• Biomolecules & Therapeutics
• /
• v.11 no.1
• /
• pp.65-71
• /
• 2003

Terbinafine is a synthetic allylamine that is available in an oral formulation and is used at a dosage of 250mg/day. It is used as an active antifungal agent and inhibits the fungal enzyme squalene epoxidase, which leads to the accumulation of the sterol squalene, which is toxic to the organism. The purpose of the present study was to evaluate the bioequivalence of two terbinafine tablets, Lamisil (Novartis Korea Ltd.) and Terbinex (C-TRI Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Eighteen normal male volunteers, 26.00$\pm$2.57 year in age and 70.51$\pm$9.36 kg in body weight, were divided into two groups and a randomized 2${\times}$2 cross-over study was employed. After one tablet containing 125 mg of terbinafine was orally administered, blood was taken at predetermined time intervals and the concentrations of terbinafine in plasma were determined using HPLC with UV detector. Pharmacokinetic parameters such as AUC, $C_{max}$ and $T_{max}$ were calculated and ANOVA test was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC, $C_{max}$ and $T_{max}$ between two tablets were －4.191％, 5.223％ and －25.720％, respectively when calculated against the Lamisil, tablet. The powers (1-$\beta$) for AUC, $C_{max}$ and $T_{max}$ were 81％, 87％ and below 60％, respectively. Minimum detectable differences(.il) at alpha=O.1 and 1-/3=0.8 were less than 20％ (e.g., 19.72％ and 17.77％ for AUC and $C_{max}$, respectively). But minimum detectable differences($\Delta$) at alpha=0.1 and 1-$\beta$=0.8 for $T_{max}$ were more than 20％ (e.g., 26.25％). The 90％ confidence intervals were within $\pm$20％ (e.g., －17.440∼9.06 and －6.713∼17.160 for AUC and $C_{max}$ respectively). But 90％ confidence intervals for $T_{max}$ were not within $\pm$20％ (e.g., －43.346∼8.083). Another ANOVA test was conducted for logarithmically transformed AUC and $C_{max}$. These results showed that there are no significant differences in AUC and $C_{max}$ between the two formulations: The differences between the formulations in these log transformed parameters were all for less than 20％ (e.g., －4.19％ and 5.22％ for AUC and $C_{max}$, respectively). The 90％ confidence intervals for the log transformed data were not the acceptance range of log 0.8 to log 1.25 in AUC but the acceptance range of log 0.8 to log 1.25 in $C_{max}$ (e.g., log 1.13∼log 1.50 and log 0.94-log 1.22 for AUC and $C_{max}$ respectively). The major parameters, AUC and $C_{max}$ met the criteria of KFDA for bioequivalence although $T_{max}$ did not meet the criteria of KFDA (1998 year) for bioequivalence, indicating that Onfran tablet is bioequivalent to Zofran tablet. But in another ANOVA test AUC did not meet the criteria of KFDA (2002) for bioequivalence but $C_{max}$ met the criteria of KFDA (2002 year) for bioequivalence.or bioequivalence.equivalence.equivalence.equivalence.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.19 no.6
• /
• pp.405-413
• /
• 2018

The purpose of this study was to investigate the influence of SNS addiction tendency, depression, and communication skill among university students. Subjects were 200 associate nursing students in Korea. The data were collected using a self-reporting questionnaire from October 11 to November 24, 2016. Data were analyzed by descriptive statistics, t-test, ANOVA, LSD test, Pearson's correlation coefficients, and multiple regression analysis using the SPSS/WIN 23.0 program. The levels of SNS addiction tendency were dependent on age (t=2.47, p=.044), connection SNS time (F=10.20, p<.001), and place of SNS use (t=2.54, p=.012). SNS addiction tendency was significantly correlated with depression. Higher SNS addiction was associated with higher rates of depression. SNS addiction tendency was not significantly correlated with communication skill in nursing students. Influential factors that affect SNS addiction tendency were depression (${\beta}=.265$, p<.001) and SNS usage time (${\beta}=.265$, p<.001), which explains about 15.5% of the variance. The results of this study indicate that nursing interventions are necessary to improve SNS addiction tendency, and early screening of nursing students is needed to develop health promotion programs for the vulnerable.

