• Proceedings of the Earthquake Engineering Society of Korea Conference
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• 2000.10a
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• pp.251-260
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• 2000

Seismic performance evaluation systems require rational classification of structure systems, proper evaluation criteria, and their scoring index for synthesis. Current seismic performance systems need expert judgments based on collection of available data, approximate analysis of important items, and various scoring system. This study presents a three-step seismic performance evaluation system for building structures in Korea. Each evaluation step determines the seismic performance and the method depends on the degree of refinement of analysis. The preliminary step evaluation involves the global attributes of structures such as vertical irregularity, asymmetric plan, redundancy, and age of structures. The second step requires an elastic analysis for estimation of forces acting on critical sections and checks the strength and ductility. The final step requires inelastic capacity of structures. Each stephas own evaluation scheme with proper weighing factor dependent on the importance and consequence. This study applies the fuzzy theory to a scoring method that synthesizes the individual quantity to a representative value.

• Phonetics and Speech Sciences
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• v.4 no.3
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• pp.111-117
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• 2012

In this paper, we compare the performance of several speaker adaptation methods for a HMM-based Korean speech synthesis system with small amounts of adaptation data. According to objective and subjective evaluations, a hybrid method of constrained structural maximum a posteriori linear regression (CSMAPLR) and maximum a posteriori (MAP) adaptation shows better performance than other methods, when only five minutes of adaptation data are available for the target speaker. During the objective evaluation, we find that the duration models are insufficiently adapted to the target speaker as the spectral envelope and pitch models. To alleviate the problem, we propose the duration rectification method and the duration interpolation method. Both the objective and subjective evaluations reveal that the incorporation of the proposed two methods into the conventional speaker adaptation method is effective in improving the performance of the duration model adaptation.

• MALSORI
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• v.68
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• pp.49-63
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• 2008

This paper describes the development and assessment of a hidden Markov model (HMM) based Tagalog speech synthesis system, where Tagalog is the most widely spoken indigenous language of the Philippines. Several aspects of the design process are discussed here. In order to build the synthesizer a speech database is recorded and phonetically segmented. The constructed speech corpus contains approximately 89 minutes of Tagalog speech organized in 596 spoken utterances. Furthermore, contextual information is determined. The quality of the synthesized speech is assessed by subjective tests employing 25 native Tagalog speakers as respondents. Experimental results show that the new system is able to obtain a 3.29 MOS which indicates that the developed system is able to produce highly intelligible neutral Tagalog speech with stable quality even when a small amount of speech data is used for HMM training.

• Journal of the Korean Institute of Telematics and Electronics B
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• v.31B no.3
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• pp.24-38
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• 1994

In this paper we develop the software simulator written in a C language for a frequency modulation synthesis and the approximate range of parameters, for a musically satisfactory timbre, obtained by using the software simulator will be applied to develop an algorithm for parameter extraction. For a frequency modulation synthesis, we also develop an algorithm for parameter extraction through waveform analysis in the time domain as well as spectrum analysis using a FFT in the frequency domain. To verify the validity of the developed algorithm as well as software simulator experimentally, we extract parameters for the several music instruments using the suggested algorithm and analyze the synthesized sound by applying the parameters to the software simulator. The evaluation of the synthesized sound is first done by listening the sound directly as a subjective testing. Secondly, to evaluate the synthesized sound objectively with an engineering sense, we compare the synthesized sound with an original one in a time domain and a frequency domain.

• Journal of information and communication convergence engineering
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• v.6 no.4
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• pp.383-390
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• 2008

Clock skew modeling is important in the performance evaluation and prediction of clock distribution network and it is one of the major constraints for high-speed operation of synchronous integrated circuits. In clock routing synthesis, it is necessary to reduce the clock skew under the specified skew bound, while minimizing the cost such as total wire length and delay. In this paper, a new efficient bounded clock skew routing method is described, which generalizes the well-known bounded skew tree method by allowing loops, i.e., link-edges can be inserted to a clock tree when they are beneficial to reduce the clock skew and/or the wire length. Furthermore, routing topology construction and wire sizing is used to reduce clock delay.

