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Antinociception Effect and Mechanisms of $Campanula$ $Punctata$ Extract in the Mouse

  • Park, Soo-Hyun;Sim, Yun-Beom;Lim, Soon-Sung;Kim, Jin-Kyu;Lee, Jin-Koo;Suh, Hong-Won
    • The Korean Journal of Physiology and Pharmacology
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    • v.14 no.5
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    • pp.285-289
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    • 2010
  • In the present study, the antinociceptive profiles of $Campanula$ $punctata$ extract were examined in ICR mice. The $Campanula$ $punctata$ contain a large dose of saponin. $Campanula$ $punctata$ extract administered orally (200 mg/kg) showed an antinociceptive effect as measured by the tail-flick and hot-plate tests. In addition, $Campanula$ $punctata$ extract attenuated the writhing numbers in the acetic acid-induced writhing test. Furthermore, the cumulative nociceptive response time for intrathecal (i.t.) injection of substance P ($0.7{\mu}g$) was diminished by $Campanula$ $punctata$ extract. Intraperitoneal (i.p.) pretreatment with yohimbine (${\alpha}_2$-adrenergic receptor antagonist) attenuated antinociceptive effect induced by $Campanula$ $punctata$ extract in the writhing test. However, naloxone (opioid receptor antagonist) or methysergide (5-HT serotonergic receptor antagonist) did not affect antinociception induced by $Campanula$ $punctata$ extract in the writhing test. Our results suggest that $Campanula$ $punctata$ extract shows an antinociceptive property in various pain models. Furthermore, this antinociceptive effect of $Campanula$ $punctata$ extract may be mediated by ${\alpha}_2$-adrenergic receptor, but not opioidergic and serotonergic receptors.

A Study of Motor Expertise about Kinematic and Kinetic Characteristics of Lower Extremity in the Seokmun Ilwol Martial Art Yin-yang Bo Gait Pattern (석문일월무예 음양보법의 숙련성에 따른 보행 패턴의 하지 운동학 및 운동역학적 특성)

  • Park, Bok-Hee;Kim, Ky-Hyoung
    • Korean Journal of Applied Biomechanics
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    • v.24 no.3
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    • pp.239-248
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    • 2014
  • The purpose of this study was to quantify kinematic and kinetic characteristics of Yin-yang Bo gait according to their motor expertise, one of the Seokmun Ilwol martial art gait patterns. Yin-yang Bo gait pattern shows initial forefoot contact instead of heel contact, and increased time of stance phase time, internal-external rotation of ankle-knee-hip joints and pelvic. It aims to produce and store the more energy through continuous homeostasis of center of gravity (COG) and performance of stretch-shortening cycle. Some of these characteristics also were similar to the gait modification strategies for reducing knee adduction moment such as toe-out progression, medial thrust, internal rotation of hip joint. To identify the characteristics, four factors of expert Yin-yang Bo gait performance group were compared to that of none expert group; 1) angles of COG displacement and rotation 2) distal joint pre-rotation in internal-external rotation of ankle-knee-hip joints and pelvic, 3) invariability pelvic potential and pelvic segment total energy 4) knee abduction moment. Six healthy(three male) subjects participated in the experiment to perform Yin-yang gait pattern. Three-dimensional and force plate data were collected. Kinematic and kinetic data were compared between two groups using t-tests. Results showed that 1) the peak point of COG internal rotation angle was reduced in expert group, 2) kneeexternal and hip joint -internal and pelvic rotation angle peak frames were more near points in expert group.

Development of Multi-Axis Control Program for Long Range AFM Using an FPGA Module (FPGA 모듈을 이용한 Long Range AFM용 다축 제어 프로그램 개발)

  • Lee J.Y.;Eom T.B.;Kim J.W.;Kang C.S.;Kim J.A.
    • Proceedings of the Korean Society of Precision Engineering Conference
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    • 2006.05a
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    • pp.289-290
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    • 2006
  • In general, atomic force microscope (AFM) used for metrological purpose has measuring range less than a few hundred micrometers. We design and fabricate an AFM with long measuring range of $200mm{\times}200mm$ in X and Y axes. The whole stage system is composed of surface plate, global stage, microstage. By combining global stage and microstage, the fine and long movement can be provided. We measure the position of the stage and angular motions of the stage by laser interferometer. A piezoresistive type cantilever is used for compact and long term stability and a flexure structure with PZT and capacitive sensor is used for Z axis feedback control. Since the system is composed of various actuators and sensors, a real time control program is required for the implementation of AFM. Therefore, in this work, we designed a multi-axis control program using a FPGA module, which has various functions such as interferometer signal converting, PID control and data acquisition with triggering. The control program achieves a loop rate more than 500 kHz and will be applied for the measurement of grating pitch and step height.

