• Journal of Life Science
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• v.19 no.3
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• pp.362-365
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• 2009

Type 2 diabetes is a typical polygenic disease complex, for which several common risk alleles have been identified. The hepatocyte nuclear factor-$4{\alpha}$ (HNF-$4{\alpha}$), a transcription factor involved in the regulation of serum lipid and glucose levels, has recently been associated with type 2 diabetes. Therefore, we investigated the genotype for the C>T polymorphism at position 12352 of the HNF-$4{\alpha}$ gene in Koreans and compared patient genotypes with those of the control group. 100 patients (63 males, 37 females) with a history of type 2 diabetes (T2DM) and 100 controls (36 males, 64 females) participated in this study. There was no association between 12352 C>T polymorphism in the HNF-$4{\alpha}$ gene and T2DM. The present study shows that HNF-$4{\alpha}$ 12352 C>T polymorphism may not be associated with the pathogenesis of T2DM. Further studies with larger populations may be needed for the development of diagnostic methods at a genetic level such as DNA chip.

• Childhood Kidney Diseases
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• v.13 no.2
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• pp.242-247
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• 2009

Type 1 diabetes mellitus (T1DM) commonly occurs in childhood and adolescence and diabetic nephropathy is a serious metabolic complication of T1DM that leads to serious morbidity. With poor glycemic control prepubertal diabetes duration contributes to the risk of long-term microvascular complications, however, the younger age at onset or longer prepubertal diabetes duration seems to prolong the time to development of microalbuminuria or later end-stage renal disease (ESRD). Therefore, there have been a few cases of diabetic nephropathy in prepubertal patients and therefore the ESRD cases developed during adolescence in T1DM children were very rare. Here we report an adolescent with T1DM who had poor glycemic control and was diagnosed as diabetic nephropathy in a prepubertal period and leading to end-stage renal disease during adolescence.

• Journal of The Korean Society of Inherited Metabolic disease
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• v.14 no.2
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• pp.168-173
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• 2014

Vascular Ehlers-Danlos syndrome (vEDS) is an autosomal dominant disorder caused by a mutation of the type III collagen (COL3A1). The manifestation of vEDS can be seen in skin, joints, blood vessels, and internal organs. The diagnosis of vEDS often is missed until the patient presents with a life-threatening complication such as spontaneous arterial rupture or bowel perforation. We report a 16-year-old male who had recurrent right thigh hematoma after simple exercise and minor trauma, respectively. He had a history of surgery due to spontaneous colon perforation at his age of 11 years. Gene test of COL3A1 revealed a novel mutation c.2931+dupT.

• Journal of the Korean Society of Fisheries and Ocean Technology
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• v.9 no.1
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• pp.1-18
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• 1973