• Toxicological Research
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• v.26 no.1
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• pp.61-66
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• 2010

Retinoids have many beneficial effects on dermatological applications. But, retinoids cause skin irritation. In this study, the safety of retinoids was clarified via both primary skin irritation test in rabbits and sensitization study using an integrated model for the differentiation of chemical-induced allergic and irritant skin reaction (IMDS), an alternative method to sensitization test. The effects of retinoids on the change of ultraviolet A (UVA)-induced matrix metalloproteinase-1 (MMP-1) in human skin fibroblasts and the modulation of type-1 pN collagen synthesis in hairless mice were examined to clarify the anti-wrinkle effects. Alltrans retinol (t-ROL) and its derivative, all-trans retinoic acid (t-RA), showed mild skin irritation but did not induce the sensitization. t-ROL and t-RA exerted anti-wrinkle effects by inhibiting the UVA-induced MMP-1 in human skin fibroblasts and increasing the type-1 pN collagen synthesis in hairless mice. These findings suggest that retinoids do not induce the allergy, and show anti-wrinkle effects by decreasing MMP-1 activation and increasing collagen synthesis.

• Biomolecules & Therapeutics
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• v.16 no.1
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• pp.28-33
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• 2008

Atorvastatin calcium salt (1) was obtained through the preparation of lactone compound (8) from 2-((4R,6R)-6-(2-(2-(4-fluorophenyl)-5-isopropyl-3-phenyl-4-(phenylcarbamoyl)-1H-pyrrol-1-yl)-ethyl)-2-phenyl-1,3,2-dioxaborinan-4-yl)acetic acid tert-butyl ester (9) by hydrolysis in basic condition. Efficient hydrolysis of boronate compound 9 aimed at the viable synthesis for commercial production and purification of Atorvastatin calcium is reported. Detail studies of evaluation procedure are also reported.

• Speech Sciences
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• v.14 no.2
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• pp.91-103
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• 2007

The purpose of this paper is to develop a model enabling to predict the prosody of Korean text-to-speech synthesis using the CART and SKES algorithms. CART prefers a prediction variable in many instances. Therefore, a partition method by F-Test was applied to CART which had reduced the number of instances by grouping phonemes. Furthermore, the quality of the text-to-speech synthesis was evaluated after applying the SKES algorithm to the same data size. For the evaluation, MOS tests were performed on 30 men and women in their twenties. Results showed that the synthesized speech was improved in a more clear and natural manner by applying the SKES algorithm.

• Archives of Pharmacal Research
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• v.24 no.3
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• pp.171-179
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• 2001

The present investigation deals with the synthesis of some new salicylamidoacetyl sulfonamides 3a,b, salicylamido ethylacetate 4, salicylamido acetic acid hydrazide 5, which is considered as the key intermediate for the synthesis of several series of new compounds such as salicylamido pyrazol 6 and pyrazolone 1. N-imido-derivatives 9, 10, 11, thiadiazole 13, oxadiazole 14, 15, Schiffs bases 16a-f. Cyclocondensation of Schiffs bases with thioglycolic acid gave thiazolidinone 18a-c while with acetylchloride afforded azitidinones 19a-c and with acetic anhydride gave 1,4-benzoxazepine-3,5-dione. Some of the compounds were tested for their analgesic and antiinflammatory activities as well as ulcerogenic effects. Some derivatives were more effective than salicylamide and ulcerogenic activity was variably lowered .

• KIEAE Journal
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• v.13 no.2
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• pp.85-92
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• 2013

Regarding urban design in this 21st century, cities pursue human-oriented urban design through which nature, cities, and human beings are unified and interact with one another. For such urban design maintenance, it is needed to conduct systematic analysis and synthesis on various and complex factors of cities expressing urban images. Also, it is necessary to secure methods to evaluate those cities based on urban users' visual information. Thereupon, this study aims to suggest urban design evaluation methods which accept human behavior or needs and also allow us to figure out desirable images. For this, the study established the construction system of the most basic urban design components that form cities through literature review and expert evaluation. And it examines correlation among those factors with statistic means. Through this, the study suggests a new urban design evaluation system and evaluation process divided into experts and users so as to reflect user behavior or needs.