• The Korean Journal of Nuclear Medicine
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• v.30 no.3
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• pp.367-371
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• 1996

The $MAG_3$ is a tubular excreting radiopharmaceutical for renal image. We synthesized benzoyl $MAG_3\;(Bz-MAG_3)$ and made a kit for labeling with $^{99m}Tc$. We checked the labeling efficieny of $^{99m}Tc$ labeled $MAG_3$ and biodistribution. Labeling efficieny was checked by TLC-SG (acetonitrile/$H_2O$=2/1). After injecting of 1 mCi of $^{99m}Tc-MAG_3$ to ICR-mice, $T_{max}(min),\;T_{1/2}(min)$ were obtained in the renogram. Sequential images (30sec, 2min, 5min, 10min, 15min, 20min) of $^{99m}Tc-MAG_3$ were compared with those of commercial $^{99m}Tc$-DTPA (Du Pont Merck Pharmaceutical Co.) kit. 1) The $R_f$ value of synthesized $^{99m}Tc-MAG_3$ was 0.78 and labeling efficiency was $97.5{\pm}1.9%$ (n=10). 2) The dynamic images of the $^{99m}Tc-MAG_3$ were better than those of the $^{99m}Tc$-DTPA. 3) The $T_{max}(min.)$ and $T_{1/2}(min.)$ of $^{99m}Tc-MAG_3$ (n=10) were $1.5{\pm}0.5$ (left), $1.4{\pm}0.4$ (right), and $4.3{\pm}1.4$ (left), $4.8{\pm}2.0$ (right), respectively. The $T_{max}(min.)$ and $T_{1/2}(min.)$ of $^{99m}Tc$-DTPA (n=7) were $2.7{\pm}1.6$ (left), $2.7{\pm}1.6$ (right), and $3.8{\pm}1.7$ (left), $4.5{\pm}2.7$ (right), respectively. The quaility of image and labeling efficiency of the synthesized $Bz-MAG_3$ kit were excellent, that it was supposed to be used in routine clinical work.

• The Korean Journal of Nuclear Medicine
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• v.34 no.2
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• pp.119-128
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• 2000

Purpose: The aim of this study was to investigate the diagnostic role of $^{99m}Tc$-Tetrofosmin in detection of breast cancer and compared with that of $^{99m}Tc$-MIBI. Material and Methods: Forty-eight patients with a clinically palpable mass or abnormal mammographic or ultrasonographic findings had $^{99m}Tc-MIBI\;and\;^{99m}Tc$-Tetrofosmin scintimammographies after intravenous injection of 925 MBq of radiopharmaceuticals. The scintimammographs were correlated with histopathologic findings. Results: Thirty-three patients were diagnosed with breast cancer and 15 patients with benign breast diseases. The numbers of true positive, true negative, false positive, and false negative cases of $^{99m}Tc$-MIBI scintimammography were 29, 10, 5, and 4 respectively. The sensitivity, specificity, positive predictive value, and negative predictive value of $^{99m}Tc$-MIBI scintimammographies were 87.8%, 66.7%, 85.3%, and 71.4% respectively. The numbers of true positive, true negative, false positive, and false negative cases of $^{99m}Tc$-Tetrofosmin were 31,10, 5, and 2 respectively. The sensitivity, specificity, positive predictive value, negative predictive value of $^{99m}Tc$-Tetrofosmin were 93.9%, 66.7%, 86.1%, and 73.3% respectively. One patient was false negative in both $^{99m}Tc-MIBI\;and\;^{99m}Tc$-Tetrofosmin acintimammographies and its size was 0.5 cm. Conclusion: $^{99m}Tc-Tetrofosmin\;and\;^{99m}Tc-MIBI$ were non-invasive and useful in detection of breast cancer and $^{99m}Tc$-Tetrofosmin was comparable to the $^{99m}Tc$-MIBI in detection of primary breast cancer.

