• Journal of Digital Convergence
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• v.15 no.9
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• pp.249-259
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• 2017

Purpose: The purpose of this study was to examine the effect of the foot-reflexology massage on sleep, depression and constipation in community-dwelling elders. Methods: A nonequivalent control group pretest-posttest design was conducted. Participants were 46 old adults, aged >65 years who were recruited from two senior welfare centers in D metropolitan city (experimental group=24, control group=22). The intervention was conducted in 10 sessions over 2 weeks, taking 20 min per session. Collected data were analyzed using descriptive statistics, ${\chi}^2-test$, independent t-test, and Pearson correlation coefficient with the SPSS 22.0 Windows program. Results: The experimental group showed significant improvements in sleep (t=-5.60, p<.001), depression (t=3.93, p<.001), and constipation (t=4.90, p<.001) after 2 weeks of the foot-reflexology massage. Conclusion: These findings indicate that the foot-reflexology massage is an effective intervention program for improving sleep, depression and constipation of old adults.

• The Pure and Applied Mathematics
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• v.22 no.3
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• pp.275-283
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• 2015

Let T be a bounded linear operator on a complex Hilbert space H. For a positive integer k, an operator T is said to be a k-quasi-2-isometric operator if T^∗k(T^∗2T² − 2T^∗T + I)T^k = 0, which is a generalization of 2-isometric operator. In this paper, we consider basic structural properties of k-quasi-2-isometric operators. Moreover, we give some examples of k-quasi-2-isometric operators. Finally, we prove that generalized Weyl’s theorem holds for polynomially k-quasi-2-isometric operators.

• IMMUNE NETWORK
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• v.22 no.1
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• pp.6.1-6.19
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• 2022

Chimeric antigen receptor (CAR) T cells, which express a synthetic receptor engineered to target specific antigens, have demonstrated remarkable potential to treat haematological malignancies. However, their transition beyond haematological malignancy has so far been unsatisfactory. Here, we discuss recent challenges and improvements for CAR T cell therapy against solid tumors: Antigen heterogeneity which provides an effective escape mechanism against conventional mono-antigen-specific CAR T cells; and the immunosuppressive tumor microenvironment which provides physical and molecular barriers that respectively prevent T cell infiltration and drive T cell dysfunction and hypoproliferation. Further, we discuss the application of CAR T cells in infectious disease and autoimmunity.

• Investigative Magnetic Resonance Imaging
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• v.22 no.2
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• pp.86-93
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• 2018

Purpose: Imaging plays a significant role in diagnosing leptomeningeal metastases. However, the most appropriate sequence for the detection of leptomeningeal metastases has yet to be determined. This study compares the efficacies of contrast-enhanced T2 fluid attenuated inversion recovery (FLAIR) and contrast-enhanced 3D T1 black-blood fast spin echo (FSE) imaging for the detection of leptomeningeal metastases. Materials and Methods: Tube phantoms containing varying concentrations of gadobutrol solution were scanned using T2 FLAIR and 3D T1 black-blood FSE. Additionally, 30 patients with leptomeningeal metastases were retrospectively evaluated to compare conspicuous lesions and the extent of leptomeningeal metastases detected by T2 FLAIR and 3D T1 black-blood FSE. Results: The signal intensities of low-concentration gadobutrol solutions (< 0.5 mmol/L) on T2 FLAIR images were higher than in 3D T1 black-blood FSE. The T2 FLAIR sequences exhibited significantly greater visual conspicuity scores than the 3D T1 black-blood sequence in leptomeningeal metastases of the pial membrane of cistern (P = 0.014). T2 FLAIR images exhibited a greater or equal extent (96.7%) of leptomeningeal metastases than 3D T1 black-blood FSE images. Conclusion: Because of its high sensitivity even at low gadolinium concentrations, contrast-enhanced T2 FLAIR images delineated leptomeningeal metastases in a wider territory than 3D T1 black-blood FSE.

