• Journal of Korean Biological Nursing Science
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• 제14권2호
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• pp.129-138
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• 2012

Purpose: Cachexia is a complex metabolic syndrome associated with wasting of skeletal muscle which contributes to nearly one-third of all cancer deaths. Cachexia lowers the frequency of response to chemotherapy and radiation and ultimately can impact survival as well as quality of life during treatment. NF-kappa B is one of the most important molecular mediators of cachexia. In this study, therefore, possible candidates for inhibitors of NF-kappa B were searched. Methods: Amino acids that regulate cellular redox potential by adjusting the level of NAD/NADH ratio, such as aspartate, pyruvate, and isocitrate were selected. Results: Pyruvate effectively inhibited luciferase activity in TNF-stimulated 293T cells transfect with an NF-kB dependent luciferase reporter vector. Pyruvate also showed protective effect on muscle atrophy of differentiated C2C12 myocyte induced by TNF/IFN. Conclusion: We might be able to develop the nutritional management strategy for cancer cachexia patients with pyruvate supplementation.

• 한국통신학회논문지
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• 제36권2A호
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• pp.172-178
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• 2011

본 논문은 차세대 유럽형 디지털 지상파 시스템으로 알려진 DVB-T2 시스템의 BICM(Bit Interleaved Coded and Modualtion) 모듈의 FER(frame error rate) 및 BER (bit error rate)성능을 전산 실험을 통해 분석하였다. AWGN 채널, flat 페이딩 Rayleigh 채널 및 15% erasure 채널에서 ETSI EN 302 555 표준에 따라 제작된 full 시뮬레이터를 통해 실험을 하였으며, 수신 모듈은 디매퍼가 LDPC 채널 디코더로부터 전달되는 apriori 정보를 이용하여 LLR(log likelihood ratio) 값을 계산하는 iterative demapping decoder (IDD) 기술을 적용하였다. 또한 DVB-T2 시스템에서 선택적으로 사용할 수 있는 성상회전(rotated constellation) 기술의 성능도 비교하였다. 실험 결과 flat 페이딩 Rayleigh 채널에서 성상회전을 사용할 경우, 사용하지 않은 시스템에 비해서 $FER=10^{-4}$에서 약 0.5dB 정도의 Eb/No[dB]의 이득을 얻을 수 있으며, 성상회전과 IDD를 동시에 적용할 경우, 1.2 dB 정도의 Eb/No[dB]의 이득을 얻을 수 있음을 확인할 수 있었다. 또 15% erasure가 있는 채널에서는 성상회전을 적용할 때 $BER=10^{-4}$ 지점에서 대략 5dB 정도의 Eb/No[dB]의 이득을 얻을 수 있으며, IDD를 적용할 경우 추가적인 3dB의 이득이 있음을 확인할 수 있었다.

• Journal of Magnetics
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• 제11권1호
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• pp.25-29
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• 2006

Recent experiments have demonstrated high TMR ratios in MTJs with the MgO barrier [1,2]. The CoFeB/MgO/CoFeB junctions showed better properties than the CoFe/MgO/CoFe junctions because the MgO layer had a good crystalline structure with (001) texture and smooth and sharp interface between CoFeB/MgO [3]. The amorphous CoFeB with 20 at%B starts the crystallization at $340^{\circ}C$ [4] and this crystallization of the CoFeB helps obtaining the high TMR ratio. In this work, the compositional changes in the MgO barrier and at the interface of CoFeB/MgO/CoFeB after the CoFeB crystallization were studied in annealed MTJs. XPS depth profiles were utilized. TEM analyses showed that the MgO barrier had (100) texture on CoFeB in the junctions. B in the bottom CoFeB layer diffused into the MgO barrier and B-oxide was formed at the interface of CoFeB/MgO/CoFeB after the CoFeB crystallization.

