• 제목/요약/키워드: T-testing

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Statistical methods for testing tumor heterogeneity (종양 이질성을 검정을 위한 통계적 방법론 연구)

  • Lee, Dong Neuck;Lim, Changwon
    • The Korean Journal of Applied Statistics
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    • v.32 no.3
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    • pp.331-348
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    • 2019
  • Understanding the tumor heterogeneity due to differences in the growth pattern of metastatic tumors and rate of change is important for understanding the sensitivity of tumor cells to drugs and finding appropriate therapies. It is often possible to test for differences in population means using t-test or ANOVA when the group of N samples is distinct. However, these statistical methods can not be used unless the groups are distinguished as the data covered in this paper. Statistical methods have been studied to test heterogeneity between samples. The minimum combination t-test method is one of them. In this paper, we propose a maximum combinatorial t-test method that takes into account combinations that bisect data at different ratios. Also we propose a method based on the idea that examining the heterogeneity of a sample is equivalent to testing whether the number of optimal clusters is one in the cluster analysis. We verified that the proposed methods, maximum combination t-test method and gap statistic, have better type-I error and power than the previously proposed method based on simulation study and obtained the results through real data analysis.

Design of Web-Based Simulation Framework for Real-Time Infographics (실시간 인포그래픽을 위한 웹 기반의 시뮬레이션 프레임워크 설계)

  • Shin, Seung-Hyeok
    • Journal of Advanced Navigation Technology
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    • v.19 no.5
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    • pp.411-416
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    • 2015
  • The service size of an IoT environment is determined by the various types of sensors. A gateway for relaying sensor information from various sensors is a representative middleware system, and an infographics showing the information with a graphical presentation of data and information is a client system for representing real-time information efficiently, it is necessary a similar test bed with IoT environment to develop a real-time infographics displaying a large amount of information effectively. The testing tools used in developing the existing network systems are mostly made to be suitable for functional testing and performance testing of the driven unit. In this paper, we proposed a mean which is web-based simulation framework to create a variety of information required for real-time infographics development, and evaluate the function of the system proposed by the test function of the comparison with the previous network test tool.

A Structural Model for Paternal Stress of Handicapped Children (장애 아동 아버지의 스트레스와 적응에 관한 구조 모형)

  • Lee, Kyung-Hee
    • The Korean Nurse
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    • v.31 no.5
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    • pp.72-87
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    • 1992
  • This study was designed to develop and lest a structural model for paternal adaplation and family stress in the families with the handicapped children. A hypothetical model was constructed on the basis of family stress theory developed by McCubbin etc. The model included 6 theoretical concepts and 11 paths. For the purpose of the model testing, empirical data were collected from May to August, 1992. The subject of the study constituted 190 mothers whose children admitted in the five special schools and one privale institutes in Seoul and Choong Nam. In data analysis, SPSS PC+ and PC-LISREL 7.13 computer program were utilized for descriptive and covariance structure analysis. The results of lhe study were as follows. (1) Hypothetical model showed a good fit to the empirical data [Chi-square = 21.19 (df = 7, P = o. 003), Goodness of Fit Index=O.986, Adjusted Goodness of Fit Indes=0.946, Root Mean Square lesidual=0.048), Non Normed Fit Index = 0.80, Normed Fit Index=0.91]. (2) The results of Hypothesis testing indicated: 1) Social support(${\gamma}_11=.238$, T=2.352), Family Functioning(${\gamma}_12=.729$, T=5.957) had direct effects on situational definition. 2) life event stress(${\gamma}_23=.284$, T=5.220) had direct effects on the effect of the handicapped chid on the family. 3) Family functioning(${\gamma}_32=-.239$, T= -3.370) had direct effects on paternal adapation. From the above results, the significance of this study can be delineated as follows : The construction and testing of the comprehensive model seem to be the first trial in Korea. The model was supported by empirical dala. Thus it was suggested that model could be adequately applied to framily nusing care with the handicapped.