• Carbon letters
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• v.22
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• pp.89-95
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• 2017

• The Pure and Applied Mathematics
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• v.22 no.2
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• pp.145-158
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• 2015

In this paper, we investigate h-stability and boundedness for solutions of the functional perturbed differential systems using the notion of t_∞-similarity.

• Journal of Korea Multimedia Society
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• v.22 no.2
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• pp.194-202
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• 2019

In the information society represented by the Fourth Industrial Revolution, various types of data and information that are difficult to see are produced, processed, and processed and circulated to enhance the value of existing goods. The IoT(Internet of Things) paradigm will change the appearance of individual life, industry, disaster, safety and public service fields. In order to implement the IoT paradigm, several elements of technology are required. It is necessary that these various elements are efficiently connected to constitute one system as a whole. It is also necessary to collect, provide, transmit, store and analyze IoT data for implementation of IoT platform. We designed and implemented a big data processing IoT platform for IoT service implementation. Proposed platform system is consist of IoT sensing/control device, IoT message protocol, unstructured data server and big data analysis components. For platform testing, fixed IoT devices were implemented as solar power generation modules and mobile IoT devices as modules for table tennis stroke data measurement. The transmission part uses the HTTP and the CoAP, which are based on the Internet. The data server is composed of Hadoop and the big data is analyzed using R. Through the emprical test using fixed and mobile IoT devices we confirmed that proposed IoT platform system normally process and operate big data.

• Corrosion Science and Technology
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• v.13 no.1
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• pp.1-5
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• 2014

A low carbon steel, Fe-2.25%Cr steel (ASTM T22), and Fe-2.25%Cr-1.6%W steel (ASTM T23) were aluminized by hot dipping into molten Al baths. After hot-dipping, a thin Al-rich topcoat and a thick alloy layer formed on the surface. The topcoat consisted primarily of a thin Al layer that contained a small amount of Fe, whereas the alloy layer consisted of Al-Fe intermetallics such as $Al_5Fe_2$ and AlFe. Cr, Mo, and W in T22 and T23 steels reduced the thickness of the topcoat and the alloy layer, and flattened the reaction front of the aluminized layer, when compared to the low carbon steel.

• IMMUNE NETWORK
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• v.22 no.1
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• pp.4.1-4.22
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• 2022

In the era of immunotherapeutic control of cancers, many advances in biotechnology, especially in Ab engineering, have provided multiple new candidates as therapeutic immuno-oncology modalities. Bispecific Abs (BsAbs) that recognize 2 different antigens in one molecule are promising drug candidates and have inspired an upsurge in research in both academia and the pharmaceutical industry. Among several BsAbs, T cell engaging BsAb (TCEB), a new class of therapeutic agents designed to simultaneously bind to T cells and tumor cells via tumor cell specific antigens in immunotherapy, is the most promising BsAb. Herein, we are providing an overview of the current status of the development of TCEBs. The diverse formats and characteristics of TCEBs, in addition to the functional mechanisms of BsAbs are discussed. Several aspects of a new TCEB-Blinatumomab-are reviewed, including the current clinical data, challenges of patient treatment, drawbacks regarding toxicities, and resistance of TCEB therapy. Development of the next generation of TCEBs is also discussed in addition to the comparison of TCEB with current chimeric antigen receptor-T therapy.

• Food Science and Biotechnology
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• v.17 no.5
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• pp.895-898
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• 2008

The mobility of water in set yogurt during fermentation was studied using nuclear magnetic resonance (NMR) relaxometry. The spin-spin relaxation was analyzed using a 2-fraction model, resulting in 2 spin-spin relaxation time constants $T_{21}$ and $T_{22}$. Both $T_{21}$ and $T_{22}$ exhibited rapid changes between 2 and 4 hr of fermentation, coinciding with the drop in pH and the rise in lactic acid bacteria count. The spin-lattice relaxation time $T_1$ increased over the fermentation period. Both $T_1$ and $T_2$ showed an increase in the mobility of water upon gel formation during fermentation. Water redistribution within the gel matrix due to casein aggregation and structure forming may be responsible for the changes in mobility.