• Journal of Ginseng Research
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• v.46 no.3
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• pp.348-356
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• 2022

Background: Gintonin is a ginseng-derived exogenous G-protein-coupled lysophosphatidic acid (LPA) receptor ligand. Gintonin exerts its neuronal and non-neuronal in vitro and in vivo effects through LPA receptor subtypes. However, it is unknown whether gintonin can bind to the plasma membrane of cells and can transactivate the epidermal growth factor (EGF) receptor. In the present study, we examined whether gintonin-biotin conjugates directly bound to LPA receptors and transactivated the EGF receptor. Methods: We designed gintonin-biotin conjugates through gintonin biotinylation and examined whether gintonin-biotin conjugate binding sites co-localized with the LPA receptor subtype binding sites. We further examined whether gintonin-biotin transactivated the EGF receptor via LPA receptor regulation via phosphor-EGF and cell migration assays. Results: Gintonin-biotin conjugates elicit [Ca²⁺]_i transient similar to that observed with unbiotinylated gintonin in cultured PC3 cells, suggesting that biotinylation does not affect physiological activity of gintonin. We proved that gintonin-biotin conjugate binding sites co-localized with the LPA1/6 receptor binding sites. Gintonin-biotin binding to the LPA1 receptor transactivates the epidermal growth factor (EGF) receptor through phosphorylation, while the LPA1/3 receptor antagonist, Ki16425, blocked phosphorylation of the EGF receptor. Additionally, an EGF receptor inhibitor AG1478 blocked gintonin-biotin conjugate-mediated cell migration. Conclusions: We observed the binding between ginseng-derived gintonin and the plasma membrane target proteins corresponding to the LPA1/6 receptor subtypes. Moreover, gintonin transactivated EGF receptors via LPA receptor regulation. Our results suggest that gintonin directly binds to the LPA receptor subtypes and transactivates the EGF receptor. It may explain the molecular basis of ginseng physiology/pharmacology in biological systems.

• Journal of the Korean Society of Surveying, Geodesy, Photogrammetry and Cartography
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• v.40 no.4
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• pp.333-342
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• 2022

This paper has theoretically and practically reviewed the ISO (International Standard Organization) 17123-8 standard not only to raise the appropriateness for introducing performance criteria of GNSS (Global Navigation Satellite Systems) surveying equipment based on RTK (Real-Time Kinematic) accuracy but also to derive its proper test procedure by introducing the international standard. Field experiments have been performed to appreciate the GNSS-RTK accuracy of five selected receivers via the full testing procedure of the ISO standard, which statistically compares the so-called experimental standard deviations with themselves and with the reference accuracy. A series of statistical tests have revealed that the RTK accuracy of the same class receivers is not identical, whereas that of the different classes can be equivalent. Such a result evidences the urgency of adopting an RTK accuracy-based specification of the GNSS equipment to the performance standard, currently referenced to the static observation technique only. It is believed that this transition helps the maximization of a new generation of cost-effective receivers to legal surveying applications. Finally, this study proposes the ISO full test, comparing an experimental standard deviation with its referenced value, for a potential field verification procedure of the new performance standard.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.42 no.3
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• pp.379-389
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• 2022

The number of public transportation users has dropped drastically due to COVID-19. In this work, my survey was conducted to uncover the factors that influence citizens' travel patterns. Data were collected and logistic regression analysis on the shifts in transportation was undertaken. Additionally, an importance-performance analysis was carried out to investigate how to effectively operate public transportation systems and improve facilities. The main research findings were as follows: First, the more individuals were concerned about COVID-19 (+) and being infected when using public transportation (+), the greater the tendency to switch to private transportation modes. Secondly, when it came to personal traits, respondents who could drive a car (+) or owned a car (+)or did more online shopping (+) or used public transportation for trips (+) tended to switch over, compared with respondents who could not drive or did not own a caror used public transportation to commute. In addition, respondents who were vaccinated (-) or had more household members tended not to switch transportation modes, compared with those who were not vaccinated or had fewer household members. Third, it is important to continue the following efforts to safeguardhygiene linked to public transportation: wearing masks, disinfecting hands, controlling diseases, and general cleaning. The conclusion was that it is important to put traffic congestion and ventilation issues first, especially in regards public transportation, which was not rated as satisfactory enough compared to its importance. The research findings can provide useful basic data when establishing countermeasures to the current COVID-19 circumstances in the areas of public transportation operation and management and in the event of an infectious disease outbreak in the future.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.42 no.3
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• pp.343-350
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• 2022