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Effect of Ni and Mo on Mechanical Properties of Submerged Arc Welds with Flexible Glasswool Backing (FGB SAW 용접부 물성에 미치는 Ni과 Mo의 영향에 관한 연구)

  • Jee, C.H.;Choi, J.T.;Kim, D.J.
    • Proceedings of the KWS Conference
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    • 2009.11a
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    • pp.55-55
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    • 2009
  • FGB(Flexible Glasswool Backing) Submerged Arc Welding has been one of the main welding processes for one side butt welding in shipbuilding industries, which can efficiently improve the welding productivity by the addition of a supplementary filler metal into the molten weld pool. As recent ships have become larger in size, the application of high tensile and higher grade of steels has been continuously increased. Single pass FGB SA welding process accompanies such a high heat input when welding thick plates that the mechanical properties of weld metal can be dramatically degraded. This study has been performed in order to obtain high toughness and tensile properties of high heat input FGB SA welds, and to evaluate the effect of alloy elements on their mechanical properties. To complete welding 25mm-thick EH36 grade steel plate by single pass, 1.2mm diameter and 1.0mm long cut wires has been distributed in the groove before welding, and three different test coupons have been made using C-1.5%Mn, C-1.8%Mn-0.5%Mo, and C-1.4%Mn-1.7%Ni cut wires to investigate the influence of nickel(Ni) and molybdenum(Mo) on the mechanical properties of welds. Test results showed that the addition of Ni and Mo effectively promotes the formation of Acicular Ferrite(AF), while significantly reducing the amount of Grain Boundary Ferrite(GBF) in weld metal microstructures, which resulted in a beneficial effect on low temperature impact toughness and strength.

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반타원 표면균열의 피로성장 거동에 관한 연구

  • 최용식;양원호;방시항
    • Transactions of the Korean Society of Mechanical Engineers
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    • v.10 no.6
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    • pp.916-922
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    • 1986
  • This paper presents the preliminary results of an experimental study on surface crack growth under fatigue loadings. The objective of this paper is to assess the effect of the initial crack size on crack propagation behaviors. Transparent PMMA plate speciments with shallow circular arc notch were used. Crack growth behaviors were observed and measured in two directions by travelling microscopes. The fatigue crack initiated at the deepest part on the initial arc shaped notch and then propagated to depth direction as well as spreading gradually along the notch tip. A considerable number of cycles was needed until the depth crack spreaded to the surface notch tip. When the fatigue crack reached the surface notch tip the crack front became an approximate semi-ellipse, primary semi-elliptical crack. Test results suggest that the relationships between fatigue crack growth rate and stress intensity factor range in both directions can be expressed by power law (Paris) and that relationship in width direction depends upon the crack ratios a$_{1}$/b$_{1}$, of the primary semi-elliptical crack. The relationship between the nondimensional crack lengths in both directions can be represented as the formula: (a/t)$^{n}$ =B(2b/W+A) where n and A are constants and B is seems to be depended upon the crack ratio a$_{1}$/b$_{1}$.

Effect of Chlorine Dioxide Gas Application to Egg Surface: Microbial Reduction Effect, Quality of Eggs, and Hatchability