• 대한전자공학회논문지TC
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• 제41권10호
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• pp.103-108
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• 2004

본 논문에서는 크로스 개구결합 급전 구조의 소형 GPS 단말기용 안테나를 소형화하기 위해 대칭적인 4개의 T-슬릿이 방사 패치에 부설되었다. 부설된 슬릿 주위에 표면 전류 경로의 증가는 등가적인 인덕턴스 성분을 유기하고 공진형 안테나의 저차 모드의 공진 주파수를 낮추어 안테나의 소형화 특성을 개선함을 확인하였다 슬릿 부설에 따른 공진 주파수는 2.545GHz에서 1.575GHz로 약 44.65%까지 감소시킬 수 있었으며, 안테나 소형화를 위해 부설된 슬릿이 원편파 기본 동작 모드에 미치는 영향을 법선 전기장 성분을 통해 확인하였다. 측정된 안테나의 임피던스 대역폭(VSWR≤2)과 3dB 축비 대역폭은 21MHz와 19MHz로 양호한 특성을 나타내었다.

• 한국안전학회지
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• 제13권4호
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• pp.79-86
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• 1998

The effect of specimen thickness on fatigue crack growth behavior has been carried out by compact tension specimens of thickness of 3mm, 10mm and 25mm for maraging steel and Al 7075-T6. The closure points were determined during the test by means of a clip-gage situated at the notch mouth. Specimen thickness have no apparent influence on the fatigue crack growth rate of maraging steel, but the crack growth rate of 25mm thickness specimen for Al 7075-T6 is faster than that of 3 and 10mm specimens. The difference of crack growth rates can be successfully explained by considering the different stress state of plane strain and plain stress due to the variation of specimen thickness. Also the crack opening ratio of 25mm specimen is greater than those of 3 and 10mm specimens. When a side groove is introduced in a 10mm specimen, the crack growth rate is approximately similar to that of 25mm specimen. The effective thickness expression of $B_e=B_o-(B_o-B_N)^2B_o$ is the most appropriate to evaluate the crack growth rate of side-grooved specimen. Fatigue crack growth rates can be well described by $\Delta K_{eff}$ of the crack closure points in regardless of all thickness and side-grooved specimens.

• Journal of Audiology & Otology
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• 제23권4호
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• pp.181-186
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• 2019

Background and Objectives: This study compared the perception of mono-syllabic and bisyllabic words in Tamil by young normal hearing adults in the presence of multi-talker speech babble at two signal-to-noise ratios (SNRs). Further for this comparison, a speech perception in noise test was constructed using existing mono-syllabic and bi-syllabic word lists in Tamil. Subjects and Methods: A total of 30 participants with normal hearing in the age range of 18 to 25 years participated in the study. Speech-in-noise test in Tamil (SPIN-T) constructed using mono-syllabic and bi-syllabic words in Tamil was used as stimuli. The stimuli were presented in the background of multi-talker speech babble at two SNRs (0 dB and +10 dB SNR). Results: The effect of noise on SPIN-T varied with SNR. All the participants performed better at +10 dB SNR, the higher of the two SNRs considered. Additionally, at +10 dB SNR performance did not vary significantly for neither mono-syllabic or bi-syllabic words. However, a significant difference existed at 0 dB SNR. Conclusions: The current study indicated that higher SNR leads to better performance. In addition, bi-syllabic words were identified with minimal errors compared to mono-syllabic words. Spectral cues were the most affected in the presence of noise leading to more of place of articulation errors for both mono-syllabic and bi-syllabic words.

• 대한청각학회지
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• 제23권4호
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• pp.181-186
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• 2019

Background and Objectives: This study compared the perception of mono-syllabic and bisyllabic words in Tamil by young normal hearing adults in the presence of multi-talker speech babble at two signal-to-noise ratios (SNRs). Further for this comparison, a speech perception in noise test was constructed using existing mono-syllabic and bi-syllabic word lists in Tamil. Subjects and Methods: A total of 30 participants with normal hearing in the age range of 18 to 25 years participated in the study. Speech-in-noise test in Tamil (SPIN-T) constructed using mono-syllabic and bi-syllabic words in Tamil was used as stimuli. The stimuli were presented in the background of multi-talker speech babble at two SNRs (0 dB and +10 dB SNR). Results: The effect of noise on SPIN-T varied with SNR. All the participants performed better at +10 dB SNR, the higher of the two SNRs considered. Additionally, at +10 dB SNR performance did not vary significantly for neither mono-syllabic or bi-syllabic words. However, a significant difference existed at 0 dB SNR. Conclusions: The current study indicated that higher SNR leads to better performance. In addition, bi-syllabic words were identified with minimal errors compared to mono-syllabic words. Spectral cues were the most affected in the presence of noise leading to more of place of articulation errors for both mono-syllabic and bi-syllabic words.

