• 정보과학회 논문지
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• 제44권5호
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• pp.545-552
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• 2017

최근 네트워크 기술과 모바일 기기의 발달로 인해 네트워크를 효율적으로 사용하여 비디오 스트리밍 서비스를 제공하기 위해 HTTP 적응적 스트리밍 서비스가 주목 받게 되었다. 사용자 중심 방송에 대한 관심이 증가함에 따라 대화형 멀티미디어에 대한 연구가 활발하게 진행되고 있다. 대화형 멀티미디어 서비스는 사용자가 선택하는 시나리오에 따라 영상을 재생하는 방식이다. 기존의 HTTP 적응적 스트리밍 방식으로 대화형 멀티미디어 서비스를 제공하면 사용자가 시나리오를 선택하는 시점에 따라 시나리오 변환에 의한 지연 및 버퍼 언더플로우를 유발하여 사용자 체감 품질을 저하시킨다. 따라서 본 논문에서는 끊김 없는 대화형 멀티미디어 스트리밍 서비스를 제공하기 위해 HTTP 적응적 스트리밍 기반의 대화형 멀티미디어 전송 기술을 제안한다. 제안하는 기법은 대화형 멀티미디어 스트리밍 서비스를 위한 시스템 구조와 프리패칭 기법이다.

• Journal of Power Electronics
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• 제15권5호
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• pp.1305-1317
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• 2015

Distributed generation systems (DGSs) have been getting more and more attention in terms of renewable energy use and new generation technologies in the past decades. The self-excited induction generator (SEIG) occupies an important role in the area of energy conversion due to its low cost, robustness and simple control. Unlike synchronous generators, the SEIG has to absorb capacitive reactive power from the outer device aiming to stabilize the terminal voltage at load changes. This paper presents a novel static VAR compensator (SVC) called a magnetic energy recovery switch (MERS) to serve as a voltage controller in SEIG powered DGSs. In addition, many small scale SEIGs, instead of a single large one, are applied and devoted to promote the generation efficiency. To begin with, an expandable mathematic model based on a d-q equivalent circuit is created for parallel SEIGs. The control method of the MERS is further improved with the objective of broadening its operating range and restraining current harmonics by parameter optimization. A hybrid control strategy is developed by taking both of the stand-alone and grid-connected modes into consideration. Then simulation and experiments are carried out in the case of single and double SEIG(s) generation. Finally, the measurement results verify that the proposed DGS with SVC-MERS achieves a better stability and higher feasibility. The major advantages of the mentioned variable reactive power supplier, when compared to the STATCOM, include the adoption of a small DC capacitor, line frequency switching, simple control and less loss.

• JSTS:Journal of Semiconductor Technology and Science
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• 제8권2호
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• pp.128-133
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• 2008

Phase-change random access memory (PRAM) chip cell phase of amorphous state is rapidly changed to crystal state above 160 Celsius degree within several seconds during Infrared (IR) reflow. Thus, on-board programming method is considered for PRAM chip programming. We demonstrated the functional 512Mb PRAM with 90nm technology using several novel core circuits, such as metal-2 line based global row decoding scheme, PN-diode cells based BL discharge (BLDIS) scheme, and PMOS switch based column decoding scheme. The reverse-state standby current of each PRAM cell is near 10 pA range. The total leak current of 512Mb PRAM chip in standby mode on discharging state can be more than 5 mA. Thus in the proposed BLDIS control, all bitlines (BLs) are in floating state in standby mode, then in active mode, the activated BLs are discharged to low level in the early timing of the active period by the short pulse BLDIS control timing operation. In the conventional sense amplifier, the simultaneous switching activation timing operation invokes the large coupling noise between the VSAREF node and the inner amplification nodes of the sense amplifiers. The coupling noise at VSAREF degrades the sensing voltage margin of the conventional sense amplifier. The merit of the proposed sense amplifier is almost removing the coupling noise at VSAREF from sharing with other sense amplifiers.

