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Effects of GamiBangkeehwangkee-tang (fángjǐhuángqí-tāng) ethanol extract on Collagen-induced Rheumatoid Arthritis model of DBA/1 mice (가미방기황기탕(加味防己黃芪湯) 주정 추출물이 류마티스 관절염 동물병태모델에 미치는 영향)

  • Sim, Boo-Yong;Choi, Hak-Joo;Bak, Ji-Won;Kim, Dong-Hee
    • The Korea Journal of Herbology
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    • v.29 no.6
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    • pp.95-102
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    • 2014
  • Objectives : The purpose of this study is to prove the effect of GamiBangkeehwangkee-tang (f$\acute{a}$ngj$\check{i}$hu$\acute{a}$ngq$\acute{i}$-t$\bar{a}$ng, BHT) ethanol extract on the immunity and rheumatoid arthritis related inflammatory cytokines. Methods : We checked viability in RAW 264.7 cell after treat by BHT. Then we measured inflammatory and immunity factors of DBA/1 mice with rheumatoid arthritis induced by collagen after BHT oral administration. Also, we checked micro-CT image, bone volume and bone inflammation ratio in micro-CT and structural parameter test. Results : BHT showed cell viability of 95% or higher in all concentration in RAW 264.7 cells. BHT treated group decreased level in serum of IgM and IgG test by 36% and 25% respectively. And BHT treated group showed significant decrease in WBC, neutrophil, lymphocyte and monocytes immune cell ratio in blood by 47%, 22%, 56% and 85% respectively. Also, BHT treated group decreased level in serum of $IL-1{\beta}$, IL-6, IL-17, $TNF-{\alpha}$ and hs-CRP tests by 29%, 33%, 32%, 24% and 56% respectively. Finally, BHT treated group showed increase ratio of bone volume that decrease ratio of bone inflammation. Conclusions : In this study, the results were observed rheumatoid arthritis factors cytokine decrease in serum. And BHT showed immunoglobulin and immune cells ratio decrease in serum and blood. Also, BHT depending on effects of inflammatory and immunity in hs-CRP test, micro-CT, structural parameter test. Thus, these results can used as a effective drug of BHT for inflammation and immunity.

Effect of Kettle Bell Swing Exercise on the Body Composition and Lower Limb Muscular Activity

  • Jeong, Ho-Jin;Kim, Yong-Seong;Cho, Woon-Soo;Kim, Won-Gi;Kim, Yong-Beom;Kim, Yong-Nam
    • The Journal of Korean Physical Therapy
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    • v.29 no.4
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    • pp.194-200
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    • 2017
  • Purpose: This study examined the effect of Kettle bell swing exercise on the body composition and lower limb muscular activity. Methods: As subjects, 26 normal adults in their twenties were divided randomly into the experiment group (n=13), in which Kettle bell exercise was applied, and the control group (n=13), in which bar exercise was applied. Both groups participated in the interventions for eight weeks with three sessions per week. Each group was assessed before training and four and eight weeks into the training to determine the effects of training intervention within and between the groups. The body composition was measured with a body composition analyzer. The changes in muscle activity were measured with a surface electromyography. An independent t-test was conducted to test the significance between the groups according to the measurement points and Repeated measured ANOVA was performed to compare the groups according to the periods with the statistical significance level set to ${\alpha}=0.05$. Results: No significant changes to the main effects of time and the interactions of time according to the measurement points were observed in the Kettle bell and control groups in the body composition (p>0.05). The muscular activity of both muscles were significantly different between the Kettle bell and control groups according to the measurement points with the exception of the right lateral gastrocnemius muscle (p<0.05). Conclusion: These findings suggest that Kettle bell swing exercise can have positive effects on the development of lower limb muscles.

The Effects of Cement Alkalinity upon the Pore Water Alkalinity and the Chloride Threshold Level of Reinforcing Steel in Concrete

  • Nam Jingak;Hartt William H.;Kim Kijoon
    • Journal of the Korea Concrete Institute
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    • v.16 no.4 s.82
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    • pp.549-555
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    • 2004
  • Cement of three alkalinities (equivalent alkalinities of 0.36,0.52 and 0.97) was employed in fabricating a set of classical G109 type specimens. To-date, these have been subjected to a one week wet-one week dry cyclic pending using 15 w/o NaCl solution. At the end of the dry period, potential and macro-cell current were measured to indicate whether the top reinforcing steel was in the passive or active state. Once this bar became active, the specimen was autopsied and the extent of corrosion was documented. Subsequent to visual inspection, concrete powder samples were collected from the upper region of the top rebar trace; and at a certain times concrete cores were taken from non-reinforced specimens. Using these, determinations were made of (1) critical chloride concentration for corrosion initiation ($Cl_{th}^-$), (2) effective chloride diffusion coefficient ($D_e$), and (3) pore water alkalinity ($[OH^-]$). The pore water alkalinity was strongly related to the alkali content of cement that was used in the mix. The chloride concentration, ($Cl^-$), was greater at active than at passive sites, presumably as a consequence of electro migration and accumulation of these species at active site subsequent to corrosion initiation. Accordingly, ($Cl^-$) at passive sites was considered indicative of the threshold concentration fur corrosion initiation. The $Cl_{th}^-$ was increased with increasing Time-to-corrosion ($T_i$). Consequently, the HA(High Alkalinity) specimens exhibited the highest $Cl_{th}^-$ and the NA(Normal Alkalinity) was the least. This range exceeds what has previously been reported in North America. In addition, the effective diffusion coefficient, $D_e$, was about 40 percent lower for concrete prepared with the HA cement compared to the NA and LA(Low Alkalinity) ones.