• Nutrition Research and Practice
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• 제1권4호
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• pp.363-370
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• 2007

Single nucleotide polymorphism (SNP) in adiponectin gene has been associated with insulin resistance, diabetes, and cardiovascular disease (CVD). This study was performed to investigate the association of SNP 276G${\rightarrow}$T at adiponectin gene with CVD risk factors in Korean type 2 diabetes mellitus (DM) patients. The subjects were 351 type 2 DM patients visited a DM clinic in Seoul, and the patients with known CVD were excluded. The adiponectin SNP 276G${\rightarrow}$T was analyzed and dietary intakes were assessed by a Food Frequency Questionnaire. The prevalence of G/G, G/T, and T/T genotype was 47.6%, 43.3%, and 9.1%, respectively. Male subjects with T/T genotype showed significantly lower level of adiponectin and HDL-cholesterol and significantly higher C-reactive protein (CRP) level compared to G/G and G/T genotypes. In G/G genotype, protein intake was negatively correlated to body weight, BMI, and waist circumference, and there were positive correlation between carbohydrate intake and BMI, waist-hip ratio, and ApoB/apoA-1 ratio in G/T genotype. However, in T/T genotype, there was no significant association between macronutrient intakes and anthropometric and hematological values. In conclusion, CVD risk would be high in type 2 DM patients with T/T genotype, and the association of macronutrient intakes with anthropometric and hematologic factors was different among the three adiponectin genotypes. These results may imply the need for different dietary management regime according to adiponectin genotype to lower CVD complications in Korean type 2 DM patients.

• 한국막학회:학술대회논문집
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• 한국막학회 2004년도 Proceedings of the second conference of aseanian membrane society
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• pp.55-58
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• 2004

Cell separation from peripheral blood was investigated using surface-modified polyurethane (PU) membranes with different functional groups. Both red blood cells and platelets could pass through unmodified PU and PU-SO$_3$H membranes, while the red blood cells preferentially passed through PU-N(C$_2$H$_{5}$ )$_2$ and PU-NHC$_2$H$_4$OH membranes. The permeation ratio of T and B cells was less than 25% for the surface-modified and unmodified PU membranes. CD34$^{+}$ cells have been recognized as various kinds of stem cells including hematopoietic and mesenchymal stem cells. The adhesiveness of CD34$^{+}$ cells on the PU membranes was found to be higher than that of red blood cells, platelets, T cells or B cells. Overall, the adhesiveness of blood cells on the PU membranes increased in the following order: red blood cells $\leq$ platelets ＜ T cells $\leq$ B cells ＜ CD34$^{+}$ cells. Treatment of PU-COOH membranes with a human albumin solution to detach adhered blood cells, allowed recovery of mainly CD34$^{+}$ cells in the permeate, while both red blood cells and platelets could be isolated in the permeate using unmodified PU membranes. The PU membranes showed different permeation and recovery ratios of specific cells depending on the functional groups attached to the membranes.mbranes.

• Steel and Composite Structures
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• 제38권6호
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• pp.617-635
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• 2021

This paper numerically investigated the behavior of built-up square concrete-filled steel tubular (CFST) columns under combined preload and axial compression. The finite element (FE) models of target columns were verified in terms of failure mode, axial load-deformation curve and ultimate strength. A full-range analysis on the axial load-deformation response as well as the interaction behavior was conducted to reveal the composite mechanism. The parametric study was performed to investigate the influences of material strengths and geometric sizes. Subsequently, influence of construction preload on the full-range behavior and confinement effect was investigated. Numerical results indicate that the axial load-deformation curve can be divided into four working stages where the contact pressure of curling rib arc gradually disappears as the steel tube buckles; increasing width-to-thickness (B/t) ratio can enhance the strength enhancement index (e.g., an increment of 1.88% from B/t=40 to B/t=100), though ultimate strength and ductility are decreased; stiffener length and lip inclination angle display a slight influence on strength enhancement index and ductility; construction preload can degrade the plastic deformation capacity and postpone the origin appearance of contact pressure, thus making a decrease of 14.81%~27.23% in ductility. Finally, a revised equation for determining strain εscy corresponding to ultimate strength was proposed to evaluate the plastic deformation capacity of built-up square CFST columns.