• Journal of Periodontal and Implant Science
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• 제39권sup2호
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• pp.205-212
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• 2009

Purpose: The aim of this retrospective study was to compare the survival rate of oxidized titanium implants and sandblasted large-grit acid etched implants in soft bone. Methods: 201 oxidized titanium implants were inserted in 84 patients between May 1999 and May 2004. 120 sandblasted large-grit acid etched implants were inserted in 74 patients between December 2000 and May 2004. The patients were followed-up 0${\sim}$5 years in ITI group or 0${\sim}$6 years in BRA group, respectively. The following information was collected from the patient records: age, gender, systemic disease, implant type, number, length and diameter of the implants, their location in the jaws, bone quantity, the number of failed implants, the causes of failure, and advanced surgery for bone augmentation. Results: In the oxidized titanium implants, 8 implants showed early failure, and 1 implant showed late failure, respectively. The cumulative survival rate was 95.48%. In the sandblasted large-grit acid etched implants, 1 implant showed late failure and cumulative survival rate was 99.10%. The cumulative survival rate and the survival rates in the case of the advanced procedure during the implant placement were not significantly different in both groups. Conclusions: Oxidized titanium implants and sandblasted large-grit acid etched implants can be used successfully in soft bone regardless of the surgical methods used during the implant placement. (J Korean Acad Periodontol 2009;39:205-212)

• 대한임상독성학회지
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• 제6권1호
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• pp.9-15
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• 2008

Purpose: Dichlorvos has been in widespread use as an organophosphate (OP) insecticide compound. The purpose of this study was to access the epidemiology and clinical features of dichlorvos in Korea. Methods: This was a 38 multi-center prospective study of dichlorvos poisoning using surveys, a structural reporting system and review of hospital records from August 2005 to July 2006. A total of 54 patients with acute dichlorvos poisoning on a national basis were enrolled. We analyzed the epidemiologic characteristics and clinical manifestations of dichlorvos poisoning. In addition, the clinical features of dichlorvos poisoning were compared with others OP compounds. Results: During the study period, compounds involving pure OP poisoning were dichlorvos (22.7%), methidathion (8.4%), and phosphamidon (6.7%). In acute dichlorvos poisoning, all ingestion routes were oral. Intentional poisoning involved 74.1% of cases. The common initial complaints involved gastrointestinal (64.8%), systemic (61.1%), central or peripheral nervous system (53.7%), and respiratory symptoms (50.0%). The median arrival time to hospital after dichlorvos poisoning was 2.6 hours and mean hospitalization duration was 7.1 days. 2-PAM was administered in 35 patients in mean doses of 6.3 g/day intravenously. Atropine was administered in 30 patients with a mean dose of 62.8 mg/day (maximal 240 mg/day). Overall mortality rate for dichlorvos poisonings were 14.8% (8/54). Immediate causes for death included sudden cardiac arrest or ventricular dysrhythmias (50%), multi-organ failure (25%), acute renal failure (12.5%), and unknown causes (12.5%). Conclusion: When compared to previous reports, dichlorvos poisoning displayed relatively moderate severity. The presence of a lower GCS score, altered mental status, serious dysrhythmias, systemic shock, acute renal failure, and respiratory complications upon presentation were associated with a more serious and fatal poisoning.

• Radiation Oncology Journal
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• 제35권3호
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• pp.189-197
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• 2017

Locally advanced prostate cancer (LAPC) is defined as histologically proven T3-4 prostatic adenocarcinoma. In this review, we define the individual roles of radiotherapy (RT), short-term (ST-) and long-term (LT-) androgen deprivation therapy (ADT), and their combination in multimodal therapy for LAPC. Despite limitations in comparing the clinical outcomes among published papers, in the present study, a trend of 10-year clinical outcomes was roughly estimated by calculating the average rates weighted by the cohort number. With RT alone, the following rates were estimated: 87% biochemical failure, 34% local failure (LF), 48% distant metastasis (DM), 38% overall survival (OS), and 27% disease-specific mortality (DSM). Those associated with ADT alone were 74% BCF, 54% OS, and 25% DSM, which appeared to be better than those of RT alone. The addition of ADT to RT produced a notable local and systemic effect, regardless of ST- or LT-ADT. The LF rate decreased from 34% with RT alone to 21% with ST-ADT and further to 15% with LT-ADT. The DM and DSM rates also showed a similar trend among RT alone, RT+ST-ADT, and RT+LT-ADT. The combination of RT+LT-ADT resulted in the best long-term clinical outcomes, indicating that both RT and ADT are important parts of multimodal therapy.

