• Structural Engineering and Mechanics
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• 제16권4호
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• pp.423-440
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• 2003

Arbitrary Lagrangian Eulerian finite element methods gain interest for the capability to control mesh geometry independently from material geometry, the ALE methods are used to create a new undistorted mesh for the fluid domain. In this paper we use the ALE technique to solve fuel slosh problem. Fuel slosh is an important design consideration not only for the fuel tank, but also for the structure supporting the fuel tank. "Fuel slosh" can be generated by many ways: abrupt changes in acceleration (braking), as well as abrupt changes in direction (highway exit-ramp). Repetitive motion can also be involved if a "sloshing resonance" is generated. These sloshing events can in turn affect the overall performance of the parent structure. A finite element analysis method has been developed to analyze this complex event. A new ALE formulation for the fluid mesh has been developed to keep the fluid mesh integrity during the motion of the tank. This paper explains the analysis capabilities on a technical level. Following the explanation, the analysis capabilities are validated against theoretical using potential flow for calculating fuel slosh frequency.

• 약학회지
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• 제41권1호
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• pp.60-73
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• 1997

In order to design a 24 hr sustained release preparation of sulindac for oral administration, fast release pellet (FR), slow release pellet (SR) and two combined formulation (1 : 1 and 1 : 2) were prepared. The pharmacokinetic effect of such preparations has been evaluated using rabbits as a suitable in vivo model, and tested in man. Dose determination was carried out using curve fitting according to RSTPJP II program. In bioavailability test using rabbit, AUCs of sulindac in a few designed formulations were similar to each other. $C_{max}$- of RF and SR were 1.8 times and 1.2 times higher, respectively, compared to that of combined formulation (FR:SR=1:1). While plasma concentration of FR and SR decreased rapidly, that of combined formulation (FR:SR 1:1) lasted at the level close to $C_{max}$ for 24 hrs. Plasma concentration of sulfide form from the combined pellet(FR:SR=1:1) lasted for 24 hrs, and its AUC value was 1.4-fold, 2.7-fold. and 1.2-fold greater than FR pellet, SR pellet and combined pellet (FR:SR 1 : 2). Thus, the combined pellet of 1:1 ratio was found to be the most effective for oral sustained release formulation. Bioavailability test in human showed that AUC of sulfide from TSRP (1 : 1) was approximately 1.5 times greater than total AUC of Immbaron$^{\circledR}$ administered twice in a day. While $T_{max}$ of sulfide from lmmbaron$^{\circledR}$ was 4.33 +/- 1.37 hr (lst administration) and 3.33 ${pm}$ 0.82 hr (2nd administration), respectively, that of sulfide from TSRP increased to 7.17 ${pm}$ 2.86 hr. Plasma concentration of sulfide from TSRP was sustained at more, than 1.0 ${\mu}g{\cdot}$hr/ml until 24 hrs after one dose administration. In addition, TSRP may decrease local adverse reaction in the stomach, since plasma concentration of sulfide from the combined pellet was low within 2hrs in the stomach. In conclusion, it is suggested that TSRP formulation may be effective for oral 24 hr sustained release formulation of sulindac dosing 300 ~ 350mg once a day.

• 한국식물병리학회:학술대회논문집
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• 한국식물병리학회 2003년도 정기총회 및 추계학술발표회
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• pp.98.1-98
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• 2003

Antagonistic effect of bacterial strains isolated from phylloplane of strawberry plants grown In greenhouse was tested on Botrytis cinerea Among the promising bacterial strains, Bacillus sp. S1-0210 showed highest inhibition of mycelial growth of B. cinerea and a broad spectrum of antifungal activities against many plant pathogenic fungi in vitro. Bacillus sp. S1-0210 was identified as Bacillus subtilis based on the analysis of 185 rDNA as well as its biochemical characteristics. Application of wettable powder formulation of B. subtiiis S1-0210 significantly reduced the incidence of gray mold on trawberry fruits during storage. Results showed that treatment of B. subtilis S1-0210 decreased the incidence of gray mold by 4.8％ whereas the incidence in control was 77.9％, indicating that the formulation of B. subtilis S1-0210 will be practically applied on strawberry fruits as a biocontrol agent of gray mold during storage.