Cyclic-Leading Tests of RC Exterior Beam-Column Joints with Non-Seismic Detailing (비내진 상세를 가진 RC 외부접합부의 반복 횡하중 실험)

  • Cha, Byung-Gi;Ko, Dong-Woo;Woo, Sung-Woo;Lee, Han-Seon
    • Journal of the Korea Concrete Institute
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    • v.15 no.1
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    • pp.11-16
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    • 2003
  • The objective of this study is to clarify the seismic capacity and the characteristics in the hysteretic behavior of RC structures with non-seismic detailing. To do this, an exterior beam-column subassemblage was selected from a ten story RC building and six 1/3-scale specimens were manufactured with three variables; (1) with and without slab, (2) upward and downward direction of anchorage for the bottom bar in beams, and (3) with and without hoop bars in the joint region. The test results have shown that (1) the existence of slab increased the strength in positive and negative moment, 25% and 52%, respectively; (2) the Korean practice of anchorage (downward and 25 $d_{b}$ anchorage length) caused the 8% reduction of strength and the early strength degradation in comparison with the case of seismic details; and (3) the existence of hoop bars in the joint region shows significant role in preventing the pull-out.t.

Manufacturing Ti-Alloy Frames of Classes with High-Precision Laser Beam Welding (초정밀 레이저용접을 이용한 티타늄 안경테 제조)

  • 황용화;김수성;이형권;민덕기;고진현
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.1 no.2
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    • pp.1-8
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    • 2000
  • An attempt was made to develop commercially pure titanium frames of glasses with a high-precision laser beam welding machine, in which a resonator with 12kw of the peak power and 200 W of maximum mean power has the capacity of variable in the range of 0.08~10 ms pulse width. In addition the optical fiber beam transmission with 400 ${\mu}{\textrm}{m}$ of the core diameter and a weld chamber to contain specimens in the inert gas atmosphere were also designed and used. In the present study. titanium frames of glasses parts such as temple plus spring hinge. bridge and top bar were experimentally manufactured by utilizing the optimum welding parameters with the optical fiber of GI 400 ${\mu}{\textrm}{m}$, 2.9J energy per pulse, and focussing position for Tee and butt joints. The titanium welded joints with laser beam welding did not reveal any severe weld defects or weld bead appearance except some pores in the weld section.

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Comparative Study of Microstructure and Tensile Properties of 600 and 700 MPa-Grade High-Strength Seismic Resistant Reinforced Steel Bars (내진용 600 및 700 MPa 급 고강도 철근의 미세조직과 인장 특성 비교)

  • Hong, T.W.;Lee, S.I.;Lee, J.H.;Shim, J.H.;Lee, M.G.;Hwang, B.
    • Transactions of Materials Processing
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    • v.27 no.5
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    • pp.281-288
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    • 2018
  • This study deals with the microstructure and tensile properties of 600 and 700 MPa-grade high-strength seismic reinforced steel bars. High-strength seismic resistant reinforced steel bars (SD 600S and SD 700S) were fabricated by TempCore process, especially the SD 700S specimen was more rapid cooled than the SD 600S specimen during the TempCore process. Although two specimens had microstructure of tempered martensite in the surface region, the SD 600S specimen had ferrite-degenerated pearlite in the center region, whereas the SD 700S specimen had bainite-ferrite-degenerated pearlite in the center region. Therefore, their hardness was highest in the surface region and revealed a tendency to decrease from the surface region to the center region because tempered martensite has higher hardness than ferrite-degenerated pearlite or bainite. The SD 700S specimen revealed higher hardness in the center region than SD 600S specimen because it contained a larger amount of bainite as well as ferrite-degenerated pearlite. On the other hand, tensile test results indicated the SD 600S and SD 700S specimens revealed continuous yielding behavior because of formation of degenerated pearlite or bainite in the center region. The SD 600S specimen had a little higher tensile-to-yield ratio because the presence of ferrite and degenerated pearlite in the center region and the lower fraction of tempered martensite enhance work hardening.

