• Clinical and Experimental Pediatrics
• /
• 제56권3호
• /
• pp.101-106
• /
• 2013

Despite developments in surgical techniques and other interventions, right ventricular (RV) failure remains an important clinical problem in several congenital heart diseases (CHD). RV function is one of the most important predictors of mortality and morbidity in patients with CHD. RV failure is a progressive disorder that begins with myocardial injury or stress, neurohormonal activation, cytokine activation, altered gene expression, and ventricular remodeling. Pressure-overload RV failure caused by RV outflow tract obstruction after total correction of tetralogy of Fallot, pulmonary stenosis, atrial switch operation for transposition of the great arteries, congenitally corrected transposition of the great arteries, and systemic RV failure after the Fontan operation. Volume-overload RV failure may be caused by atrial septal defect, pulmonary regurgitation, or tricuspid regurgitation. Although the measurement of RV function is difficult because of many reasons, the right ventricle can be evaluated using both imaging and functional modalities. In clinical practice, echocardiography is the primary mode for the evaluation of RV structure and function. Cardiac magnetic resonance imaging is increasingly used for evaluating RV structure and function. A comprehensive evaluation of RV function may lead to early and optimal management of RV failure in patients with CHD.

• BMB Reports
• /
• 제38권3호
• /
• pp.266-274
• /
• 2005

High temperature requirement A (HtrA) and its homologues constitute the HtrA familiy proteins, a group of heat shock-induced serine proteases. Bacterial HtrA proteins perform crucial functions with regard to protein quality control in the periplasmic space, functioning as both molecular chaperones and proteases. In contrast to other bacterial quality control proteins, including ClpXP, ClpAP, and HslUV, HtrA proteins contain no regulatory components or ATP binding domains. Thus, they are commonly referred to as ATP-independent chaperone proteases. Whereas the function of ATP-dependent chaperone-proteases is regulated by ATP hydrolysis, HtrA exhibits a PDZ domain and a temperature-dependent switch mechanism, which effects the change in its function from molecular chaperone to protease. This mechanism is also related to substrate recognition and the fine control of its function. Structural and biochemical analyses of the three HtrA proteins, DegP, DegQ, and DegS, have provided us with clues as to the functional regulation of HtrA proteins, as well as their roles in protein quality control at atomic scales. The objective of this brief review is to discuss some of the recent studies which have been conducted regarding the structure and function of these HtrA proteins, and to compare their roles in the context of protein quality control.

• 경영과정보연구
• /
• 제2권
• /
• pp.335-354
• /
• 1998

In this study I construct CAN(Controller Area Network) for automobiles similar to LAN(Local Area Network) and build communication modules in the major part of an automobile to link several sub-systems. Since each station replaces the communication function of sub-systems and has various types of sensor, actuator, controller, and switch, every information about automobile's status is obtained from the network. The manufactured system showed a superior capability. The following is the contents of study. 1. The definition of communication packet through the analysis of CAN protocol. 2. The Design of modules using micro-controller 80C196CA. 3. The Network configuration.

• 전자공학회논문지B
• /
• 제31B권3호
• /
• pp.53-59
• /
• 1994

A new fully differential sample-and-hold circuit which can effectively compensate the offset voltage of an operational amplifier and the charge injection of a MOS switch is presented. The proposed circuit shows a true sample-and-hold function without a reset period or an input-track period. The prototype fabricated using a 1.2$\mu$m double-polysilicon CMOS process occupies an area of 550$\mu$m$\times$288$\mu$m and the error of the sampled ouput is 0.056% on average for 3V input at DC.

• 한국디자인학회:학술대회논문집
• /
• 한국디자인학회 2000년도 추계 학술발표대회 논문집
• /
• pp.8-9
• /
• 2000

기존의 자동차 인테리어 디자인은 인간공학적이나 스타일링을 위주로 하는 경우가 많았다. 그러나 본 연구는 운전자의 '사용성' 이라는 측면에서 운전부를 중심으로 운행에 관계된 이그니션콘트롤(ignition control), 멀티펑션스위치(multi function switch)와 차량의 상태를 알려주는 클러스터게이지(cluster gauge)를 중심으로 조사해 보았다. (중략)

• 대한전기학회:학술대회논문집
• /
• 대한전기학회 2005년도 제36회 하계학술대회 논문집 D
• /
• pp.3034-3036
• /
• 2005

High speed PC-based digital I/O system, PCI-bus master and slave. set is developed, which features are distributed structure, input/output function interchangeability by switch settings, and high speed(20Mbps). Library and application software for a DIO system that have a secure and a convenient functionality are developed.

• 대한전기학회:학술대회논문집
• /
• 대한전기학회 2005년도 제36회 하계학술대회 논문집 D
• /
• pp.3031-3033
• /
• 2005

High speed PC-based digital I/O system hardware, PCI-bus master and slave set is developed, which features are distributed structure, input/output function interchangeability by switch setting, high speed 20Mbps to update 1000 points in less than 1 ms, etc.

• 제어로봇시스템학회:학술대회논문집
• /
• 제어로봇시스템학회 1995년도 Proceedings of the Korea Automation Control Conference, 10th (KACC); Seoul, Korea; 23-25 Oct. 1995
• /
• pp.436-439
• /
• 1995

In this paper we present a method to construct fuzzy model with multi-dimension input membership function, which can construct fuzzy inference system on one node of the network directly. This method comes from a common framework called Universal Learning Network (ULN). The fuzzy model under the framework of ULN is called Universal Learning Network-based Fuzzy Inference System (ULNFIS), which possesses certain advantages over other networks such as neural network. We also introduce how to imitate a real system with ULN and a control scheme using ULNFIS.

• 한국통신학회:학술대회논문집
• /
• 한국통신학회 1986년도 춘계학술발표회 논문집
• /
• pp.134-137
• /
• 1986

The Remote Subscriber Switch system was developed for a purpose of expanding th service area of TDX-1, for a small group of remote subscribers. RSS system capacity of 512 subscriber, is connected directly to TDX-over 5 T1 carrier lines. This paper describes the RSS system architecture and major function of RSS.

• Investigative Magnetic Resonance Imaging
• /
• 제22권1호
• /
• pp.26-36
• /
• 2018

Purpose: Children born with single ventricle physiology demonstrate poor growth rate and suffer from malnutrition, which lead to increased morbidity and mortality in this population. We assume that an anabolic steroid, oxandrolone, will promote growth in these infants by improving myocardial energy utilization. The purpose of this paper is to study the efficacy of oxandrolone on myocardial energy consumption in these infants. Materials and Methods: We modeled single ventricle physiology in a lamb by prenatally shunting the aorta to the pulmonary artery and then postnatally, we monitored cardiac energy utilization by quantitatively measuring the first order reaction rate constant, $k_f$ of the creatine-kinase reaction in the heart using magnetization transfer $^{31}P$ magnetic resonance spectroscopy, home built $^1H/^{31}P$ transmit/receive double tuned coil, and transmit/receive switch. We also performed cine MRI to study the structure and dynamic function of the myocardium and the left ventricular chamber. The spectroscopy data were processed using home-developed python software, while cine data were analyzed using Argus software. Results: We quantitatively measured both the first order reaction rate constant and ejection fraction in the control, shunted, and the oxandrolone-treated lambs. Both $k_f$ and ejection fraction were found to be more significantly reduced in the shunted lambs compared to the control lambs, and they are increased in oxandrolone-treated lambs. Conclusion: Some improvement was observed in both the first order reaction rate constant and ejection fraction for the lamb treated with oxandrolone in our preliminary study.