• Genomics & Informatics
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• v.11 no.4
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• pp.254-262
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• 2013

The multidrug resistance protein 2 (MRP2, ABCC2) gene may determine individual susceptibility to adverse drug reactions (ADRs) in the central nervous system (CNS) by limiting brain access of antiepileptic drugs, especially valproic acid (VPA). Our objective was to investigate the effect of ABCC2 polymorphisms on ADRs caused by VPA in Korean epileptic patients. We examined the association of ABCC2 single-nucleotide polymorphisms and haplotype frequencies with VPA related to adverse reactions. In addition, the association of the polymorphisms with the risk of VPA related to adverse reactions was estimated by logistic regression analysis. A total of 41 (24.4%) patients had shown VPA-related adverse reactions in CNS, and the most frequent symptom was tremor (78.0%). The patients with CNS ADRs were more likely to have the G allele (79.3% vs. 62.7%, p=0.0057) and the GG genotype (61.0% vs. 39.7%, p=0.019) at the g.-1774delG locus. The frequency of the haplotype containing g.-1774Gdel was significantly lower in the patients with CNS ADRs than without CNS ADRs (15.8% vs. 32.3%, p=0.0039). Lastly, in the multivariate logistic regression analysis, the presence of the GG genotype at the g.-1774delG locus was identified as a stronger risk factor for VPA related to ADRs (odds ratio, 8.53; 95% confidence interval, 1.04 to 70.17). We demonstrated that ABCC2 polymorphisms may influence VPA-related ADRs. The results above suggest the possible usefulness of ABCC2 gene polymorphisms as a marker for predicting response to VPA-related ADRs.

• The Journal of the Korea Contents Association
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• v.8 no.2
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• pp.74-82
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• 2008

This paper investigates chrominance reconstruction methods that reconstruct subsampled chrominance information efficiently using the correlation between luminance and chrominance components in the decompression process of compressed images, and analyzes drawbacks involved in the adaptive-weighted 2-dimensional linear interpolation among the methods, which shows higher efficiency in the view of computational complexity than other methods. To improve the drawback that the spatial frequency distribution is not considered for the decompressed image and to support the application on a low-performance system in behalf of 2-dimensional linear interpolation, this paper proposes the multi-mode reconstruction method which uses three reconstruction methods having different computational complexity from each other according to the degree of edge response of luminance component. The performance evaluation on a development platform for embedded systems showed that the proposed reconstruction method supports the similar level of image quality for decompressed images while reducing the overall computation time for chrominance reconstruction in comparison with the 2-dimensional linear interpolation.

• Journal of Korean society of Dental Hygiene
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• v.21 no.5
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• pp.675-683
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• 2021

Objectives: This study aimed to verify the relations of COVID-19 infection-related knowledge, dental infection control performance, and psychosocial health of dental hygienists. Methods: From the data was analyzed through the frequency analysis, t-test, one way ANOVA, and pearson's correlation analysis with a total of 198 dental hygienists using SPSS Statistics 21.0. Results: The correct answer rate for knowledge about COVID-19 was higher with a bachelor's degree or higher. Thus, when the level of education was higher, the performance was also high (p<0.01). COVID-19 infection control performance was highly shown in case of high age (4.43) (p<0.05) and the married (4.42) (p<0.01). Infection control performance was high when they had an educational experience of COVID-19 infection control (4.46), and when the infection control guidebooks were equipped in their workplaces (p<0.001). Degree of psychosocial health of research subjects was shown in the order of potential stress (60.6%), high-risk stress (23.7%), and healthy (15.7%). Infection control performance was higher, the psychosocial health was healthy. Conclusions: For the response to COVID-19 infectious disease and the preparation for mutated viruses and new infectious diseases in the future, it would be necessary to establish the concrete measures for establishing the strict infection control system for dental clinics and also enhancing the psychosocial health of dental hygienists.

