• Microbiology and Biotechnology Letters
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• v.27 no.4
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• pp.344-348
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• 1999

A competitive enzyme-linked immunosorbent assay(ELISA) for the detection of antibodies to Treponema pallidum(T.pallidum) was developed and evaluated. T.apllidum lysate was immobilized on the surface of microplate wells and horseradish peroxidase labeled human anti-T.pallidum lysate was immobilized on the surface of microplate wells and horseradish peroxidase labeled human anti-T.pallidum was prepared and used as a tracer. The performance of the competitive ELISA was evaluated by using different specimens. The competitive ELISA showed a sensitivity of 100% in a performance panel consisting of serum and plasma with anti-T.pallidum reactivity ranging from negative to strong positive by FTA-ABS test system and 120 plasma samples positive by TPHA. The specificity of the competitive ELISA was 100% in 1,200 plasma samples collected from healthy seronegative blood donors. These results suggest that the competitive ELISA provides an excellent assay method for the detection of antibodies to T.pallidum, and may be particularly useful for serological blood screening of syphilis.

• Journal of Preventive Medicine and Public Health
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• v.22 no.1 s.25
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• pp.45-50
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• 1989

The purpose of this study was to select the manageable diseases which are prevalent in Korea for periodic health examinations and to evaluate the sensitivity and specificity of periodic health examination in detecting these diseases. The data was derived from reimbursement data of the Korea Medical Insurance Corporation over a two year period (April 15, 1986 to April 14,1988) and interviews with Yonsei Medical School professors. This study demonstrated that: 1. The manageable diseases which were selected for periodic health examinations are pulmonary tuberculosis, viral hepatitis, diabetes mellitus, syphilis groups, essential hypertension, renal disease groups, and iron deficiency anemia. 2. The sensitivity of the health screening for each disease was as follows: pulmonary tuberculosis 51.5%, viral hepatitis 60.3%, diabetes mellitus 64.7%, syphilis groups 63.3%, essential hypertension 49.9%, renal disease groups 44.0%, and iron deficiency anemia 80.9%. We conclude that peiodic health esaminations should focus on the manageable diseases that we have defined. The number of items in periodic health screening tests and hospital quality control should be increased for the diseases with a demonstrated low sensitivity.

• Journal of Trauma and Injury
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• v.28 no.1
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• pp.9-14
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• 2015

Purpose: The aim of this study was to estimate the seropositive prevalence of blood-borne infection in neurotrauma patients who underwent emergent surgical intervention, especially patients with hepatitis B virus (HBV), hepatitis C virus (HCV), syphilis and human immunodefIciency virus (HIV). Methods: A retrospective review identified 559 patients with traumatic brain injury and spinal trauma who underwent emergent surgery between 2007 and 2014. We reviewed the medical records and extracted data, including age, sex, location of lesion, result of serologic tests, time interval of admission and surgery after presenting to emergency room. Serologic tests for HBV, HCV, syphilis and HIV were performed and analyzed to determine whether the seropositive results were confirmed by the surgeon before surgery. Results: The majority of the patients were male (74.6%), and the mean age was $55.4{\pm}20.2years$. Most patients underwent surgery due to traumatic brain injury (90.0%). Fifty-three patients (10.0%) showed a positive result on at least one serologic test. Seropositive rates according to pathogens were 0.5% for syphilis, 5.2% for HBV and 3.9% for HCV. No positive results were noted on the serologic tests for HIV. HBV in patients with spinal cord injury and age from 40 to 49 years were associated with high serologic positive rate, and that result was statistically significant. However, no statistically significant differences were found in the other variables. Serologic results could not confirmed before surgery in the majority of the cases (62.1%), and 10.4% of these patients showed seropositive results. Conclusion: The results of this study emphasize the importance of taking precautions and conducting rapid serologic testing in preventing the occupational transmission of blood-borne viruses to health-care workers.

• Journal of Chest Surgery
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• v.4 no.2
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• pp.81-86
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• 1971

Aneurysm of the Aorta is a grave disease mostly producing disabling symptoms and ultimate death by rupture and hemorrhage without surgical intervention. Aneurysm of the thoracic aorta is more common in arteriosclerosis than syphilitic origin,since the incidence of cardiovascular syphilis has been reduced significantly in recent decades and the life span of population has increase. We have experienced a case of luetic aneurysm of aortic arch without pulse in tile left arm which was succesfully treated by surgical intervention.

• Journal of the korean academy of Pediatric Dentistry
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• v.11 no.1
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• pp.255-259
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• 1984

Ectodermal dysplasia is a rare hereditary abnormality of which the outstanding characteristics are hypodontia, hypohidrosis and hypotricosis. Patient afflicted with this malformation shows a typical face resembling that of congenital-syphilis. Dental abnormality (delayed eruption, oligodontia) becomes apparent in this child and causes the parents to bring him to the dentist. Prosthetic appliances are usually indicated and he must be adjusted or be remade as the child matures.