• Proceedings of the International Microelectronics And Packaging Society Conference
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• 2007.04a
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• pp.115-127
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• 2007

[ ${\blacktriangleright$ ] Various Factors to affect TC Reliability of 4 array RES has been Investigated through Simulation Tool and Daisy Chain Board Test ${\blacktriangleright$ Solder Joint Crack Mechanism of 4 array RES has been Examined Also, It has been Examined Thoroughly What Influence Each Factors gibes to TC Reliability and Why Those Factors gives an Influence to it ${\blacktriangleright$ BGA Type RES is Suggested to Improve TC Reliability (Patented) ${\blacktriangleright$ Through this Study, Best Design Parameter has been Optimized to Increase TC Reliability of 4 Array RES

• The Korean Journal of Nuclear Medicine
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• v.24 no.1
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• pp.49-55
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• 1990

For the development of $^{99m}Tc-labelled$ 3-iodo-2,4,6-trimethyl-iminodiacetic acid $(^{99m}Tc-IOTIDA)$, various experiments such as synthesis of IOTIDA, establishment of labelling conditions, determination of radiochemical purity, examination of stability, and organ distribution of rat were carried out. 1) IOTIDA was synthesized with a total yield of 42% from the starting material of 2,4-6-trimethylaniline via chloroacetylation, iodination, and condensation with iminodiacetic acid (IDA). 2) Freeze-dried instant labelling kits were prepared from aqueous solution $(pH\;5.8\sim6.0)$ so as to contain 40 mg IDA compound and 0.4 mg $SnCl_2$, per vial. Labelling of the contents of kit vials with $Na^{99m}TcO_4$, exhibited formation of two kinds of complex which was identified by ITLC-SA. After labelling, complex ( I ) was gradually converted to complex (II) with time. Labelling yield and radiochemical purity were above 99.5% based on the two complexes over-all. 3) $^{99m}Tc-IOTIDA$ maintained high radiochemical purity of above 99% until 6 hours after preparation at room temperature. Instant labelling kits stored at $4^{\circ}C$ for 6 month period also exhibited high labelling yield of above 99%. 4) Results obtained from animal experiments showed that most of the $^{99m}Tc-IOTIDA$ was rapidly excreted through hepatobiliary track into the intestines but with negligible renal excretion.

• Progress in Medical Physics
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• v.19 no.1
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• pp.1-8
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• 2008

Technisium $(^{99m}Tc)$ is one of the most widely used radioactive isotopes for diagnosis in nuclear medicine. In general, technisium is produced inside the so called $^{99m}Tc$ generator which is usually made out of lead to shield relatively high energy radiation from $^{99}Mo$ and its daughter nuclide $^{99m}Tc$. In this paper, a GEANT4 simulation is carried out to test the safety of the $^{99m}Tc$ generator, taking the Daiichi product with radioactivity of 500 mCi as an example. According to the domestic regulation on radiation safety, the dose at 10 cm and 100 cm away from the surface of shielding container should not exceed 2.0 mSv/h and 0.02 mSv/h, respectively. The simulated dose turned out to be less than the limit, satisfying the domestic regulation.

• Journal of the Korea Safety Management & Science
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• v.17 no.4
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• pp.381-396
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• 2015

The study proposes multiple TRIZ contradiction solution strategies for addressing PC (Physical Contradiction) and TC (Technical Contradiction) by implementing TRIZ cause-and-effect tree. The problem associated with TC of the ends is solved by PC of means which employs a causal relationship between causes and effects. The TRIZ contradiction solution strategies demonstrated in this research are classified into 3 types of combined strategy as follows: 1. To-Be PC and AS-Is PC, 2.To-Be PC and As-Is TC, 3.As-Is PC and To-Be TC. The combined strategy of To-Be PC and As-Is PC is similar to a divide-and-conquer technique. This strategy adopts parallel strategies using 4 separation principles in time, in space, between parts and the whole, and upon condition of two reversed-PCs. Moreover, its application elucidates the conflict relationship of two TCs from the study. The integrated 4 separation principles and 40 inventive principles present an effective synergy effect from the combination, and further addresses the problems in the TRIZ contradiction resolution strategies. Combined strategy of To-Be PC and As-Is TC implements the 40 inventive principles that To-Be PC of the means resolves the As-Is TC of the ends. Combined strategy of As-Is PC and To-Be TC also uses inventive principles to the As-Is PC of the means to solve the To-Be TC of the ends. In addition, propositional and logical relationship of necessary and sufficient conditions between TC and PC is used to support the validity of 3 TRIZ contradiction solution strategies. In addition, 3 other strategies of necessary and sufficient conditions validate the contraposition relationship of the truth table. This study discusses TRIZ case studies from National Quality Circle Contest from the years between 2011 and 2014 to provide the usage guidelines of TRIZ contradiction solutions for quality purposes. Examining analysis from the case studies and investigating combined strategies allows the users to obtain comprehensive understanding.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 1998.04a
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• pp.280-281
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• 1998

