• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• 제32권1호
• /
• pp.1-7
• /
• 2006

The present study was aimed to explore the role of sympathetic and parasympathetic nerves in the regulation of sodium transporters and water channels in the salivary gland. Rats were denervated of their sympathetic and parasympathetic nerves to the submandibular gland, and the glandular expression of sodium transporters and water channels was determined by Western blot analysis. The expression of either ${\alpha}1$ or ${\beta}1$ subunit of Na, K-ATPase was not significantly affected either by the sympathetic or by the parasympathetic denervation. The expression of subunits of epithelial sodium channels was significantly increased both in the denervated and contralateral glands either by the sympathetic or by the parasympathetic denervation. Neither the sympathetic nor the parasympathetic denervation significantly altered the expression of aquaporin-1 (AQP1). Nor was the expression of AQP4 affected significantly by the parasympathetic or the sympathetic denervation. On the contrary, the expression of AQP5 was significantly increased not only by the parasympathetic but also by the sympathetic denervation. These results suggest that sympathetic and parasympathetic nerves have tonic regulatory effects on the regulation of certain sodium transporters and AQP water channels in the salivary gland.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
• /
• 제31권1호
• /
• pp.24-30
• /
• 2005

타액선에서 교감 신경과 부교감 신경이 나트륨 운반체와 수분 통로의 조절에 어떠한 기능을 하는지 알아 보고자 흰쥐 악하선을 지배하는 교감 신경과 부교감 신경을 절제하고 나서 타액선내 나트륨 운반체와 수분 통로의 발현을 조사하여 다음과 같은 성적을 얻었다. 1. Na,K-ATPase의 ${\alpha}1,\;{\beta}1$ 소단위는 교감 신경 절제에 의해 크게 영향받지 않았으나 부교감 신경 절제에 의해서는 두 소단위의 발현이 모두 감소되었다. 2. ENaC ${\alpha}-,\;{\beta}-,\;{\gamma}-$ 소단위는 그 발현이 교감 신경 절제에 의해 영향 받지 않았으나 부교감 신경 절제에 의해서 도리어 증가하였다. 3. NHE3는 교감 신경 및 부교감 신경 절제에 의해 모두 크게 감소했다. 4. 교감 신경 절제시 AQP1의 발현이 크게 증가했으나, 부교감 신경 절제시 영향 받지 않았다. 5. 교감 신경 절제 및 부교감 신경 절제는 AQP4 발현을 크게 증가시켰다. 6. AQP5는 교감 신경 절제시 영향을 받지 않았으나, 부교감 신경 절제시 크게 감소되었다. 이상의 실험성적을 요약할 때 악하선을 지배하는 교감 신경 및 부교감 신경은 선의 나트륨 운반체 및 수분 통로 발현에 긴장성 조절을 영위함으로써 타액의 전해질 및 수분 조성을 결정하는 데 공헌함을 알 수 있다. 그리고 이 신경의 절제시 보이는 나트륨 운반체와 수분 통로의 변화는 기능적으로 신경 절제 타액선에서의 타액 분비량과 타액의 무기질 조성 변화의 원인이 될 것이라 생각된다.

• The Korean Journal of Physiology and Pharmacology
• /
• 제10권2호
• /
• pp.65-69
• /
• 2006

The present study was undertaken to explore the role of autonomic nerves in the regulation of sodium transporters and water channels in the salivary gland. Rats were denervated of their sympathetic or parasympathetic nerves to the submandibular gland. One week later, the expression of Na,K-ATPase, epithelial sodium channels (ENaC), and aquaporins (AQP) was examined in the denervated and contralateral glands. The sympathetic denervation slightly but significantly decreased the expression of ${\alpha}1$ subunit of Na,K-ATPase, whereas the parasympathetic denervation increased it. The expression of ${\alpha}$-subunit of ENaC was significantly increased in both the denervated and contralateral glands either by the sympathetic or parasympathetic denervation. The sympathetic denervation significantly increased the expression of AQP5 in both the denervated and contralateral glands, whereas the parasympathetic denervation decreased it. It is suggested that the autonomic nerves have a tonic effect on the regulation of sodium transporters and AQP water channels in the salivary gland.

