• Title/Summary/Keyword: Symptoms and signs

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Antigenicity Tests of BR92021, a Vi polysaccharide Typhoid Vaccine, in Guinea Pigs (기니픽을 이용한 BR92021(정제 브이아이 장티푸스 백신)의 항원성 평가)

  • 정태천;김갑호;배주현;구희경;서정은;박종일;차신우;임상민;정한선
    • Biomolecules & Therapeutics
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    • v.7 no.3
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    • pp.300-306
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    • 1999
  • To study the antigenicity of BR92021(Vi polysaccharide typhoid vaccine), active systemic ana-phylaxis and passive cutaneous anaphylaxis were tested in guinea pigs. The groups were as follows: group I(low dose, 30 $\mu\textrm{l}$/kg), group II(high dose, 300 $\mu\textrm{l}$/kg), group III(300 $\mu\textrm{l}$/kg plus complete Freund's adjuvant), group IV(positive control, ovalbumin plus complete Freund's adjuvant) and group V(saline-treated control). Male Hartley guinea pigs at 7 weeks of age were sensitized subcutaneously with the test article or saline three times per week for three weeks(j.e., total 9 times). For groups III and IV, animals were sensitized subcutaneously with either the test article or ovalbumin plus complete Freund's adjuvant once per three week for 6 weeks(i.e., total 3 times). Twelve days after the last sensitization, the blood was collected from the sensitized animals for the passive cutaneous anaphylaxis test. In addition, the sensitized animals were subjected to the active systemic anaphylaxis test on fourteen days after the last sensitization by an intravenous challenge with either the test article or ovalbumin. In group I, mild(1/5) or moderate(4/5) symptoms of anaphylactic shock were observed. In group II, no sign(1/5), moderate(3/5) and severe(1/5) symptoms were observed. In group III, four animals of revealed moderate signs and one of 5 showed no signs of anaphylactic shock. In group IV, all 5 animals showed severe signs of shock. In group V, one of 5 revealed moderate and four of 5 showed no signs. The necropsy findings related to the active systemic anaphylaxis were observed in most animals of groups I to V In the passive cutaneous anaphylaxis test, the antiserum was diluted 10- to 5120- fold and was injected intradermally on the clipped back of recipient animals, followed by an intravenous challenge with either the test article or ovalbumin. No animals in groups I, II, III and V showed the positive reaction, whereas all animals in group IV, the positive control, showed the positive reaction at the dilution range of x1280 to x5120. Our results indicate that the test article, BR92021, may have weak antigenic potential in male guinea pigs.

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The Impact of CTD on Industry and an Ergonomic Prevention program (누적외상병이 산업계에 미치는 영향과 인간공학적 예방프로그램)

  • 김철홍
    • Journal of Korean Society of Industrial and Systems Engineering
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    • v.19 no.40
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    • pp.311-319
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    • 1996
  • Cumulative trauma disorders (CTD) refer to a category of physical signs and symptoms due to chronic musculoskeletal injuries where the antecedents appear to be related to some aspect of repetitive work which can be found commonly in modern industries. This paper describes impacts of CTD on modern industry and summarizes recent resent research efforts and suggests an ergonomic program to prevent incident of CTD in hand-intensive industry.

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A Study on Concept Analysis of Loneliness

  • Jung, Yun-kung;Lee, Jeong-hwa
    • Journal of Korean Clinical Health Science
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    • v.6 no.2
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    • pp.1097-1105
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    • 2018
  • Purpose: Loneliness is an extremely subjective experience that is influenced by life experiences and circumstances. This study attempted to provide basic data for the development of nursing intervention strategies to understand the concept of loneliness and to reduce loneliness on various topics. Methods: The research analysis method is based on the framework of concept analysis proposed by Walker and Avant (1988). Results: The results of this study are as follows: 1) Self-alienation 2) Isolation of human beings 3) Psychological damage reaction 4) Pain 5) Loneliness is the loss of a comfortable "frame". The prerequisites can be divided into personal characteristics and situational characteristics. Empirical criteria include intimate others, lack of social relationships or problems, family and friendship, belonging, recognition or expression of loneliness, emotional state changes and changes in health behavior, and physical symptoms. Conclusions: Loneliness is an important indicator of well-being and a cause of physical and mental illnesses, so nurses facing various subjects should be able to recognize the signs and symptoms of loneliness. By promoting and sustaining their interest, they should be able to enjoy lonely people.

Consideration of the location of Disease (병위에 대한 소고)

  • Shin Hyun Jong;Lee Kwang Gyu
    • Journal of Physiology & Pathology in Korean Medicine
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    • v.17 no.1
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    • pp.31-36
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    • 2003
  • The causes of disease as well as the mechanisms that result in the presenting signs and symptoms of patients are basic elements in oriental medicine. The location of the disease is the region on which the cause and the nature of the disease acts. Syndrome reflects the cause of the disease and the pathological change and the location of the disease. It is customary to classify the location of the disease into two major categories. First is based on the exterior and interior and the second is based on the five internal organs. Exterior syndrome is caused by the invasion of exopathogen in skin and hair, channels and collaterals. Interior syndrome refers to the syndrome located deeply in the interior of the body such as five internal organs. The location of the disease is very important to distinguish different syndromes in the diagnosis and the treatment of a disease.