• Childhood Kidney Diseases
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• 제24권1호
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• pp.58-61
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• 2020

Pseudohypoaldosteronism type 1 (PHA1) is a rare salt-wasting disorder caused by resistance to mineralocorticoid action. PHA1 is of two types with different levels of disease severity and phenotype as follows: systemic type with an autosomal recessive inheritance (caused by mutations of the epithelial sodium channel) and renal type with an autosomal dominant inheritance (caused by mutations in the mineralocorticoid receptor). The clinical manifestations of PHA1 vary widely; however, PHA1 commonly involves hyponatremia, hyperkalemia, metabolic acidosis and elevated levels of renin and aldosterone. The earliest signs of both type of PAH1 also comprise insufficiency weight gain due to chronic dehydration and failure to thrive during infancy. Here, we report a case of renal PAH1 in a 28-day-old male infant harboring a novel heterozygous mutation in NR3C2 gene (c.1341_1345dupAAACC in exon 2), showing only failure to thrive without the characteristic of dehydration.

• 대한임상독성학회지
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• 제3권1호
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• pp.56-59
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• 2005

Blister beetles produce cantharidin, which is toxic to people and animals. Cantharidin has been believed to be an aphrodisiac and an abortifacient based on its tendency to cause marked irritation to the genitourinary system leading to priapism in men and pelvic congestion in women for many years. Cantharidin was used by oriental traditional medicine for more than 2000 years. Typical signs related to cantharidin ingestion are gastrointestinal tract and urinary tract irritation, endotoxemia, shock and myocardial dysfunction. Cantharidin is a severe irritant to epithelial linings (gastrointestinal tract, urinary tract, and skin) and develop systemic inflammatory response syndrome. We report a case of corrosive esophagogastritis and acute renal failure by ingestion of cantharidin.

• Radiation Oncology Journal
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• 제2권1호
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• pp.93-100
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• 1984

Among 238 patients with Non-Hodgkin's lymphoma received radiotherapy at Yonsei Cancer center, Yonsei University Medical College, from 1970 to 1981, 30 patients presented with localized(Stage I&II ) gastrointestinal lymphomas. Retrospective analysis of these 30 cases in an attempt to evaluate the influence of various prognostic factors and the effectiveness of therapy is presented. Overall 5 year survival rate of 30 cases of primary gastrointestinal lymphoma was $48\%$. Bulk of residual disease after initial surgery and stage were significant prognostic factors. Stage I with small residual disease treated with post-op irradiation achieved $100\%$ 5 year survival rate. So above group is considered curable with surgery and post-op irradiation. $80\%$ of Stage II with large residual disease were died with intra-abdominal local tumor control failure. Stage II with small residual disease showed $31.5\%$ 5 year survival rate. Non of them died with local failure. So, we suggest that complete surgical resection of tumor mass should be attempted initially in the management of localized gastrointestinal lypmhomas and systemic chemotherapy is needed in addition to post-op irradiation in the cases of Stage II and large residual disease after initial surgery.

• Childhood Kidney Diseases
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• 제14권2호
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• pp.236-239
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• 2010

장티푸스에 의한 신장 합병증은 전체 환자의 2-3% 정도로, 소아에서는 드물게 발견되며 최근 위생상태의 호전으로 장티푸스 발생율은 점점 감소하고 있다. 저자들은 장기간의 발열, 구토, 설사를 보였던 환아에서 단백뇨, 신기능 저하 소견이 나타나 경피적 신생검을 시행하여 급성 간질성 신염 소견이 증명된 환자를 경험하였기에 이를 보고하는 바이다.

• 한국안전학회지
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• 제39권1호
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• pp.16-26
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• 2024

This study aims to introduce a method for risk assessment analysis aimed at preventing electrical fires within the manufacturing industry. Initially, we provided a functional block diagram illustrating the electrical equipment employed in various processes within a food manufacturing company in Chungcheongbuk-do. Subsequently, we categorized the components of each machine outlined in the functional block diagram and determined the priority of failure for each classified component. Upon implementing the model in the frying process of the food manufacturing company, specific components, including MC, motor, mixer heater, electric wiring, and terminal block, exhibit a risk priority number (RPN) of 40 or higher. This identified an electrical issue within the manufacturing process and environment. Consequently, we propose a methodology to identify latent failure modes that could escalate into fires or systemic issues if not promptly addressed. It is essential to note that while the FMEA presented in this study may not immediately impact food manufacturing, its applicability extends to various workplaces.