• 약학회지
• /
• 제35권6호
• /
• pp.486-496
• /
• 1991

Spinal parasympathetic outflows originate in the sacral parasympathetic nuclei. The sacral parasympathetic nuclei receive inputs from the brainstem. Many areas in the medulla appear to influence sympathetic outflow of the spinal cord. Whether neurons in these areas of the medulla may project to the lumbosacral cord to affect the parasympathetic outflow has not been studied clearly. Thus, this study was intended to investigate origins of cells projecting from the medulla to the sacral parasympathetic nuclei of the spinal cord. In 3 cats, horseradish peroxidase (HRP) was injected into the lower lumbar spinal cord. HRP labeled neurons were found mainly in the following areas: nucleus retroambiguus, nucleus tractus solitarius, raphe complex and ventrolateral area of the rostral medulla. Most of these areas are known to be involved in regulation of sympathetic activity, and, thus, these results indicate that these areas are likely to affect the sacral parasympathetic outflow as they do for the sympathetic nerves.

• 한국한의학연구원논문집
• /
• 제16권1호
• /
• pp.157-171
• /
• 2010

This study aimed to investigate the effect of four common types of Qigong position (standing, sitting, supine, and horse-riding position) on the autonomic nervous system. Thirty healthy subjects participated in this study once a week for four weeks. Electroencephalogram (EEG) was measured three times (before, during, and after the position) while the subject maintained one of four positions for ten minutes. There were significant changes in HRV components compared with EEG power spectra in the standing position. Especially, the ratio of low-to-high frequency (LF/HF) which represents a state of balance of autonomic nervous system was increased. In the sitting position, $\beta$ wave which reflects a state of alert consciousness was increased and both the sympathetic and parasympathetic nerves were activated. On the other hand, in the spine position, $\theta$ wave which signifies a state of relaxation was increased and heart rate (HR) was decreased. Activation of sympathetic and parasympathetic nerves was also observed in this position. Significant increases of indices related to awakening and concentration were observed accompanied by increase of HR and a sympathetic nerve was activated in the riding-horse position. In the present study, it was shown that each Qigong position caused various and significant changes in autonomic nervous system. It would be expected that these results can be applied in the choice of appropriate Qigong position according to objective of Qigong therapy although it is remained to further evaluate the effects of long-term maintenance of Qigong positions and repeated Qigong training.

• 한국한의학연구원논문집
• /
• 제17권2호
• /
• pp.85-100
• /
• 2011

Objectives : This study aimed to investigate the effect of four common types of Qigong position (standing, sitting, supine, and horse-riding position) on the autonomic nervous system. Method : Thirty healthy subjects participated in this study once a week for four weeks. Heart Rate Variability (HRV) was measured three times (before, during, and after the position) while the subject maintained one of four positions for ten minutes. Result : There were significant changes HRV in the standing position. In the sitting position, both the sympathetic and parasympathetic nerves were activated. On the other hand, in the spine position, heart rate (HR) was decreased. Activation of sympathetic and parasympathetic nerves was also observed in this position. Significant increases of indices related to awakening and concentration were observed accompanied by increase of HR and a sympathetic nerve was activated in the riding-horse position. Conclusions : In the present study, it was shown that each Qigong position caused various and significant changes in autonomic nervous system. It would be expected that these results can be applied to choose appropriate Qigong position according to objective of Qigong therapy although it is remained to further evaluate the effects of long-term maintenance of Qigong positions and repeated Qigong training.

