• Korean Journal of Clinical Laboratory Science
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• v.38 no.3
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• pp.166-172
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• 2006

Metallo-${\beta}$-lactamase (MBL) can hydrolyze all ${\beta}$-lactams except monobactams and frequently coexists with various antibiotic resistance genes such as aminoglycoside resistance, sulfonamide resistance gene, etc. Therefore, the effective antibiotics against infections by these bacteria are markedly limited or can't even be found. We tried to search in-vitro antimicrobial combinations with synergistic effects for a VIM-2 type MBL producing Pseudomonas aeruginosa, isolated from clinical specimen. On the selection of antibiotic combinations with synergistic effects, we performed a one disk synergy test, modified Pestel's method, in agar without aztreonam (AZT). The bacteriostatic synergistic effects of this tests were scored as $S_1$ (by susceptibility pattern in agar without antibiotics), $S_2$ (by the change of susceptibility in agar with or without antibiotics) and $S_3$ ($S_1$ + $S_2$) and was classified into weak (1 point), moderate (2 points) and strong (3 points) by $S_3$ score. Subsequently, we carried out the time-killing curve for the antibiotic combinations with the strong synergistic bacteriostatic effect. One VIM-2 type MBL producing P. aeruginosa confirmed by the PCR showed all resistance against all ${\beta}$-lactams except AZT, aminoglycoside and ciprofloxacin. In the one disk synergy test, this isolate showed a strong bacteriostatic synergistic effect for the antibiotic combination of AZT and piperacillin-tazobactam (PIP-TZP) or AZT and amikacin (AN). On the time-killing curve after six hours of incubation, the colony forming units (CFUs/mL) of this bacteria in the medium broth with both combination antibiotics were decreased to 1/18.7, 1/17.1 of the least CFUs of each single antibiotics. The triple antibiotic combination therapy including AZT, PIP-TZP and AN was shown to be significantly synergistic after 8 hrs of exposure. In a VIM-2 MBL producing P. aeruginosa with susceptibility for AZT, the triple antibiotic combination therapy including AZT, PIP-TZP and AN may be considered as an alternative antibiotics modality against the infection by some MBL type. But the antimicrobial combination therapy for many more MBL producing isolates is essential to know as soon as possible for the selection of effective treatment against the infection by this bacteria.

• Journal of Microbiology and Biotechnology
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• v.27 no.4
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• pp.685-693
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• 2017

Candidiasis involving the biofilms of Candida albicans is a threat to immunocompromised patients. Candida biofilms are intrinsically resistant to the antifungal drugs and hence novel treatment strategies are desired. The study intended to evaluate the anti-Candida activity of allyl isothiocyanate (AITC) alone and with fluconazole (FLC), particularly against the biofilms. Results revealed the concentration-dependent activity of AITC against the planktonic growth and virulence factors of C. albicans. Significant (p <0.05) inhibition of the biofilms was evident at ${\leq}1mg/ml$ concentrations of AITC. Notably, a combination of 0.004 mg/ml of FLC and 0.125 mg/ml of AITC prevented the biofilm formation. Similarly, the preformed biofilms were significantly (p <0.05) inhibited by the AITC-FLC combination. The fractional inhibitory concentration indices ranging from 0.132 to 0.312 indicated the synergistic activity of AITC and FLC against the biofilm formation and the preformed biofilms. No hemolytic activity at the biofilm inhibitory concentrations of AITC and the AITC-FLC combination suggested the absence of cytotoxic effects. The recognizable synergy between AITC and FLC offers a potential therapeutic strategy against biofilm-associated Candida infections.

• Computers and Concrete
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• v.20 no.1
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• pp.99-110
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• 2017

Service life assessments which do not include the synergy between mechanical and environmental loading are neglecting a factor that can have a significant impact on structural safety and durability assessment. The degradation of concrete structure is a result of the combined effect of environmental and mechanical factors. In order to make service life design realistic it is necessary to consider both of these factors acting simultaneously. This paper deals with the advanced modelling of concrete carbonation and chloride ingress into concrete using stochastic 1D and 2D models. Widely accepted models incorporated into the new fib Model Code 2010 are extended to include factors that reflect the coupled effects of mechanical and environmental loads on the durability and reliability of reinforced concrete structures. An example of cooling tower degradation by carbonation and an example of a bended reinforced concrete beam kept for several years in salt fog are numerically studied to show the capability of the stochastic approach. The modelled degradation measures are compared with experimental results, leading to good agreement.

