• Korean Journal of Biological Psychiatry
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• v.13 no.1
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• pp.32-37
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• 2006

Background : Several studies have suggested that alterations of cytokine level could be related to the pathophysiology of bipolar disorder. In this study, we measured plasma level of Interleukin-12(IL-12), a pro-inflammatory cytokine and transforming growth factor-${\beta}$1(TGF-${\beta}$1), an anti-inflammatory cytokine before and after treatment in acute manic patients. Methods : The plasma concentrations of IL-12 and TGF-${\beta}$1 were measured using quantitative ELISA in 18 bipolar disorder patients and 25 normal controls at admission and 6 weeks later. The psychopathology was measured by Brief Psychiatric Rating Scale(BPRS) and Young Mania Rating Scale(YMRS). Results : IL-12 levels were significantly higher in bipolar manic patients than in controls before treatment. Following the 6-week treatment, the IL-12 level was decreased than before treatment, but sustained still higher level than normal control. TGF-${\beta}$1 level was not significant different between manic patients and normal controls before treatment, but was increased after treatment comparing with before treatment in bipolar patients. The ratio of IL-12 and TGF-${\beta}$1 was significantly decreased after treatment. Conclusion : Cytokine abnormalities in bipolar disorder might be involved in the pathophysiology of the illness. It is possible that TGF-${\beta}$1 plays an important role in the regulation of immunological imbalance in bipolar disorder.

• Macromolecular Research
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• v.11 no.5
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• pp.334-340
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• 2003

In order to fabricate new sustained delivery device of nerve growth factor (NGF), we developed NGF-loaded biodegradable poly(L-lactide-co-glycolide) (PLGA, the mole ratio of lactide to glycolide 75:25, molecular weight: 83,000 and 43,000 g/mole, respectively) film by novel and simple sandwich solvent casting method for the possibility of the application of neural tissue engineering. PLGA was copolymerized by direct condensation reaction and the molecular weight was controlled by reaction time. Released behavior of NGF from NGF-loaded films was characterized by enzyme linked immunosorbent assay (ELISA) and degradation characteristics were observed by scanning electron microscopy (SEM) and gel permeation chromatography (GPC). The bioactivity of released NGF was identified using a rat pheochromocytoma (PC-12) cell based bioassay. The release of NGF from the NGF-loaded PLGA films was prolonged over 35 days with zero-order rate of 0.5-0.8 ng NGF/day without initial burst and could be controlled by the variations of molecular weight and NGF loading amount. After 7 days NGF released in phosphate buffered saline and PC-12 cell cultured on the NGF-loaded PLGA film for 3 days. The released NGF stimulated neurite sprouting in cultured PC-12 cells, that is to say, the remained NGF in the NGF/PLGA film at 37 $^{\circ}C$ for 7 days was still bioactive. This study suggested that NGF-loaded PLGA sandwich film is released the desired period in delivery system and useful neuronal growth culture as nerve contact guidance tube for the application of neural tissue engineering.

• KOREAN JOURNAL OF CROP SCIENCE
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• v.39 no.5
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• pp.453-457
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• 1994

Six local strains collected in Korea and one cultivar (Samdo) introduced from Japan were applied for comparative cultivation to investigate growth characteristics, root yield potentials and saikosaponin contents of root in Bupleurum falcatum L. The one and two year old plants of the native local strains flowered in August 2~3 and July 16~18, respectively, whereas Samdo was late flowering type, being delayed by 18~32days and sustained the growth of above ground parts to the end of November. All the native local strains have similiar characteristics but Samdo was completely different in plant and root type. Local strain collected from Chunchon showed better in growth and root characteristics, consequently resulting high yield of dry roots and saikosaponin contents in both one and two year old plants. The average yield of two year cultivation system was 2.6 times high as 105Kg /10a, compared with that of one year.