• Journal of the Korea Academia-Industrial cooperation Society
• /
• v.20 no.3
• /
• pp.535-543
• /
• 2019

This study was conducted to identify the factors related to the patient demographics and smoking factors on smoking cessation success and maintenance of subjects at the 6th and 12th week at a public hospital. This study utilized secondary data collected through the smoking cessation program of the 2014 public health care program, which is mediated for 6 weeks and checked for maintenance on the 12th week. The data were analyzed by the chi-square test, t-test and logistic regression analysis. There were 90 subjects in total, 85 men (94.45%) and 5 women (5.55%). The smoking success group and smoking failure group showed significant differences in family type (${\chi}^2=4.496$, p=0.037), education (${\chi}^2=12.253$, p=0.002), smoking amount per day before program (t=-2.906, p=0.005), and nicotine dependence before program (t=-3.081, p=0.003) after 6 weeks. Factors influencing smoking cessation success were religion (OR=3.719, 95% CI=1.076-12.859) and nicotine dependence before program (OR=0.713, 95% CI=0.520-0.976). Factors influencing smoking cessation maintenance were family type (OR=0.017, 95% CI=0.001-0.507) and no-smoking willingness (OR=2.062, 95% CI=1.059-4.015). For smoking cessation to be successful and sustainable, it is necessary to develop programs specific for the characteristics of the subjects; accordingly, continuous research and support are needed.

• Journal of Digital Convergence
• /
• v.19 no.6
• /
• pp.429-438
• /
• 2021

This study aims to prevent maternal social isolation by analyzing the causes of postpartum obesity and postpartum depression and stress in Korea. Gneral characteristics of mothers as a result of the study: 91.1% (102 people) answered that they had social experience, and only 8% (9 people) answered that they had no social experience. In the question of whether to return to society, 17.9% responded that they have already returned, 54.5% did not, and 18.8% were on maternity leave. As a result of examining the level of BMI increase among mothers through chi-square test of BMI changes before and after childbirth and general characteristics, 55% experienced below-average BMI increase; 45% experienced above-average BMI increase. Those in their 30s accounted for 40.2%, and those in their 40s accounted for 57.1%. Postpartum obesity and maternal psychological status (t-test): Mothers with postpartum obesity were more hypersensitive (t = -1.997, p = 0.048) and more prone to suffer from hard breathing (t = -1.930, p = 0.056), emptiness (t = -2.673, p = 0.010), and body numbness (t = -2.315, p = 0.024) than mothers who are not suffering from not postpartum obesity. Per the results of postpartum BMI increase and maternal psychological state (t-test) analysis, mothers with an average increase in postpartum BMI were more depressed than mothers who did not. Research Results - Postpartum obesity due to pregnancy and childbirth has been identified as an important individual cause affecting mental and physical problems after childbirth. In conclusion, I also think that the government should support the management of maternal obesity and the elimination of depression through the results of this study.

• The Journal of Korea CHUNA Manual Medicine
• /
• v.5 no.1
• /
• pp.93-100
• /
• 2004

Low back pain(LBP) is known as one of the diseases that produce severe pains with 80% of the whole population having experienced it and reported that, even at this moment, 20-30% of the world population is suffering from it. The writer has performed 'Conservative remedies (non-surgical procedures taken)' from $1^{st}$ of January 2003 to $31^{st}$ of December the same year for 76 cases who have been hospitalized in Jaseng Hospital and adopted as having been diagnosed either HIVD L4-5 or HIVD L5-S 1 or as having both. The clinical analysis was made through statistical researches which include : the changing degree in SLR test of the Cheongpa-Jeon(CP) taking patient group and the non-taking group, the change of VAS (Visual analogue scale) against pains, and the days of hospital treatment. The result demonstrated that the CP taking group showed higher changes in SLR test, bigger reduction In VAS changes and the days for hospitalization shorter than the group that didn't take CP.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
• /
• v.23 no.3
• /
• pp.251-260
• /
• 2005

The Development of CCD has contributed to great advancement in mapping technology with giving benefits to research community of photogrammetry. The purpose of this paper is to find the best selection of interpolation method for creating a terrain model form close range digital photogrammetry. T-test as a kind of statistical analysis was conducted to analyze the similarity of hydraulic model with close range digital photogrammetry and trigonometric leveling. Also, many interpolation methods such as inverse distance, kriging, nearest neighbor and TIN about the hydraulic model interpolation were conducted to compare the results for computer to display actual terrain an optimum interpolation of the digital elevation model form close range digital photogrammetry. The results revealed that kriging and TIN interpolation were efficient methods to judge the hazard interpolation law by analyzing geometric similarity of hydraulic model against hydraulic model application.