• The Mathematical Education
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• v.58 no.3
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• pp.403-422
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• 2019

As the informal graph was introduced newly in the area of function in middle school mathematics curriculum revised in 2015, ten publishing company became to have a concern on how to represent the graph content uniquely and newly. At this time, it may be meaningful and useful to compare and analyze the content of the graph unit shown on each textbook published by publishing companies. To accomplish this, on fundamentally the basis of diverse prior researches this study tried to select the elements of expression and interpretation of the graph and establish an analytic frameworks of expression and interpretation of the graph respectively. This study executed the frequency analysis and cross analysis by textbook system, textbook, and the number of the graph drawn on a coordinate plane on the representation and interpretation of the graph. As a result, the textbook contains more items on interpretation than the representation of the graph, and students showed a learning effect on the graph unit but showed a neutral response to the impact of learning. This basic and essential paper shed light on developing the practical and more creative textbook which has diversity and characteristic respectively, while adjusting the scope of the elements of the graph's representations and interpretations and providing proper level and quality content.

• Journal of the Korea institute for structural maintenance and inspection
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• v.23 no.5
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• pp.48-59
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• 2019

In recent years, the type of bridge where cables such as suspension bridge and cable-stayed bridge are the main factors in the construction of long-range bridges has been soaring. The effects of cables on these structures are very large, and for structural analysis, it is necessary to study the cable and the structural changes according to the mode characteristics of the cables. In particular, cables are directly connected to camber adjustment, which conveys load effects on girders to tower, and are important components in the overall structure, and since the initial tension on the construction is compared with the tension over time, this study was conducted to help identify the condition of the bridge's aging and abnormalities. Therefore, in this study, the characteristics of the mode from the mode analysis through the impact hammer to the mass of the cable and the change in the length of the cable are analyzed.

• Journal of the Semiconductor & Display Technology
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• v.18 no.1
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• pp.15-20
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• 2019

Inspection and measurement of surface quality is one of the most critical processes for manufacturing products such as semiconductor wafers, sapphire substrates, and display panels. The vibrations of the inspection and measurement devices are supposed to be the most dominant factors for severe measurement errors and longer measuring time. In this study, dynamic characteristics of an inspection and measurement device are analyzed through frequency response experiment and computer simulation to obtain parameters such as frequencies, magnitudes, mode shapes, and periods of vibrations. And then an active damper which consists of sensor, interface board, and actuator is designed based on the parameters to formulate the most effective reaction signal to suppress the vibrations which is generated by an interface board, and provided by an actuator. If the vibrations are measured by the sensor, the active damper immediately generates and provides the corresponding reaction signal to inspection and measurement device. The result shows that the active damper can suppress structural vibrations effectively and reduce measuring time of the device and enhance the productivity.

• The Korean Journal of Franchise Management
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• v.12 no.2
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• pp.35-49
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• 2021

Purpose: The major objective of this study is to develop a model for the impact of franchisors' Gapjil (verbal·nonverbal Gapjil, abusing bargaining position, refusing transaction, false or exaggerated information, restrictive practices, unfair damage compensation) on franchisee's recontract intention. We also examine the mediating role of economic satisfaction and social satisfaction in the relationship between franchisors' Gapjil and franchisee's contract intention. Research design, data, and methodology: Data were collected from franchisee owners located nationwide in Korea. Out of 256 questionaires distributed, a total of 256 questionnaires were returned. After excluding 10 invalid respondent questionnaires, we coded and analyzed 246 valid questionnaires (effective response rate of 96.09%) using frequency, confirmatory factor analysis, correlations analysis, and structural equation modeling with SPSS 22.O and SmartPLS 3.0. Results: The findings of this study are summarized as follows: First, among the Gapjil of the franchisors, restrictive practices and unfair damage compensation had negative effects on economic and social satisfaction, but verbal and nonverbal Gapjil for economic and social satisfaction was not significant. Second, abusing bargaining positions and false or exaggerated information had negative effects on social satisfaction, but for economic satisfaction, found to be insignificant. Third, economic and social satisfaction had positive effects on the franchisee's recontract intention to the franchisor. Conclusion: The following implications of this study are as follows. First, the construct of Gapjil that occurs between the franchisors and the franchisees was first presented, and the franchisors' Gapjil is divided into interpersonal Gapjil and structural Gapjil. Second, the Gapjil of the franchisors can be an important predictor variable in maintaining and developing a long-term relationship between the franchisors and the franchisees. Third, solving conflict due to the Gapjil problem between franchisors and franchisees can be an important factor for franchisors and franchisees to co-survive and thrive in Korean franchise system. Fourth, this study suggest that managing the Gapjil of the franchisors was a important antecedent factor in maintaining long-term relationship between the franchisors and the franchisees. Therefore, this study will help franchisors formulate effective symbiotic marketing strategies to satisfy relationships with franchisees and consequently enhance long-term orientation.