High-resolution data are needed to understand water body mixing patterns at river junctions. In particular, in river analysis, hydrological and water quality characteristics are used as basic data for aquatic ecological health, so observation through continuous monitoring is necessary. In addition, since measurement is carried out through a one-dimensional and fixed measurement method in existing monitoring systems, a hydrological and water quality characteristics investigation of an entire river, except for in the immediate vicinity of the measurement point, is not undertaken. In order to obtain high-resolution measurement data, a measurer has to consider multiple factors, and the area or time that can be measured is limited. Although the resolution might be lowered, an appropriate interpolation method must be selected in order to acquire a wide range of data. Therefore, in this study, a high-elevation measurement method at a river junction was introduced, and the interpolation method according to the measurement results was compared. The overall hydraulic and water quality information of the river was indicated through the visualization of the prediction and interpolation method in the low-resolution measurement result. By comparing each interpolation method, Inverse Distance Weighting, Natural Neighbor, and Kriging techniques were applied in river mapping to improve the precision of river mapping through visualized data and quantitative evaluation. It is thought that this study will offer a new method for measuring rivers through spatial interpolation.

• The Journal of the Korea institute of electronic communication sciences
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• v.17 no.4
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• pp.555-562
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• 2022

This study measured and analyzed the propagation characteristics at frequencies 6, 10, and 17 GHz to discover the new propagation demands in a semi-basement indoor corridor environment for meeting the 4th industrial revolution requirements. The measured indoor environment is a straight corridor consisting of three lecture rooms and glass windows on the outside. The measurement scenario development and measurement system were constructed to match this environment. The transmitting antenna was fixed, and the frequency domain and time domain propagation characteristics were measured and analyzed in the line-of-sight environment based on the distance of the receiving antenna location. In the frequency domain, reliability was determined by the parameters of the floating intercept (FI) path loss model and an R-squared value of 0.5 or more. In the time domain, the root mean square (RMS) delay spread and the cumulative probability of K-factor were used to determine that 6 GHz had high propagation power and 17 GHz had low propagation power. These research results will be effective in providing ultra-connection and ultra-delay artificial intelligence services for WIFI 6, 5G, and future systems in a semi-basement indoor corridor environment.

• Journal of the Society of Disaster Information
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• v.19 no.1
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• pp.60-68
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• 2023

Purpose: In order to find out stability condition which governs design of drystone masonry retaining walls and changing patterns of installed width of blocks of the wall for each stability conditions, typical wall was assumed and designed. Method: For the purpose of this study, 10 m high drystone masonry retaining wall with general block size and soil properties were considered and dimensions of the wall were determined by applying stability conditions of sliding and overturning and the design results were compared with each other. Result: According to the design results, installed width of blocks determined by considering stability of sliding were greatly less than those determined by considering stability of overturning and these differences were not decreased noticeably even though same values of factors of safety for sliding and overturning were applied. Between the two methods of determining the installed width of blocks, it could be seen that the method of considering failure wedge of lower part of overturning parts of the wall governed the design instead of considering horizontal base of overturning parts of the wall. Conclusion: In case of considering failure wedge of lower part of overturning parts of the wall, it could be seen that the installed width of blocks increased as the inclination angle of failure wedge increased. In case of considering overturning at the lower part of the wall with certain assumed inclination angle of failure wedge, it could be seen that installed width of blocks decreased as the inclination angle of failure wedge decreased by geometric restrictions of the wall.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.23 no.2
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• pp.157-162
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• 2023

