus on minimizing the usage of memory and power consumptions, they are not capable of supporting the management of tasks that need their real-time execution and fast average response time. We first analyze how to structure periodic or aperiodic task decomposition in the TinyOS-based sensor node platform as regard to guaranteeing the deadlines of ail the periodic tasks and aiming to providing aperiodic tasks with average good response time. Then we present the application and efficiency of the proposed real-time sensor node platform in the sensor node equipped with a low-power 8-bit microcontroller, an IEEE802.15.4 compliant 2.4GHz RF transceiver, and several sensors. Extensive experiments show that our sensor node platform yields efficient performance in terms of three significant, objective goals: deadline miss ratio of periodic tasks, average response time of aperiodic tasks, and processor utilization of periodic and aperiodic tasks.

• Translational and Clinical Pharmacology
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• v.25 no.3
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• pp.153-156
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• 2017

UI14SDF100CW is a chewable tablet of sildenafil citrate, which was developed to improve compliance through convenience of administration. The purpose of this study was to compare the pharmacokinetic (PK) properties of sildenafil citrate chewable tablets (UI14SDF100CW) and conventional sildenafil citrate film-coated tablets ($Viagra^{(R)}$, Pfizer). A randomized, open-label, single dose, two-treatment, two-period, two-way crossover study was conducted in 60 healthy male volunteers. In each period, the subjects received a single oral dose of UI14SDF100CW or $Viagra^{(R)}$ (both tablets contain 140.45 mg of sildenafil citrate, which is equivalent to 100 mg of sildenafil). Serial blood samples were collected up to 24 h post-dose for PK analysis. The plasma concentration of sildenafil was determined using a validated HPLC-MS/MS assay. PK parameters of sildenafil were calculated using non-compartmental methods. The plasma concentration-time profiles of sildenafil in both formulations were similar. For UI14SDF100CW, the $C_{max}$ and $AUC_{last}$ of sildenafil were $1068.69{\pm}458.25$ (mean${\pm}$standard deviation) mg/L and $3580.59{\pm}1680.29h{\cdot}mg/L$, and the corresponding values for $Viagra^{(R)}$ were $1146.84{\pm}501.70mg/L$ and $3406.35{\pm}1452.31h{\cdot}mg/L$, respectively. The geometric mean ratios (90% confidence intervals) of UI14SDF100CW to $Viagra^{(R)}$ for $C_{max}$ and $AUC_{last}$ were 0.933 (0.853-1.021) and 1.034 (0.969-1.108), respectively, which met the bioequivalence criteria of Korean regulatory agency. In conclusion, UI14SDF100CW and $Viagra^{(R)}$ showed similar PK properties. Therefore, UI14SDF100CW can be an alternative to sildenafil for the treatment of erectile dysfunction, providing better compliance.

• Journal of Mushroom
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• v.17 no.2
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• pp.64-69
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• 2019

The present study was conducted to investigate the synergistic effects caused by single and co-inoculation of the phosphate solubilizing bacteria (PSB), Paraburkholderia phenazinium YH3 and Paraburkholderia metrosideri YH4. Phosphate solubilization was assessed by measuring the phosphorus contents for 7 days in a single and co-inoculation medium. Co-inoculation of the two strains was found to release the highest content of soluble phosphorus ($1,250{\mu}g\;mL^{-1}$) into the medium, followed by the single inoculation of P. metrosideri YH4 ($1196.59{\mu}g\;mL^{-1}$) and P. phenazinium YH3 ($994.34{\mu}g\;mL^{-1}$). The highest pH reduction, organic acid production and glucose consumption was also observed in the co-inoculation medium of the two strains. A plant growth promotion bioassay revealed that co-inoculation with the two strains enhanced the growth of romaine lettuce more than single inoculation with either of the two strains (28.5% for leaf and 16.6% for root). Although there was no significant difference between single and co-inoculation of bacterial strains in terms of phosphorous release and plant growth, the synergistic effects of co-inoculation with PSB could be beneficial for crop growth.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.51 no.2
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• pp.157-162
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• 2018