• Interaction and multiscale mechanics
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• 제6권2호
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• pp.237-255
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• 2013

In this paper, a meshfree-enriched finite element method (ME-FEM) is introduced for the large deformation analysis of nonlinear path-dependent problems involving contact. In linear ME-FEM, the element formulation is established by introducing a meshfree convex approximation into the linear triangular element in 2D and linear tetrahedron element in 3D along with an enriched meshfree node. In nonlinear formulation, the area-weighted smoothing scheme for deformation gradient is then developed in conjunction with the meshfree-enriched element interpolation functions to yield a discrete divergence-free property at the integration points, which is essential to enhance the stress calculation in the stage of plastic deformation. A modified variational formulation using the smoothed deformation gradient is developed for path-dependent material analysis. In the industrial metal forming problems, the mortar contact algorithm is implemented in the explicit formulation. Since the meshfree-enriched element shape functions are constructed using the meshfree convex approximation, they pose the desired Kronecker-delta property at the element edge thus requires no special treatments in the enforcement of essential boundary condition as well as the contact conditions. As a result, this approach can be easily incorporated into a conventional displacement-based finite element code. Two elasto-plastic problems are studied and the numerical results indicated that ME-FEM is capable of delivering a volumetric locking-free and pressure oscillation-free solutions for the large deformation problems in metal forming analysis.

• Structural Engineering and Mechanics
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• 제22권5호
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• pp.613-629
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• 2006

In this paper a recently developed scaled boundary finite element method (SBFEM) is applied to simulate stress concentration for two-dimensional structures. In addition, a simple and independent formulation for evaluating the coefficients, not only of the singular term but also higher order non-singular terms, of the stress fields near crack-tip is presented. The formulation is formed by comparing the displacement along the radial points ahead of the crack-tip with that of standard Williams' eigenfunction solution for the crack-tip. The validity of the formulation is examined by numerical examples with different geometries for a range of crack sizes. The results show good agreement with available solutions in literatures. Based on the results of the study, it is conformed that the proposed numerical method can be applied to simulate stress concentrations in both cracked and uncracked structure components more easily with relatively coarse and simple model than other computational methods.

• Archives of Pharmacal Research
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• 제17권2호
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• pp.80-86
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• 1994

The bioavailability of digoxin generic tablets manufactures in Korea (formulations A & B) wwere compared to a standard (formulation C; Lanoxin brand digoxin, Burroughs Wellcome, USA) in 12 healthy Korean male volunteers (mean age 31.4 years) in a single dose, randomized, complete block crossover study. Using a latin square design, each of the subjects was randomized to the order number and allocated to each of the three treatments of 0.5mg oral digoxin. Digoxin conc4ntrations in serum and urine samples collected for 48 hours after dosing were measured by fluoprescence polarization immunoassy and radioimmunoassy, respectively. Treatments were compared by using nonlinear least squares regession analysis to evaluate the following pharmacokinetic parameters : maximum serum concentation $(C_{max})$; time of maximum serum concentation $(T_{max})$; area under the serum concentration-time curve $AUC_{0-12}$, $C_{max}$\;and\;(AUC_{0-12})$; and cummulative urinary excretion for 0-48 hours $(CLE_{0-48}.\;Mean\;AUC_{0-12},\;C_{max},\;and\;CUE_{0-48}$ values for formulations B and C were significantly different from formulation A (P<0.001), but not significantly diffeerent form each other. Basede on $AUL_{0-12}\;and\;CUE_{0-48}$ respectively, the relative availability of formulation B was 87.5% and 89.6% and the relative availability of formultation A was 43% and 35% when compared to formulation C(the standard).

• 동의생리병리학회지
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• 제29권2호
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• pp.168-173
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• 2015

Bangpungtongseong-san(BPTSS, Fangfengtongsheng-san in Chineses) is a traditional herbal formula comprising 18 medicinal herbs. In the present study, we performed the simultaneous analysis for four compounds of BPTSS and examined anti-allergic effects in human keratinocytes and mouse splenocytes. The column for separation of four compounds was used Luna C18 column and maintained at 40℃. The mobile phase for gradient elution consisted of two solvent systems. The analysis was carried out at a flow rate of 1.0 mL/min with PDA detection at 254 and 280 nm. To evaluate production and expression of Th2 chemokines, ELISA and RT-PCR were conducted in tumor necrosis factor (TNF)-α and interferon (IFN)-γ-stimulated HaCaT cells with or without BPTSS or silymarin, a positive control for skin inflammation. To measure Th2 cytokines, primary mouse splenocytes were treated with BPTSS and performed ELISA for interleukin (IL)-4, 5, 13. Calibration curves were acquired with r2>0.9999. The contents of geniposide, liquiritin, baicalin, and glycyrrhizin in BPTSS were 5.06 ㎎/g, 7.33 ㎎/g, 27.56 ㎎/g, and 7.81 ㎎/g, respectively. BPTSS reduced TARC and RANTES production and mRNA expression in TNF-α and IFN-γ-treated HaCaT cells. BPTSS inhibited IL-4, 5, and 13 production in mouse splenocytes. Our data will be a helpful information to upgrade quality control and anti-allergic effects of BPTSS.