For regulating the depth of midwater trawl nets towed at the optimum constant speed, the changes in the shape of warps caused by adding a weight on an arbitrary point of the warp of catenary shape is studied. The shape of a warp may be approximated by a catenary. The resultant inferences under this assumption were experimented. Accordingly feasibilities for the application of the result of this study to the midwater trawl nets were also discussed. A series of experiments for basic midwater trawl gear models in water tank and a couple of experiments of a commercial scale gears at sea which involve the properly designed depth control devices having a variable attitude horizontal wing were carried out. The results are summarized as follows: 1. According to the dimension analysis the depth y of a midwater trawl net is introduced by $$y=kLf(\frac{W_r}{R_r},\;\frac{W_o}{R_o},\;\frac{W_n}{R_n})$$) where k is a constant, L the warp length, f the function, and $W_r,\;W_o$ and $W_n$ the apparent weights of warp, otter board and the net, respectively, 2. When a boat is towing a body of apparent weight $W_n$ and its drag $D_n$ by means of a warp whose length L and apparent weight $W_r$ per unit length, the depth y of the body is given by the following equation, provided that the shape of a warp is a catenary and drag of the warp is neglected in comparison with the drag of the body: $$y=\frac{1}{W_r}\{\sqrt{{D_n^2}+{(W_n+W_rL)^2}}-\sqrt{{D_n^2+W_n}^2\}$$ 3. The changes ${\Delta}y$ of the depth of the midwater trawl net caused by changing the warp length or adding a weight ${\Delta}W_n$_n to the net, are given by the following equations: $${\Delta}y{\approx}\frac{W_n+W_{r}L}{\sqrt{D_n^2+(W_n+W_{r}L)^2}}{\Delta}L$$ $${\Delta}y{\approx}\frac{1}{W_r}\{\frac{W_n+W_rL}{\sqrt{D_n^2+(W_n+W_{r}L)^2}}-{\frac{W_n}{\sqrt{D_n^2+W_n^2}}\}{\Delta}W_n$$ 4. A change ${\Delta}y$ of the depth of the midwater trawl net by adding a weight $W_s$ to an arbitrary point of the warp takes an equation of the form $${\Delta}y=\frac{1}{W_r}\{(T_{ur}'-T_{ur})-T_u'-T_u)\}$$ Where $$T_{ur}^l=\sqrt{T_u^2+(W_s+W_{r}L)^2+2T_u(W_s+W_{r}L)sin{\theta}_u$$ $$T_{ur}=\sqrt{T_u^2+(W_{r}L)^2+2T_uW_{r}L\;sin{\theta}_u$$ $$T_{u}^l=\sqrt{T_u^2+W_s^2+2T_uW_{s}\;sin{\theta}_u$$ and $T_u$ represents the tension at the point on the warp, ${\theta}_u$ the angle between the direction of $T_u$ and horizontal axis, $T_u^2$ the tension at that point when a weights $W_s$ adds to the point where $T_u$ is acted on. 5. If otter boards were constructed lighter and adequate weights were added at their bottom to stabilize them, even they were the same shapes as those of bottom trawls, they were definitely applicable to the midwater trawl gears as the result of the experiments. 6. As the results of water tank tests the relationship between net height of H cm velocity of v m/sec, and that between hydrodynamic resistance of R kg and the velocity of a model net as shown in figure 6 are respectively given by $$H=8+\frac{10}{0.4+v}$$ $$R=3+9v^2$$ 7. It was found that the cross-wing type depth control devices were more stable in operation than that of the H-wing type as the results of the experiments at sea. 8. The hydrodynamic resistance of the net gear in midwater trawling is so large, and regarded as nearly the drag, that sweeping depth of the gear was very stable in spite of types of the depth control devices. 9. An area of the horizontal wing of the H-wing type depth control device was $1.2{\times}2.4m^2$. A midwater trawl net of 2 ton hydrodynamic resistance was connected to the devices and towed with the velocity of 2.3 kts. Under these conditions the depth change of about 20m of the trawl net was obtained by controlling an angle or attack of $30^{\circ}$.

• Proceedings of the Korean Institute of Navigation and Port Research Conference
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• 2018.05a
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• pp.104-105
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• 2018

해사안전정보(MSI)는 항행경보, 기상특보, 안전관련 긴급 정보로 구성되어 NAVTEX와 SafetyNet 체계를 통해 서비스되고 있으며, 서비스 개선을 위한 요구사항으로 해사안전정보의 필터링과 전자해도 시스템과의 연계 방안이 제시된 바 있다. 국제해사기구의 e-Navigation 전략이행계획의 해사서비스목록(MSP)으로 해사안전정보 서비스(MSP5)가 포함되었고, 국내외 e-Navigation 프로젝트에서는 국제표준에 기반한 해사안전정보 서비스 개발이 진행 중에 있다. 본 연구에서는 한국형 e-Navigation 사업의 중점 서비스로 개발 중인 S-124 표준기반 해사안전정보 서비스 기술 개발 배경과 주요 내용을 소개 한다. S-124는 항행경보와 T&P 항행경보를 포함하는 표준으로, 본 연구에서는 S-124 데이터 모델에 기반 하여 한국형 e-Navigation의 서비스 플랫폼인 MCP(Maritime Cloud Platform)를 통한 서비스 프로토타입 개발 결과를 기술 하였다.

• Journal of the Microelectronics and Packaging Society
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• v.11 no.1
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• pp.29-36
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• 2004

A flexible packaging scheme, which includes chip packaging, has been developed using a thinned silicon chip. Mechanical characteristics of thinned silicon chips are examined by bending tests and finite element analysis. Thinned silicon chips (t<30 $\mu\textrm{m}$) are fabricated by chemical etching process to avoid possible surface damages on them. And the chips are stacked directly on $Kapton^{Kapton}$film by thermal compressive bonding. The low height difference between the thinned silicon chip and $Kapton^{Kapton}$film allows electroplating for electrical interconnection method. Because the 'Chip' is embedded in the flexible substrate, higher packaging density and wearability can be achieved by maximized usable packaging area.