A feeding trial was conducted to investigate the effects of supplementation with four phosphorus (P) additives [mono-calcium phosphate (MCP), dicalcium phosphate (DCP), tricalcium phosphate (TCP) and magnesium hydrogen phosphate (MHP)] on the growth, feed utilization and whole body mineral composition of juvenile olive flounders Paralichthys olivaceus. A basal diet without P supplementation was prepared as a negative control and four supplemental P sources were added at a level of 2%. Triplicate groups of fish (initial mean body weight 11 g) were fed one of the experimental diets to apparent satiation twice a day, at 08:30 and 18:00 for 10 weeks. The final body weights of fish fed the experimental diets ranged from 29.4 g (DCP) to 34.2 g (MCP) and did not differ significantly (P>0.05) among treatments. Similar tendencies were found for all parameters including weight gain (%), specific growth rate (SGR), feed conversion ratio (FCR), protein efficiency ratio (PER), feed intake (FI) and survival rate (SR). The hematocrit (%), hemoglobin (g/dL), serum inorganic P and whole body mineral composition did not differ significantly different (P>0.05) among the treatments. Therefore, dietary P addition is not necessary for juvenile olive flounder fed a fish meal-based diet.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.8 no.5
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• pp.1726-1743
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• 2014

DDoS (Distributed Denial of Service) has been a continuous threat to the cyber world with the growth in cyber technology. This technical evolution has given rise to a number of ultra-sophisticated ways for the attackers to perform their DDoS attack. In general, the attackers who generate the denial of service, use the vulnerabilities of the TCP. Some of the vulnerabilities like SYN (synchronization) flooding, and IP spoofing are used by the attacker to create these Distributed Reflected Denial of Service (DrDoS) attacks. An attacker, with the assistance of IP spoofing creates a number of attack packets, which reflects the flooded packets to an attacker's intended victim system, known as the primary target. The proposed scheme, Efficient Spoofed Flooding Defense (ESFD) provides two level checks which, consist of probing and non-repudiation, before allocating a service to the clients. The probing is used to determine the availability of the requested client. Non-repudiation is taken care of by the timestamp enabled in the packet, which is our major contribution. The real time experimental results showed the efficiency of our proposed ESFD scheme, by increasing the performance of the CPU up to 40%, the memory up to 52% and the network bandwidth up to 67%. This proves the fact that the proposed ESFD scheme is fast and efficient, negating the impact on the network, victim and primary target.

• Translational and Clinical Pharmacology
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• v.26 no.4
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• pp.160-165
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• 2018

Indobufen ($Ibustrin^{(R)}$), a reversible inhibitor of platelet aggregation, exists in two enantiomeric forms in 1:1 ratio. Here, we characterized the anti-platelet effect of S- and R-indobufen using response surface modeling using $NONMEM^{(R)}$ and predicted the therapeutic doses exerting the maximal efficacy of each enantioselective S- and R-indobufen formulation. S- and R-indobufen were added individually or together to 24 plasma samples from drug-naïve healthy subjects, generating 892 samples containing randomly selected concentrations of the drugs of 0-128 mg/L. Collagen-induced platelet aggregation in platelet-rich plasma was determined using a Chrono-log Lumi-Aggregometer. Inhibitory sigmoid $I_{max}$ model adequately described the anti-platelet effect. The S-form was more potent, whereas the R-form showed less inter-individual variation. No significant interaction was observed between the two enantiomers. The anti-platelet effect of multiple treatments with 200 mg indobufen twice daily doses was predicted in the simulation study, and the effect of S- or R-indobufen alone at various doses was predicted to define optimal dosing regimen for each enantiomer. Simulation study predicted that 200 mg twice daily administration of S-indobufen alone will produce more treatment effect than S-and R-mixture formulation. S-indobufen produced treatment effect at lower concentration than R-indobufen. However, inter-individual variation of the pharmacodynamic response was smaller in R-indobufen. The present study suggests the optimal doses of R-and S-enantioselective indobufen formulations in terms of treatment efficacy for patients with thromboembolic problems. The proposed methodology in this study can be applied to the develop novel enantio-selective drugs more efficiently.