• 한국임상약학회지
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• 제25권4호
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• pp.246-253
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• 2015

Background & Object: Ankylosing spondylitis (AS) is a chronic inflammatory disease that causes ankylosis and deformation of axial joints. Since current medicine cannot cure the disease yet, alleviating pain and preventing deformation with medications are the main therapy for patients with AS. The key medications for these purposes include nonsteroidal anti-inflammatory drugs (NSAIDs), and tumor necrosis $factor-{\alpha}$ ($TNF-{\alpha}$) inhibitors. This study aims to analyze prescribing patterns of AS patients in South Korea. Method: National Patients Sample data compiled by the Health Insurance Review and Assessment Service from 2013 was analyzed. Patients with AS were identified with Korean Standard Classification of Diseases code-6, which was M45. The rates of prescription, discontinuation, and switching ingredients were calculated for each medication during 2013. Results: Total number of patients was 655, and most of them were male (n = 514, 78.5%). Of all age groups, the proportion of 30-40 year old patients was the greatest (35.1%). The most utilized drug class was NSAIDs (82.4%). Less than half of patients were prescribed $TNF-{\alpha}$ inhibitors (n = 212, 32.4%). Meloxicam, aceclofenac, and celecoxib were the most frequently prescribed NSAIDs. In case of $TNF-{\alpha}$ inhibitors, adalimumab, etanercept and infliximab were the top three most prescribed drugs. Although not recommended by the current practice guideline, significant proportions of patients were identified using disease modifying anti-rheumatic drugs (DMARDs). Conclusion: Considering the current practice guideline and previous studies about the efficacy, the use of DMARDs should be reduced and medical insurance term in South Korea should be re-examined.

• 화약ㆍ발파
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• 제28권1호
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• pp.19-26
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• 2010

이 논문은 필리핀 석회석 광산에 적용한 연구 결과로서 이 광산에서는 파쇄석 입도분포가 좋지 않고 벽면의 유지나 파쇄석 더미의 분산이 불량하였다. 기폭패턴을 대각선 방식에서 V 타입으로 바꾸고 전색장을 조정하여 저항과 가스압의 유지기간을 향상시켰다. 이를 통하여 발파결과가 향상되었다. 특히 공당발파영역이 넓어진 것으로써 그 성과를 확인할 수 있다. 공당발파영역은 기존의 $8.96m^2$에서 $12m^2$로 넓어졌다. 화약계수는 증가하였고 대괴의 수는 감소하였으며, 전방적재기의 행정시간이 감소하였다. 또 공전 시간이 줄었으며 적재높이가 향상되었다.

• 방송공학회논문지
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• 제19권6호
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• pp.826-835
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• 2014

최근 공간 상관성이 존재하는 채널상황에서 수신 성능을 향상시킬 수 있는 공간 변조(spatial modulation, SM) 기법이 활발히 연구되고 있다. 공간 변조 기법은 수신된 신호들 간의 간섭을 제거하기 위하여 여러 개의 송신안테나 중에서 일부만을 이용하여 신호를 전송하고, 안테나 조합에 따라 추가적인 정보를 전송할 수 있다. 따라서 공간 변조 기법을 사용하여 기존 다중안테나(multi-input multi-output, MIMO) 시스템에 적용하면 도심무선채널환경의 상관성에 의한 간섭을 극복할 수 있다. 그러나 상관성이 존재하는 도심무선채널환경에서 공간 변조 기법들의 수신 성능 분석이 정확하게 이루어지지 않고 있다. 그러므로 본 논문에서는 상관성을 가진 도심 채널 모델에서 여러가지 공간 변조 기법들의 수신 성능 및 채널효율을 분석하고, 도심무선채널환경에 적합한 공간 변조 시스템을 제안한다.

• 한국미생물·생명공학회지
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• 제21권4호
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• pp.354-365
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• 1993

A novel control method with automatic tuning of PID controller parameters has been developed for efficient regulation of dissolved oxygen concentration in fed-batch fermentations of Escherichia coli. Agitation speed and oxygen partial pressure in the inlet gas stream were chosen to be the manipulated variables. A heuristic reasoning allowed improved tuning decisions from the supervision of control performance indices and it coule obviate the needs for process assumptions or disturbance patterns. The control input consisted of feedback and feedforword parts. The feedback part was determined by PID control and the feedforward part is determined from the feed rate. The proportional gain was updated on-line by a set of heuristics rules based on the supervision of three performance indices. These indices were output error covariance, the average value of output error, and input covariance, which were calculated on-line using a moving window. The integral and derivative time constants were determined from the period of output response. The specific growth rate was maintained at a low level to avoid acetic acid accumulation and thus to achieve a high cell density. The specific growthe rate was estimated from the carbon dioxide evolution rate. In fed-batch fermentation, the simutaneous control of dissolved oxygen concentration (at 0.2; fraction of saturated value) and specific growth rate (at 0.25$hr^{-1}$) was satisfactory for the entire culture period in spite of the changes in the feed rate and the switching of control input.