Cervical Traction: Review of Literature and Treatment Guidelines (경추견인: 문헌고찰과 치료지침)

  • Kim Han-Soo;Lee Yong-Deok;Kwon Won-An
    • The Journal of Korean Physical Therapy
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    • v.14 no.3
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    • pp.24-44
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    • 2002
  • Traction has been used since ancient times in the treatment of painfull spinal conditions, but the literature on traction and its clinical effectiveness Is limited. Traction can be defined as a drawing or pulling tension applied to a body segment. Cervical traction is a technique that applies a longitudinal force of the cervical spine and associated structures. Goals of traction include reduction of radicular signs and symptoms associated with conditions such as disk protrusion, degenerative disk disease, lateral stenosis, muscle spasm, and subluxations. The various mechanical factors most relevant to cervical traction are organized and discussed. The factors presented are 1) angle of pull, 2) Traction force, 3) duration of traction, 4) neck position and clinical application, and 5) frequency of treatment. It should allow physical therapists to adjust traction protocol to match the patient's symptoms and diagnosis. The purpose of this study is to provide a comprehensive overview of the cervical traction and treatment guidelines.

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Clinical Study of Infectious Mononucleosis (전염성 단핵구증의 임상적 고찰)

  • 이형석;이승환;권순욱;김경래;허영돈
    • Korean Journal of Bronchoesophagology
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    • v.5 no.1
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    • pp.22-29
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    • 1999
  • Background: Infectious mononucleosis is a disease precipitated by Epstein-Barr virus(EBV) in mostly children, some seronegative adolescents and young adults comprising clinical symptoms such as fever, lymphadenopathy, and pharyngitis as well as laboratory findings such as hetero-phil antibodies and atypical lymphocytosis. It is confirmed by serologic test for EBV. Materials and Methods: A retrospective evaluation of 26 patients who diagnosed with infectious mononucleosis was peformed through the analysis of typical symptom, sign and laboratory findings. Results : Infectious mononucleosis occurs mostly at 3 to 10 years (74.9%), common symptoms and signs are fever, cervical lymphadenopathy, tonsillar enlargement and exudate. Positive ratio of atypical Lymphocyte(>10%) and hetrophil antibodies are 61.5%, 35.2% respectively, it is less diagnostic. EBV-viral capsid antigen(VCA) IgM are positive in all cases, so it is most diagnostic findings. Conclusion: Infectious mononucleosis should be considered as a cause of cervical lymphadenopathy and pharyngotonsillitis in children and young adults, the assessment of EBV-VCA IgM is necessary for the diagnosis.

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Surgical treatment of postpneumonectomy empyema associated with bronchopleural fistula; A report of Three cases (기관지늑막루를 동반한 농흉의 외과적 치료-3 치험례-)

  • Kim, Yong-Jin;Kim, Hyeon-Sun;Seo, Gyeong-Pil
    • Journal of Chest Surgery
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    • v.15 no.3
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    • pp.295-298
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    • 1982
  • Persistent bronchopleural fistula still presents a troublesome therapeutic challenge and demands an aggressive approach when conventional measures fail. Empyema associated bronchopleural fistula developed after resectional surgery and their primary diseases were lung abscess in one case, bronchiectasis in two cases. Three cases of postpneumonectomy empyema associated bronchopleural fistula were treated surgically with a pedicled intercostal muscle grafting and concomittent thoracoplasty. After the procedure, patients had no recurrent symptoms or signs of bronchopleural fistula and discharged from hospital with improved condition.

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Cystinuria in Siblings (남매에서 발생한 Cystinuria)

  • Lee, Dong Hwan
    • Journal of The Korean Society of Inherited Metabolic disease
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    • v.1 no.1
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    • pp.18-22
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    • 2001
  • Renal colic, hematuria, dysuria and stone passage were developed in younger brother (4 year 6 month old boy). But the elder sister (6 year old girl)had no specific symptoms and signs. The identification of the disease was proved by cyanide nitroprusside test and amino acid analysis of urine. In our patients the chromatographic amino acid patterns of urine showed remarkably increased excretion of cystine, ornithine, lysine, and arginine. They are managed by adequate hydration with Shohl solution for rendering the urine more alkaline, and alpha-mercaptopropionylglycine (Thiola).

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CASE REPORT ON THE DENTIGEROUS CYST OCCURED TO THE PERIPHERY OF THE IMPACTED SUPERNUMERARY TOOTH (매복치(埋伏齒) 주위(周圍)에 발생(發生)한 치성낭종(齒性囊腫)의 치험례(治驗例))

  • Yoo, K.W.
    • Restorative Dentistry and Endodontics
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    • v.6 no.1
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    • pp.149-152
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    • 1980
  • In this article, we found the dentigerous cyst due to the impacted supernumerary tooth. Involved teeth were treated with immediat canal filling and root resection technique. The cystic walls and its contents were marsupialized and perfectly enucleated with surgical techniques. After the operations, no clinical signs and symptoms were found, Radiographic findings after I months of the operations reveal the decrease of the radiolucency on the surgical field. The author thinks that it indicate the formation of the osteoid tissue.

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Retro-odontoid Synovial Cyst with Os Odontoideum and Atlantoaxial Instability

  • Kim, Sang-Woo;Chang, Chul-Hoon;Kim, Seong-Ho
    • Journal of Korean Neurosurgical Society
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    • v.39 no.3
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    • pp.221-223
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    • 2006
  • We report the case of a patient with a retro-odontoid synovial cyst, coupled with os odontoideum and atlantoaxial instability. We observed the regression of the cyst after C1-2 transarticular screw fixation and posterior wiring without direct surgical excision of the cyst on the follow-up MR images, which were obtained two and three months postoperatively. The myelopathic symptoms and signs of this patient were resolved by degrees.