• World Technopolis Review
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• v.3 no.1
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• pp.39-54
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• 2014

Recently, investment to basic science has been increased and infrastructure of science and technology has been expanded in developed countries like U.S.A, UK and Japan to foster high-tech industries. Science and research parks are built and under operation to acquire national competitive power and to activate regional economy over the world today. It is argued that more synergy effects are generated when science and research parks are operated in cooperation with related organizations and facilities such as firms, universities, research institutes and governments than it is operated by one organization. The aim of this paper is to develop a governance model of science and research parks. One comprehensive model and three individual governance models were developed according to the structure and relations of industry-science/research park-supporting organization interactions. When governance model of science and research parks is established and properly managed, national development capacity would be greatly enhanced through the acceleration of technology transfer, industrial production rise and enhancement of efficiency in the area of R&D and supporting system etc. One of the key factors in building governance system for science and research parks is establishing a control tower that supervises governance system comprehensively and systematically.

• Journal of Family Resource Management and Policy Review
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• v.10 no.3
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• pp.113-130
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• 2006

This main goal of this program is to prove the effectiveness of family leadership program that was developed on the theoretical basis of strengths of family life. The family leadership program comprised four steps through the FGI and qualitative interview with experts. The steps 1 and 2 were planned to help the middle-aged married women to cultivate the individual leadership by establishing visions and understanding the role. The steps 3 and 4 were set to build up the relational leadership through the communication competency and synergy creation between family. This program was applied to 15 respondents by the multidimensional promotion strategies. As a result, it was recognized that the middle-aged married women had developed the leadership that created the synergy effects by setting family visions, role and improvement of communication strategies. Overall, this study positively achieved the objective to improve the individual and relational leadership of family CEO.

• Journal of Korean Institute of Industrial Engineers
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• v.26 no.1
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• pp.36-47
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• 2000

DEA has been effectively applied to various areas which need the evaluation of relative efficiency. We propose a DEA model based on fuzzy LP in order to consider uncertain synergy effects due to M&A of existing organization. We apply the suggested approach to forecasting the efficiency of merged academic departments in a university in Korea. We expect that our approach can be utilized to effectively realign existing departments.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2000.04a
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• pp.445-448
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• 2000

Researches about an evaluation system for military officers have been studied because it is one of the most important elements for managing units and improving combat power. This paper proposes an evaluation system that enhance justice of evaluation, accomplish a distintion among evaluating elements and improve synergy effects between higher level officers and lower level officers. The evaluation system in this study not only suggests evaluating items and methods but also determines the final evaluation ranking among the evaluated that have their own evaluation criteria, items and duties using the median rank method used in statistics.

• Proceedings of the Korean Operations and Management Science Society Conference
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• 2000.04a
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• pp.569-572
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• 2000

DEA has been effectively applied to various areas which need the evaluation of relative efficiency. We propose a DEA model based on fuzzy LP combined with Genetic Algorithm in order to consider uncertain synergy effects due to M&A of existing organization. We apply the suggested approach to forecasting the efficiency of merged academic departments in a university in Korea. We expect that our approach can be utilized to effectively realign existing departments.

• Animal Bioscience
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• v.36 no.9
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• pp.1305-1313
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• 2023

Synthetic antioxidants have shown adverse effects on consumers. The review, thus, aims to assess the effect of marinating broiler meat with plant leaves-derived antioxidants potential for improving shelf-life and human health. Broiler meat loss and waste due to spoilage is more than three million kg annually, thus, extending shelf-life by reducing initial microbial load and autoxidation is essential. Adding various antioxidants would reduce oxidation of protein and fatty acids improving nutritional shelf-life through synergic interactions. Antioxidant synergetic effects also improves reduction in microbiota proliferation leading to the delayed development of off flavours and deterioration of meat colour. To reduce initial microbial load and autoxidation effects, the inclusion of polyphenols and antioxidants from varying sources by mixing various antioxidants would lead to improved synergic effects.

• Journal of Environmental Impact Assessment
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• v.17 no.5
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• pp.299-309
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• 2008

Cumulative effects can be defined as impacts on environment which results from incremental impacts of a proposed project, which covers other past, present, and reasonably foreseeable future actions. The necessity of Cumulative Effect Assessment is that, when there are several projects near the project area, environmental effects of individual project can be larger or smaller than those of individual project without having projects nearby because of synergy, ascending and descending effects. This study was intended to help Environmental Impact Assessment practitioners identify spatial and temporal boundaries during the scoping stage. To do this, literature review of domestic and foreign legislations, guidelines, textbooks and papers related to Environmental Impact Assessment and Cumulative Effect Assessment was accomplished. This study suggests that continuous research be needed in order to identify spatial boundaries for other assessment fields and to develop methodologies for cumulative effect assessment.