이 글의 구성은 다음과 같다. 1. 소개 2. 한국의 활동 3. ISO 규격 제정단계 4. TC 108 22차 총회 내용 5. TC 108/SC 5 4차 분과위원회 내용

• Journal of Radiation Protection and Research
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• v.33 no.1
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• pp.41-46
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• 2008

To estimate the finger dose absorbed by $^{99m}Tc$ injection, simulations are carried out to calculate the dose equivalent of each finger per second with radioactivity of 370 MBq, based on the GEANT4 simulator. For the $^{99m}Tc$ source of the volume of 0.4mL and the radioactivity of 370 MBq, we obtained the dose equivalent of the right thumb ($0.29\;{\mu}Sv{\cdot}sec^{-1}$), the right index finger ($1.19\;{\mu}Sv{\cdot}sec^{-1}$), the right middle finger ($1.07\;{\mu}Sv{\cdot}sec^{-1}$), the left thumb ($4.36\;{\mu}Sv{\cdot}sec^{-1}$), and the left index finger ($3.37\;{\mu}Sv{\cdot}sec^{-1}$), respectively. This simulation results may serve as a useful data in the prediction of finger dose absorbed by $^{99m}Tc$ injection.

• Ecology and Resilient Infrastructure
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• v.4 no.1
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• pp.63-70
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• 2017

Tetracycline (TC) groups, widely used veterinary antibiotics, can enter into environment through animal manure application. TC forms a ligand complex with multivalent metal cations via chelation that can affect sorption and mobility of TC in soil. So far, however, it has been confirmed through the reaction of the soil outside in the aqueous solution and the evaluation of the performance in the soil cultivation process is insufficient. The purpose of this study was to examine effects of copper on TC toxicity to lettuce growth. In this research, $750mg\;kg^{-1}$ of TC and 2.5, 7.5, $17.5mg\;kg^{-1}$ of Cu are treated in soil and lettuce was cultivated in the treated soil. Growth difference of lettuce by treatment was observed. As a result, $750mg\;kg^{-1}$ of TC treated soil showed toxic effect to lettuce and the effect is alleviated by copper treatment.

• International Journal of Fluid Machinery and Systems
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• v.4 no.3
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• pp.307-316
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• 2011

In order to clarify the features of tip leakage vortex near blade tip region in a half-ducted axial fan with large bellmouth, the experimental investigation was carried out using a 2-dimensional LDV system. Three sizes of tip clearance (TC) were tested: those sizes were 1mm (0.55% of blade chord length at blade tip), 2mm (1.11% of blade chord length at blade tip) and 4mm (2.22% of blade chord length at blade tip), and those were shown as TC=1mm, TC=2mm and TC=4mm, respectively. Fan characteristic tests and the velocity field measurements were done for each TC. Pressure - flow-rate characteristics and two-dimensional velocity vector maps were shown. The vortex trace and the vortex intensity distribution were also illustrated. As a result, a large difference on the pressure - flow-rate characteristics did not exist for three tip clearance sizes. In case of TC=4mm, the tip leakage vortex was outflow to downstream of rotor was not confirmed at the small and reference flow-rate conditions. Only at the large flow-rate condition, its outflow to downstream of rotor existed. In case of TC=2mm, overall vortex behaviors were almost the same ones in case of TC=4mm. However, the vortex trace inclined toward more tangential direction. In case of TC=1mm, the clear vortex was not observed for all flow-rate conditions.