Among the failures of photovoltaic power generation facilities, failures caused by surges account for 20% of the total failure rate, and energy emissions of tens to hundreds [A] during power generation and electrical damage to inverters and connection boards lead to electrical safety accidents. In particular, in the case of lightning, an abnormal voltage is induced in an electric circuit to destroy insulation, and the current flowing at this time causes a fire and acts as a factor that accelerates the deterioration of parts. Due to this action, the problem of electrical safety of solar power generation devices spreading from outside the city center to the inside of the city center such as houses, apartments, and government offices is emerging. Since lightning strikes cause both field-based and conducted electrical interference, this effect increases with increasing cable length or conductor loops. In addition, surge damages not only solar modules, inverters and monitoring devices, but also building facilities, which can eventually cause operational shutdown due to fire of the photovoltaic power generation system and consequent financial loss. Therefore, in this paper, a lightning protection system for solar power generation devices is studied for the purpose of reducing property damage and human casualties due to the increase in fire and electrical safety accidents caused by lightning strikes in photovoltaic power generation systems.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.23 no.2
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• pp.169-174
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• 2023

Currently, overall power usage is also increasing as power demand such as homes, offices, and factories increases. The increase in power use also raised interest in standby power as a change in awareness of energy saving appeared. Home and office devices are consuming power even in standby conditions. Accordingly, there is a growing need to reduce standby power, and it aims to have standby power of 1W or less. An intelligent outlet uses a near-field wireless network to connect to a home network and cut or reduce standby power of a lamp or appliance connected to an outlet. This research aims to develop a monitoring system and an intelligent outlet that can remotely monitor the amount of electricity used in a lighting lamp or a home appliance connected to an outlet using a short-range wireless network (Zigbee). Also, The intelligent outlet and monitoring system developed makes it possible for a user to easily cut off standby power by using a portable device. Intelligent outlets will not only reduce standby power but also be applicable to fire prevention systems. Devices that cut off standby power include intelligent outlets and standby power cutoff switches, so they will prevent short circuits and fires.

• Journal of Broadcast Engineering
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• v.28 no.1
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• pp.145-148
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• 2023

Open-loop Octonion space-time block code for 4 transmit antenna system is considered and random phases are applied to 4 transmit antennas for physical layer security. When an illegal hacker estimates the random phases of 1 through 4 transmit antennas with maximum likelihood (ML), this letter analyzes the bit error rate (BER) performances versus signal-to-noise ratio (SNR). And the Octonion code in the literature[1] does not have full orthogonality so, this letter employs the perfect orthogonal Octonion code. When the hacker knows that the random phases are 2-PSK constellations and he should estimate all the 4 random phases, the hacking is impossible until 100dB. When the hacker possibly know that some of the random phases, bit error rate goes down to 10^-3 so, the transmit message could be hacked.

• Journal of Intelligence and Information Systems
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• v.29 no.1
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• pp.233-247
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• 2023

Recently, research on detecting objects in hidden spaces beyond the direct line-of-sight of observers has received attention. Most studies use optical equipment that utilizes the directional of light, but sound that has both diffraction and directional is also suitable for non-line-of-sight(NLOS) research. In this paper, we propose a novel method of detecting objects in non-line-of-sight (NLOS) areas using acoustic signals in the audible frequency range. We developed a deep learning model that extracts information from the NLOS area by inputting only acoustic signals and predicts the properties and location of hidden objects. Additionally, for the training and evaluation of the deep learning model, we collected data by varying the signal transmission and reception location for a total of 11 objects. We show that the deep learning model demonstrates outstanding performance in detecting objects in the NLOS area using acoustic signals. We observed that the performance decreases as the distance between the signal collection location and the reflecting wall, and the performance improves through the combination of signals collected from multiple locations. Finally, we propose the optimal conditions for detecting objects in the NLOS area using acoustic signals.