• Molecules and Cells
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• 제44권1호
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• pp.1-12
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• 2021

The nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) is the master transcriptional regulator in adipogenesis. PPARγ forms a heterodimer with another nuclear receptor, retinoid X receptor (RXR), to form an active transcriptional complex, and their transcriptional activity is tightly regulated by the association with either coactivators or corepressors. In this study, we identified T-cell death-associated gene 51 (TDAG51) as a novel corepressor of PPARγ-mediated transcriptional regulation. We showed that TDAG51 expression is abundantly maintained in the early stage of adipogenic differentiation. Forced expression of TDAG51 inhibited adipocyte differentiation in 3T3-L1 cells. We found that TDAG51 physically interacts with PPARγ in a ligand-independent manner. In deletion mutant analyses, large portions of the TDAG51 domains, including the pleckstrin homology-like, glutamine repeat and proline-glutamine repeat domains but not the proline-histidine repeat domain, are involved in the interaction with the region between residues 140 and 506, including the DNA binding domain, hinge, ligand binding domain and activation function-2 domain, in PPARγ. The heterodimer formation of PPARγ-RXRα was competitively inhibited in a ligand-independent manner by TDAG51 binding to PPARγ. Thus, our data suggest that TDAG51, which could determine adipogenic cell fate, acts as a novel negative regulator of PPARγ by blocking RXRα recruitment to the PPARγ-RXRα heterodimer complex in adipogenesis.

• Journal of Korea Society of Industrial Information Systems
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• 제27권6호
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• pp.127-140
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• 2022

With the recent development of the ICT (information and communication technology), the revolution of the industry has moved on from the third industry to the fourth. There is no doubt that the companies would not survive in the future without adopting these technologies. The purpose of this research is to analyze the intellectual structure of the internet of things(IoT) literature for the Industry 4.0 to suggest a better insight for the field. The data for this research is extracted from the Web of Science database. Total of 1,631 documents and 72,754 references are used for the research with the analysis program CiteSpace. Author co-citation analysis is used to analyze the intellectual structure and performed clustering, timeline and burst detection analysis. We identified 12 sub-areas of IoT for the Industry 4.0 which are 'Supply Chain', 'Digital Twin', 'Smart Manufacturing System' and etc. Through the timeline analysis we can find out which clusters will increase or decrease its reputation. As concluding remarks, limitations and further research suggestions are discussed.

• Journal of Hospice and Palliative Care
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• 제4권1호
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• pp.14-25
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• 2001

Purpose : To determine whether there exist gender differences in pain in Korean cancer patients and whether the depression and performance that are often expressed differently between men and women with cancer interact with pain. Method : The results of survey were collected from 140 in- and out-patients (78 male and 62 female) who had cancer treatment at one of the university hospital in Seoul for four months from February of 1999. The severity and interference of pain were examined with the self-reported survey based on Korean version of Brief Pain Inventory (BPI-K). Demographic and clinical information for all patient were compiled by reviewing their medical records, and the level of depression was examined with the Korean version of Beck Depression Inventory (BDI-K). Usual statistical methods, e.g., frequences, means and SDs were used to characterize the sample. The chi-square tests for categorical data and t-test for numerical data were used for group comparison. And the correlation between variables were performed using Pearson correlation coefficient. Resuts : 1) The mean scores of the worst pain for last 24-hours measured with the pain severity of BPI-K were 5.77 in male and 6.45 in female. The pain interference of BPI-K in men was in the order of mood (5.49), enjoy (5.36), and work (5.00), and in women were work (7.48), enjoy (7.16), and mood (6.53). 2) In pain severity, significant difference was found between men and women in the average pain for last 24-hours (t=-2.130, P=.035). In pain interference, significant difference was found between men and women in activity (t=-2.450, P=.015), mood (t=-2,321, P=.022), walk (t=-2.762, P=.007), work (t=-4.946, P=.000), relate (t=-2.595, P=.010), sleep (t=-2.071, P=.040), enjoy (t=-3.198, P=.001). 3) It was found that the items of pain and depression are significantly correlated in men but not in women. Men also exhibited higher correlation in the items of pain and performance status than women. Conclusions : Women report significantly greater average pain for last 24-hours and for all items of pain interference than men. Pain and depression are significantly correlated in men. The results of this study suggest that gender differences in pain should be considered for planning effective pain management program.