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Comparison and analysis of multiple testing methods for microarray gene expression data (유전자 발현 데이터에 대한 다중검정법 비교 및 분석)

  • Seo, Sumin;Kim, Tae Houn;Kim, Jaehee
    • Journal of the Korean Data and Information Science Society
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    • v.25 no.5
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    • pp.971-986
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    • 2014
  • When thousands of hypotheses are tested simultaneously, the probability of rejecting any true hypotheses increases, and large multiplicity problems are generated. To solve these problems, researchers have proposed different approaches to multiple testing methods, considering family-wise error rate (FWER), false discovery rate (FDR) or false nondiscovery rate (FNR) as a type I error and some test statistics. In this article, we discuss Bonferroni (1960), Holm (1979), Benjamini and Hochberg (1995) and Benjamini and Yekutieli (2001) procedures based on T statistics, modified T statistics or local-pooled-error (LPE) statistics. We also consider Sun and Cai (2007) procedure based on Z statistics. These procedures are compared in the simulation and applied to Arabidopsis microarray gene expression data to identify differentially expressed genes.

Construction of a Low Magnetic Field Standard System Using a Precision Solenoid (정밀솔레노이드를 사용한 저자장 표준시스템 제작)

  • 박포규;손대락;우병칠;김창석
    • Journal of the Korean Magnetics Society
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    • v.2 no.2
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    • pp.150-155
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    • 1992
  • The low magnetic field standard below 1 mT with resolution of 100 nT has been established for the calibration and testing of low field magnetometers. A precision single layered solenoid, which is made of quartz tube and bare copper wire, was constructed in order to generate a precise magnetic field. To improve the field homogeneity in the solenoid, three-current method was employed. The injected current and injection points on the solenoid were optimized by computer simulation. The magnetic field uncertainty in the solenoid was 0.1 % and 0.01 % in the range of ${\pm}5\;cm$ from the center for a single and three-current methods respectively. We also constructed a testing system for the dynamic properties of low field magnetometers.

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Performance analysis of EVT-GARCH-Copula models for estimating portfolio Value at Risk (포트폴리오 VaR 측정을 위한 EVT-GARCH-코퓰러 모형의 성과분석)

  • Lee, Sang Hun;Yeo, Sung Chil
    • The Korean Journal of Applied Statistics
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    • v.29 no.4
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    • pp.753-771
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    • 2016
  • Value at Risk (VaR) is widely used as an important tool for risk management of financial institutions. In this paper we discuss estimation and back testing for VaR of the portfolio composed of KOSPI, Dow Jones, Shanghai, Nikkei indexes. The copula functions are adopted to construct the multivariate distributions of portfolio components from marginal distributions that combine extreme value theory and GARCH models. Volatility models with t distribution of the error terms using Gaussian, t, Clayton and Frank copula functions are shown to be more appropriate than the other models, in particular the model using the Frank copula is shown to be the best.

Experimental Investigation of Fatigue Crack Growth Behavior in Friction Stir Welded 7075-T651 Aluminum Alloy Joints under Constant Stress Intensity Factor Range Control Testing (For LT Orientation Specimen) (일정 응력확대계수범위 제어 시험하의 마찰교반용접된 7075-T651 알루미늄 합금 용접부의 피로균열전파 거동의 실험적 고찰 (LT 방향의 시험편에 대하여))

  • Jeong, Yeui Han;Kim, Seon Jin
    • Transactions of the Korean Society of Mechanical Engineers A
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    • v.37 no.6
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    • pp.775-782
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    • 2013
  • In this study, as a series of studies aimed at investigating the spatial randomness of fatigue crack growth for friction stir welded (FSWed) 7075-T651 aluminum alloy joints, the fatigue crack growth behavior of FSWed 7075-T651 aluminum alloy joints was investigated for LT orientation specimens. Fatigue crack growth tests were conducted under constant stress intensity factor range (SIFR) control for 5 specimens of the FSWed 7075-T651 aluminum alloy, including base metal (BM), heat affected zone (HAZ), and weld metal (WM) specimens. The mean fatigue crack growth rate of WM specimens was found to be the highest, whereas that of HAZ and WM specimens was the lowest. Furthermore, the variability of fatigue crack growth rate was found to be the highest in WM specimens and lowest in BM specimens.

Degradation Assessment of Aluminum Alloy 6061-T6 Using Ultrasonic Attenuation Measurements (초음파 감쇠 측정을 이용한 Al6061-T6 열화 평가)

  • Kim, Hun-Hee;Kang, To;Seo, Mu-Kyung;Song, Sung-Jin;Kim, Hak-Joon;Kim, Kyung-Cho;Kim, Young-Bum
    • Journal of the Korean Society for Nondestructive Testing
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    • v.33 no.1
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    • pp.20-25
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    • 2013
  • Ultrasonic methods are widely used to degradation assessment. Remaining-life cycle of metal can be estimated by ultrasonic parameters because ultrasonic velocity and attenuation are affected by change of material properties with accumulated fatigue in the metal. Therefore, in this study, we will estimate overall change of material properties by 2D C-scan image. Fatigued aluminum alloy 6061-T6 samples from 0 to 85% were prepared for evaluating fatigue life cycle. Also, degraded image of materials using attenuation is proposed to estimate degree of material degradation for determining degraded area of fatigued samples. Finally, we will predicts process pf degradation with measured attenuation of fatigued aluminum alloy 6061-T6 samples.