• Journal of Pharmaceutical Investigation
• /
• v.35 no.4
• /
• pp.287-293
• /
• 2005

The purpose of the present study was to evaluate the bioequivalence of two glimepiride tablets, Amaryl tablet (Handok & Aventis Korea, reference drug) and Mepiril tablet (Myungmoon Pharm. Co., Ltd., Korea, test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). After adding an internal standard (glibenclamide) to human plasma, plasma samples were extracted using 1mL of methyl tertiary butyl ether. Compounds extracted were analyzed by reverse-phase HPLC with multiple reaction monitoring (MRM) mode analyte detection. This method for determination glimepiride proved accurate and reproducible, with a limit of quantitation of 2 ng/mL in human plasma. Twenty-four healthy male Korean volunteers received each medicine at the glimepiride dose of 2 mg in a $2{\times}2$ crossover study. There was a one-week washout period between the doses. Plasma concentrations of glimepiride were monitored by a LC-MS/MS for over a period of 12 hr after the administration. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 12 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for Amaryl/Mepiril were log 0.9583-log 1.1357 and log 1.0570-log 1.2376, respectively. These values were within the acceptable bioequivalence intervals of log 0.80-log 1.25. Taken together, our study demonstrated the bioequivalence of Amaryl and Mepiril with respect to the rate and extent of absorption.

• The Journal of the Korea Contents Association
• /
• v.18 no.7
• /
• pp.423-431
• /
• 2018

The purpose of the present study was to investigate the effect of caption-embedded video on character recognition and vocabulary ability of the primary school students, The subjects of this study were the students in two elementary schools in G city, Jeonbuk province. They were divided into two groups including a control group which used utilization video materials without captions, and a experimental group which used utilization video materials with captions. Each group was tested over the course of two months (10 classes). And then a statistical analysis was conducted to find out the effects of captions on character recognition and vocabulary ability through independent samples t-test and paired samples t-test. There were no significant differences in a comparison between the groups, but significant differences were found within the groups. Pedagogical implications based on the research findings and suggestions for further research were also discussed.

• Research in Community and Public Health Nursing
• /
• v.15 no.1
• /
• pp.5-17
• /
• 2004

Purpose: The purpose of this study is to identify the health promoting lifestyle and need assessment of a health promotion program. and to develop a health promotion program for rural elderly. Method: The subjects of the study were 366 adults chosen from 24 villages located in Geochang Gun, Korea. Data sampling used a quota sampling method. Analysis of the data was done by using descriptive statistics, t test, ANOVA and the Scheffe test with SPSS. Results: 1) The average score of performance in the health promoting lifestyle was 1.85. In the subscales, the highest degree of performance was 'nutrition', followed by 'interpersonal relationships', 'health responsibility', 'stress management', 'spiritual growth', and the lowest degree of performance was 'physical activity'. 2) Health promoting lifestyles were significantly correlated with such demographic variables as age (F=2.684, p=.047), education (F=10.989, p=.000), monthly pocket money (F=3.516, p=.008), religion (F=7.160, p=.000), current health status F=3.375, p=.035), health education (t=2.476, p=.014). 3) Health promoting lifestyles were significantly correlated with such life style pattern variables as milk drinking (F=3.767, p=0.035), hobbies (t=3.072, p=0.002), exercise (t=7.186, p=0.000). 4) There is a high level of need for the need assesment of the health promotion program for the elderly in the rural area. Conclusion: With the above findings. I propose that it is necessary to understand a health promoting lifestyle and need assessment for a health promotion program, and to develop a health promotion program considering regional and environmental elements.

• The Journal of Advanced Prosthodontics
• /
• v.12 no.5
• /
• pp.265-272
• /
• 2020

PURPOSE. The aims of this study were to investigate mechanical properties and hydrothermal degradation behaviour of the cubic-containing translucent yttrium oxide stabilized tetragonal zirconia polycrystal (Y-TZP). MATERIALS AND METHODS. Four groups of Y-TZP (T, ST, XT, and P), containing different amount of cubic crystal, were examined. Specimens were aged by autoclaving at 122℃ under 2 bar pressure for 8 h. Phase transformation was analyzed using X-ray diffraction (XRD) to measure phase transformation (t→m). Kruskal-Wallis test was used to determine the difference. Surface hardness, biaxial flexural strength, and fracture toughness in values among the experimental groups and verified with Wilcoxon matched pairs test for hardness values and Mann Whitney U for flexural strength and fracture toughness. RESULTS. XRD analysis showed no monoclinic phase in XT and P after aging. Only Group T showed statistically significant decreases in hardness after aging. Hydrothermal aging showed a significant decrease in flexural strength and fracture toughness in group T and ST, while group XT and P showed no effect of aging on fractural strength and fracture toughness with P<.05. CONCLUSION. Hydrothermal aging caused reduction in mechanical properties such as surface hardness, biaxial flexural strength, and fracture toughness of Y-TZP zirconia. However, cubic-containing zirconia (more than 30% by volume of cubic crystal) was assumed to have high resistance to hydrothermal degradation. Clinical significance: Cubic-containing zirconia could withstand the intraoral aging condition. It could be suggested to use as a material for fabrication of esthetic dental restoration.