• Journal of Gastric Cancer
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• 제20권1호
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• pp.41-49
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• 2020

Purpose: Patients with pathological stage T1N+ or T2-3N0 gastric cancer may experience disease recurrence following curative gastrectomy. However, the current Japanese Gastric Cancer Treatment Guidelines do not recommend postoperative adjuvant chemotherapy for such patients. This study aimed to identify the prognostic factors for patients with pT1N+ or pT2-3N0 gastric cancer using a multi-institutional dataset. Materials and Methods: We retrospectively analyzed the data obtained from 401 patients with pT1N+ or pT2-3N0 gastric cancer who underwent curative gastrectomy at 9 institutions between 2010 and 2014. Results: Of the 401 patients assessed, 24 (6.0%) experienced postoperative disease recurrence. Multivariate analysis revealed that age ≥70 years (hazard ratio [HR], 2.62; 95% confidence interval [CI], 1.09-7.23; P=0.030) and lymphatic and/or venous invasion (lymphovascular invasion (LVI): HR, 7.88; 95% CI, 1.66-140.9; P=0.005) were independent prognostic factors for poor recurrence-free survival. There was no significant association between LVI and the site of initial recurrence. Conclusions: LVI is an indicator of poor prognosis in patients with pT1N+ or pT2-3N0 gastric cancer.

• Safety and Health at Work
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• 제9권4호
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• pp.398-407
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• 2018

Background: Occupational skin diseases (OSDs) are frequent in professions with exposure to skin hazards. Thus, a health educational intervention for apprentices of high-risk professions was conducted. It was the aim of this study to gain insight into possible effects of this intervention. Methods: A one-time skin protection seminar was conducted in 140 apprentices of health-related and non-health-related professions [trained cohort (TC)]. In addition, 134 apprentices of the same occupations were monitored [untrained cohort (UTC)]. The OSD-specific knowledge and the skin condition of the hands were assessed at baseline (T0), after the seminar (T1), and after 6 (T2) and 12 months (T3). Results: The OSD-specific knowledge increased in all cohorts from T0 to T3, but we found a significantly higher knowledge in the TC at T2 (p < 0.001, t = 3.6, df = 196, 95% confidence interval = 0.9, 3.3) and T3 (p < 0.001, t = 3.8, df = 196, 95% confidence interval = 1.0, 3.2) compared to the UTC. Our results indicated a better skin condition of the hands in the TC of the health-related professions but not in the non-health-related professions. Conclusion: The study indicates that an educational intervention may positively influence the disease-specific knowledge and the prevalence of OSD in apprentices. However, definite conclusions cannot be drawn because of the heterogeneous study cohorts and the study design. Future research should aim at tailoring primary prevention to specific target groups, e.g., in view of the duration and frequency of skin protection education, different professions, and gender-specific prevention approaches.

• Journal of Food Hygiene and Safety
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• 제34권1호
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• pp.58-64
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• 2019

In the current study, 109 commercial nut samples were collected from different Korean markets and analyzed for the contamination of 5 different mycotoxins (aflatoxin, ochratoxin A, deoxynivalenol, zearalenone, and T-2 toxin) using ELISA kits. The results revealed that the most frequently detected mycotoxin was zearalenone (n=36, 33%), followed by aflatoxin (n=31, 28.4%) and ochratoxin A (n=30, 27.5%). Deoxynivalenol and T-2 toxin were also detected in 22 (20.3%) samples, respectively. Among 109 nut samples, 33 samples (30.3%) were contaminated only with one kind of mycotoxin, whereas 43 samples had at least 2 kinds of mycotoxins. Two samples were contaminated with as many as 4 different mycotoxins, and they were both walnuts. Although the monitoring results revealed the amount of aflatoxin contamination was under the safety criteria, there is no current safety guideline for other kinds of mycotoxins or multiple contaminations in Korea. Therefore, further studies should be performed to reveal the distribution of mycotoxin in different foods and propose appropriate safety guidelines for Korean markets.

• Journal of the Korean Society of School Health
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• 제27권3호
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• pp.140-147
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• 2014

Purpose: This study aimed to identify the factors affecting on depression among female middle school students. Methods: A survey was conducted on 217 first and second grade female middle school students in C city. Participants' general characteristics, home environment, level of depression, paternal, maternal, peer attachment, school adjustment were measured by self-reporting questionnaire. With SPSS 18.0 program, measured variables were analyzed and compared using descriptive statistics, t-test, ANOVA, Scheff$\acute{e}$ post hoc test, and stepwise multiple regression analysis. Results: The level of depression among female middle school students were higher among students with lower economic status, second in birth order, and second grade in school. The level of depression was negatively associated with the level of paternal attachment (r=-.522), maternal attachment (r=-.487), peer attachment (r=-.376), relationship with teachers in school adjustment (r=-.274), relationship with friends in school adjustment (r=-.378), classroom behavior (r=-.450), school regulation (r=-.267). About 42% of depression among female middle school students were explained by paternal attachment, relationship with friends in school adjustment, and classroom behavior. Conclusion: Paternal attachment was identified as the most influencing factor on depression among female middle school students. Encouraging paternal involvement in the process of school adjustment might be a useful intervention to decrease depression among middle school girls.