Microstructure and Mechanical Properties of AA6061/AA5052/AA6061 Complex Sheet Fabricated by Cold-Roll Bonding Process (냉간압연접합법에 의해 제조된 AA6061/AA5052/AA6061 복합판재의 미세조직 및 기계적 성질)

  • Hwang, Ju-Yeon;Lee, Seong-Hee
    • Korean Journal of Materials Research
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    • v.29 no.6
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    • pp.392-397
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    • 2019
  • A cold roll-bonding process is applied to fabricate an AA6061/AA5052/AA6061 three-layer clad sheet. Two AA6061 and one AA5052 sheets of 2 mm thickness, 40 mm width, and 300 mm length are stacked, with the AA5052 sheet located in the center. After surface treatment such as degreasing and wire brushing, sample is reduced to a thickness of 1.5 mm by multi-pass cold rolling. The rolling is performed at ambient temperature without lubricant using a 2-high mill with a roll diameter of 400 mm at rolling speed of 6.0 m/sec. The roll bonded AA6061/AA5052/AA6061 complex sheet is then hardened by natural aging(T4) and artificial aging(T6) treatments. The microstructures of the as-roll bonded and age-hardened Al complex sheets are revealed by optical microscopy; the mechanical properties are investigated by tensile testing and hardness testing. After rolling, the roll-bonded AA6061/AA5052/AA6061 sheets show a typical deformation structure in which grains are elongated in the rolling direction. However, after T4 and T6 aging treatment, there is a recrystallization structure consisting of coarse equiaxed grains in both AA5052 and AA6061 sheets. The as roll-bonded specimen shows a sandwich structure in which an AA5052 sheet is inserted into two AA6061 sheets with higher hardness. However, after T4 and T6 aging treatment, there is a different sandwich structure in which the hardness of the upper and lower layers of the AA6061 sheets is higher than that of the center of the AA5052 sheet. The strength values of the T4 and T6 age-treated specimens are found to increase by 1.3 and 1.4 times, respectively, compared to that value of the starting material.

Microstructure and Mechanical Properties of Cold Roll-Bonded Layered AA6061/AA5052/AA6061/AA5052 Aluminum Alloy Sheet (냉간압연접합된 층상 AA6061/AA5052/AA6061/AA5052 알루미늄합금판재의 미세조직 및 기계적 성질)

  • Jo, Sang-Hyeon;Park, Bo-Bae;Lee, Seong-Hee
    • Korean Journal of Materials Research
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    • v.32 no.3
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    • pp.161-167
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    • 2022
  • A cold roll-bonding process is applied to fabricate an AA6061/AA5052/AA6061/AA5052 layered sheet. Two AA6061 and one AA5052 sheets of 2mm thickness, 40mm width and 300mm length are alternately stacked, then reduced to a thickness of 2.0 mm by multi-pass cold rolling after surface treatment such as degreasing and wire brushing. The rolling is performed at ambient temperature without lubricant using a 2-high mill with a roll diameter of 400 mm at a rolling speed of 6.0 m/sec. The roll-bonded AA6061/AA5052/AA6061/AA5052 layered sheet is then hardened by natural aging (T4) and artificial aging (T6) treatments. The microstructure of the as-roll bonded and the age-hardened Al sheets was revealed by SEM observation; the mechanical properties were investigated by tensile testing and hardness testing. After T4 and T6 aging treatment, the specimens had a recrystallization structure consisting of coarse equiaxed grains in both AA5052 and AA6061 regions. The as-roll-bonded specimen showed a clad structure in which the hardness of AA5052 regions was higher than that of AA6061 regions. However, after T4 and T6 aging treatment, specimens exhibited different structures, with hardness of AA6061 regions higher than that of AA5052 regions. Strengths of T6 and T4 age-treated specimens were found to increase by 1.55 and 1.36 times, respectively, compared to the value of the starting material.