• KDI Journal of Economic Policy
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• v.14 no.2
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• pp.155-187
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• 1992

The Korean economy has sustained high growth rate for almost three decades, that have been associated with the rapid expansion of manufacturing industries. In the beginning stage of development, the high growth of the Korean economy has been based on improvements in productivity obtained by the economies of scale. In that period, the improvements in productivity could be secured by the economies of scale in the export-oriented industries which are the labor- and material-intensive industries. In the latter half of the 1980s, the Korean economy went through rapid transition. Now Korea is at another juncture in its development process, where economic restructuring is critical to sustain high growth. However, economic restructuring in the 1990s call for much more concerted effort than before, since changes in internal and external conditions have profoundly altered the environment for economic development. If Korea is to sustain high growth in the 1990s, it has to promote balanced economic and social development in coordination with the smooth facilitation of industrial restructuring. There are no inherent conflicts among the issues involved, so they can be resolved by restructuring the economy to facilitate, in a global context, the development of knowledge- and technology-intensive activities and to ensure that the benefts of growth are reflected of qualitative improvements in national living standards. In this paper, we examined a scenario of structural changes using a mid- and long-term multisector model, in order to understand the conditions needed for realizing the growth potential. This examination explains the important features of the development course and policy directions that will help sustain high growth in the 1990s.

• Journal of Aquaculture
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• v.21 no.4
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• pp.272-277
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• 2008

We investigated the growth and survival in seedling production, and growth performance was compared with the different rearing tanks and protein source of formulated feed for juvenile Pacific bluefin tuna Thunnus orientalis (PBT). The survival rate at the end of nursery culture at 30 days after hatching was $0.69{\pm}0.40%$, and total length and mean body weight were $49.83{\pm}2.52\;mm$ and $1.03{\pm}0.09\;g$, respectively. Growth performance has no significant difference in fish reared by different tanks forms for 10 days. In order to develop an artificial diet, we evaluated the dietary utility of enzyme treated fish meal (Bio-CP, BIO) for juvenile PBT. Only diet BIO sustained similar growth and higher feed efficiency, and final carcass lipid content as compared to those of Sand lance (SL) These results revealed that BIO-CP a suitable dietary protein source, could sustain growth of PBT.

• The korean journal of orthodontics
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• v.27 no.2
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• pp.181-196
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• 1997

The purpose of this study was to describe growth changes of soft tissue profile in koreans with normal occlusion and to get differences between male and female. The biennial serial cephalometric radiographs of 26 samples (15 males, 11 females) with normal occlusion from 8.5 years to 18.5 years of age were used in this study. The following results were obtained : 1. Both sexes had lower facial parts more protruded at 18.5 years of age than 8.5 years of age : in total facial convexity angle, male showed a decrease(P<0.01) and female showed no significant difference(P>0.05). 2. In the growth changes of soft tissue thickness, male outgrew female in the areas of nose and upper and lower lips, and female outgrew male in the pogonion area 3. In the growth changes of upper facial height and upper part of lower facial height, male's was higher than female's growth (P<0.05). 4. The ratio of the upper facial height over the lower facial height showed a decrease at 18.5 years of age than 8.5 years of age(P<0.01). The ratio of upper vs lower part of lower facial height and that of upper lip height vs lower lip height showed no significant difference(P>0.05). 5. Male showed a sustained change into older age compared with female in soft tissue profiles.

• Clinical and Experimental Pediatrics
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• v.52 no.11
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• pp.1249-1259
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• 2009

Purpose:From a societal perspective, we evaluated the cost-effectiveness of a novel sustained-release injection of recombinant human growth hormone (GH) administered on a weekly basis compared with that of the present daily GH injection for the treatment of children with GH deficiency. Methods:Health-related utility for GH therapy was measured based on the visual analogue scale. During July 2008, caregivers of 149 children receiving GH therapy form 2 study sites participated in a web-based questionnaire survey. The survey required the caregivers to rate their current subjective utility with daily GH injections or expected utility of weekly GH injections. Because there was no difference in the costs of the daily and weekly therapies, for the purposes of this study, only drug acquisition costs were considered. Results:Switching from daily to weekly injection of GH increased the utility from 0.584 to 0.784 and incurred an extra cost of 4,060,811 Korean won (KW) per year. The incremental cost-utility ratio (ICUR) for a base case was 20,305,055 KW per quality-adjusted life year (QALY) gained. Scenario analyses showed that the ICUR ranged from 15,751,198 to 25,489,929 KW per QALY. Conclusion:The ICUR for a base case and worst case scenario analyses ranged from 0.85 to 1.37-times per capita gross domestic product of Korea, which is considered to be within the generally accepted willingness-to-pay threshold. Thus, it is concluded that switching from daily to weekly injection of GH would be cost-effective.