• Journal of Korea Foundry Society
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• v.19 no.6
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• pp.451-455
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• 1999

펩셀주형을 사용하여 한 주형내에 두께가 20, 26, 32 및 38 mm인 4 종류의 T 형 시편을 배치시킨 후 구상흑연주철을 제조하였으며 이로부터 구상흑연립의 수, 페라이트의 함량, 브린넬경도 및 내부결함의 발생위치를 측정하였다. 시편의 상부를 절단한 후 8 위치에서 경도를 측정하였으며 역시 같은 위치에서 구상흑연립의 수 및 페라이트함량을 측정하였다. 압탕의 경우 응고후 급탕효과를 관찰하기위하여 X-선찰영을 하였는 바 시편의 두께가 20 mm에서 38 mm로 갈수록 압탕으로부터의 급탕이 원활하게 이루어졌음을 알 수 있었다. 또한 시편내부의 응고수축결함의 발생을 관찰하기 위하여 절단한 결과 20 및 26 mm의 두께에는 응고수축결함이 T 형시편의 연결부에 발생한 반면 32 및 38 mm에는 발생되지 않았다. 위에서 얻어진 실험적인 데이터는 구상흑연주철의 모델링을 검증하는 벤치마크의 연구로 유용하게 사용될 것이다.

• Resources Recycling
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• v.9 no.4
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• pp.56-62
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• 2000

This study was introduced an amalgamated septic tank system using mineral sintered body was made from non-metallic minerals with a ability being attached or accelerating a vitality of soil microorganism for the effective wastewater treatment. Experimentally, we made an amalgamated septic tank appling anaerobic-aerobic process experimental facilities to two personal houses for handling a residental sewage directly on a small scale from the place of origin. The results are shown as follows; The COD\ulcorner and BOD of effluent were about 10 mg/l after the treatments and T-N removal efficiency was 60-70%. Moreover these results suggested the possibility of denitrification without adding organics and more than 80% of T-P removal also showed the possibility of wastewater treatment biologically.

• Journal of Navigation and Port Research
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• v.31 no.3 s.119
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• pp.197-204
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• 2007

Busan Port has been facing critical situation in terms of container handling volume, especially growth rate of transshipment(T/S) container of the year of 2006 was at a standstill. Annual average growth rate of T/S container during the period of 2003 to 2006 slowed down to 7.7% while it recorded over 34% to the period of 1999 to 2002. It has mainly resulted from the change of circumstance of Northeast Asian ports, that is, firstly mega carriers' increasing direct call to Northern Chinese ports such as Qingdao, Tianjin and Dairen effected to T/S container volume of Busan port, secondly start to operate deep-water port of Shanghai, thirdly Japanese super hub port project to handle their local containers at domestic ports. This paper aims to analyze the T/S type of inter-routes and hub and spoke and statistical status of Busan port. The purpose of the paper is to propose new concept which is to attract T/S container utilizing hub port function of Busan port in Northeast Asia It is that mega carriers are given dedicated terminals to use Busan port as T/S base in the region.

• Parasites, Hosts and Diseases
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• v.35 no.3
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• pp.155-164
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• 1997

Studies were conducted from May, 1993 to April, 1995 to determine the changing patterns of infection Ity the liver fluke, Clonorchis sinensis, among residents and fish hosts in Kyongbuk Province. The infection rate among residents was 7.7% by stool examination. The rate in males (11.3%) was significantly higher than females (4.1%) Positive rate of intradermal test was 27.6% in the same population. The special type of a simple catalytic model was applied for the analysis of intradermal positive reactors by age arid sex, ann the equation was Y= 0.4776 t (1 -e-0.0375t) for mates ann, y : 0.2085 (1-e-0.0138t) for females. Analysis of stool examination data by two-stage catalytic model revealed y : 0.025 (e-0.0047t _ e-0.0235t). The annual Clonorchis infection rate was 4.7 per 1,000 susceptibles and the annual loss rate was 23.5 per 1,000 infected. The frequency distribution by the eggs per gram (EPG) was calculated as well as the cumulative percentages of positives. The regression equations were y : 0.929+ 1.506 log x for males and, y : 0.473 + 1.767 log x for females. Of the 25 fish species, 7 species were infected with Clonorchis mrtacercariae. Infection rates varied by the species, and ranged from 2.8% in Punfun,Bia herzi to 30.0% in Pseudorasbora panic. Average number of the matacercariae per gram of flesh was 58.1 in p. pnnpa, followed by 10.2 in Gncthopogon atromoculntus, 7.0 in Saurosobio dobryj, and 3.0 in Pcrccheilogncthus rhonlben. The present study indicates that clonorchiasis in Kyongbuk Province is less prevalent than that of several decades ago.