• 한국축산식품학회지
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• 제39권1호
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• pp.121-138
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• 2019

In the present study, comparative efficacy of natural as well as synthetic tenderizers on the quality characteristics of restructured spent hen meat slices (RSHS) was studied. Four different batches of RSHS viz. Control (without any tenderizer), T1 (1.25% calcium chloride replacing salt in formulation), T2 and T3 (1.5% each of pineapple rind and fig powder, replacing binder in the formulation) were developed in pre-standardized formulation. Vacuum tumbling was performed for 2.5 h and cooked product (RSHS) was assayed for quality attributes. Samples were packaged in aerobic conditions, stored for 21 days under refrigeration ($4{\pm}1^{\circ}C$) and were evaluated for pH, oxidative and microbial quality parameters at regular interval of 7 days. Water holding capacity of T2 was recorded the highest and significantly higher (p<0.05) than all other samples. The textural attributes of T2 were comparable to T1 but significantly higher (p<0.05) than C and T3. The colour attributes ($L^*$, $a^*$, and $b^*$ value) of T2 and T3 were improved due to use of natural tenderizers. During sensory evaluation, tenderness scores for T2 samples were recorded the highest. Throughout storage period, thiobarbituric acid reactive substances (TBARS), free fatty acids (FFA) and peroxide value (PV) followed an increasing trend for control as well as treated products; however, T2 showed a significantly (p<0.05) lower value than control and other treated samples. It can be concluded that good quality RSHS with better storage stability could be prepared by utilizing 1.5% pineapple rind powder as natural tenderizer.

• 한국버섯학회지
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• 제19권3호
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• pp.160-165
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• 2021

느티만가닥버섯 '햇살' 품종에 대한 봉지재배 안정생산 재배기술을 개발하기 위하여 포플러(미루나무) 톱밥을 주배지로 하고 밀기울, 미강, 건비지, 면실박, 팜커널등 5종의 영양원배지 재료를 혼합하여 배지를 조성하여 재배시험을 수행하였다. 배지혼합 전 재료들에 대한 열수추출 배지들에 대한 버섯균사 생장은 팜커널에서 가장 우수하였으며 균사밀도의 경우 포플러배지를 제외하고 모두 우수하였다. 조성배지들에 대한 버섯발생 안정성, 재배기간, 수량성을 기준으로 조사한 결과 포플러톱밥, 밀기울, 미강, 건비지, 팜커널이 55:15:20:5:65(v/v) 수준으로 조합된 T6배지에서 생육기간이 단축되고 수량이 높아 봉지재배에 적합한 배지로 선발하였다. 선발배지에 대한 균사배양 완료기간은 38.0일로 대조로 이용된 T1배지에 비하여 1.7일 더 소요되었다. 그러나 균긁기 이후 수확시까지 소요되는 기간은 18.0일로 대조배지(T1)를 이용한 재배기간보다 1.0일 단축됨에 따라 총 재배기간은 68.0일이 소요되었다. 선발배지에 대한 수량은 144.7 g으로 대조배지(T1) 수량 112.5 g보다 약 28.6%가 증가되었다. 이상의 연구결과를 통해 느티만가닥버섯 '햇살' 품종의 봉지재배 적합배지로 포플러톱밥, 밀기울, 미강, 건비지, 팜커널이 55:15:20:5:5(v/v) 비율로 혼합된 배지조성을 선발하였다. 선발배지에 대한 이화학적 특성으로 수분함량은 60.8%, pH 6.0, 전질소 함량은 0.83% 수준이었다.

• 한국식품과학회지
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• 제25권5호
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• pp.481-486
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• 1993

본 연구는 유화형 소시지 제조시 전보에서 분석된 원료육의 성분과 기능성 자료를 데이타베이스로 하여, 컴퓨터를 이용한 최소가격배합을 자성하여 그 적용의 실례를 들고 제한조건의 하나로 설정된, 결착지수의 부합도를 실제 제품제조를 통해 검토한 후 적정 결착지수 제한조건을 찾기 위하여 실시하였다. 결착지수 제한조건을 달리하여 최소가격배합비로 제조한 프랑크푸르터소시지의 실측 결착성을 측정한 결과 예측치와 일치하지는 않았으나 비례하여 나타났으며, 일치하지 않은 이유는 결착지수가 모형시스템에 의해서 구해진 관계로 실제 제조공정과 조건이 다른 것으로 사려된다. 또한 조직감 분석대상들을 결착지수와 비교했을 때 소시지의 조직감을 표현하는 바람직한 지표로서 cohesiveness와 함께 hardness를 동시에 고려할 필요가 있었다. 시중 제품의 결착성과 경도를 고려하여 볼 때 본 연구의 결착지수 제한조건은 $0.16{\sim}0.17$로 설정될 수 있었다.