• Environmental Mutagens and Carcinogens
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• v.26 no.1
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• pp.1-6
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• 2006

To enhance our understanding of toxicity mediated through the pathway by which TCDD stimulates gene expression, we have investigated genes whose expressions are changed after treatment with TCDD and/or MNNG in human Chang liver cell. First, we treated with MNNG and TCDD for two weeks to transform human Chang liver cell. We obtained cell looks like to be transformed and compared the differential gene expression by using cDNA chip (Macrogen) which carrys genes related with signal transduction pathways, oncogenes and tumor suppressor genes, etc. We found that TCDD up- or down-regulated 203 and 111 genes including oncogenes and tumor suppressor genes in human Chang liver cell two fold or more, respectively. Second, we compared the differential gene expression after treatment with TCDD only by using cDNA chip (Superarray) which carrys genes related with cell cycle regulations, and found that TCDD up regulated genes related with cell proliferation as well as cell growth inhibition in human Chang liver cell two fold or more, respectively. These results suggest that toxicity induced by TCDD may reflect sustained alterations in the expression of many genes and that the changes reflect both direct and indirect effects of TCDD.

• Journal of Environmental Science International
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• v.9 no.6
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• pp.449-454
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• 2000

Sustainable development has been the key concept, both in economic policies and in environmental management. On the basis of an systems ecology perspective, this suggests the sustainable development of Korea\`s natural environment and economic activity using the EMERGY evaluation. The total EMERGY use(7,730E20sej/yr) in Korea is 81 percent from imported sources, fuels and goods and services. The ratio of outside investment to attracting natural resources is already large, like other industrialized countries. Continued availability of purchased inputs at a favorable balance of EMERGY trade, currently about 2.85 to 1 net EMERGY, tis the basis for present economic activity and must decrease as the net EMERGY of purchased inputs including fossil fuels goes down. EMERGY yield ratio and environmental loading ratio were 1.23 and 20.30, respectively. The population level is already in excess of carrying capacity. Its carrying capacity for steady state on its renewable sources is only 2.2 million people, compared to 45.9 million in 1977. EMERGY sustainability index is therefore less than one, which is indicative of highly developed consumer oriented economies. Until now the development of a country has been achieved by the economic growth, but it can be sustained in the long run by the use of renewable resource systems. the efficiency of energy usage, and the transformation of the social-economic structure based on an ecological-recycling concept.

• Journal of The Korean Digital Architecture Interior Association
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• v.4 no.2
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• pp.35-43
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• 2004

Transformations of the urban spatial structure, from sub-area redevelopment to newtown development, results great influences upon existing urban condition and spatial configuration. The purpose of the study is to analyse the effect of the urban spatial configuration of Uijongbu city where experienced changes after newly development of city center and new residential area. The west part of the city where is limited in growth by military bases, ego U.S Army basecamp, were planned and established as the other axis of the city center since mid 1980's. After that new residential area which is located in far east of the city were also developed. Space syntax as a methodology has been adopted to conduct quantitative analysis which is able to interpret differences between sub-areas ; old city center, new city center, new residential area. The results of the analysis are follows ; 1) existing structure of the urban fabric, especially old city center, is sustained and intensified, 2) new city center which is west part of the city has failed to achieve organic spatial connection adjacent to old city center, 3) there is less spatial depecdency relationship between city center and new residential area where is identified as another small self-support city within the city.