• The Journal of Advanced Prosthodontics
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• 제12권3호
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• pp.140-149
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• 2020

PURPOSE. This study evaluated the color stabilities of two computer-aided design and computer-aided manufacturing (CAD/CAM) blocks and a nanofill composite resin and the microtensile bond strength (µTBS) between the materials. MATERIALS AND METHODS. Twelve specimens of 4 mm height were prepared for both Lava Ultimate (L) and Vita Enamic (E) CAD/CAM blocks. Half of the specimens were thermocycled (10,000 cycle, 5° to 55℃) for each material. Both thermocycled and non-thermocycled specimens were surface treated with one of the three different methods (Er,Cr:YSGG laser, bur, or control). For each surface treatment group, one of the thermocycled and one of non-thermocycled specimens were restored using silane (Ceramic Primer II), universal adhesive (Single Bond Universal), and nanofill composite resin of 4-mm height (Filtek Ultimate). The other specimens were restored with the same procedure without using silane. For each group, 1 × 1 × 8 mm bar specimens were prepared using a microcutting device. Bar specimens were thermocycled (10,000 cycle, 5° to 55℃) and microtensile tests were performed. Staining of the materials in coffee solution was also compared using a spectrophotometer. Data were analyzed using one-way ANOVA, t-test and post-hoc Scheffe tests. RESULTS. µTBS were found similar between the thermocycled and non-thermocycled groups (P>.05). The highest µTBS (20.818 MPa) was found in the non-thermocycled, bur-ground, silane-applied E group. Silane increased µTBS at some E groups (P<.05). Composite resin specimens showed more staining than CAD/CAM blocks (P<.05). CONCLUSION. CAD/CAM blocks can be repaired with composite resins after proper surface treatments. Using silane is recommended in repair process. Color differences may be shown between CAD/CAM blocks and the nanofill composite after a certain time period.

• Research in Community and Public Health Nursing
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• 제19권2호
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• pp.317-325
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• 2008

Objectives: The purpose of this study was to investigate factors influencing the health status and life satisfaction of elders in welfare facilities. Methods: The subjects of this study were selected randomly among those without cognitive impairment from free (140 persons) and charged (140 persons) welfare facilities in the Yeongnam area. Data was analyzed using t-test and stepwise multiple regression. Results: Health status and life satisfaction were 2.52 and 1.98, respectively, in the elders from free welfare facilities, and 2.67 and 2.08 respectively, in the elders from charged welfare facilities. In those from free facilities, life satisfaction and motivation for getting into the welfare facility were the influencing factors of health status. In those from charged facilities, life satisfaction, gender, motivation for getting into the welfare facility, limited service such as physiotherapy, age, and lack of staff and professionalism were the influence factors of health status. In those from free facilities, health status, relationship conflict with fellow elders, lack of staff and professionalism, insufficient facilities and inadequate environment, and indifference of sons and daughters were the influence factors of life satisfaction. In those from charged facilities, health status, education and age were the influence factors of life satisfaction. Conclusions: It was found that both health status and life satisfaction of elders in charged welfare facilities were higher than those in free welfare facilities.

• Journal of the Korean Society of Industry Convergence
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• 제5권3호
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• pp.201-208
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• 2002

The machine tool which operates by hand is replacing by CNC machine tool to improve the quality of the product and the productivity in modem mechanic industry. The precision of machine part is influenced greatly the surface roughness by cutting condition of machine tool. So this study was performed to examine the aluminium surface roughness of section according to change of strength rating, nose radius, cutting speed, using live center. The results of this study are as follows; 1. In the case of 56mm diameter of test piece(length is below triple of diameter), whether establish the live center or not, doesn't influence to the surface roughness, and it is possible to make product without the live center. 2. The average surface roughness of 42mm diameter(length is quadruple of diameter) is similar to the 56mm diameter in the cutting condition of nose radius 0.8mm and cutting speed 140mm/min, but there are increases and differences in other cutting conditions. 3. In the case of test piece length more 70m/min(140m/mm) and nose radius improved greatly using the live center. 4. In the case of test piece length is quintuple of diameter, the nose radius must choose big tool and increase the cutting speed in preference live center establishment availability to improve that is surface roughness. Conclusively, if aluminum test piece length is fewer than triple of diameter, can process without establishing live center. If aluminum test piece length is more than quintuple of diameter, cutting conditions to improve surface roughness are (1) cutting speed (2) nose radius (3) whether the live center uses or not.