• Radiation Oncology Journal
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• 제23권2호
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• pp.71-77
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• 2005

목적:. 비인강암 환자들을 대상으로 방사선치료 성적을 후향적으로 분석하여 방사선치료의 효과 및 생존에 영향을 주는 요인들을 알아보고자 이 연구를 시행하였다. 대상 및 방법: 1987년부터 2002년까지 계명대학교 동산의료원 방사선종양학과에서 비인강암으로 확진되어 근치적 방사선치료를 받은 43명을 대상으로 하였다. 대상 환자는 AJCC 병기 제 II기, III기, IV기가 각각 12명 ($27.9\%$), 13명($30.2\%$), 18명($41.9\%$)이었고, 조직병리학적으로는 편평세포암이 15명($34.9\%$), 비케라틴형성암이 8명($18.6\%$), 미분화암이 17명($39.5\%$), 림프상피종이 3명($7.0\%$)이었다. 치료방법은 방사선단독요법 31명($72.1\%$), 동시 항암화학방사선요법 5명($11.5\%$), 전보조항암화학요법 7명($16.3\%$)이었다. 항암화학요법을 받은 12명 중 11명 은 Cisplatin과 5-Fluorouracil을 4회, 1명 은 Cisplatin과 Taxotere를 6회 치료받았다. 총조사선량은 $61.2\~84Gy$였고 중앙값은 70.4 Gy였다. 생존 환자의 추적기간은 $2\~197$개월이었고 중앙값은 84개월이었다. 결과: 방사선치료 6개월 후 39명($90.7\%$)은 완전관해를, 4명($9.3\%$)은 부분관해를 보였다. 전체 환자의 5년 생존율 및 무병생존율은 각각, $50.7\%$, $48.9\%$였으며 중앙생존기간은 73개월, 57개월이었고, 단변량분석에서 연령, T-병기, 전체병기 및 치료방법에 따라서 유의한 차이를 보였다(p<0.05). 다변량분석 결과, 5년 생존율 및 5년 무병생존율에 영향을 주는 변수로는 연령, N-병기 및 전체병기가 통계적으로 유의하였으며(p<0.05), $T_{1-3}$병기와 $T_4$병기 간에 유의한 차이를 보였다(p<0.01). 방사선치료 후 재발은 국소재발 단독 3명($7.0\%$), 원격전이 단독 11명($25.6\%$), 국소 및 원격전이 동시재발 1명($2.3\%$)이었다. 결론: 비인강암의 생존에 영향을 주는 예후 인자는 연령, T-병기($T_{1-3}$과 $T_4$), N-병기 및 전체병기임을 알 수 있었고 원격전이가 주된 실패 양상으로 분석되어 원격전이를 감소시키기 위해 적극적인 전신 항암화학요법이 필요하며 보다 효과적인 항암제와 투여방법에 관한 연구가 필요할 것으로 생각된다.

• The Journal of Advanced Prosthodontics
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• 제3권4호
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• pp.229-235
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• 2011

PURPOSE. The aim of this retrospective study was to evaluate cumulative survival rate (CSR) of Implantium implants followed for 5 years and association between risk factors and the CSR. MATERIALS AND METHODS. A total of two hundred forty-nine Implantium Implants System (Dentium, Seoul, Korea) placed in ninety-five patients from 2004 to 2009 were investigated with several identified risk factors (sex, systemic disease, smoking, alchohol, reason of tooth loss, length, arch (maxilla or mandible), replace tooth type (incisor, canine, premolar or molar) Kennedy classification, prosthodontic type, prosthodontic design, opposite dentition, abutment type, occlusal material, occlusal unit, splint to tooth, cantilever, other surgery). Clinical examination (mobility, percussion, screw loosening, discomfort, etc.) and radiographic examination data were collected from patient records including all problems during follow-up period according to protocols described earlier. Life table analysis was undertaken to examine the CSR. Cox regression method was conducted to assess the association between potential risk factors and overall CSR. RESULTS. Five of 249 implants were failed. Four of these were lost before loading. The 5-year implant cumulative survival rate was 97.37%. Cox regression analysis demonstrated a significant predictive association between overall CSR and systemic disease, smoking, reason of tooth loss, arch, Kennedy classification and prosthodontic design (P<.05). The screw related complication was rare. Two abutment screw fractures were found. Another complications of prosthetic components were porcelain fracture, resin facing fracture and denture fracture (n=19). CONCLUSION. The 5-year CSR of Implantium implants was 97.37 %. Implant survival may be dependent upon systemic disease, smoking reason of tooth loss, arch, Kennedy classification and prosthodontic design (P<.05). The presence of systemic diseases and combination of other surgical procedures may be associated with increased implant failure.