  • Chung, Hansung;Kim, Hyobi;Myeong, Donghoon;Kim, Seongjoon;Choe, Nong-Hoon
    • Food Science of Animal Resources
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    • v.38 no.3
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    • pp.487-497
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    • 2018
  • Controlling of microorganisms in the industrial process is important for production and distribution of hatching and table eggs. In the previous study, we reported that chlorine dioxide ($ClO_2$) gas of a proper concentration and humidity can significantly reduce the load of Salmonella spp. on eggshells. In this study, we compared microbial reduction efficacy on egg's surface using hatching eggs and table eggs, internal quality of table eggs, and hatchability after both the conventional method (washing and UV expose, fumigation with formalin) and $ClO_2$ gas disinfection. Application of 40 ppm $ClO_2$ gas to the table and hatching eggs, respectively, reduced the aerobic plate count (APC) with no statistical difference compared with the conventional methods. Additionally, we didn't observed that any significant difference in albumin height, Haugh unit (HU), and yolk color, this result confirms that 40 ppm $ClO_2$ had no effect on the internal quality of the table eggs, when comparing with the UV treatment method. The hatchability of hatching eggs was not statistical different between formaldehyde fumigation and 80 ppm $ClO_2$ gas treatment, though the value was decreased at high concentration of 160 ppm $ClO_2$ gas. From these results, we recommend that $ClO_2$ gas can be used as a safe disinfectant to effectively control egg surface microorganisms without affecting egg quality.

Design of a IMVA Single-Phase HTS Power Transformer

  • Kim, Sung-Hoon;Kim, Woo-Seok;Park, Chan-Bae;Hahn, Song-yop;Park, Kyeong-Dal;Joo, Hyeong-Gil;Hong, Gye-Won
    • Progress in Superconductivity
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    • v.4 no.1
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    • pp.86-89
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    • 2002
  • In this paper, the design of a IMVA single-phase high temperature superconducting(HTS) power transformer with BSCCO-2223 HTS tapes is presented. The rated voltages of each sides of the transformer are 22.9 ㎸ and 6.6 ㎸, respectively The winding of 1MVA HTS transformer is consisted of double pancake type HTS windings, which have advantages of insulation and distribution of high voltage, and are cooled by subcooled liquid nitrogen of 65K. Four HTS tapes were wound in parallel for the windings of low voltage side and the four parallel conductors are transposed. The design of 1MVA HTS transformer, a shell type core made of laminated silicon steel plate is chosen, and the core is separated with the windings by a cryostat with a room temperature bore. The cryostat made of non-magnetic and non-conducting material and a liquid nitrogen sub-cooling system is designed in order to maintain the coolant's temperature of 65K. For electromagnetic analysis of 1MVA HTS transformer, a finite element method of an axis of symmetry is used. The maximum perpendicular component of magnetic flux density of pancake windings is about 0.15T. And through analyzing the magnetic field distribution, an optimal winding arrangement of 1MVA HTS transformer is obtained.

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A Study on the Formation of Acicular Ferrite in HAZ of Ti-Oxide Steel (Ti 산화물강의 용접열영향부에서 Acicular Ferrite의 형성에 관한 연구)

  • Won, Hyeong-Min;Kim, Yong-Deok;Ha, Hyeon-Seung;Kim, Jun-Gi;Kim, Seon-Jin;Gang, Gye-Myeong
    • Korean Journal of Materials Research
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    • v.6 no.12
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    • pp.1221-1232
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    • 1996
  • 용접부 인성을 향상시키기 위해 Ti 산화물을 첨가한 Ti 산화물강에 대하여 용접시 최고가 열온도와 냉각속도의 변화가 용접열영향부의 미세조직에 미치는 영향을 조사하였다. 용접열영향부의 인성향상에 기여하는 acicular ferrite는 140$0^{\circ}C$ 이상의 최고가열온도와 $\Delta$t800-500가 40초보다 빠른 냉각속도에서 활발해 생성되었다. 오스테나이트 결정립내에서 개재물로부터 핵생성된 일차 acicular ferite의 생성량은 전체 aicular ferrite의 약 20% 정도로 적었으며 대부분의 acicular ferrite는 일차 acicular ferrite로부터 생성된 이차 acicular ferrite인 것으로 나타났다. 이차 acicular ferrite는 plate사이에 Fe3C층이 존재하는 것으로 보아 확산기구에 의해 생성되는 것으로 생각된다. 개재물은 TiO, TiO2, TiN, MnS, AI2O3 MnO(galaxite)등으로 구성된 복합상이었으며 개재물이 일차 acicular ferrite의 핵생성 site로 작용하기 위해서는 약 1$\mu\textrm{m}$이상의 크기가 효과적인 것으로 나타났다. Ti 산화물과 TiN는 직접적인 acicular ferrite의 핵생성 site로 작용하기보다는 MnS, galaxite 등의 석출 site로 작용하여 개재물의 크기를 증가시킴으로써 acicular ferrite의 생성을 촉진시키는 것으로 생각된다.