• The Journal of the Korean Society for Microbiology
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• v.3 no.1
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• pp.5-14
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• 1968

Prostitutes living in Songdo beach in Pusan, for two years period (from September 4, 1964 to August 28, 1966) were investigated for the present status and Venereal Diseases. The following results were obtained. 1. Age distribution:The youngest was 18 years old and the oldest 29. The group between 22-25 years old was 72.8%, approximately three fourth of all prostitute. 2. Educational background: From illiterate to college graduated. The group of graduated primary school was 80.7%, approximately four fifth of all prostitutes. 3. Distribution of birth places: From all cities and provinces in Korea except Chejudo Island province. Kyongsang Namdo province was highest(24%), Kyongsan Pukdo province 18%, Pusan city 12%, and Seoul city 11%. 4. Monthly and weekly Venereal Diseases examination to prostitutes: Total examined cases were 7757, consisting of 323 monthly, and 75 weekly. Total numbers of disqualified persons were 592(7.63% of total examined), consisting of 25 monthly, and 6 weekly. 5. Clinical and laboratory findings of the rejected prostitutes at the Venereal Disease examination: Among total cases of rejected 592, gonococcal positive cases were 2.89%, staining by gram's method, cervical erosions 3.53%, and numerous pus cells but gonococcal negative 1.53%. 6. Seasonal distribution of prostitutes : Songdo beach is one of the famous sea shore sightseeing resort in Pusan. Therefore, numbers of prostitutes were increasing in hot season, summer and decreasing in cold season, winter. 7. Number of disqualified prostitutes at the Venereal Disease examination by seasonal trend: In autumn 18.04%, winter 8.68%, spring 5.85%, and summer 4.43%, in order as described, the decreasing tendency was observed. 8. Serolgical tests for syphilis: VDRL slide method and Kolmer-Wassermann reaction were performed to the prostitutes. STS were positive by VDRL slide method in 8.33-33.87%, Kolmer-Wassermann reaction in 8.33-27.42% of the prostitutes. The results of sero-positive of syphilis showed tendency toward gradually increase from 1964 to 1966. 9. Authors were observed only 1 case or soft chancer, but neither lymphogranuloma venereum nor granuloma inguinale were detected.

• Research in Community and Public Health Nursing
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• v.15 no.4
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• pp.655-665
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• 2004

Purpose: This study was aimed to investigate the physical and psychological health status of the homeless in shelters, and to suggest the basic data for caring them. Method: Study subjects were 153 homeless people who were registered in the shelters of Dong-gu, Busan, between September 1st, 2003 and March 15th, 2004. Data on their physical health status were collected by measuring weight and height (BMI), taking X-rays (tuberculosis), testing blood (syphilis, glucose, HBsAb and HBsAb). Psychological health status was measured with Rosenberg's self-esteem scale and Beck's depression scale. Data were analyzed with descriptive statistics, $x^2-test$, t-test or F-test using SPSS (Win10.0), at 0=0.05, two tailed test. Results: Mean age was 42.8 years old, high school graduated was 43.8%, and 60.8% didn't have medical benefits. Singles were 47.7%, 34.7% had bad family relationships and 39.2% hoped to live with family, 96.1% had a normal in chest X-ray test, and 96.1% had negative syphilis test 92.2% were negative for hepatitis antigen, 51.0% were antibody, 25.5% had hypertension, and 60.8% had a normal BMI test, and 84.3% had a normal blood sugar test. 39.2% were severely depressed, and 75.8% had a normal self-esteem level. Conclusion: Physical health status of the homeless was relatively good. However, depression levels were high and self-esteem was low. Therefore, it is necessary to take an action to improve the psychological health status for the homeless.

• International Journal of Oral Biology
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• v.33 no.2
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• pp.45-50
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• 2008

Treponema denticola is the best studied oral spirochete and numerous studies have shown that it is strongly associated with periodontitis and expresses several putative virulence factors. In this study, we report on a surface protein of T. denticola, Td92, which is homologous to Tp92 of Treponema pallidum, an agent of syphilis. Immunofluorescence assay and immunogold labeling with anti-Td92 Ab revealed that Td92 had surface-exposed epitopes. And Td92 was capable of binding to fibronectin and KB cells, an oral epithelial cell line. In addition, Td92 could enter the KB cells. These results indicate that Td92 is a fibronectin-binding protein which can bind to and internalize into the host cells, facilitating the virulence of T. denticola.

• Korean Journal of Health Education and Promotion
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• v.3 no.1
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• pp.98-103
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• 1985

근래에 이르러 예전의 좀 감정적인 용도로서의 성병(venereal disease)이라는 용어보다는 "성적으로" 전염되는 질환(sexually transmitted diseases; STDs)이라는 용어를 사용한다. STDs는 전염성 질환의 일단으로 그 주요한 전염경로가 성행위에 의한 것이다. 예전 용어 그 자체의 함축된 의미를 극소화시킬 필요성은 그렇다하더라도, 임질(gonorrhoea), 매독(syphilis), 비특이성(non-specific) 혹은 비임균성(non-gonococcal) 요도염 (urethritis), 연성하감(chancroid), 림포그래뉼로마 베네레움(lymphogranuloma venereum), 그래뉼로마 잉규나레(granuloma inguinale), 크라미디아 질환(chlamydial infection), 음부 혜르페스(genital herpes), 음부 사마귀(genital warts), 캔디다증(condidiasis), 트리코모나스(trichomoniasis), 마이코프라스마(mycoplasma))을 포함한 성병 (venereal disease)의 범위를 확대해야 할 필요가 있다. B형 간염(hepatitis B), B형 연쇄상구균(B-streptococcus), 사이토메가로바이러스(cytomegalovirus)도 역시 성적 전염이 가능하다. 전염이 가능하다.

• Korean Journal of Pharmacognosy
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• v.33 no.3 s.130
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• pp.169-172
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• 2002

Chinese crude drug 'To Bog Ryung' has been to cure chronic aperient, syphilis cough and diabetes. The botanical origin of the crude drug has never been studied pharmacognostically. To clarify the botanical origin of To Bog Ryung, the morphological and anatomical characteristics of the rhizomes of Smilax species growing in Korea, i.e. S. china, S. riparia var. ussuriensis, S. nipponica, S. sieboldii were compared. As a result, it was determined that To Bog Ryung was the rhizome of Smilax china and Smilax sieboldii.