• Tuberculosis and Respiratory Diseases
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• v.44 no.1
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• pp.162-174
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• 1997

Background : Metabolic cooperation via gap junctional intercellular communication (GJIC) is an important mechanism of the bystander effect in gene therapy using the Herpes Simplex Virus thymidine kinase/ganciclovir (HSVtk) "prodrug" system. Since retinoids have been reported to increase GJIC by induction of connexin 43 expression, we hyporthesized that treatment of tumor cells with retinoic acid could augment the bystander effect of the HSVtk/GCV system and result in improved tumor cell killing by enhancing GJIC. Methods : We transferred HSVtk gene to SKHep-J cell line that does not express connexin43, and also transferred the gene to human and murine mesothelioma cell lines that express connexin43. We verified that retinoic acid enhanced GJIC utilizing a functional double-dye transfer study and evaluated the effects of retinoic acid on the growth rate of tumor cells. We then tested the effects of retinoic acid on bystander-mediated cell killing. Results : Addition of all-trans retinoic acid (RA) increased GJIC in cell lines expressing connexin 43 and was asspciated with more efficient in vitro bystander killing in cells transduced with HSVtk via adenoviral and retroviral vectors. In contrast, there was no increase in the efficiency of the bystander effect after exposure to RA in a cell line which had no delectable connexin 43. Conclusion : These results provide evidence that retinoids can augment the efficiency of cell killing with the HSVtk/GCV system by enhancing bystander effect and may thus be a promising new approach to improve responses in gene therapy utilizing the HSVtk system to treat tumors.

• Proceedings of the Korean Society of Veterinary Clinics Conference
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• 2008.05a
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• pp.101-101
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• 2008

• Proceeding of EDISON Challenge
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• 2017.03a
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• pp.712-714
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• 2017

미병의 예방과 관리의 중요성이 거론되고 있으나, 미병에 대한 분류나 진단을 위한 확고한 근거가 미약한 상황으로서 미병 진단 인자 분류를 위한 생리시스템 모델 개발이 필요한 시점이다. 본 연구의 목적은 개발한 생리학적 모델이 미병 단계를 구별하는데 효과 및 유용성이 있는지를 임상 검증하기 위하여 생리학적 모델 인공지능 시뮬레이션을 개발하고자 함이다. 인공지능 계산은 3층으로 구성된 네트워크를 이용하였으며 각 층은 30개의 neuron들로 구성하였다. 인공지능망의 입력 값은 나이, 수축기 혈압, 이완기 혈압, 심박수 값 (입력 값 4개)이고 출력 값은 혈관 저항값인 Ra이다. 머신러닝 차수를 높이면서 인공지능을 사용하지 않은 생리적 모델로부터 도출된 결과와 인공지능을 통하여 계산된 결과를 비교하였다. 개발된 인공지능계산을 이용한 생리시스템 모델은 대량의 표본집단에서 임상 검증에 기여할 것이다.

• Korean Journal of Fisheries and Aquatic Sciences
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• v.40 no.5
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• pp.276-281
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• 2007

The toxicity of two species of puffer fish, Takifugu xanthopterus and T. stictonotus, collected from coastal regions of Korea, was determined using a mouse bioassay. The highest toxin scores in the muscle, skin, fins, and testis in both species were below 50 mouse units (MU) per gram, and for each organ of both species the proportion of toxic specimens containing ${\geq}10MU/g$ was less than about 10%. In T. xanthopterus, the highest toxin levels in the liver, gallbladder, and ovary exceeded 1,000 MU/g (1,275-1,910), while less than 200 MU/g (12-136) was detected in the same organs of T. stictonotus. Therefore, the toxicities of muscle, skin, and testis in both species of puffer fish were within acceptable levels for human consumption.

• International Journal of Contents
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• v.16 no.1
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• pp.57-64
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• 2020

We sought to compare upper extremity muscle activity between handwriting on paper and touchscreen with dominant and non-dominant hands in younger adults (age 23.90±1.12) and the elderly (age 75.55±5.76). Muscle activity (percent of maximum voluntary contraction) in the biceps brachii muscle, triceps brachii muscle, flexor carpi ulnaris muscle, and extensor carpi ulnaris muscle was measured using an electromyography device. As a result, our data indicate that muscle activity is lower in younger adults than the elderly. Besides, muscle activity is lower in the dominant versus non-dominant hand, and lower when writing using a touchscreen than on paper. These results can be used to support recommending touchscreens in the elderly. Also, they can be used as baseline data for comparing the performance of non-paretic side and paretic side in patients relative to the central nervous system.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.55 no.3
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• pp.233-242
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• 2019