• 생물정신의학
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• 제10권2호
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• pp.141-146
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• 2003

Objective:To find out the optimal assessment that can relieve amenorrhea associated with risperidone. Methods:Sixteen female outpatients who have taken risperidone for more than 3 months reported voluntarily amenorrhea during Nov 2001 to May 2002. Since the reports of the amenorrhea, the resolution of amenorrhea has been prospectively followed during the next six months. The dosage of risperidone was reduced or discontinued in nine of sixteen patients, while risperidone was switched to olanzapine or quetiapine in other 7 patients according to the clinician's decision. Results:Fourteen of 16 patients showed higher levels of prolactin than normal level. Five patients of the risperidone-reduction group recovered from the amenorrhea while all subjects of the drug-switch group recovered. The resolved patients of the former group recovered from amenorrhea in the dosage below 3mg per day of risperidone. Two patients of the risperidone-reduction group were dropped out during the reduction. Conclusion:These findings suggest that risperidone-induced amenorrhea may be alleviated by reducing dosage to less 3mg per day(including discontinuation) or by switching to other antipsychotic drugs. Whether we would choose which method depends on patient's clinical status, diagnosis, and dose of medication and so on.

• Biomolecules & Therapeutics
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• 제16권3호
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• pp.255-260
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• 2008

The purpose of this study was to evaluate the bioequivalence of the test (Daewoo Hydrocortisone 10 mg, Daewoo Pharm. Co., Busan, Korea) and reference (Jenapharm Hydrocortisone 10 mg, JayTech Biogen, Seoul, Korea) hydrocortisone tablets. Twenty-four healthy male Korean volunteers were divided into two groups with a randomized $2{\times}2$ cross-over design. In order to suppress the endogenous cortisol secretion, a single oral dose of Dexamethasone (4 mg) was administered 10 hr prior to hydrocortisone administration. Blood samples were withdrawn for 10 hr at the predetermined intervals after a single oral dose of hydrocortisone (20 mg). The serum concentration of hydrocortisone was analyzed by HPLC/UV using a column switching method after liquid-liquid extraction process. The pharmacokinetic parameters ($AUC_{0{\sim}10hr}$, $C_{max}$, and $T_{max}$) of the test and reference hydrocortisone tablets were determined while the secretion of endogenous cortisol was being suppressed. The pharmacokinetic parameters of the test tablet were not statistically different from those of the reference tablet at ex value was 0.05. The 90% confidence intervals for the average ratio (test/reference) of $AUC_{0{\sim}10hr}$ and $C_{max}$ were within the Korea Food and Drug Administration acceptance range of 0.80-1.25 ($0.89{\sim}0.99$ and $0.86{\sim}0.99$ for $AUC_{0{\sim}10hr}$ and $C_{max}$, respectively). Therefore it was concluded that the test tablet, Daewoo Hydrocortisone tablet was bioequivalent to the reference tablet, Jenapharm Hydrocortisone tablet.

• 멤브레인
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• 제20권1호
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• pp.8-12
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• 2010

전도성 고분자 중 안정성이 높은 Poly(3,4-ethylenedioxythiophene) (PEDOT)을 이용하여 전기변색 박막을 제조하고 박막제조 방법에 따른 전기변색 특성을 연구하였다. PEDOT 박막은 전기중합법과 증기중합법에 의해 제조되었고, 두가지 방법 모두 도핑되지 않은 중성 상태에서 짙은 푸른색을 띠는 박막으로 제조되었다. 전기변색 특성을 평가하기 위하여 UV-Vis spectrophotometer와 Cyclic voltammetry가 사용되었으며, 산화/환원 시 표면은 AFM으로 관찰되었다. 전기 중합법으로 제조된 PEDOT 박막에 비해 증기중합에 방법에 의해 제작된 PEDOT 박막의 표면이 거칠기 50 nm 이내로 균일 하였다. 특히 증기 중합법을 이용하여 제조된 전기 변색 소재의 특성도 응답성 1.5초 이내, 49%의 투과율 차이, 402의 변색 효율을 보여 박막의 특성 향상으로 전기변색특성이 향상 된 결과를 보였다.