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Petrochemical Study on the Precambrian Granitic Rocks in the Basement Area of Hambaeg Basin (함백익지(咸白益地) 기반지역(基盤地域)에 분포(分布)하는 선(先)캠브리아 화강암질암류(花崗岩質岩類)의 암석화학적(岩石化學的) 연구(硏究))

  • Yun, Hyun Sao;Lee, Dai Sung
    • Economic and Environmental Geology
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    • v.19 no.1
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    • pp.35-55
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    • 1986
  • The area of this study is located in the Sang dong district, Youngwol Gun, Kangwon Do, where the Ogcheon fold belt comes into contact with the Ryongnam massif. The area is covered by the Precambrian metasedimentary rocks of Yulri Group in the south from the line of Ungyosan-Maebongsan-Jansan-Taebaegsan Mountains and by the Cambro-Ordovician sedimentary rocks of Choseon Supergroup in the north. The Choseon Supergroup unconformably overlies the Yulri group. Several granitic intrusives occur in the Precambrian and Cambro-Ordovician terrain. The purpose of this study is to clarify the geochronology, mineralogical composition, geochemical characteristics, petrogenesis and tectonic settings of the Precambrian granitic rocks, and to evaluate the P.T. conditions of granitic intrusions. The K/Ar ages obtained from the muscovite of Nonggeori Granite, Naedeogri granite and pegmatite intruded into the Yulri Group are Early Proterozoic ($1805{\pm}18Ma$ to $1642{\pm}23Ma$), and those from the migmatitic pegmatite are Late Carboniferous ($305{\pm}4Ma$), respectively. The Precambrian granitic rocks are characterized by the presence of muscovite, tourmaline and grey feldspar with faint lineation of mafic minerals. In terms of mineralogical and chemical composition, the granitic rocks are felsic, calc-alkalic, peraluminous and S-type (ilmenite-series). The geochemical characteristics of major and trace elements indicate that the granitic rocks belong to syn-collision setting at the compressional plate margin. They were formed by progressive melting of relatively homogeneous crustal materials under 1~3kb and $670^{\circ}{\sim}720^{\circ}C$ in aqueous fluid conditions, and the Naedeogri granite was more fractionated than the Nonggeori granite. During the Taebaeg disturbance, Nonggeori granite, Naedeogri granite and pegmatite were intruded and emplaced into the Yulri Group. Migmatitic pegmatite occurring in the southwestern area, however, gave much younger muscovite age than the pegmatite intruded into the Yulri Group in rest of the area did, that might be due to the regional metamorphism of the Post-Choseon disturbance. The Geodo granitic mass and the Imog granite were intruded during the Bulgugsa disturbance.

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A Study on the Stress Analysis and Parameters of Bucking in Spherical Shell (반 구형 각의 좌굴현상에 대한 응력해석 및 영향인자에 관한 연구)

  • Kim, Yeong-Su;An, Du-Seong
    • Journal of the Korean Society of Fisheries and Ocean Technology
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    • v.21 no.2
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    • pp.142-150
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    • 1985
  • In this paper, stress distribution were given in consideration of bending effects in hemi-spherical shell and a modified equation of buckling load was represented with implicating the effects of plastic deformations and shape parameters. Especially, the distributions of shell near it's vertex were analyzed numerically, according to several cases of loading. For the sake of more good estimation of plastic dissipating energy, we used the yield-line method from plate theory. The modified criterion of bucking, P super(*) sub(cr), that was suggested in this study, was applied to SUS 302 stain-less steel hemi-spherical shell which had it's Poisson's ratio and Young's modulus with 0.33 and 19700 kg/mm$^2$. From some experiments and comparisons with other results, 재 suggested the critical buckling-load-equation with P super(*) sub(cr)=2E super(*).(t super(2)/a super(2)).{3(1-ν super(*2)} and computed the buckling initiation load with this equation. Because these result from modified criterion have more coincidence than previous one, we prospect this equation can be magnified it's utilities to the other materials.

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