• BMB Reports
• /
• 제57권4호
• /
• pp.167-175
• /
• 2024

Cancer progression is driven by genetic mutations, environmental factors, and intricate interactions within the tumor microenvironment (TME). The TME comprises of diverse cell types, such as cancer cells, immune cells, stromal cells, and neuronal cells. These cells mutually influence each other through various factors, including cytokines, vascular perfusion, and matrix stiffness. In the initial or developmental stage of cancer, neurotrophic factors such as nerve growth factor, brain-derived neurotrophic factor, and glial cell line-derived neurotrophic factor are associated with poor prognosis of various cancers by communicating with cancer cells, immune cells, and peripheral nerves within the TME. Over the past decade, research has been conducted to prevent cancer growth by controlling the activation of neurotrophic factors within tumors, exhibiting a novel attemt in cancer treatment with promising results. More recently, research focusing on controlling cancer growth through regulation of the autonomic nervous system, including the sympathetic and parasympathetic nervous systems, has gained significant attention. Sympathetic signaling predominantly promotes tumor progression, while the role of parasympathetic signaling varies among different cancer types. Neurotransmitters released from these signalings can directly or indirectly affect tumor cells or immune cells within the TME. Additionally, sensory nerve significantly promotes cancer progression. In the advanced stage of cancer, cancer-associated cachexia occurs, characterized by tissue wasting and reduced quality of life. This process involves the pathways via brainstem growth and differentiation factor 15-glial cell line-derived neurotrophic factor receptor alpha-like signaling and hypothalamic proopiomelanocortin neurons. Our review highlights the critical role of neurotrophic factors as well as central nervous system on the progression of cancer, offering promising avenues for targeted therapeutic strategies.

• Journal of Magnetics
• /
• 제18권2호
• /
• pp.192-196
• /
• 2013

We have investigated the changes of electroencephalography (EEG) and electrocardiography (ECG) under pulsed magnetic field (PMF) and acupuncture stimulus on acupoint PC9. In order to compare quantitatively the effect of PMF and acupuncture stimulus, the difference of alpha activities are calculated from EEG spectra, and the spectrum curves of ECG were analyzed in the frequency domain of heart rate variability (HRV). The increase of alpha activities after both stimuli could be explained that the impulse of stimulus on PC9 might pass through sensory nerve following meridian and approach the cerebral cortex, causing the central nervous system (CNS) to be activated for pacifying emotion and calming the mind. The decrease in sympathovagal activity of HRV after both stimuli indicates that parasympathetic nerves were activated and the sympathetic nerves were in constrained condition. These findings suggest that PMF could be patient-friendly alternative non-invasive medical treatment for influencing human physiology, in comparison with acupuncture inserting the needle and inducing nervous and anxious state to subject.

• 척추신경추나의학회지
• /
• 제4권2호
• /
• pp.47-60
• /
• 2009

Objectives : The purpose of this study is to investigate the effect of chuna treatment on cervical sprain caused by traffic accident in early stage. Methods : This study carried out on 20 patients who have received hospital treatment in Daejeon Univ. cheonan Oriental Hospital. Non-chuna group got acupunture-therapy, herbal medication, physical therapy and Chuna group got chuna treatment besides. We measured Heart Rate Variability(HRV) and Visual Analog Scale(VAS) on 2nd, 4th day. Results : After being treated by our methods, Chuna Group showed the inclination to balance the sympathetic and parasympathetic nerve. In chuna group, an autonomic nerve activity showed the inclination to increase. But there were no significant difference between both groups. Chuna group's VAS were significantly decreased(p=0.043). Conclusions : The results suggest that Chuna treatment help traffic accident patients in early stage to reduce pain. Refer to autonomic nerve system, chuna treatment seem to do positive effect but Further long tenn study in a large scale is needed.

• 생물정신의학
• /
• 제15권3호
• /
• pp.147-151
• /
• 2008

This review briefly summarizes the relevant knowledge of psychoneuroimmunological basis for neuroimmunology, with particular emphasis on bidirectional neural-immune interactions. The immune system and the nervous system maintain extensive communication, including hardwiring of sympathetic and parasympathetic nerves to lymphoid organs. Immune system is modulated by various neurotransmitters such as acetylcholine, norepinephrine, substance P and histamine. Neuroendocrine hormones such as corticotrophin-releasing hormone(CRH) or substance P regulate cytokine balance. The immune system modulates brain activity including sleep and body temperature. Recent studies have revealed that psychological factors which influence immunity and immune-related disease may modulate brain-to -immune interaction. But, we still await the scientific research and evidences to prove whether or how behavioral or treatment intervention of stress can influence the development, progress or prevention of a specific disease.