• Journal of Audiology & Otology
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• v.24 no.2
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• pp.85-90
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• 2020

Background and Objectives: The present study aimed to compare thresholds of direct bone-conduction (BC direct) with those of behaviorally measured BC pure-tone audiometry (PTA) and objectively measured BC auditory brainstem response (ABR) to confirm the clinical feasibility of their relationships. Subjects and Methods: Young adults with normal hearing participated in the study to determine the thresholds from three measurements at four testing frequencies. In the BC direct, the vibrator of a bone-anchored hearing aid softband was placed on the right mastoid of each subject. In both PTA and ABR, a B71 bone oscillator was placed on the subject's right mastoid. While the subject's thresholds of BC direct and BC PTA were determined with a clinically routine 5-dB step procedure, BC ABR was conducted to determine the individual's hearing sensitivity by a peak V of the waveform using tone-burst and click stimuli. Results: The BC direct showed a different pattern between low and high frequencies. Precisely, its thresholds were 13.25 and 12.25 dB HL at 0.5 and 1 kHz, respectively, but 19 and 19.75 dB HL at 2 and 4 kHz, respectively. A significant positive correlation existed between BC direct and PTA at 1 kHz, which was also correlated with ABR. Conclusions: Based on the current data, the thresholds of BC direct were similar to BC PTA at low frequencies and BC ABR at high frequencies. The thresholds of BC direct might be predictable at approximately 5 dB higher (or lower) than that in PTA, although a large data set is required for standardization.

• Korean Journal of Audiology
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• v.24 no.2
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• pp.85-90
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• 2020

Background and Objectives: The present study aimed to compare thresholds of direct bone-conduction (BC direct) with those of behaviorally measured BC pure-tone audiometry (PTA) and objectively measured BC auditory brainstem response (ABR) to confirm the clinical feasibility of their relationships. Subjects and Methods: Young adults with normal hearing participated in the study to determine the thresholds from three measurements at four testing frequencies. In the BC direct, the vibrator of a bone-anchored hearing aid softband was placed on the right mastoid of each subject. In both PTA and ABR, a B71 bone oscillator was placed on the subject's right mastoid. While the subject's thresholds of BC direct and BC PTA were determined with a clinically routine 5-dB step procedure, BC ABR was conducted to determine the individual's hearing sensitivity by a peak V of the waveform using tone-burst and click stimuli. Results: The BC direct showed a different pattern between low and high frequencies. Precisely, its thresholds were 13.25 and 12.25 dB HL at 0.5 and 1 kHz, respectively, but 19 and 19.75 dB HL at 2 and 4 kHz, respectively. A significant positive correlation existed between BC direct and PTA at 1 kHz, which was also correlated with ABR. Conclusions: Based on the current data, the thresholds of BC direct were similar to BC PTA at low frequencies and BC ABR at high frequencies. The thresholds of BC direct might be predictable at approximately 5 dB higher (or lower) than that in PTA, although a large data set is required for standardization.

• Journal of Industrial Convergence
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• v.20 no.12
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• pp.71-78
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• 2022

This study was conducted with the purpose of examining the effect of material deprivation on the subjective mental health of youth and the moderating effect of social support in these relationships. For this purpose, frequency analysis, descriptive statistics, correlation analysis, and moderating effect model were analyzed using the response data of 2,041 youth who participated in the '2021 Youth Social and Economic Survey'. As a result of the analysis, first, it was found that the material deprivation of youth negatively and significantly affects subjective mental health. Second, it was found that social support moderated the effect of material deprivation on the subjective mental health of youth. The results of this study show that in order to improve the subjective mental health level of youth, it is necessary to not only strengthen public policies and systems to prevent the situation of material deprivation of youth in advance, but also to strengthen the social support system by raising the level of social support.