Effects of Bangkeehwangkee-tang ($f{\acute{a}}ngj{\check{i}}hu{\acute{a}}ngq{\acute{i}}-t{\bar{a}}ng$) Treatment on the Monosodium Iodoacetate-induced Osteoarthritis in Rats (방기황기탕이 Monosodium Iodoacetate로 유발된 흰쥐의 골관절염에 미치는 영향)

  • Kim, Dae-Hun;Kang, Sung-In;Song, Min-Yeong;Choi, Jin-Bong;Bae, Kil-Joon;Han, Jeong-Seok;Yang, Mi-Sung;Sin, Yong-Jeen
    • Journal of Korean Medicine Rehabilitation
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    • v.24 no.2
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    • pp.15-29
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    • 2014
  • Objectives We have studied to know effects of Bangkeehwangkee-tang on the monosodium iodoacetate (MIA) induced osteoarthritis in rats. Methods Osteoarthritis was induced by injection of monosodium iodoacetate into knee joint cavity of rats. Rats are devided into 4 groups; Sham, control, Bangkeehwangkee-tang, Shinbaro. Sham group was injected by normal saline into knee joint cavity only. Control group was taken no treatment and Experimental groups were taken extracts of Bangkeehwangkee-tang and Shinbaro by orally once a day for 4 weeks. The content of TNF-$\alpha$, IL- $1{\beta}$ and IL-6 in synovial fluids were analysed. COX-2 in chondrocytes and blood PGE2 concentration were analysed. Histopathological examination was performed by Safranin-O fast green staining and Mankins score checking. Results The content of TNF-$\alpha$, IL-$1{\beta}$ in experimental groups were decreased compared with control group. COX-2 in chondrocytes and blood PGE2 concentration in experimental groups were decreased compared with control group. Histopathologically, osteoarthritic scores of experimental groups were decreased compared with control group. But the content of IL-6 in synovial fluids was not significantly compared with control group. Conclusions According to these results, it can be suggested that Bangkeehwangkee-tang has anti-arthritic effects on the MIA induced osteoarthritis in rats.

An Experimental Study on Structural Performance of HRC Composite Beam according to types of Connection Plate with Stud Bolts (HRC 복합보의 연결플레이트 보강법에 따른 구조성능실험)

  • Lee, Soo-Kueon;Yang, Jae-Guen;Song, Chang-Seok;Jang, Eun-Young;Moon, Jun-Chul
    • Journal of Korean Society of Steel Construction
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    • v.23 no.3
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    • pp.377-384
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    • 2011
  • Recently, for the purpose of reducing work terms and improving performance for construction work, various methods in structure field were developed. This included the HRC system which is applicable to a typical structure (e.g., parking and office building). The HRC system introduced the Gerber Joint to raise structural efficiency and used connection plate to bolt HRC composite beam to H beam in the construction field. In this research, the experimental tests for six specimens, which were in the same field conditions, were conducted with several parameters such as the length and height of the connection plate and the number of stub bolts. The test result was compared with those made by current design codes for the deflection and strains of the main bar. Within the given load, the integration of concrete in beam and connection plate, welded with stud bolts, was verified.

Enhancing the Performance of High-Strength Concrete Corbels Using Steel Fibers and Headed Bars (강섬유 및 헤디드 바를 활용한 고강도 콘크리트 내민받침의 성능 향상)

  • Yang, Jun-Mo;Lee, Joo-Ha;Shin, Hyun-Oh;Yoon, Young-Soo
    • Journal of the Korea Concrete Institute
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    • v.21 no.6
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    • pp.697-703
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    • 2009
  • High-strength concrete corbels with varying percentage of steel fibers and two different anchorage types (welding to transverse bar, headed) for the main tension tie were constructed and tested. The results showed that performance in terms of load carrying capacities, stiffness, ductility, and crack width was improved, as the percentage of steel fibers was increased. In addition, the corbel specimens in which headed bars were used as the main tension tie reinforcements showed superior load carrying capacities, stiffness, and ductility compared to the corbel specimens in which the main tension ties were anchored by welding to the transverse bars. From the test results, it is expected that load carrying capacities, durability, and constructibility of high strength concrete corbels would be improved by using steel fibers and headed bars. Experimental results presented in this paper were also compared with various prediction models proposed by researchers and presented in codes. The truss model proposed by Fattuhi provides fairly good predictions for fiber reinforced high-strength concrete corbels.

An Experimental Study on the Mechanical Properties of Porous Concrete Using Coal Ash and Polymer (석회석 골재를 사용한 강섬유보강 포러스콘크리트의 강도특성에 관한 실험적 연구)

  • Lee, Byung-Jae;Park, Seong-Bum;Jang, Young-Il;Jeon, Heum-Jin;Lee, Taek-Woo
    • Proceedings of the Korea Concrete Institute Conference
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    • 2008.11a
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    • pp.685-688
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    • 2008
  • Concrete is strong on the compressive property, but weak on the tensile and flexural properties. To improve these problems, the reinforcing bar is used in concrete. But porous concrete with steel fiber has a weak point when exposed to air, because porous concrete has the vast continuous void on its inside and steel fiber is easily rusted by air. For these reasons, this study investigated the void ratio, compressive strength, bending strength and bending toughness as steel fiber mixing ratio and target void ratio. From test results, actual void ratio and strength properties increased as the mixing ratio of steel fiber increase. In case the mixing ratio of steel fiber over the fixed ratio, strength is decreased. And from the toughness evaluation, compared to the porous concrete which isn't mixed with steel fiber, the deflection variation efficiency is remarkably improved. Consequently we can confirm the possibility of porous concrete with steel fiber for the secondary product and pavement material to improve strength and bending resistance efficiency.

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