Species composition and yearly variation of fish eggs and larval fishes were investigated from 2014 to 2016. During the study period, the fish eggs were identified as belonging to 14 taxa. The dominant species of fish eggs were Leiognathus nuchalis, Engraulis japonicus, and Konosirus punctatus. These three species accounted for 97.4% of the total number of individuals collected. The collected larval fishes were identified into 37 taxa, 22 families, and seven orders. The dominant species of larval fish were Leiognathus nuchalis, and Gobiidae fishes. These three species accounted for 85.4% of the total number of individuals collected. The diversity index of the larval fishes was the highest in 2014 (H' = 1.60) and the lowest in 2015 (H' = 1.15). The evenness index was the highest in 2016 (J = 0.51) and the lowest in 2015 (J = 0.39). The dominance index was the highest in 2015 (D = 83.5%) and the lowest in 2016 (D = 70.9%). In addition, the economically important species in this area were Engraulis japonicus, Konosirus punctatus, Hippocampus coronatus, Sebastes schlegelii, Acanthopagrus schlegeli, and Cynoglossus joyneri.

• Journal of Trauma and Injury
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• v.36 no.4
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• pp.435-440
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• 2023

Mesenteric injury occurs rarely in cases associated with blunt abdominal trauma. Despite its low incidence, mesenteric injury can lead to fatal outcomes such as hypovolemic shock due to hemoperitoneum or sepsis due to intestinal ischemia, or perforation-related peritonitis. For mesenteric injuries, especially those involving massive bleeding, intestinal ischemia, and perforation, the standard treatment is surgery. However, in the case of operative management, it should be borne in mind that there is a possibility of complications and mortality during and after surgery. The usefulness of transcatheter arterial embolization (TAE) is well known in solid organs but is controversial for mesenteric injury. We present a 75-year-old man with mesenteric injury due to blunt abdominal trauma. Initial abdominal computed tomography showed no hemoperitoneum, but a mesenteric contusion and pseudoaneurysm with a diameter of 17 mm were observed near the origin of the superior mesenteric artery. Since there were no findings requiring emergency surgery such as free air or intestinal ischemia, it was decided to perform nonoperative management with TAE using microcoils in hybrid emergency room system. TAE was performed successfully, and there were no complications such as bleeding, bowel ischemia, or delayed bowel perforation. He was discharged on the 23rd day after admission with percutaneous catheter drainage for drainage of mesenteric hematoma. The authors believe that treatment with TAE for highly selected elderly patients with mesenteric injuries has the positive aspect of minimally invasive management, considering the burden of general anesthesia and the various avoidable intraoperative and postoperative complications.

• Proceedings of the KIEE Conference
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• 2008.04a
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• pp.232-233
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• 2008

There are various large shocks in optical disc drive system like human touch and speak sound. In this paper, a nonlinear controller and a detection method are proposed. First, a relay nonlinear controller with dead zone is introduced. The structure of this nonlinear controller is simple and has a small amount of calculation. However, this controller has chattering problem when it is working. We suggest a disturbance detection algorithm using Kalman filter in this paper and it shows effective reduction of chattering. The proposed nonlinear controller using this detection algorithm had good performance for the shock.

• Information and Communications Magazine
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• v.30 no.5
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• pp.43-50
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• 2013

2012년 지상파 아날로그 TV 방송의 종료 및 디지털 TV 전환에 따라 디지털 TV를 활용한 차세대 방송서비스에 대한 연구가 진행되고 있다. 뿐만 아니라 2005년 전국 방송을 시작으로 현재 5000만대 이상의 수신기가 보급되어 있는 지상파 DMB(T-DMB:Terrestrial Digital Multimedia Broadcasting)의 효과적인 활용을 위한 연구도 활발히 진행되고 있다. 이러한 서비스 중 안전에 대한 인식이 증대되면서 재난 발생시 최단시간에 관련된 정보를 수신할 수 있는 방송서비스에 대한 요구가 증가하고 있다. 특히 재난 시 방송을 시청하지 않더라도 자동으로 재난상황을 인지하여 Wake-up할 수 있는 기술에 대한 연구가 필요하다. 본 고에서는 기존의 국내 및 해외의 재난 경보 방송시스템에 대해 검토하고 지상파 디지털 TV와 T-DMB를 통한 차세대 방송서비스로 연구되고 있는 자동인지 Wake-up기술에 대해 소개한다.

• Journal of Trauma and Injury
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• v.29 no.4
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• pp.172-175
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• 2016

Penetrated injury of common carotid artery (CCA) is rare and extremely lethal. Carotid artery injury tends to bleed actively and potentially occlude the trachea. It can cause fatal neurological complications. An accurate diagnosis and adequate treatment are very needed to the successful outcome of the penetrating vascular injury in zone 1, 2, and 3 of the neck. Open surgical treatment is more invasive and complicated than endovascular treatment. We experienced a case with penetrating injury in neck zone 2. Here, we report the case successfully treated with endovascular stent graft technique.